About the Authors

Amidou N'Diaye

Contributed equally to this work with: Amidou N'Diaye, Gary K. Chen, Cameron D. Palmer

Affiliation Montreal Heart Institute, Montréal, Canada

Gary K. Chen

Contributed equally to this work with: Amidou N'Diaye, Gary K. Chen, Cameron D. Palmer

Affiliation Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, United States of America

Cameron D. Palmer

Contributed equally to this work with: Amidou N'Diaye, Gary K. Chen, Cameron D. Palmer

Affiliations Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America, Divisions of Genetics and Endocrinology and Program in Genomics, Children's Hospital Boston, Boston, Massachusetts, United States of America

Bing Ge

Affiliation Department of Human Genetics, McGill University and Genome Quebec Innovation Centre, Montreal, Canada

Bamidele Tayo

Affiliation Department of Preventive Medicine and Epidemiology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois, United States of America

Rasika A. Mathias

Affiliation Department of Medicine, The Johns Hopkins GeneSTAR Research Program, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Jingzhong Ding

Affiliation Sticht Center on Aging, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America

Michael A. Nalls

Affiliation Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

Adebowale Adeyemo

Affiliation NIH Intramural Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

Véronique Adoue

Affiliation Department of Human Genetics, McGill University and Genome Quebec Innovation Centre, Montreal, Canada

Christine B. Ambrosone

Affiliation Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, United States of America

Larry Atwood

Affiliation Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America

Elisa V. Bandera

Affiliation The Cancer Institute of New Jersey, New Brunswick, New Jersey, United States of America

Lewis C. Becker

Affiliation Department of Medicine, The Johns Hopkins GeneSTAR Research Program, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Sonja I. Berndt

Affiliation Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

Leslie Bernstein

Affiliation Division of Cancer Etiology, Department of Population Science, Beckman Research Institute, City of Hope, Duarte, California, United States of America

William J. Blot

Affiliations International Epidemiology Institute, Rockville, Maryland, United States of America, Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University, Nashville, Tennessee, United States of America, Vanderbilt–Ingram Cancer Center, Nashville, Tennessee, United States of America

Eric Boerwinkle

Affiliation Human Genetics Center and Institute of Molecular Medicine and Division of Epidemiology, University of Texas Health Science Center, Houston, Texas, United States of America

Angela Britton

Affiliation Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

Graham Casey

Affiliation Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, United States of America

Stephen J. Chanock

Affiliation Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

Ellen Demerath

Affiliation Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, Minnesota, United States of America

Sandra L. Deming

Affiliations Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University, Nashville, Tennessee, United States of America, Vanderbilt–Ingram Cancer Center, Nashville, Tennessee, United States of America

W. Ryan Diver

Affiliation Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, United States of America

Caroline Fox

Affiliation Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States of America

Tamara B. Harris

Affiliation Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

Dena G. Hernandez

Affiliation Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

Jennifer J. Hu

Affiliation Sylvester Comprehensive Cancer Center and Department of Epidemiology and Public Health, University of Miami Miller School of Medicine, Miami, Florida, United States of America

Sue A. Ingles

Affiliation Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, United States of America

Esther M. John

Affiliations Cancer Prevention Institute of California, Fremont, California, United States of America, School of Medicine and Stanford Cancer Center, Stanford University, Stanford, California, United States of America

Craig Johnson

Affiliation Department of Biostatistics, University of Washington, Seattle, Washington, United States of America

Brendan Keating

Affiliation Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

Rick A. Kittles

Affiliation Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America

Laurence N. Kolonel

Affiliation Epidemiology Program, Cancer Research Center, University of Hawaii, Honolulu, Hawaii, United States of America

Stephen B. Kritchevsky

Affiliation Sticht Center on Aging, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America

Loic Le Marchand

Affiliation Epidemiology Program, Cancer Research Center, University of Hawaii, Honolulu, Hawaii, United States of America

Kurt Lohman

Affiliation Sticht Center on Aging, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America

Jiankang Liu

Affiliation University of Mississippi Medical Center, Jackson, Mississippi, United States of America

Robert C. Millikan

Affiliation Department of Epidemiology, Gillings School of Global Public Health and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States of America

Adam Murphy

Affiliation Department of Urology, Northwestern University, Chicago, Illinois, United States of America

Solomon Musani

Affiliation Jackson Heart Study, Department of Medicine, Division of Cardiovascular Disease, University of Mississippi Medical Center, Jackson, Mississippi, United States of America

Christine Neslund-Dudas

Affiliation Department of Biostatistics and Research Epidemiology, Henry Ford Hospital, Detroit, Michigan, United States of America

Kari E. North

Affiliations Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, United States of America, Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, North Carolina, United States of America

Sarah Nyante

Affiliation Department of Epidemiology, Gillings School of Global Public Health and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States of America

Adesola Ogunniyi

Affiliation Department of Medicine, University of Ibadan, Ibadan, Nigeria

Elaine A. Ostrander

Affiliation Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

George Papanicolaou

Affiliation National Heart, Lung, and Blood Institute (NHLBI), Division of Cardiovascular Sciences, National Institutes of Health, Bethesda, Maryland, United States of America

Sanjay Patel

Affiliation Division of Sleep Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

Curtis A. Pettaway

Affiliation Department of Urology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America

Michael F. Press

Affiliation Department of Pathology, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, United States of America

Susan Redline

Affiliation Division of Sleep Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

Jorge L. Rodriguez-Gil

Affiliation Sylvester Comprehensive Cancer Center and Department of Epidemiology and Public Health, University of Miami Miller School of Medicine, Miami, Florida, United States of America

Charles Rotimi

Affiliation NIH Intramural Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

Benjamin A. Rybicki

Affiliation Department of Biostatistics and Research Epidemiology, Henry Ford Hospital, Detroit, Michigan, United States of America

Babatunde Salako

Affiliation Department of Medicine, University of Ibadan, Ibadan, Nigeria

Pamela J. Schreiner

Affiliation Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, United States of America

Lisa B. Signorello

Affiliations International Epidemiology Institute, Rockville, Maryland, United States of America, Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University, Nashville, Tennessee, United States of America, Vanderbilt–Ingram Cancer Center, Nashville, Tennessee, United States of America

Andrew B. Singleton

Affiliation Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

Janet L. Stanford

Affiliation Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

Alex H. Stram

Affiliation Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, United States of America

Daniel O. Stram

Affiliation Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, United States of America

Sara S. Strom

Affiliation Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America

Bhoom Suktitipat

Affiliations Department of Medicine, The Johns Hopkins GeneSTAR Research Program, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America

Michael J. Thun

Affiliation Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, United States of America

John S. Witte

Affiliation Institute for Human Genetics, Departments of Epidemiology and Biostatistics and Urology, University of California San Francisco, San Francisco, California, United States of America

Lisa R. Yanek

Affiliation Department of Medicine, The Johns Hopkins GeneSTAR Research Program, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Regina G. Ziegler

Affiliation Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

Wei Zheng

Affiliations Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University, Nashville, Tennessee, United States of America, Vanderbilt–Ingram Cancer Center, Nashville, Tennessee, United States of America

Xiaofeng Zhu

Affiliation Department of Biostatistics and Epidemiology, Case Western Reserve University, Cleveland, Ohio, United States of America

Joseph M. Zmuda

Affiliation Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Alan B. Zonderman

Affiliation Laboratory of Personality and Cognition, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

Michele K. Evans

Affiliation Health Disparities Research Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

Yongmei Liu

Affiliation Sticht Center on Aging, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America

Diane M. Becker

Affiliation Department of Medicine, The Johns Hopkins GeneSTAR Research Program, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Richard S. Cooper

Affiliation Department of Preventive Medicine and Epidemiology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois, United States of America

Tomi Pastinen

Affiliation Department of Human Genetics, McGill University and Genome Quebec Innovation Centre, Montreal, Canada

Brian E. Henderson

Affiliation Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, United States of America

Joel N. Hirschhorn

joelh@broadinstitute.org (JN Hirschhorn); guillaume.lettre@umontreal.ca (G Lettre); haiman@usc.edu (CA Haiman)

Affiliations Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America, Divisions of Genetics and Endocrinology and Program in Genomics, Children's Hospital Boston, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

Guillaume Lettre

joelh@broadinstitute.org (JN Hirschhorn); guillaume.lettre@umontreal.ca (G Lettre); haiman@usc.edu (CA Haiman)

Affiliations Montreal Heart Institute, Montréal, Canada, Département de Médecine, Université de Montréal, Montréal, Canada

Christopher A. Haiman

joelh@broadinstitute.org (JN Hirschhorn); guillaume.lettre@umontreal.ca (G Lettre); haiman@usc.edu (CA Haiman)

Affiliation Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JN Hirschhorn, G Lettre, CA Haiman. Performed the experiments: A N'Diaye, GK Chen, CD Palmer, B Ge, V Adoue, AB Singleton, T Pastinen, JN Hirschhorn, G Lettre, CA Haiman. Analyzed the data: A N'Diaye, GK Chen, CD Palmer, B Ge, V Adoue, AB Singleton, T Pastinen, JN Hirschhorn, G Lettre, CA Haiman. Contributed reagents/materials/analysis tools: A N'Diaye, GK Chen, CD Palmer, B Ge, B Tayo, CB Ambrosone, RA Mathias, J Ding, MA Nalls, A Adeyemo, V Adoue, L Atwood, EV Bandera, LC Becker, SI Berndt, L Bernstein, WJ Blot, E Boerwinkle, A Britton, G Casey, SJ Chanock, E Demerath, SL Deming, WR Diver, C Fox, TB Harris, DG Hernandez, JJ Hu, SA Ingles, EM John, C Johnson, B Keating, RA Kittles, LN Kolonel, SB Kritchevsky, L Le Marchand, K Lohman, J Liu, RC Millikan, A Murphy, S Musani, C Neslund-Dudas, KE North, S Nyante, A Ogunniyi, EA Ostrander, G Papanicolaou, S Patel, CA Pettaway, MF Press, S Redline, JL Rodriguez-Gil, C Rotimi, BA Rybicki, B Salako, PJ Schreiner, LB Signorello, AB Singleton, JL Stanford, AH Stram, DO Stram, SS Strom, B Suktitipat, MJ Thun, JS Witte, LR Yanek, RG Zieger, W Zheng, X Zhu, JM Zmuda, AB Zonderman, MK Evans, Y Liu, DM Becker, RS Cooper, T Pastinen, BE Henderson, JN Hirschhorn, G Lettre, CA Haiman. Wrote the paper: A N'Diaye, GK Chen, CD Palmer, T Pastinen, JN Hirschhorn, G Lettre, CA Haiman.