About the Authors

Niedzica Camacho

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Division of Genetics and Epidemiology, The Institute Of Cancer Research, London, United Kingdom, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America, Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America

Peter Van Loo

Roles Methodology, Software, Supervision, Writing – original draft

Affiliations Cancer Genomics Laboratory, The Francis Crick Institute, London, United Kingdom, Department of Human Genetics, University of Leuven, Leuven, Belgium

Sandra Edwards

Roles Investigation, Project administration, Writing – review & editing

Affiliation Division of Genetics and Epidemiology, The Institute Of Cancer Research, London, United Kingdom

Jonathan D. Kay

Roles Investigation, Methodology

Affiliations Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, Cambridge, Cambridgeshire, United Kingdom, Molecular Diagnostics and Therapeutics Group, University College London, London, United Kingdom

Lucy Matthews

Roles Data curation, Investigation, Methodology

Affiliation Division of Genetics and Epidemiology, The Institute Of Cancer Research, London, United Kingdom

Kerstin Haase

Roles Formal analysis, Validation, Writing – review & editing

Affiliation Cancer Genomics Laboratory, The Francis Crick Institute, London, United Kingdom

Jeremy Clark

Roles Investigation, Methodology, Supervision, Writing – review & editing

Affiliation Norwich Medical School, University of East Anglia, Norwich, Norfolk, United Kingdom

Nening Dennis

Roles Investigation, Resources

Affiliation Cancer Genetics Unit, Royal Marsden NHS Foundation Trust, London, United Kingdom

Sarah Thomas

Roles Investigation, Project administration, Resources

Affiliation Cancer Genetics Unit, Royal Marsden NHS Foundation Trust, London, United Kingdom

Barbara Kremeyer

Roles Data curation, Formal analysis

Affiliation Cancer, Ageing and Somatic Mutation, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom

Jorge Zamora

Roles Data curation, Investigation, Software

Affiliation Cancer, Ageing and Somatic Mutation, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom

Adam P. Butler

Roles Project administration, Software, Supervision

Affiliation Cancer, Ageing and Somatic Mutation, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom

Gunes Gundem

Roles Data curation, Project administration

Affiliations Cancer, Ageing and Somatic Mutation, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom, Epidemiology & Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

Sue Merson

Roles Investigation, Resources

Affiliation Division of Genetics and Epidemiology, The Institute Of Cancer Research, London, United Kingdom

Hayley Luxton

Roles Investigation, Resources

Affiliations Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, Cambridge, Cambridgeshire, United Kingdom, Molecular Diagnostics and Therapeutics Group, University College London, London, United Kingdom

Steve Hawkins

Roles Investigation, Resources

Affiliation Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, Cambridge, Cambridgeshire, United Kingdom

Mohammed Ghori

Roles Data curation, Project administration, Software

Affiliation Cancer, Ageing and Somatic Mutation, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom

Luke Marsden

Roles Investigation, Resources

Affiliation Department of Physiology, University of Oxford, Oxford, Oxfordshire, United Kingdom

Adam Lambert

Roles Investigation, Resources

Affiliation Department of Oncology, CRUK/MRC Oxford Institute for Radiation Oncology, Oxford, Oxfordshire, United Kingdom

Katalin Karaszi

Roles Investigation, Resources

Affiliations Department of Oncology, CRUK/MRC Oxford Institute for Radiation Oncology, Oxford, Oxfordshire, United Kingdom, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, Oxfordshire, United Kingdom

Gill Pelvender

Roles Investigation, Resources

Affiliation Nuffield Department of Surgical Sciences, University of Oxford, Oxford, Oxfordshire, United Kingdom

Charlie E. Massie

Roles Investigation, Project administration, Writing – review & editing

Affiliations Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, Cambridge, Cambridgeshire, United Kingdom, CRUK Cambridge Centre, Early Detection Programme, Urological Malignancies Programme, Hutchison-MRC Research Centre, Cambridge, Cambridgeshire, United Kingdom

Zsofia Kote-Jarai

Roles Resources, Supervision

Affiliation Division of Genetics and Epidemiology, The Institute Of Cancer Research, London, United Kingdom

Keiran Raine

Roles Resources, Software

Affiliation Cancer, Ageing and Somatic Mutation, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom

David Jones

Roles Resources, Software

Affiliation Cancer, Ageing and Somatic Mutation, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom

William J. Howat

Roles Investigation, Resources

Affiliation Histopathology and in situ hybridization Research Group, Cancer Research UK Cambridge Institute, Cambridge, Cambridgeshire, United Kingdom

Steven Hazell

Roles Investigation, Resources

Affiliation Cancer Genetics Unit, Royal Marsden NHS Foundation Trust, London, United Kingdom

Naomi Livni

Roles Investigation, Resources

Affiliation Cancer Genetics Unit, Royal Marsden NHS Foundation Trust, London, United Kingdom

Cyril Fisher

Roles Investigation, Resources

Affiliation Cancer Genetics Unit, Royal Marsden NHS Foundation Trust, London, United Kingdom

Christopher Ogden

Roles Investigation, Resources

Affiliation Cancer Genetics Unit, Royal Marsden NHS Foundation Trust, London, United Kingdom

Pardeep Kumar

Roles Investigation, Resources

Affiliation Cancer Genetics Unit, Royal Marsden NHS Foundation Trust, London, United Kingdom

Alan Thompson

Roles Investigation, Resources

Affiliation Cancer Genetics Unit, Royal Marsden NHS Foundation Trust, London, United Kingdom

David Nicol

Roles Investigation, Resources

Affiliation Cancer Genetics Unit, Royal Marsden NHS Foundation Trust, London, United Kingdom

Erik Mayer

Roles Investigation, Resources

Affiliation Cancer Genetics Unit, Royal Marsden NHS Foundation Trust, London, United Kingdom

Tim Dudderidge

Roles Investigation, Resources

Affiliation Cancer Genetics Unit, Royal Marsden NHS Foundation Trust, London, United Kingdom

Yongwei Yu

Roles Investigation, Resources

Affiliation Department of Epidemiology, Second Military Medical University, Shanghai, China

Hongwei Zhang

Roles Investigation, Resources

Affiliation Department of Epidemiology, Second Military Medical University, Shanghai, China

Nimish C. Shah

Roles Investigation, Resources

Affiliation Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, United Kingdom

Vincent J. Gnanapragasam

Roles Investigation, Resources, Supervision

Affiliation Academic Urology Group, Department of Surgery, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom

The CRUK-ICGC Prostate Group

Membership of the CRUK-ICGC Prostate Group is provided in S3 Appendix.

William Isaacs

Roles Resources

Affiliation School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America

Tapio Visakorpi

Roles Data curation, Resources

Affiliation Faculty of Medicine and Life Sciences and BioMediTech Institute, University of Tampere and Tampere University Hospital, Tampere, Finland

Freddie Hamdy

Roles Investigation, Resources

Affiliation Nuffield Department of Surgical Sciences, University of Oxford, Oxford, Oxfordshire, United Kingdom

Dan Berney

Roles Investigation, Resources

Affiliation Centre for Molecular Oncology, Barts Cancer Institute, The Barts and London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

Clare Verrill

Roles Investigation, Resources

Affiliation Department of Cellular Pathology and Oxford Biomedical Research Centre, Oxford University Hospitals NHS Trust, Oxford, Oxfordshire, United Kingdom

Anne Y. Warren

Roles Investigation, Resources

Affiliation Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, United Kingdom

David C. Wedge

Roles Project administration, Resources, Supervision, Writing – review & editing

Affiliations Cancer, Ageing and Somatic Mutation, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom, Oxford Big Data Institute & Oxford Centre for Cancer Gene Research, Wellcome Trust Centre for Human Genetics, Oxford, Oxfordshire, United Kingdom

Andrew G. Lynch

Roles Investigation, Project administration, Resources, Writing – review & editing

‡ CSC and DSB are joint senior authors on this work. AGL, CSF, GSB, UM, DEN, RE, CSC, and DSB are senior principal investigators of this project and the CRUK-ICGC Prostate Group.

Affiliations Statistics and Computational Biology Laboratory, Cancer Research UK Cambridge Institute, Cambridge, Cambridgeshire, United Kingdom, School of Mathematics and Statistics/School of Medicine, University of St Andrews, St Andrews, Fife, Scotland

Christopher S. Foster

Roles Funding acquisition, Investigation, Project administration, Resources, Writing – review & editing

‡ CSC and DSB are joint senior authors on this work. AGL, CSF, GSB, UM, DEN, RE, CSC, and DSB are senior principal investigators of this project and the CRUK-ICGC Prostate Group.

Affiliation HCA Pathology Laboratories, HCA Healthcare, London, United Kingdom

Yong Jie Lu

Roles Data curation, Investigation, Resources, Writing – review & editing

Affiliation Centre for Molecular Oncology, Barts Cancer Institute, The Barts and London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

G. Steven Bova

Roles Investigation, Resources, Supervision, Writing – review & editing

‡ CSC and DSB are joint senior authors on this work. AGL, CSF, GSB, UM, DEN, RE, CSC, and DSB are senior principal investigators of this project and the CRUK-ICGC Prostate Group.

Affiliation Faculty of Medicine and Life Sciences and BioMediTech Institute, University of Tampere and Tampere University Hospital, Tampere, Finland

Hayley C. Whitaker

Roles Investigation, Resources, Supervision

Affiliations Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, Cambridge, Cambridgeshire, United Kingdom, Molecular Diagnostics and Therapeutics Group, University College London, London, United Kingdom

Ultan McDermott

Roles Funding acquisition, Investigation, Resources, Supervision

‡ CSC and DSB are joint senior authors on this work. AGL, CSF, GSB, UM, DEN, RE, CSC, and DSB are senior principal investigators of this project and the CRUK-ICGC Prostate Group.

Affiliation Cancer, Ageing and Somatic Mutation, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom

David E. Neal

Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

‡ CSC and DSB are joint senior authors on this work. AGL, CSF, GSB, UM, DEN, RE, CSC, and DSB are senior principal investigators of this project and the CRUK-ICGC Prostate Group.

Affiliations Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, Cambridge, Cambridgeshire, United Kingdom, Academic Urology Group, Department of Surgery, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom

Rosalind Eeles

Roles Conceptualization, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – review & editing

‡ CSC and DSB are joint senior authors on this work. AGL, CSF, GSB, UM, DEN, RE, CSC, and DSB are senior principal investigators of this project and the CRUK-ICGC Prostate Group.

Affiliations Division of Genetics and Epidemiology, The Institute Of Cancer Research, London, United Kingdom, Cancer Genetics Unit, Royal Marsden NHS Foundation Trust, London, United Kingdom

Colin S. Cooper

Roles Conceptualization, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

‡ CSC and DSB are joint senior authors on this work. AGL, CSF, GSB, UM, DEN, RE, CSC, and DSB are senior principal investigators of this project and the CRUK-ICGC Prostate Group.

Affiliations Division of Genetics and Epidemiology, The Institute Of Cancer Research, London, United Kingdom, Norwich Medical School, University of East Anglia, Norwich, Norfolk, United Kingdom

Daniel S. Brewer

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

d.brewer@uea.ac.uk

‡ CSC and DSB are joint senior authors on this work. AGL, CSF, GSB, UM, DEN, RE, CSC, and DSB are senior principal investigators of this project and the CRUK-ICGC Prostate Group.

Affiliations Norwich Medical School, University of East Anglia, Norwich, Norfolk, United Kingdom, Organisms and Ecosystems, The Earlham Institute, Norwich, Norfolk, United Kingdom

Competing Interests

I have read the journal's policy and the authors of this manuscript have the following competing interests: RE has received educational grants from Illumina and GenProbe (formerly Tepnel), Vista Diagnostics and Janssen Pharmaceuticals, as well as honoraria from Succint Communications for talks on prostate cancer genetics.