About the Authors
- Zari Dastani
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Contributed equally to this work with: Zari Dastani, Marie-France Hivert, Nicholas Timpson, John R. B. Perry, Xin Yuan, Robert A. Scott, Peter Henneman, Iris M. Heid, Jorge R. Kizer, Leo-Pekka Lyytikäinen, Christian Fuchsberger
Affiliation Department of Epidemiology, Biostatistics, and Occupational Health, Jewish General Hospital, Lady Davis Institute, McGill University, Montreal, Canada
- Marie-France Hivert
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Contributed equally to this work with: Zari Dastani, Marie-France Hivert, Nicholas Timpson, John R. B. Perry, Xin Yuan, Robert A. Scott, Peter Henneman, Iris M. Heid, Jorge R. Kizer, Leo-Pekka Lyytikäinen, Christian Fuchsberger
Affiliations Department of Medicine, Université de Sherbrooke, Sherbrooke, Canada, General Medicine Division, Massachusetts General Hospital, Boston, Massachusetts, United States of America
- Nicholas Timpson
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Contributed equally to this work with: Zari Dastani, Marie-France Hivert, Nicholas Timpson, John R. B. Perry, Xin Yuan, Robert A. Scott, Peter Henneman, Iris M. Heid, Jorge R. Kizer, Leo-Pekka Lyytikäinen, Christian Fuchsberger
Affiliation MRC CAiTE Centre and School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
- John R. B. Perry
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Contributed equally to this work with: Zari Dastani, Marie-France Hivert, Nicholas Timpson, John R. B. Perry, Xin Yuan, Robert A. Scott, Peter Henneman, Iris M. Heid, Jorge R. Kizer, Leo-Pekka Lyytikäinen, Christian Fuchsberger
Affiliations Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Genetics of Complex Traits, Peninsula Medical School, University of Exeter, Exeter, United Kingdom
- Xin Yuan
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Contributed equally to this work with: Zari Dastani, Marie-France Hivert, Nicholas Timpson, John R. B. Perry, Xin Yuan, Robert A. Scott, Peter Henneman, Iris M. Heid, Jorge R. Kizer, Leo-Pekka Lyytikäinen, Christian Fuchsberger
Affiliation Genetics, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America
- Robert A. Scott
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Contributed equally to this work with: Zari Dastani, Marie-France Hivert, Nicholas Timpson, John R. B. Perry, Xin Yuan, Robert A. Scott, Peter Henneman, Iris M. Heid, Jorge R. Kizer, Leo-Pekka Lyytikäinen, Christian Fuchsberger
Affiliation MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom
- Peter Henneman
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Contributed equally to this work with: Zari Dastani, Marie-France Hivert, Nicholas Timpson, John R. B. Perry, Xin Yuan, Robert A. Scott, Peter Henneman, Iris M. Heid, Jorge R. Kizer, Leo-Pekka Lyytikäinen, Christian Fuchsberger
Affiliation Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
- Iris M. Heid
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Contributed equally to this work with: Zari Dastani, Marie-France Hivert, Nicholas Timpson, John R. B. Perry, Xin Yuan, Robert A. Scott, Peter Henneman, Iris M. Heid, Jorge R. Kizer, Leo-Pekka Lyytikäinen, Christian Fuchsberger
Affiliation Department of Epidemiology and Preventive Medicine, Regensburg University Medical Center, Regensburg, Germany
- Jorge R. Kizer
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Contributed equally to this work with: Zari Dastani, Marie-France Hivert, Nicholas Timpson, John R. B. Perry, Xin Yuan, Robert A. Scott, Peter Henneman, Iris M. Heid, Jorge R. Kizer, Leo-Pekka Lyytikäinen, Christian Fuchsberger
Affiliation Departments of Medicine and Public Health, Weill Cornell Medical College, New York, New York, United States of America
- Leo-Pekka Lyytikäinen
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Contributed equally to this work with: Zari Dastani, Marie-France Hivert, Nicholas Timpson, John R. B. Perry, Xin Yuan, Robert A. Scott, Peter Henneman, Iris M. Heid, Jorge R. Kizer, Leo-Pekka Lyytikäinen, Christian Fuchsberger
Affiliation Department of Clinical Chemistry, University of Tampere and Tampere University Hospital, Tampere, Finland
- Christian Fuchsberger
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Contributed equally to this work with: Zari Dastani, Marie-France Hivert, Nicholas Timpson, John R. B. Perry, Xin Yuan, Robert A. Scott, Peter Henneman, Iris M. Heid, Jorge R. Kizer, Leo-Pekka Lyytikäinen, Christian Fuchsberger
Affiliation Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America
- Toshiko Tanaka
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Affiliation Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, United States of America
- Andrew P. Morris
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Affiliation Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
- Kerrin Small
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Affiliations Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom
- Aaron Isaacs
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Affiliations Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, Centre for Medical Systems Biology, Leiden, The Netherlands
- Marian Beekman
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Affiliation Section of Molecular Epidemiology, Leiden University Medical Center and The Netherlands Genomics Initiative, The Netherlands Consortium for Healthy Aging, Leiden, The Netherlands
- Stefan Coassin
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Affiliation Division of Genetic Epidemiology, Innsbruck Medical University, Innsbruck, Austria
- Kurt Lohman
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Affiliation Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America
- Lu Qi
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Affiliation Harvard School of Public Health, Boston, Massachusetts, United States of America
- Stavroula Kanoni
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Affiliation Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom
- James S. Pankow
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Affiliation Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, United States of America
- Hae-Won Uh
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Affiliation Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
- Ying Wu
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Affiliation Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America
- Aurelian Bidulescu
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Affiliation Cardiovascular Research Institute, Morehouse School of Medicine, Atlanta, Georgia, United States of America
- Laura J. Rasmussen-Torvik
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Affiliation Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
- Celia M. T. Greenwood
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Affiliation Lady Davis Institute for Medical Research, Department of Oncology, McGill University, Montreal, Canada
- Martin Ladouceur
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Affiliation Department of Human Genetics McGill University, Montreal, Canada
- Jonna Grimsby
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Affiliations General Medicine Division, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
- Alisa K. Manning
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Affiliation Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America
- Ching-Ti Liu
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Affiliation Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America
- Jaspal Kooner
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Affiliation Cardiology, Ealing Hospital National Health Service (NHS) Trust, London, United Kingdom
- Vincent E. Mooser
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Affiliation Genetics, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America
- Peter Vollenweider
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Affiliation Department of Internal Medicine, University of Lausanne, Lausanne, Switzerland
- Karen A. Kapur
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Affiliation Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland
- John Chambers
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Affiliation Epidemiology and Biostatistics, Imperial College London, London, United Kingdom
- Nicholas J. Wareham
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Affiliation MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom
- Claudia Langenberg
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Affiliation MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom
- Rune Frants
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Affiliation Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
- Ko Willems-vanDijk
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Affiliation Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
- Ben A. Oostra
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Affiliations Centre for Medical Systems Biology, Leiden, The Netherlands, Deptartment of Clinical Genetics and Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
- Sara M. Willems
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Affiliation Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
- Claudia Lamina
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Affiliation Division of Genetic Epidemiology, Innsbruck Medical University, Innsbruck, Austria
- Thomas W. Winkler
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Affiliation Department of Epidemiology and Preventive Medicine, Regensburg University Medical Center, Regensburg, Germany
- Bruce M. Psaty
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Affiliations Cardiovascular Health Research Unit, Departments of Medicine and Epidemiology, University of Washington, Seattle, Washington, United States of America, Group Health Research Institute, Group Health Cooperative, Seattle, Washington, United States of America
- Russell P. Tracy
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Affiliation Departments of Pathology and Biochemistry, University of Vermont, Burlington, Vermont, United States of America
- Jennifer Brody
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Affiliation Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America
- Ida Chen
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Affiliation Medical Genetics Research Institute, Cedars Sinai Medical Center, Los Angeles, California, United States of America
- Jorma Viikari
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Affiliation Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland
- Mika Kähönen
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Affiliation Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland
- Peter P. Pramstaller
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Affiliations Center for Biomedicine, European Academy Bozen/Bolzano (EURAC) (Affiliated Institute of the University of Lübeck, Lübeck, Germany), Bolzano, Italy, Department of Neurology, General Central Hospital, Bolzano, Italy, Department of Neurology, University of Lübeck, Lübeck, Germany
- David M. Evans
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Affiliation MRC CAiTE Centre and School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
- Beate St. Pourcain
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Affiliation School of Social and community medicine, University of Bristol, Bristol, United Kingdom
- Naveed Sattar
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Affiliation British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom
- Andrew R. Wood
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Affiliation Genetics of Complex Traits, Peninsula Medical School, University of Exeter, Exeter, United Kingdom
- Stefania Bandinelli
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Affiliation Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy
- Olga D. Carlson
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Affiliation Laboratory of Clinical Investigation, National Institute of Aging, Baltimore, Maryland, United States of America
- Josephine M. Egan
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Affiliation Laboratory of Clinical Investigation, National Institute of Aging, Baltimore, Maryland, United States of America
- Stefan Böhringer
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Affiliation Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
- Diana van Heemst
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Affiliation Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
- Lyudmyla Kedenko
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Affiliation First Department of Internal Medicine, St. Johann Spital, Paracelsus Private Medical University Salzburg, Salzburg, Austria
- Kati Kristiansson
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Affiliation Public Health Genomics Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, and Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland
- Marja-Liisa Nuotio
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Affiliation Public Health Genomics Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, and Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland
- Britt-Marie Loo
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Affiliation Population Studies Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku, Finland
- Tamara Harris
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Affiliation Intramural Research Program, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America
- Melissa Garcia
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Affiliation Intramural Research Program, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America
- Alka Kanaya
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Affiliation Division of General Internal Medicine, Women's Health Clinical Research Center, University of California San Francisco, San Francisco, California, United States of America
- Margot Haun
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Affiliation Division of Genetic Epidemiology, Innsbruck Medical University, Innsbruck, Austria
- Norman Klopp
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Affiliation Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany
- H.-Erich Wichmann
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Affiliations Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany, Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany, Klinikum Großhadern, Munich, Germany
- Panos Deloukas
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Affiliation Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom
- Efi Katsareli
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Affiliation Harokopio University, Athens, Greece
- David J. Couper
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Affiliation Collaborative Studies Coordinating Center, Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
- Bruce B. Duncan
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Affiliations School of Medicine, Federal University of Rio Grande do Sul, Porto Alegre, Brazil, Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
- Margreet Kloppenburg
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Affiliation Department of Rheumatology and Department of Clinical Epidemiology, Leiden, The Netherlands
- Linda S. Adair
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Affiliation Department of Nutrition, University of North Carolina, Chapel Hill, North Carolina, United States of America
- Judith B. Borja
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Affiliation Office of Population Studies Foundation, University of San Carlos, Cebu City, Philippines
- DIAGRAM+ Consortium
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¶‡ Memberships of these consortia are provided in the Acknowledgments.
- MAGIC Consortium
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¶‡ Memberships of these consortia are provided in the Acknowledgments.
- GLGC Investigators
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¶‡ Memberships of these consortia are provided in the Acknowledgments.
- MuTHER Consortium
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¶‡ Memberships of these consortia are provided in the Acknowledgments.
- James G. Wilson
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Affiliation Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, United States of America
- Solomon Musani
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Affiliation Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States of America
- Xiuqing Guo
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Affiliation Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America
- Toby Johnson
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Affiliations Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland, University Institute of Social and Preventative Medicine, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne, Lausanne, Switzerland, Swiss Institute of Bioinformatics, Lausanne, Switzerland
- Robert Semple
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Affiliation Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom
- Tanya M. Teslovich
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Affiliation Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America
- Matthew A. Allison
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Affiliation Department of Family and Preventive Medicine, University of California San Diego, La Jolla, California, United States of America
- Susan Redline
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Affiliation Brigham and Women's Hospital, Boston, Massachusetts, United States of America
- Sarah G. Buxbaum
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Affiliation Jackson Heart Study Coordinating Center, Jackson State University, Jackson, Mississippi, United States of America
- Karen L. Mohlke
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Affiliation Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America
- Ingrid Meulenbelt
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Affiliation Section of Molecular Epidemiology, Leiden University Medical Center and The Netherlands Genomics Initiative, The Netherlands Consortium for Healthy Aging, Leiden, The Netherlands
- Christie M. Ballantyne
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Affiliation Baylor College of Medicine and Methodist DeBakey Heart and Vascular Center, Houston, Texas, United States of America
- George V. Dedoussis
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Affiliation Harokopio University, Athens, Greece
- Frank B. Hu
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Affiliation Harvard School of Public Health, Boston, Massachusetts, United States of America
- Yongmei Liu
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Affiliation Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America
- Bernhard Paulweber
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Affiliation First Department of Internal Medicine, St. Johann Spital, Paracelsus Private Medical University Salzburg, Salzburg, Austria
- Timothy D. Spector
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Affiliation Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom
- P. Eline Slagboom
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Affiliation Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
- Luigi Ferrucci
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Affiliation Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, United States of America
- Antti Jula
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Affiliation Population Studies Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku, Finland
- Markus Perola
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Affiliation Public Health Genomics Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, and Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland
- Olli Raitakari
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Affiliation Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and the Department of Clinical Physiology, Turku University Hospital, Turku, Finland
- Jose C. Florez
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Affiliations Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Diabetes Research Center, Diabetes Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America
- Veikko Salomaa
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¶These authors also contributed equally to this work.
Affiliation Chronic Disease Epidemiology and Prevention Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland
- Johan G. Eriksson
-
¶These authors also contributed equally to this work.
Affiliations Diabetes Prevention Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland, Unit of General Practice, Helsinki University Central Hospital, Helsinki, Finland, Folkhalsan Research Centre, Helsinki, Finland, Vaasa Central Hospital, Vaasa, Finland, Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland
- Timothy M. Frayling
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¶These authors also contributed equally to this work.
Affiliation Genetics of Complex Traits, Peninsula Medical School, University of Exeter, Exeter, United Kingdom
- Andrew A. Hicks
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¶These authors also contributed equally to this work.
Affiliation Center for Biomedicine, European Academy Bozen/Bolzano (EURAC) (Affiliated Institute of the University of Lübeck, Lübeck, Germany), Bolzano, Italy
- Terho Lehtimäki
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¶These authors also contributed equally to this work.
Affiliation Department of Clinical Chemistry, University of Tampere and Tampere University Hospital, Tampere, Finland
- George Davey Smith
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¶These authors also contributed equally to this work.
Affiliation MRC CAiTE Centre and School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
- David S. Siscovick
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¶These authors also contributed equally to this work.
Affiliation University of Washington, Seattle, Washington, United States of America
- Florian Kronenberg
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¶These authors also contributed equally to this work.
Affiliation Division of Genetic Epidemiology, Innsbruck Medical University, Innsbruck, Austria
- Cornelia van Duijn
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¶These authors also contributed equally to this work.
Affiliations Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, Centre for Medical Systems Biology, Leiden, The Netherlands
- Ruth J. F. Loos
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¶These authors also contributed equally to this work.
Affiliation MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom
- Dawn M. Waterworth
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¶These authors also contributed equally to this work.
Affiliation Genetics, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America
- James B. Meigs
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¶These authors also contributed equally to this work.
Affiliations General Medicine Division, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
- Josee Dupuis
-
¶These authors also contributed equally to this work.
Affiliations Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America, National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, United States of America
- J. Brent Richards
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* E-mail: brent.richards@mcgill.ca
Affiliations Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom, Departments of Medicine, Human Genetics, Epidemiology, and Biostatistics, Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, Canada
Competing Interests
DM Waterworth, X Yuan, and VE Mooser are full-time employees of GlaxoSmithKline. P Vollenweider received grant money from GlaxoSmithKline to fund the CoLaus study. The other authors declare no competing financial interests.
Author Contributions
Conceived and designed the experiments: Z Dastani, JB Richards, DM Waterworth, VE Mooser, C van Duijn, A Isaacs, JB Meigs, JC Florez, M-F Hivert, F Kronenberg, IM Heid, PP Pramstaller, JR Kizer, DS Siscovick, BM Psaty, O Raitakari, T Lehtimäki, JG Eriksson, M Perola, V Salomaa, RJF Loos, NJ Wareham, T Harris, L Qi, FB Hu, I Meulenbelt, M Kloppenburg, CM Ballantyne, H-E Wichmann, B Paulweber, L Kendenko, JG Wilson, A Bidulescu, S Musani, SG Buxbaum, S Redline, MA Allison, KL Mohlke, AP Morris, K Small. Performed the experiments: L Ferrucci, JM Egan, OD Carlson, P Vollenweider, C Lamina, NJ Wareham, J Chambers, J Kooner, R Frants, K Willems-vanDijk, SM Willems, TM Frayling, S Böhringer, F Kronenberg, AA Hicks, BM Psaty, I Chen, RP Tracy, M Kähönen, J Viikari, K Kristiansson, M-L Nuotio, K Lohman, A Kanaya, PE Slagboom, M Beekman, D van Heemst, I Meulenbelt, M Kloppenburg, CM Ballantyne, N Klopp, S Coassin, E Katsareli, A Bidulescu, MA Allison, LJ Rasmussen-Torvik, X Guo, JB Borja, LS Adair, M Haun. Analyzed the data: Z Dastani, N Timpson, T Tanaka, KA Kapur, R Semple, X Yuan, P Henneman, A Isaacs, J Dupuis, J Grimsby, AK Manning, CT Liu, JRB Perry, AR Wood, F Kronenberg, IM Heid, TW Winkler, C Langenberg, C Fuchsberger, J Brody, L-P Lyytikäinen, RA Scott, Y Liu, M Garcia, L Qi, FB Hu, M Beekman, I Meulenbelt, H-W Uh, JS Pankow, S Kanoni, A Bidulescu, SG Buxbaum, Y Wu, AP Morris, K Small, TM Teslovich, BA Oostra, AR Wood. Contributed reagents/materials/analysis tools: DM Evans, B St. Pourcain, N Sattar, CMT Greenwood, TD Spector, M Ladouceur, CV Dedoussis, JB Meigs, F Kronenberg, IM Heid, TW Winkler, C Langenberg, AA Hicks, PP Pramstaller, BM Psaty, I Chen, RP Tracy, A Jula, B-M Loo, PE Slagboom, S Bandinelli, I Meulenbelt, H-W Uh, M Kloppenburg, DJ Couper, H-E Wichmann, B Paulweber, GV Dedoussis, P Deloukas, S Redline, T Johnson, BA Oostra, GD Smith. Wrote the paper: Z Dastani, JB Richards, CMT Greenwood, N Timpson, DM Waterworth, VE Mooser, CV Dedoussis, A Isaacs, JB Meigs, JC Florez, J Dupuis, JRB Perry, M-F Hivert, F Kronenberg, IM Heid, T Lehtimäki, M Perola, RA Scott, C Langenberg, RJF Loos, T Harris, DJ Couper, CM Ballantyne, BB Duncan, H-E Wichmann, KL Mohlke, AP Morris, K Small, R Semple. Undertook meta-analysis: Z Dastani, J Dupuis. Did multi-ethnic analysis: AP Morris. Did expression analysis: K Small. Wrote the first draft of the manuscript: Z Dastani.