About the Authors

Scott R. Kennedy

Affiliation Department of Pathology, University of Washington, Seattle, Washington, United States of America

Eric M. Schultz

Affiliation Department of Pathology, University of Washington, Seattle, Washington, United States of America

Thomas M. Chappell

Affiliation Department of Entomology, North Carolina State University, Raleigh, North Carolina, United States of America

Brendan Kohrn

Affiliation Department of Pathology, University of Washington, Seattle, Washington, United States of America

Gary M. Knowels

Affiliation Department of Pathology, University of Washington, Seattle, Washington, United States of America

Alan J. Herr

alanherr@uw.edu

Affiliation Department of Pathology, University of Washington, Seattle, Washington, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SRK EMS AJH. Performed the experiments: SRK EMS GMK AJH. Analyzed the data: SRK EMS TMC BK GMK AJH. Contributed reagents/materials/analysis tools: SRK TMC BK AJH. Wrote the paper: SRK EMS TMC BK GMK AJH. Micromanipulation of yeast cells: EMS GMK AJH. DNA sample prep for sequencing: EMS GMK AJH. Sequence data analysis: SRK BK AJH. Finite mixture modeling: TMC. Simulation: BK SRK AJH. Replication timing analysis: AJH SRK.