About the Authors

Mark P. Keller

Affiliation Department of Biochemistry, University of Wisconsin, Madison, Wisconsin, United States of America

Pradyut K. Paul

Affiliation Department of Biochemistry, University of Wisconsin, Madison, Wisconsin, United States of America

Mary E. Rabaglia

Affiliation Department of Biochemistry, University of Wisconsin, Madison, Wisconsin, United States of America

Donnie S. Stapleton

Affiliation Department of Biochemistry, University of Wisconsin, Madison, Wisconsin, United States of America

Kathryn L. Schueler

Affiliation Department of Biochemistry, University of Wisconsin, Madison, Wisconsin, United States of America

Aimee Teo Broman

Affiliation Department of Biostatistics & Medical Informatics, University of Wisconsin, Madison, Wisconsin, United States of America

Shuyun Isabella Ye

Affiliation Department of Statistics, University of Wisconsin, Madison, Wisconsin, United States of America

Ning Leng

Affiliation Department of Biostatistics & Medical Informatics, University of Wisconsin, Madison, Wisconsin, United States of America

Christopher J. Brandon

Affiliation Department of Biochemistry, University of Wisconsin, Madison, Wisconsin, United States of America

Elias Chaibub Neto

Affiliation Sage Bionetworks, Seattle, Washington

Christopher L. Plaisier

Affiliation Institute for Systems Biology, Seattle, Washington

Shane P. Simonett

Affiliation Department of Biochemistry, University of Wisconsin, Madison, Wisconsin, United States of America

Melkam A. Kebede

Affiliation Department of Biochemistry, University of Wisconsin, Madison, Wisconsin, United States of America

Gloria M. Sheynkman

Affiliation Department of Chemistry, University of Wisconsin, Madison, Wisconsin, United States of America

Mark A. Klein

Affiliation Department of Biochemistry, University of Wisconsin, Madison, Wisconsin, United States of America

Nitin S. Baliga

Affiliation Institute for Systems Biology, Seattle, Washington

Lloyd M. Smith

Affiliation Department of Chemistry, University of Wisconsin, Madison, Wisconsin, United States of America

Karl W. Broman

Affiliation Department of Biostatistics & Medical Informatics, University of Wisconsin, Madison, Wisconsin, United States of America

Brian S. Yandell

Affiliation Department of Statistics, University of Wisconsin, Madison, Wisconsin, United States of America

Christina Kendziorski

Affiliation Department of Biostatistics & Medical Informatics, University of Wisconsin, Madison, Wisconsin, United States of America

Alan D. Attie

adattie@wisc.edu

Affiliation Department of Biochemistry, University of Wisconsin, Madison, Wisconsin, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceptualization: MPK ADA. Data curation: MPK PKP MER DSS KLS ATB SIY NL GMS KWB BSY. Formal analysis: MPK PKP MER DSS ATB SIY CJB NL ECN CLP SPS GMS. Funding acquisition: MPK PKP CJB ECN CLP NSB LMS KWB CK ADA. Investigation: MPK PKP MER DSS KLS ATB SIY NL CJB SPS MAKe GMS MAKl. Methodology: MPK PKP MER DSS KLS ATB SIY NL ECN CLP GMS KWB BSY CK ADA. Project administration: MPK NSB LMS KWB BSY CK ADA. Resources: MER DSS KLS ATB NSB LMS KWB BSY CK ADA. Supervision: MPK NSB LMS KWB BSY CK ADA. Validation: MPK PKP MER DSS ATB CJB SPS BSY. Visualization: MPK PKP DSS ATB CJB SPS BSY. Writing – original draft: MPK ADA. Writing – review & editing: MPK PKP MER DSS NL CJB SPS MAKe GMS BSY CK ADA.