COE Loss-of-Function Analysis Reveals a Genetic Program Underlying Maintenance and Regeneration of the Nervous System in Planarians

Martis W. Cowles; Kerilyn C. Omuro; Brianna N. Stanley; Carlo G. Quintanilla; Ricardo M. Zayas

doi:10.1371/journal.pgen.1004746

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Open Access

Peer-reviewed

Research Article

COE Loss-of-Function Analysis Reveals a Genetic Program Underlying Maintenance and Regeneration of the Nervous System in Planarians

Martis W. Cowles,

Affiliation Department of Biology, San Diego State University, San Diego, California, United States of America
⨯
Kerilyn C. Omuro,

Affiliation Department of Biology, San Diego State University, San Diego, California, United States of America
⨯
Brianna N. Stanley,

Affiliation Department of Biology, San Diego State University, San Diego, California, United States of America
⨯
Carlo G. Quintanilla,

Affiliation Department of Biology, San Diego State University, San Diego, California, United States of America
⨯
Ricardo M. Zayas

* E-mail: rzayas@mail.sdsu.edu

Affiliation Department of Biology, San Diego State University, San Diego, California, United States of America
⨯

COE Loss-of-Function Analysis Reveals a Genetic Program Underlying Maintenance and Regeneration of the Nervous System in Planarians

Martis W. Cowles,
Kerilyn C. Omuro,
Brianna N. Stanley,
Carlo G. Quintanilla,
Ricardo M. Zayas

Published: October 30, 2014
https://doi.org/10.1371/journal.pgen.1004746

About the Authors

Martis W. Cowles

Affiliation Department of Biology, San Diego State University, San Diego, California, United States of America

Kerilyn C. Omuro

Affiliation Department of Biology, San Diego State University, San Diego, California, United States of America

Brianna N. Stanley

Affiliation Department of Biology, San Diego State University, San Diego, California, United States of America

Carlo G. Quintanilla

Affiliation Department of Biology, San Diego State University, San Diego, California, United States of America

Ricardo M. Zayas

* E-mail: rzayas@mail.sdsu.edu

Affiliation Department of Biology, San Diego State University, San Diego, California, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MWC RMZ. Performed the experiments: MWC KCO BNS CGQ. Analyzed the data: MWC KCO CGQ RMZ. Wrote the paper: MWC RMZ.

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Central nervous system
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Planarians
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Gene expression
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RNA interference
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Nerve regeneration
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Neurons
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Transcription factors
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Neuronal differentiation
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