About the Authors

Connor A. Emdin

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America

Mary E. Haas

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliations Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America

Amit V. Khera

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliations Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America

Krishna Aragam

Roles Formal analysis, Investigation, Writing – review & editing

Affiliations Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America

Mark Chaffin

Roles Investigation, Writing – review & editing

Affiliation Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America

Derek Klarin

Roles Data curation, Formal analysis, Investigation, Validation, Writing – review & editing

Affiliation Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America

George Hindy

Roles Data curation, Formal analysis, Validation, Writing – review & editing

Affiliation Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America

Lan Jiang

Roles Data curation, Formal analysis, Investigation, Validation, Writing – review & editing

Affiliations Departments of Biomedical Informatics, Vanderbilt University, Vanderbilt, Tennessee, United States of America, Departments of Medicine, Vanderbilt University, Vanderbilt, Tennessee, United States of America

Wei-Qi Wei

Roles Data curation, Investigation, Writing – review & editing

Affiliation Departments of Biomedical Informatics, Vanderbilt University, Vanderbilt, Tennessee, United States of America

Qiping Feng

Roles Data curation, Formal analysis, Investigation, Validation, Writing – review & editing

Affiliation Departments of Medicine, Vanderbilt University, Vanderbilt, Tennessee, United States of America

Juha Karjalainen

Roles Data curation, Formal analysis, Investigation, Validation, Writing – review & editing

Affiliations Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, FI, Helsinki, Finland

Aki Havulinna

Roles Data curation, Formal analysis, Investigation, Validation, Writing – review & editing

Affiliation Institute for Molecular Medicine Finland (FIMM), University of Helsinki, FI, Helsinki, Finland

Tuomo Kiiskinen

Roles Validation, Writing – review & editing

Affiliation Institute for Molecular Medicine Finland (FIMM), University of Helsinki, FI, Helsinki, Finland

Alexander Bick

Roles Data curation, Formal analysis, Investigation, Writing – review & editing

Affiliation Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America

Diego Ardissino

Roles Data curation, Formal analysis, Funding acquisition, Project administration, Writing – review & editing

Affiliations Division of Cardiology, Azienda Ospedaliero–Universitaria di Parma, Parma, Italy, Associazione per lo Studio Della Trombosi in Cardiologia, Pavia, Italy

James G. Wilson

Roles Data curation, Funding acquisition, Project administration, Writing – review & editing

Affiliation Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, United States of America

Heribert Schunkert

Roles Data curation, Funding acquisition, Project administration, Writing – review & editing

Affiliation Deutsches Herzzentrum München, Technische Universität München, Deutsches Zentrum für Herz-Kreislauf-Forschung, München, Germany

Ruth McPherson

Roles Data curation, Formal analysis, Funding acquisition, Project administration, Writing – review & editing

Affiliation University of Ottawa Heart Institute, Ottawa, Ontario, Canada

Hugh Watkins

Roles Data curation, Funding acquisition, Project administration, Writing – review & editing

Affiliations Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

Roberto Elosua

Roles Data curation, Funding acquisition

Affiliations Cardiovascular Epidemiology and Genetics, Hospital del Mar Research Institute, Barcelona, Spain, CIBER Enfermedades Cardiovasculares (CIBERCV), Barcelona, Spain, Facultat de Medicina, Universitat de Vic-Central de Cataluña, Vic, Spain

Matthew J. Bown

Roles Data curation, Funding acquisition, Investigation, Writing – review & editing

Affiliation Department of Cardiovascular Sciences, University of Leicester, and NIHR Leicester Biomedical Research Centre, Leicester, United Kingdom

Nilesh J. Samani

Roles Data curation, Formal analysis, Investigation, Writing – review & editing

Affiliation Department of Cardiovascular Sciences, University of Leicester, and NIHR Leicester Biomedical Research Centre, Leicester, United Kingdom

Usman Baber

Roles Data curation, Formal analysis, Writing – review & editing

Affiliation The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America

Jeanette Erdmann

Roles Data curation, Formal analysis, Investigation, Writing – review & editing

Affiliations Institute for Cardiogenetics, University of Lübeck, Lübeck, Germany, DZHK (German Research Centre for Cardiovascular Research), partner site Hamburg/Lübeck/Kiel, Lübeck, Germany

Namrata Gupta

Roles Data curation, Formal analysis, Funding acquisition, Writing – review & editing

Affiliation Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America

John Danesh

Roles Data curation, Formal analysis, Investigation, Writing – review & editing

Affiliations Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom, Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom, National Institute of Health Research Blood and Transplant; Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, United Kingdom

Danish Saleheen

Roles Data curation, Formal analysis, Writing – review & editing

Affiliations Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Center for Non-Communicable Diseases, Karachi, Pakistan

Kyong-Mi Chang

Roles Data curation, Formal analysis, Investigation, Writing – review & editing

Affiliation Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Marijana Vujkovic

Roles Data curation, Formal analysis, Investigation, Writing – review & editing

Affiliation Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Ben Voight

Roles Data curation, Formal analysis, Writing – review & editing

Affiliation Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Scott Damrauer

Roles Data curation, Funding acquisition, Investigation, Project administration, Writing – review & editing

Affiliation Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Julie Lynch

Roles Data curation, Investigation, Writing – review & editing

Affiliation Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

David Kaplan

Roles Data curation, Formal analysis, Writing – review & editing

Affiliation Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Marina Serper

Roles Data curation, Formal analysis, Project administration, Writing – review & editing

Affiliation Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Philip Tsao

Roles Data curation, Formal analysis, Writing – review & editing

Affiliation Veterans Affairs Palo Alto Health Care System, Palo Alto, California, United States of America

Million Veteran Program
Josep Mercader

Roles Data curation, Formal analysis, Investigation, Writing – review & editing

Affiliations Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America

Craig Hanis

Roles Data curation, Formal analysis, Writing – review & editing

Affiliation Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America

Mark Daly

Roles Data curation, Formal analysis, Investigation, Writing – review & editing

Affiliation Institute for Molecular Medicine Finland (FIMM), University of Helsinki, FI, Helsinki, Finland

Joshua Denny

Roles Data curation, Formal analysis, Investigation, Writing – review & editing

Affiliations Departments of Biomedical Informatics, Vanderbilt University, Vanderbilt, Tennessee, United States of America, Departments of Medicine, Vanderbilt University, Vanderbilt, Tennessee, United States of America

Stacey Gabriel

Roles Data curation, Formal analysis, Investigation, Project administration, Writing – review & editing

Affiliation Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America

Sekar Kathiresan

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

skathiresan@vervetx.com

Affiliations Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Verve Therapeutics, Boston, Massachusetts, United States of America

Competing Interests

CAE reports consulting fees from Navitor Pharma, Novartis and Deerfield Management. AVK has received research grants from IBM Research and the Novartis Institute for Biomedical Research and has served as a consultant to or received honoraria from Color Genomics, Illumina, Novartis, Maze Therapeutics, and Navitor Pharmaceuticals; and has a patent related to a genetic risk predictor (20190017119). SK is an employee of Verve Therapeutics and has received a research grant from Bayer Healthcare; and consulting fees from Merck, Novartis, Sanofi, AstraZeneca, Alnylam Pharmaceuticals, Leerink Partners, Noble Insights, MedGenome, Aegerion Pharmaceuticals, Regeneron Pharmaceuticals, Quest Diagnostics, Color Genomics, Genomics PLC, and Eli Lilly and Company; and holds equity in San Therapeutics, Catabasis Pharmaceuticals, Verve Therapeutics and Maze Therapeutics. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.