About the Authors

Elinor Sawyer

Contributed equally to this work with: Elinor Sawyer, Rebecca Roylance

elinor.sawyer@kcl.ac.uk

Affiliation Research Oncology, Division of Cancer Studies, Kings College London, Guy's Hospital, London, United Kingdom

Rebecca Roylance

Contributed equally to this work with: Elinor Sawyer, Rebecca Roylance

Affiliation Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom

Christos Petridis

Affiliation Research Oncology, Division of Cancer Studies, Kings College London, Guy's Hospital, London, United Kingdom

Mark N. Brook

Affiliation Division of Genetics and Epidemiology, Institute of Cancer Research, London, United Kingdom

Salpie Nowinski

Affiliation Research Oncology, Division of Cancer Studies, Kings College London, Guy's Hospital, London, United Kingdom

Efterpi Papouli

Affiliation Biomedical Research Centre, King's College London, Guy's Hospital, London, United Kingdom

Olivia Fletcher

Affiliation Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom

Sarah Pinder

Affiliation Research Oncology, Division of Cancer Studies, Kings College London, Guy's Hospital, London, United Kingdom

Andrew Hanby

Affiliation Leeds Institute of Molecular Medicine, St James's University Hospital, Leeds, United Kingdom

Kelly Kohut

Affiliation Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom

Patricia Gorman

Affiliation Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom

Michele Caneppele

Affiliation Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom

Julian Peto

Affiliation London School of Hygiene and Tropical Medicine, London, United Kingdom

Isabel dos Santos Silva

Affiliation London School of Hygiene and Tropical Medicine, London, United Kingdom

Nichola Johnson

Affiliation Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom

Ruth Swann

Affiliation Department of Molecular and Applied Biosciences, University of Westminster, London, United Kingdom

Miriam Dwek

Affiliation Department of Molecular and Applied Biosciences, University of Westminster, London, United Kingdom

Katherine-Anne Perkins

Affiliation Department of Molecular and Applied Biosciences, University of Westminster, London, United Kingdom

Cheryl Gillett

Affiliation Research Oncology, Division of Cancer Studies, Kings College London, Guy's Hospital, London, United Kingdom

Richard Houlston

Affiliation Division of Genetics and Epidemiology, Institute of Cancer Research, London, United Kingdom

Gillian Ross

Affiliation The Royal Marsden NHS Foundation Trust, London, United Kingdom

Paolo De Ieso

Affiliation The Royal Marsden NHS Foundation Trust, London, United Kingdom

Melissa C. Southey

Affiliation Department of Pathology, The University of Melbourne, Melbourne, Australia

John L. Hopper

Affiliation Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, The University of Melbourne, Melbourne, Australia

Elena Provenzano

Affiliation NIHR Cambridge Biomedical Research Centre, Addenbrookes Hospital, Cambridge, United Kingdom

Carmel Apicella

Affiliation Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, The University of Melbourne, Melbourne, Australia

Jelle Wesseling

Affiliation Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands

Sten Cornelissen

Affiliation Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands

Renske Keeman

Affiliation Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands

Peter A. Fasching

Affiliations David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, California, United States of America, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany

Sebastian M. Jud

Affiliation Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany

Arif B. Ekici

Affiliation Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany

Matthias W. Beckmann

Affiliation Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany

Michael J. Kerin

Affiliation Surgery, Clinical Science Institute, National University of Ireland, Galway, Ireland

Federick Marme

Affiliations Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany, National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany

Andreas Schneeweiss

Affiliations Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany, National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany

Christof Sohn

Affiliation Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany

Barbara Burwinkel

Affiliations Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany, Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany

Pascal Guénel

Affiliations Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, Villejuif, France, University Paris-Sud, UMRS 1018, Villejuif, France

Therese Truong

Affiliations Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, Villejuif, France, University Paris-Sud, UMRS 1018, Villejuif, France

Pierre Laurent-Puig

Affiliation Université Paris Sorbonne Cité, UMR-S775 Inserm, Paris, France

Pierre Kerbrat

Affiliation Centre Eugène Marquis, Department of Medical Oncology, Rennes, France

Stig E. Bojesen

Affiliation Copenhagen General Population Study and Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark

Børge G. Nordestgaard

Affiliation Copenhagen General Population Study and Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark

Sune F. Nielsen

Affiliation Copenhagen General Population Study and Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark

Henrik Flyger

Affiliation Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark

Roger L. Milne

Affiliation Genetic & Molecular Epidemiology Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre [CNIO], Madrid, Spain

Jose Ignacio Arias Perez

Affiliation Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Oviedo, Spain

Primitiva Menéndez

Affiliation Servicio de Anatomía Patológica, Hospital Monte Naranco, Oviedo, Spain

Javier Benitez

Affiliation Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre [CNIO], Madrid, Spain

Hermann Brenner

Affiliation Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany

Aida Karina Dieffenbach

Affiliation Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany

Volker Arndt

Affiliation Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany

Christa Stegmaier

Affiliation Saarland Cancer Registry, Saarbrücken, Germany

Alfons Meindl

Affiliation Division of Gynaecology and Obstetrics, Technische Universität München, Munich, Germany

Peter Lichtner

Affiliation Institute of Human Genetics, Technische Universität, Munich, Germany

Rita K. Schmutzler

Affiliation Centre for Familial Breast and Ovarian Cancer and Centre for Integrated Oncology, University Hospital Cologne, Cologne, Germany

Magdalena Lochmann

Affiliation Division of Gynaecology and Obstetrics, Technische Universität München, Munich, Germany

Hiltrud Brauch

Affiliations Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany, University of Tübingen, Tübingen, Germany

Hans-Peter Fischer

Affiliation Institute of Pathology, Medical Faculty of the University of Bonn, Bonn, Germany

Yon-Dschun Ko

Affiliation Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus, Bonn, Germany

The GENICA Network

Membership of the GENICA Network and kConFab Investigators is provided in the acknowledgments.

Affiliations Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany, University of Tübingen, Tübingen, Germany, Institute for Occupational Medicine and Maritime Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-University Bochum (IPA), Bochum, Germany

Heli Nevanlinna

Affiliation Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland

Taru A. Muranen

Affiliation Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland

Kristiina Aittomäki

Affiliation Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki, Finland

Carl Blomqvist

Affiliation Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland

Natalia V. Bogdanova

Affiliation Department of Radiation Oncology, Hannover Medical School, Hannover, Germany

Thilo Dörk

Affiliation Gynaecology Research Unit, Hannover Medical School, Hannover, Germany

Annika Lindblom

Affiliation Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden

Sara Margolin

Affiliation Department of Oncology - Pathology, Karolinska Institutet, Stockholm, Sweden

Arto Mannermaa

Affiliations School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Joensuu, Finland, Cancer Center, Kuopio University Hospital, Kuopio, Finland

Vesa Kataja

Affiliations School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Joensuu, Finland, Cancer Center, Kuopio University Hospital, Kuopio, Finland

Veli-Matti Kosma

Affiliations School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Joensuu, Finland, Cancer Center, Kuopio University Hospital, Kuopio, Finland

Jaana M. Hartikainen

Affiliations School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Joensuu, Finland, Cancer Center, Kuopio University Hospital, Kuopio, Finland

Georgia Chenevix-Trench

Affiliation Department of Genetics, QIMR Berghofer Institute of Medical Research, Brisbane, Australia

KConFab Investigators

Membership of the GENICA Network and kConFab Investigators is provided in the acknowledgments.

Affiliation Peter MacCallum Cancer Center, Melbourne, Australia

Diether Lambrechts

Affiliations Vesalius Research Center (VRC), VIB, Leuven, Belgium, Department of Oncology, University of Leuven, Leuven, Belgium

Caroline Weltens

Affiliation University Hospital Gashuisberg, Leuven, Belgium

Erik Van Limbergen

Affiliation University Hospital Gashuisberg, Leuven, Belgium

Sigrid Hatse

Affiliation University Hospital Gashuisberg, Leuven, Belgium

Jenny Chang-Claude

Affiliation Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

Anja Rudolph

Affiliation Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

Petra Seibold

Affiliation Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

Dieter Flesch-Janys

Affiliation Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

Paolo Radice

Affiliations Unit of Molecular Bases of Genetic Risk and Genetic Testing, Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy, IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy

Paolo Peterlongo

Affiliation IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy

Bernardo Bonanni

Affiliation Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy

Sara Volorio

Affiliation IFOM, Fondazione Istituto FIRC di Oncologia Molecolare and Cogentech Cancer Genetic Test Laboratory, Milan, Italy

Graham G. Giles

Affiliations Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia, Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, The University of Melbourne, Melbourne, Australia

Gianluca Severi

Affiliations Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia, Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, The University of Melbourne, Melbourne, Australia

Laura Baglietto

Affiliations Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia, Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, The University of Melbourne, Melbourne, Australia

Catriona A. Mclean

Affiliation Department of Pathology, The Alfred Hospital, Prahran, Victoria, Australia

Christopher A. Haiman

Affiliation Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

Brian E. Henderson

Affiliation Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

Fredrick Schumacher

Affiliation Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

Loic Le Marchand

Affiliation Epidemiology Program, Cancer Research Center, University of Hawaii, Honolulu, Hawaii, United States of America

Jacques Simard

Affiliation Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec, Canada

Mark S. Goldberg

Affiliations Department of Medicine, McGill University, Montreal, Quebec, Canada, Division of Clinical Epidemiology, McGill University Health Centre, Royal Victoria Hospital, Montreal, Quebec, Canada

France Labrèche

Affiliation Département de médecine sociale et préventive, Département de santé environnementale et santé au travail, Université de Montréal, Montreal, Quebec, Canada

Martine Dumont

Affiliation Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec, Canada

Vessela Kristensen

Affiliations Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway, Faculty of Medicine (Faculty Division Ahus), UiO, Oslo, Norway

Robert Winqvist

Affiliation Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, NordLab/Oulu University Hospital, Oulu, Finland

Katri Pylkäs

Affiliation Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, NordLab/Oulu University Hospital, Oulu, Finland

Arja Jukkola-Vuorinen

Affiliation Department of Oncology, Oulu University Hospital, University of Oulu, Oulu, Finland

Saila Kauppila

Affiliation Department of Oncology, Oulu University Hospital, University of Oulu, Oulu, Finland

Irene L. Andrulis

Affiliations Ontario Cancer Genetics Network, Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

Julia A. Knight

Affiliations Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada, Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada

Gord Glendon

Affiliation Ontario Cancer Genetics Network, Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada

Anna Marie Mulligan

Affiliation Laboratory Medicine Program, University Health Network, Toronto, Ontario; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada

Peter Devillee

Affiliation Department of Human Genetics & Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands

Rob A. E. M. Tollenaar

Affiliation Department of Surgical Oncology, Leiden University Medical Center, Leiden, The Netherlands

Caroline M. Seynaeve

Affiliation Family Cancer Clinic, Department of Medical Oncology, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam, The Netherlands

Mieke Kriege

Affiliation Family Cancer Clinic, Department of Medical Oncology, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam, The Netherlands

Jonine Figueroa

Affiliation Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland, United States of America

Stephen J. Chanock

Affiliation Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland, United States of America

Mark E. Sherman

Affiliation Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland, United States of America

Maartje J. Hooning

Affiliation Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, The Netherlands

Antoinette Hollestelle

Affiliation Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, The Netherlands

Ans M. W. van den Ouweland

Affiliation Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands

Carolien H. M. van Deurzen

Affiliation Department of Pathology, Erasmus University Medical Center, Rotterdam, The Netherlands

Jingmei Li

Affiliation Human Genetics Division, Genome Institute of Singapore, Singapore

Kamila Czene

Affiliation Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

Keith Humphreys

Affiliation Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

Angela Cox

Affiliation CRUK/YCR Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield, Sheffield, United Kingdom

Simon S. Cross

Affiliation Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, United Kingdom

Malcolm W. R. Reed

Affiliation CRUK/YCR Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield, Sheffield, United Kingdom

Mitul Shah

Affiliation Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom

Anna Jakubowska

Affiliation Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland

Jan Lubinski

Affiliation Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland

Katarzyna Jaworska-Bieniek

Affiliations Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland, Postgraduate School of Molecular Medicine, Warsaw Medical University, Warsaw, Poland

Katarzyna Durda

Affiliation Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland

Anthony Swerdlow

Affiliation Division of Genetics and Epidemiology and Division of Breast Cancer Research, The Institute of Cancer Research, Sutton, Surrey, United Kingdom

Alan Ashworth

Affiliation Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, The Institute of Cancer Research, London, United Kingdom

Nicholas Orr

Affiliation Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, The Institute of Cancer Research, London, United Kingdom

Minouk Schoemaker

Affiliation Division of Genetics and Epidemiology, Institute of Cancer Research, London, United Kingdom

Fergus J. Couch

Affiliation Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America

Emily Hallberg

Affiliation Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America

Anna González-Neira

Affiliation Human Genotyping-CEGEN Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre [CNIO], Madrid, Spain

Guillermo Pita

Affiliation Human Genotyping-CEGEN Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre [CNIO], Madrid, Spain

M. Rosario Alonso

Affiliation Human Genotyping-CEGEN Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre [CNIO], Madrid, Spain

Daniel C. Tessier

Affiliation McGill University and Génome Québec Innovation Centre, Montréal, Québec, Canada

Daniel Vincent

Affiliation McGill University and Génome Québec Innovation Centre, Montréal, Québec, Canada

Francois Bacot

Affiliation McGill University and Génome Québec Innovation Centre, Montréal, Québec, Canada

Manjeet K. Bolla

Affiliation Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

Qin Wang

Affiliation Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

Joe Dennis

Affiliation Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

Kyriaki Michailidou

Affiliation Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

Alison M. Dunning

Affiliation Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom

Per Hall

Affiliation Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

Doug Easton

Affiliation Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

Paul Pharoah

Affiliations Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom, Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

Marjanka K. Schmidt

Affiliation Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands

Ian Tomlinson

Affiliation Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom

Montserrat Garcia-Closas

Affiliations Division of Genetics and Epidemiology, Institute of Cancer Research, London, United Kingdom, Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ES RR IT MGC. Performed the experiments: CP EPa AGN GP MRA DCT DV FB JD AMD. Analyzed the data: ES CP MNB SN MKB QW KM IT MGC. Contributed reagents/materials/analysis tools: ES RR CP MNB SN EPa OF SP AHa KK PGo MC JP IdSS NJ RS MDw KAP CG RH GR PDI MCS JLH EPr CA JW SC RK PAF SMJ ABE MWB MJK FM ASc CSo BBu PGu TT PLP PK SEB BGN SFN HF RLM JIAP PM JB HBre AKD VA CSt AMe PL RKS ML HBra HPF YDK HN TAM KA CB NVB TD AL SM AMa VKa VMK JMH GCT DL CW EVL SH JCC AR PS DFJ PR PPe BBo SV GGG GS LB CAM CAH BEH FS LLM JS MSG FL MDu VKr RW KP AJV SK ILA JAK GG AMM PD RAEMT CMS MK JF SJC MES MJH AHo AMWvdO CHMvD JLi KC KH AC SSC MWRR MSh AJ JLu KJB KD ASw AA NO MSc FJC EH AGN GP MRA DCT DV FB MKB QW JD KM AMD PH DE PPh MKS IT MGC. Wrote the paper: ES IT MGC RR PH PPh MKS. Histopathology Review: SP AHa. Provided critical review of the manuscript: ES RR CP MNB SN EPa OF SP AHa KK PGo MC JP IdSS NJ RS MDw KAP CG RH GR PDI MCS JLH EPr CA JW SC RK PAF SMJ ABE MWB MJK FM ASc CSo BBu PGu TT PLP PK SEB BGN SFN HF RLM JIAP PM JB HBre AKD VA CSt AMe PL RKS ML HBra HPF YDK HN TAM KA CB NVB TD AL SM AMa VKa VMK JMH GCT DL CW EVL SH JCC AR PS DFJ PR PPe BBo SV GGG GS LB CAM CAH BEH FS LLM JS MSG FL MDu VKr RW KP AJV SK ILA JAK GG AMM PD RAEMT CMS MK JF SJC MES MJH AHo AMWvdO CHMvD JLi KC KH AC SSC MWRR MSh AJ JLu KJB KD ASw AA NO MSc FJC EH AGN GP MRA DCT DV FB MKB QW JD KM AMD PH DE PPh MKS IT MGC. Approved the final version of the manuscript: ES RR CP MNB SN EPa OF SP AHa KK PGo MC JP IdSS NJ RS MDw KAP CG RH GR PDI MCS JLH EPr CA JW SC RK PAF SMJ ABE MWB MJK FM ASc CSo BBu PGu TT PLP PK SEB BGN SFN HF RLM JIAP PM JB HBre AKD VA CSt AMe PL RKS ML HBra HPF YDK HN TAM KA CB NVB TD AL SM AMa VKa VMK JMH GCT DL CW EVL SH JCC AR PS DFJ PR PPe BBo SV GGG GS LB CAM CAH BEH FS LLM JS MSG FL MDu VKr RW KP AJV SK ILA JAK GG AMM PD RAEMT CMS MK JF SJC MES MJH AHo AMWvdO CHMvD JLi KC KH AC SSC MWRR MSh AJ JLu KJB KD ASw AA NO MSc FJC EH AGN GP MRA DCT DV FB MKB QW JD KM AMD PH DE PPh MKS IT MGC.