About the Authors

Gary W. Beecham

Affiliation John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America

Kara Hamilton

Affiliation John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America

Adam C. Naj

Affiliation Division of Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Eden R. Martin

Affiliation John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America

Matt Huentelman

Affiliation Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona, United States of America

Amanda J. Myers

Affiliation Department of Psychiatry & Behavioral Sciences, University of Miami, Miami, Florida, United States of America

Jason J. Corneveaux

Affiliation Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona, United States of America

John Hardy

Affiliation Department of Molecular Neuroscience, University College London, London, United Kingdom

Jean-Paul Vonsattel

Affiliation New York Brain Bank, Columbia University, New York, New York, United States of America

Steven G. Younkin

Affiliation Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida, United States of America

David A. Bennett

Affiliation Department of Neurological Sciences, Rush University, Chicago, Illinois, United States of America

Philip L. De Jager

Affiliation Department of Neurology and Psychiatry, Brigham and Women's Hospital, Boston, Harvard Medical School, Boston, Massachusetts, United States of America

Eric B. Larson

Affiliation Group Health Research Institute, Seattle, Washington, United States of America

Paul K. Crane

Affiliation Department of Medicine, University of Washington, Seattle, Washington, United States of America

M. Ilyas Kamboh

Affiliation Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, United States of America

Julia K. Kofler

Affiliation Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

Deborah C. Mash

Affiliation Department of Neurology, University of Miami, Miami, Florida, United States of America

Linda Duque

Affiliation Department of Neurology, University of Miami, Miami, Florida, United States of America

John R. Gilbert

Affiliation John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America

Harry Gwirtsman

Affiliation Department of Psychiatry, Vanderbilt University, Nashville, Tennessee, United States of America

Joseph D. Buxbaum

Affiliation Department of Psychiatry, Mount Sinai Hospital, New York, New York, United States of America

Patricia Kramer

Affiliation Department of Neurology, Oregon Health & Science University, Portland, Oregon, United States of America

Dennis W. Dickson

Affiliation Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida, United States of America

Lindsay A. Farrer

Affiliation Biomedical Genetics, Boston University School of Public Health, Boston, Massachusetts, United States of America

Matthew P. Frosch

Affiliation C.S. Kubik Laboratory for Neuropathology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America

Bernardino Ghetti

Affiliation Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, Indiana, United States of America

Jonathan L. Haines

Affiliation Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

Bradley T. Hyman

Affiliation Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Walter A. Kukull

Affiliation Department of Epidemiology, National Alzheimer's Coordinating Center, University of Washington, Seattle, Washington, United States of America

Richard P. Mayeux

Affiliation Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, United States of America

Margaret A. Pericak-Vance

Affiliation John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America

Julie A. Schneider

Affiliations Department of Neurological Sciences, Rush University, Chicago, Illinois, United States of America, Department of Pathology (Neuropathology), Rush University Medical Center, Chicago, Illinois, United States of America

John Q. Trojanowski

Affiliation Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Eric M. Reiman

Affiliations Arizona Alzheimer's Consortium, Banner Alzheimer's Institute, Phoenix, Arizona, United States of America, Department of Psychiatry, University of Arizona, Phoenix, Arizona, United States of America

the Alzheimer's Disease Genetics Consortium (ADGC)

Membership of the Alzheimer’s Disease Genetics Consortium (ADGC) is provided in Text S1.

Gerard D. Schellenberg

Affiliation Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Thomas J. Montine

tmontine@uw.edu

Affiliation Department of Pathology, University of Washington, Seattle, Washington, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GWB DWD MPF BG JAS EMR GDS TJM. Analyzed the data: GWB GDS KH ACN ERM MH JJC LD JRG HG JDB LAF JLH MAPV. Contributed reagents/materials/analysis tools: DWD MPF BG JAS EMR TJM AJM JH JPV SGY DAB PLDJ EBL PKC MIK JKK DCM PK BTH WAK RPM JQT. Wrote the paper: GWB GDS TJM. Critically reviewed manuscript: KH ACN ERM MH JJC LD JRG HG JDB LAF JH JLH MAPV DWD MPF BG JAS EMR AJM JPV SGY DAB PLDJ EBL PKC MIK JKK DCM PK BTH WAK RPM JQT.