About the Authors

Eimear E. Kenny

Current address: Department of Genetics, Stanford University School of Medicine, Stanford, California, United States of America

Affiliation Department of Computer Sciences, Columbia University, New York, New York, United States of America

Itsik Pe'er

Affiliation Department of Computer Sciences, Columbia University, New York, New York, United States of America

Amir Karban

Affiliation Department of Gastroenterology, Rambam Health Care Campus, B. Rappaport Institute for Research in the Medical Sciences, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel

Laurie Ozelius

Affiliation Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, United States of America

Adele A. Mitchell

Affiliation Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, United States of America

Sok Meng Ng

Affiliation Department of Medicine, Section of Digestive Diseases, Yale University, New Haven, Connecticut, United States of America

Monica Erazo

Affiliation Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, United States of America

Harry Ostrer

Affiliation Department of Pathology, Albert Einstein College of Medicine, New York, New York, United States of America

Clara Abraham

Affiliation Department of Medicine, Section of Digestive Diseases, Yale University, New Haven, Connecticut, United States of America

Maria T. Abreu

Affiliation Division of Gastroenterology, University of Miami Miller School of Medicine, Miami, Florida, United States of America

Gil Atzmon

Affiliation Genetic Core for Longevity, Institute for Aging Research and the Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York, United States of America

Nir Barzilai

Affiliation Genetic Core for Longevity, Institute for Aging Research and the Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York, United States of America

Steven R. Brant

Affiliations Meyerhoff Inflammatory Bowel Disease Center, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America

Susan Bressman

Affiliations Mirken Department of Neurology, Beth Israel Medical Center, New York, New York, United States of America, The Saul R. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, United States of America

Edward R. Burns

Affiliation Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, United States of America

Yehuda Chowers

Affiliation Department of Gastroenterology, Rambam Health Care Campus, B. Rappaport Institute for Research in the Medical Sciences, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel

Lorraine N. Clark

Affiliation Department of Pathology and Cell Biology, Columbia University, New York, New York, United States of America

Ariel Darvasi

Affiliation The Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem, Israel

Dana Doheny

Affiliation Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, United States of America

Richard H. Duerr

Affiliations Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Rami Eliakim

Affiliation Department of Gastroenterology and Hepatology, Sheba Medical Center, Raman Gan, Israel

Nir Giladi

Affiliation Department of Neurology, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel-Aviv, Israel

Peter K. Gregersen

Affiliation Robert S. Boas Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, New York, United States of America

Hakon Hakonarson

Affiliation Center for Applied Genomics, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

Michelle R. Jones

Affiliation Division of Endocrinology, Diabetes, and Metabolism, Graduate Program in Biomedical Sciences and Translational Medicine, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

Karen Marder

Affiliations Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America

Dermot P. B. McGovern

Affiliations Department of Translational Medicine, Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

Jennifer Mulle

Affiliation Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, United States of America

Avi Orr-Urtreger

Affiliation Genetic Institute, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel-Aviv, Israel

Deborah D. Proctor

Affiliation Department of Medicine, Section of Digestive Diseases, Yale University, New Haven, Connecticut, United States of America

Ann Pulver

Affiliations Epidemiology-Genetics Program in Schizophrenia, Bipolar Disorders, and Related Disorders, Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America, Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America

Jerome I. Rotter

Affiliation Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

Mark S. Silverberg

Affiliation IBD Group, Mount Sinai Hospital, University of Toronto, Toronto, Canada

Thomas Ullman

Affiliation Division of Gastroenterology, Department of Medicine, Mount Sinai School of Medicine, New York, New York, United States of America

Stephen T. Warren

Affiliations Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, United States of America, Departments of Biochemistry and Pediatrics, Emory University School of Medicine, Atlanta, Georgia, United States of America

Matti Waterman

Affiliation Department of Gastroenterology, Rambam Health Care Campus, B. Rappaport Institute for Research in the Medical Sciences, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel

Wei Zhang

Affiliation Department of Medicine, Section of Digestive Diseases, Yale University, New Haven, Connecticut, United States of America

Aviv Bergman

Affiliation Department of Systems and Computational Biology, Albert Einstein College of Medicine, New York, New York, United States of America

Lloyd Mayer

Affiliation Division of Gastroenterology, Department of Medicine, Mount Sinai School of Medicine, New York, New York, United States of America

Seymour Katz

Affiliation Albert Einstein College of Medicine, North Shore University Hospital-Long Island Jewish Hospital Systems, St. Francis Hospital, Great Neck, New York, United States of America

Robert J. Desnick

Affiliation Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, United States of America

Judy H. Cho

judy.cho@yale.edu (JH Cho) (JC); inga.peter@mssm.edu (I Peter) (IP)

Affiliation Department of Medicine, Section of Digestive Diseases, Yale University, New Haven, Connecticut, United States of America

Inga Peter

judy.cho@yale.edu (JH Cho) (JC); inga.peter@mssm.edu (I Peter) (IP)

Affiliation Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: I Peter, JH Cho, I Pe'er, EE Kenny, RJ Desnick. Performed the experiments: AA Mitchell, M Erazo, SM Ng, PK Gregersen, J Mulle. Analyzed the data: EE Kenny, I Pe'er, MR Jones, DPB McGovern. Contributed reagents/materials/analysis tools: A Karban, L Ozelius, H Ostrer, C Abraham, MT Abreu, G Atzmon, N Barzilai, SR Brant, S Bressman, ER Burns, Y Chowers, LN Clark, D Doheny, RH Duerr, R Eliakim, N Giladi, H Hakonarson, K Marder, DPB McGovern, A Orr-Urtreger, A Darvasi, DD Proctor, A Pulver JI Roter, MS Silverberg, T Ullman, ST Warren, M Waterman, W Zhang, A Bergman, L Mayer, S Katz, JH Cho, I Peter. Wrote the paper: I Peter, JH Cho, I Pe'er, EE Kenny.