About the Authors

Laura M. Raffield

Contributed equally to this work with: Laura M. Raffield, Jacob C. Ulirsch, Rakhi P. Naik

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America

Jacob C. Ulirsch

Contributed equally to this work with: Laura M. Raffield, Jacob C. Ulirsch, Rakhi P. Naik

Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

Affiliations Division of Hematology/Oncology, The Manton Center for Orphan Disease Research, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

Rakhi P. Naik

Contributed equally to this work with: Laura M. Raffield, Jacob C. Ulirsch, Rakhi P. Naik

Roles Conceptualization, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Hematology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America

Samuel Lessard

Roles Formal analysis, Investigation, Methodology

Affiliations Department of Medicine, Université de Montréal, Montréal, Quebec, Canada, Montreal Heart Institute, Montréal, Quebec, Canada

Robert E. Handsaker

Roles Data curation, Methodology, Resources, Writing – review & editing

Affiliations Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

Deepti Jain

Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing

Affiliation Department of Biostatistics, University of Washington, Seattle, Washington, United States of America

Hyun M. Kang

Roles Data curation, Resources, Writing – review & editing

Affiliation Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America

Nathan Pankratz

Roles Writing – review & editing

Affiliation Department of Laboratory Medicine & Pathology, School of Medicine, University of Minnesota, Minneapolis, Minnesota, United States of America

Paul L. Auer

Roles Writing – review & editing

Affiliation Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, United States of America

Erik L. Bao

Roles Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing

Affiliations Division of Hematology/Oncology, The Manton Center for Orphan Disease Research, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

Joshua D. Smith

Roles Data curation, Resources, Writing – review & editing

Affiliation Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

Leslie A. Lange

Roles Writing – review & editing

Affiliation Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, United States of America

Ethan M. Lange

Roles Writing – review & editing

Affiliation Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, United States of America

Yun Li

Roles Funding acquisition, Supervision, Writing – review & editing

Affiliations Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America, Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina, United States of America, Department of Computer Science, University of North Carolina, Chapel Hill, North Carolina, United States of America

Timothy A. Thornton

Roles Writing – review & editing

Affiliation Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America

Bessie A. Young

Roles Writing – review & editing

Affiliations Division of Nephrology, Department of Medicine, University of Washington, Seattle, Washington, United States of America, Seattle Epidemiologic Research and Information Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, United States of America

Goncalo R. Abecasis

Roles Data curation, Resources, Supervision, Writing – review & editing

Affiliation Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, United States of America

Cathy C. Laurie

Roles Data curation, Resources, Supervision, Writing – review & editing

Affiliation Department of Biostatistics, University of Washington, Seattle, Washington, United States of America

Deborah A. Nickerson

Roles Data curation, Resources, Writing – review & editing

Affiliation Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

Steven A. McCarroll

Roles Methodology, Supervision, Writing – review & editing

Affiliations Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

Adolfo Correa

Roles Supervision, Writing – review & editing

Affiliation Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States of America

James G. Wilson

Roles Supervision, Writing – review & editing

Affiliation Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, United States of America

NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Hematology & Hemostasis, Diabetes, and Structural Variation TOPMed Working Groups

Membership of TOPMed and Hematology & Hemostasis, Diabetes, Structural Variation, and Kidney Function TOPMed Working Group is in included in the Supplemental Material.

Guillaume Lettre

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

‡ GL, VGS, and APR also contributed equally to this work.

Affiliations Department of Medicine, Université de Montréal, Montréal, Quebec, Canada, Montreal Heart Institute, Montréal, Quebec, Canada

Vijay G. Sankaran

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

apreiner@uw.edu (APR); sankaran@broadinstitute.org (VGS)

‡ GL, VGS, and APR also contributed equally to this work.

Affiliations Division of Hematology/Oncology, The Manton Center for Orphan Disease Research, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

Alex P. Reiner

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

apreiner@uw.edu (APR); sankaran@broadinstitute.org (VGS)

‡ GL, VGS, and APR also contributed equally to this work.

Affiliation Department of Epidemiology, University of Washington, Seattle, Washington, United States of America

Competing Interests

The authors have declared that no competing interests exist.