About the Authors

Ayşe Demirkan

Contributed equally to this work with: Ayşe Demirkan, Cornelia M. van Duijn, Peter Ugocsai, Aaron Isaacs, Peter P. Pramstaller, Gerhard Liebisch, James F. Wilson, Åsa Johansson, Igor Rudan

Affiliation Genetic Epidemiology Unit, Departments of Epidemiology and Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands

Cornelia M. van Duijn

Contributed equally to this work with: Ayşe Demirkan, Cornelia M. van Duijn, Peter Ugocsai, Aaron Isaacs, Peter P. Pramstaller, Gerhard Liebisch, James F. Wilson, Åsa Johansson, Igor Rudan

Affiliations Genetic Epidemiology Unit, Departments of Epidemiology and Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands, Centre for Medical Sytems Biology, Leiden, The Netherlands, Netherlands Consortium for Healthy Aging, Netherlands Genomics Initiative, Leiden, The Netherlands

Peter Ugocsai

Contributed equally to this work with: Ayşe Demirkan, Cornelia M. van Duijn, Peter Ugocsai, Aaron Isaacs, Peter P. Pramstaller, Gerhard Liebisch, James F. Wilson, Åsa Johansson, Igor Rudan

Affiliation Institute for Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany

Aaron Isaacs

Contributed equally to this work with: Ayşe Demirkan, Cornelia M. van Duijn, Peter Ugocsai, Aaron Isaacs, Peter P. Pramstaller, Gerhard Liebisch, James F. Wilson, Åsa Johansson, Igor Rudan

a.isaacs@erasmusmc.nl

Affiliations Genetic Epidemiology Unit, Departments of Epidemiology and Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands, Centre for Medical Sytems Biology, Leiden, The Netherlands

Peter P. Pramstaller

Contributed equally to this work with: Ayşe Demirkan, Cornelia M. van Duijn, Peter Ugocsai, Aaron Isaacs, Peter P. Pramstaller, Gerhard Liebisch, James F. Wilson, Åsa Johansson, Igor Rudan

Affiliations Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy, Department of Neurology, General Central Hospital, Bolzano, Italy, Department of Neurology, University of Lubeck, Lubeck, Germany

Gerhard Liebisch

Contributed equally to this work with: Ayşe Demirkan, Cornelia M. van Duijn, Peter Ugocsai, Aaron Isaacs, Peter P. Pramstaller, Gerhard Liebisch, James F. Wilson, Åsa Johansson, Igor Rudan

Affiliation Institute for Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany

James F. Wilson

Contributed equally to this work with: Ayşe Demirkan, Cornelia M. van Duijn, Peter Ugocsai, Aaron Isaacs, Peter P. Pramstaller, Gerhard Liebisch, James F. Wilson, Åsa Johansson, Igor Rudan

Affiliation Centre for Population Health Sciences, The University of Edinburgh Medical School, Edinburgh, United Kingdom

Åsa Johansson

Contributed equally to this work with: Ayşe Demirkan, Cornelia M. van Duijn, Peter Ugocsai, Aaron Isaacs, Peter P. Pramstaller, Gerhard Liebisch, James F. Wilson, Åsa Johansson, Igor Rudan

Affiliation Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden

Igor Rudan

Contributed equally to this work with: Ayşe Demirkan, Cornelia M. van Duijn, Peter Ugocsai, Aaron Isaacs, Peter P. Pramstaller, Gerhard Liebisch, James F. Wilson, Åsa Johansson, Igor Rudan

Affiliations Centre for Population Health Sciences, The University of Edinburgh Medical School, Edinburgh, United Kingdom, Institute for Clinical Medical Research, University Hospital “Sestre Milosrdnice”, Zagreb, Croatia, Croatian Centre for Global Health, Faculty of Medicine, University of Split, Split, Croatia

Yurii S. Aulchenko

Affiliation Genetic Epidemiology Unit, Departments of Epidemiology and Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands

Anatoly V. Kirichenko

Affiliation Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia

A. Cecile J. W. Janssens

Affiliation Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands

Ritsert C. Jansen

Affiliation Groningen Bioinformatics Centre, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, The Netherlands

Carsten Gnewuch

Affiliation Institute for Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany

Francisco S. Domingues

Affiliation Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy

Cristian Pattaro

Affiliation Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy

Sarah H. Wild

Affiliation Centre for Population Health Sciences, The University of Edinburgh Medical School, Edinburgh, United Kingdom

Inger Jonasson

Affiliations Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden, Croatian Centre for Global Health, Faculty of Medicine, University of Split, Split, Croatia

Ozren Polasek

Affiliation Croatian Centre for Global Health, Faculty of Medicine, University of Split, Split, Croatia

Irina V. Zorkoltseva

Affiliation Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia

Albert Hofman

Affiliations Netherlands Consortium for Healthy Aging, Netherlands Genomics Initiative, Leiden, The Netherlands, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands

Lennart C. Karssen

Affiliation Genetic Epidemiology Unit, Departments of Epidemiology and Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands

Maksim Struchalin

Affiliation Genetic Epidemiology Unit, Departments of Epidemiology and Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands

James Floyd

Affiliation Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

Wilmar Igl

Affiliation Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden

Zrinka Biloglav

Affiliation Andrija Stampar School of Public Health, Faculty of Medicine, University of Zagreb, Zagreb, Croatia

Linda Broer

Affiliation Genetic Epidemiology Unit, Departments of Epidemiology and Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands

Arne Pfeufer

Affiliation Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy

Irene Pichler

Affiliation Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy

Susan Campbell

Affiliation Centre for Population Health Sciences, The University of Edinburgh Medical School, Edinburgh, United Kingdom

Ghazal Zaboli

Affiliation Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden

Ivana Kolcic

Affiliation Croatian Centre for Global Health, Faculty of Medicine, University of Split, Split, Croatia

Fernando Rivadeneira

Affiliations Netherlands Consortium for Healthy Aging, Netherlands Genomics Initiative, Leiden, The Netherlands, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands

Jennifer Huffman

Affiliation Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Edinburgh, United Kingdom

Nicholas D. Hastie

Affiliation Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Edinburgh, United Kingdom

Andre Uitterlinden

Affiliations Netherlands Consortium for Healthy Aging, Netherlands Genomics Initiative, Leiden, The Netherlands, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands

Lude Franke

Affiliation Genetics Department, University Medical Centre Groningen and University of Groningen, Groningen, The Netherlands

Christopher S. Franklin

Affiliation Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

Veronique Vitart

Affiliations Centre for Population Health Sciences, The University of Edinburgh Medical School, Edinburgh, United Kingdom, Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Edinburgh, United Kingdom

DIAGRAM Consortium

‡ Memberships of the consortia are provided in Text S1.

Christopher P. Nelson

Affiliation Department of Cardiovascular Science, University of Leicester, Leicester, United Kingdom

Michael Preuss

Affiliation Institut fur Medizinische Biometrie und Statistik and Medizinische Klinik II, Universitat zu Lubeck, Lubeck, Germany

CARDIoGRAM Consortium

‡ Memberships of the consortia are provided in Text S1.

Joshua C. Bis

Affiliation Cardiovascular Health Research Unit and Department of Medicine, University of Washington, Seattle, Washington, United States of America

Christopher J. O'Donnell

Affiliations National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, United States of America, Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Nora Franceschini

Affiliation Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

CHARGE Consortium
Jacqueline C. M. Witteman

Affiliations Netherlands Consortium for Healthy Aging, Netherlands Genomics Initiative, Leiden, The Netherlands, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands

Tatiana Axenovich

Affiliation Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia

Ben A. Oostra

These authors were joint senior authors on this work.

Affiliations Centre for Medical Sytems Biology, Leiden, The Netherlands, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands, Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands

Thomas Meitinger

These authors were joint senior authors on this work.

Affiliations Institut for Human Genetics, Helmholtz-Zentrum München, Neuherberg, Germany, Institute of Human Genetics, Technische Universität München, München, Germany, Munich Heart Alliance, Munich, Germany

Andrew A. Hicks

These authors were joint senior authors on this work.

Affiliation Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy

Caroline Hayward

These authors were joint senior authors on this work.

Affiliation Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Edinburgh, United Kingdom

Alan F. Wright

These authors were joint senior authors on this work.

Affiliation Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Edinburgh, United Kingdom

Ulf Gyllensten

These authors were joint senior authors on this work.

Affiliation Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden

Harry Campbell

These authors were joint senior authors on this work.

Affiliation Centre for Population Health Sciences, The University of Edinburgh Medical School, Edinburgh, United Kingdom

Gerd Schmitz

These authors were joint senior authors on this work.

Affiliation Institute for Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany

on behalf of the EUROSPAN consortium

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GS HC UG AFW CH AAH TM BAO NDH IR JFW PPP CMvD AI. Performed the experiments: GL CG IR PU IJ CH SC OP IK GZ ZB IP SHW TM UG JFW HC ÅJ. Analyzed the data: AD AI YSA AVK ACJWJ IVZ TA MS LF LCK FSD LB CSF VV. Contributed reagents/materials/analysis tools: RCJ CP OP AH JF WI AP FR JH NDH AU JCMW CPN MP JCB CJO NF DIAGRAM CARDIoGRAM CHARGE. Wrote the paper: AD AI CMvD AAH CH HC BAO FSD.