About the Authors

Gerhard Sengle

Current address: Center for Biochemistry, Medical Faculty, University of Cologne, Cologne, Germany

Affiliations Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, Oregon, United States of America, Shriners Hospital for Children, Portland, Oregon, United States of America

Ko Tsutsui

Affiliations Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, Oregon, United States of America, Shriners Hospital for Children, Portland, Oregon, United States of America, Laboratory of Extracellular Matrix Biochemistry, Institute for Protein Research, Osaka University, Osaka, Japan

Douglas R. Keene

Affiliation Shriners Hospital for Children, Portland, Oregon, United States of America

Sara F. Tufa

Affiliation Shriners Hospital for Children, Portland, Oregon, United States of America

Eric J. Carlson

Affiliations Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, Oregon, United States of America, Shriners Hospital for Children, Portland, Oregon, United States of America

Noe L. Charbonneau

Affiliation Shriners Hospital for Children, Portland, Oregon, United States of America

Robert N. Ono

Affiliation Shriners Hospital for Children, Portland, Oregon, United States of America

Takako Sasaki

Current address: Nikolaus Fiebiger Center for Molecular Medicine, University of Erlangen-Nuremberg, Erlangen, Germany

Affiliations Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, Oregon, United States of America, Shriners Hospital for Children, Portland, Oregon, United States of America

Mary K. Wirtz

Affiliation Casey Eye Institute, Department of Ophthalmology, Oregon Health and Science University, Portland, Oregon, United States of America

John R. Samples

Affiliation Casey Eye Institute, Department of Ophthalmology, Oregon Health and Science University, Portland, Oregon, United States of America

Liselotte I. Fessler

Affiliation Department of Molecular, Cell, and Developmental Biology and Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, United States of America

John H. Fessler

Affiliation Department of Molecular, Cell, and Developmental Biology and Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, United States of America

Kiyotoshi Sekiguchi

Affiliation Laboratory of Extracellular Matrix Biochemistry, Institute for Protein Research, Osaka University, Osaka, Japan

Susan J. Hayflick

Affiliation Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, Oregon, United States of America

Lynn Y. Sakai

lys@shcc.org

Affiliations Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, Oregon, United States of America, Shriners Hospital for Children, Portland, Oregon, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GS DRK LYS. Performed the experiments: GS KT DRK SFT EJC NLC RNO TS. Analyzed the data: GS KT DRK SFT EJC NLC RNO TS MKW JRS LIF JHF KS SJH LYS. Contributed reagents/materials/analysis tools: GS KT DRK SFT EJC NLC RNO TS MKW JRS LIF JHF KS SJH LYS. Wrote the paper: GS DRK EJC TS MKW JRS JHF KS SJH LYS.