About the Authors

Sabine Lagger

Current address: Unit of Pathology of Laboratory Animals, University of Veterinary Medicine Vienna, Vienna, Austria

‡ These authors share first authorship on this work.

Affiliation Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, United Kingdom

John C. Connelly

‡ These authors share first authorship on this work.

Affiliation Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, United Kingdom

Gabriele Schweikert

‡ These authors share first authorship on this work.

Affiliations Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, United Kingdom, School of Informatics, University of Edinburgh, Edinburgh, United Kingdom

Shaun Webb

Affiliation Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, United Kingdom

Jim Selfridge

Affiliation Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, United Kingdom

Bernard H. Ramsahoye

Affiliation Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

Miao Yu

Affiliations Department of Chemistry and Institute for Biophysical Dynamics, University of Chicago, Chicago, Illinois, United States of America, Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois, United States of America

Chuan He

Affiliations Department of Chemistry and Institute for Biophysical Dynamics, University of Chicago, Chicago, Illinois, United States of America, Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois, United States of America

Guido Sanguinetti

Affiliation School of Informatics, University of Edinburgh, Edinburgh, United Kingdom

Lawrence C. Sowers

Affiliation Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas, United States of America

Malcolm D. Walkinshaw

Affiliation Centre for Translational and Chemical Biology, University of Edinburgh, Edinburgh, United Kingdom

Adrian Bird

a.bird@ed.ac.uk

Affiliation Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceptualization: SL JCC GSc SW GSa AB. Formal analysis: GSc SW GSa. Funding acquisition: SL GSc LCS GSa AB. Investigation: SL JCC GSc SW BHR CH MY LCS MDW JS. Project administration: SL JCC GSc AB. Resources: LCS JS GSa. Supervision: AB. Validation: SL JCC GSc AB. Visualization: SL. Writing – original draft: AB. Writing – review & editing: SL JCC GSc SW JS BHR MY CH GSa LCS MDW AB.