About the Authors

John S. K. Kauwe

Affiliation Department of Biology, Brigham Young University, Provo, Utah, United States of America

Matthew H. Bailey

Affiliation Department of Biology, Brigham Young University, Provo, Utah, United States of America

Perry G. Ridge

Affiliation Department of Biology, Brigham Young University, Provo, Utah, United States of America

Rachel Perry

Affiliation Department of Biology, Brigham Young University, Provo, Utah, United States of America

Mark E. Wadsworth

Affiliation Department of Biology, Brigham Young University, Provo, Utah, United States of America

Kaitlyn L. Hoyt

Affiliation Department of Biology, Brigham Young University, Provo, Utah, United States of America

Lyndsay A. Staley

Affiliation Department of Biology, Brigham Young University, Provo, Utah, United States of America

Celeste M. Karch

Affiliations Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, United States of America, Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri, United States of America

Oscar Harari

Affiliation Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, United States of America

Carlos Cruchaga

Affiliations Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, United States of America, Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri, United States of America

Benjamin J. Ainscough

Affiliation The Genome Institute, Washington University School of Medicine, St Louis, Missouri, United States of America

Kelly Bales

Affiliation Neuroscience Research Unit, Worldwide Research and Development, Pfizer Inc., Groton, Connecticut, United States of America

Eve H. Pickering

Affiliation Neuroscience Research Unit, Worldwide Research and Development, Pfizer Inc., Groton, Connecticut, United States of America

Sarah Bertelsen

Affiliation Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, United States of America

the Alzheimer's Disease Neuroimaging Initiative

Membership of the Alzheimer's Disease Neuroimaging Initiative is provided in the Acknowledgments.

Anne M. Fagan

Affiliations Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri, United States of America, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St Louis, Missouri, United States of America, Department of Neurology, Washington University School of Medicine, St Louis, Missouri, United States of America

David M. Holtzman

Affiliations Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri, United States of America, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St Louis, Missouri, United States of America, Department of Neurology, Washington University School of Medicine, St Louis, Missouri, United States of America, Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri, United States of America

John C. Morris

Affiliations Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri, United States of America, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St Louis, Missouri, United States of America, Department of Neurology, Washington University School of Medicine, St Louis, Missouri, United States of America, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, United States of America

Alison M. Goate

goatea@psychiatry.wustl.edu

Affiliations Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, United States of America, Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri, United States of America, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St Louis, Missouri, United States of America, Department of Neurology, Washington University School of Medicine, St Louis, Missouri, United States of America, Department of Genetics, Washington University School of Medicine, St Louis, Missouri, United States of America

Competing Interests

EHP and KB are employed by Pfizer Global Research and Development, Groton, CT, and St. Louis, MO and therefore, Pfizer Global played a role in study design, data collection and analysis, decision to publish, and preparation of the manuscript.

Author Contributions

Conceived and designed the experiments: JSKK CC KB EHP AMF DMH JCM AMG. Performed the experiments: JSKK MHB PGR. Analyzed the data: JSKK MHB PGR RP MEW KLH LAS OH BJA SB. Contributed reagents/materials/analysis tools: KB EHP AMF DMH JCM AMG. Wrote the paper: JSKK MHB RP CMK AMF DMH JCM AMG.