About the Authors

Jared M. Schrader

Affiliation Department of Developmental Biology, Stanford University, Stanford, California, United States of America

Bo Zhou

Affiliation Department of Developmental Biology, Stanford University, Stanford, California, United States of America

Gene-Wei Li

Affiliation Department of Cellular and Molecular Pharmacology, California Institute of Quantitative Biology, Center for RNA Systems Biology, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, California, United States of America

Keren Lasker

Affiliation Department of Developmental Biology, Stanford University, Stanford, California, United States of America

W. Seth Childers

Affiliation Department of Developmental Biology, Stanford University, Stanford, California, United States of America

Brandon Williams

Affiliation Department of Developmental Biology, Stanford University, Stanford, California, United States of America

Tao Long

Affiliation Department of Developmental Biology, Stanford University, Stanford, California, United States of America

Sean Crosson

Affiliation Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois, United States of America

Harley H. McAdams

Affiliation Department of Developmental Biology, Stanford University, Stanford, California, United States of America

Jonathan S. Weissman

Affiliation Department of Cellular and Molecular Pharmacology, California Institute of Quantitative Biology, Center for RNA Systems Biology, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, California, United States of America

Lucy Shapiro

shapiro@stanford.edu

Affiliation Department of Developmental Biology, Stanford University, Stanford, California, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JMS. Performed the experiments: JMS. Analyzed the data: JMS BZ. Contributed reagents/materials/analysis tools: GWL KL TL SC HHM JSW. Wrote the paper: JMS BZ HHM LS. Performed genome annotation analysis: JMS BZ. Performed ribosome pausing analysis: JMS GWL. Performed cell growth assays and western blots: JMS WSC BW.