About the Authors
- Olga Gorlova
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Contributed equally to this work with: Olga Gorlova, Jose-Ezequiel Martin, Blanca Rueda, Bobby P. C. Koeleman, Spanish Scleroderma Group
* E-mail: oygorlov@mdanderson.org (O Gorlova); martin@ipb.csic.es (J Martin)
Affiliation Department of Epidemiology, M. D. Anderson Cancer Center, Houston, Texas, United States of America
- Jose-Ezequiel Martin
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Contributed equally to this work with: Olga Gorlova, Jose-Ezequiel Martin, Blanca Rueda, Bobby P. C. Koeleman, Spanish Scleroderma Group
Affiliation Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas, Granada, Spain
- Blanca Rueda
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Contributed equally to this work with: Olga Gorlova, Jose-Ezequiel Martin, Blanca Rueda, Bobby P. C. Koeleman, Spanish Scleroderma Group
Affiliation Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas, Granada, Spain
- Bobby P. C. Koeleman
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Contributed equally to this work with: Olga Gorlova, Jose-Ezequiel Martin, Blanca Rueda, Bobby P. C. Koeleman, Spanish Scleroderma Group
Affiliation Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands
- Jun Ying
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Affiliation Department of Epidemiology, M. D. Anderson Cancer Center, Houston, Texas, United States of America
- Maria Teruel
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Affiliation Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas, Granada, Spain
- Lina-Marcela Diaz-Gallo
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Affiliation Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas, Granada, Spain
- Jasper C. Broen
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Affiliation Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
- Madelon C. Vonk
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Affiliation Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
- Carmen P. Simeon
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Affiliation Servicio de Medicina Interna, Hospital Valle de Hebron, Barcelona, Spain
- Behrooz Z. Alizadeh
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Affiliation University Medical Centre Groningen, Department of Epidemiology, Groningen, The Netherlands
- Marieke J. H. Coenen
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Affiliation Department of Human Genetics, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
- Alexandre E. Voskuyl
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Affiliation VU University Medical Center, Amsterdam, The Netherlands
- Annemie J. Schuerwegh
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Affiliation Department of Rheumatology, University of Leiden, Leiden, The Netherlands
- Piet L. C. M. van Riel
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Affiliation Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
- Marie Vanthuyne
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Affiliation Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium
- Ruben van 't Slot
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Affiliation Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands
- Annet Italiaander
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Affiliation Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands
- Roel A. Ophoff
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Affiliation Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands
- Nicolas Hunzelmann
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Affiliation Department of Dermatology, University of Cologne, Cologne, Germany
- Vicente Fonollosa
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Affiliation Servicio de Medicina Interna, Hospital Valle de Hebron, Barcelona, Spain
- Norberto Ortego-Centeno
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Affiliation Servicio de Medicina Interna, Hospital Clínico Universitario, Granada, Spain
- Miguel A. González-Gay
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Affiliation Servicio de Reumatología, Hospital Marqués de Valdecilla, Santander, Spain
- Francisco J. García-Hernández
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Affiliation Servicio de Medicina Interna, Hospital Virgen del Rocio, Sevilla, Spain
- María F. González-Escribano
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Affiliation Servicio de Inmunología, Hospital Virgen del Rocío, Sevilla, Spain
- Paolo Airo
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Affiliation Rheumatology Unit and Chair, Spedali Civili, Università degli Studi, Brescia, Italy
- Jacob van Laar
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Affiliation Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, United Kingdom
- Jane Worthington
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Affiliation Department of Rheumatology and Epidemiology, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom
- Roger Hesselstrand
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Affiliation Department of Clinical Sciences, Division of Rheumatology, Lund University, Lund, Sweden
- Vanessa Smith
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Affiliation Ghent University, Ghent, Belgium
- Filip de Keyser
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Affiliation Ghent University, Ghent, Belgium
- Fredric Houssiau
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Affiliation Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium
- Meng May Chee
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Affiliation Centre for Rheumatic Diseases, Glasgow Royal Infirmary Glasgow, United Kingdom
- Rajan Madhok
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Affiliation Centre for Rheumatic Diseases, Glasgow Royal Infirmary Glasgow, United Kingdom
- Paul G. Shiels
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Affiliation Department of Surgery, Western Infirmary Glasgow, University of Glasgow, Glasgow, United Kingdom
- Rene Westhovens
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Affiliation Katholieke Universiteit Leuven, Leuven, Belgium
- Alexander Kreuter
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Affiliation Department of Dermatology, Josefs-Hospital, Ruhr University Bochum, Germany
- Elfride de Baere
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Affiliation Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium
- Torsten Witte
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Affiliation Hannover Medical School, Hannover, Germany
- Leonid Padyukov
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Affiliation Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
- Annika Nordin
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Affiliation Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
- Raffaella Scorza
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Affiliation Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico and University of Milan, Milan, Italy
- Claudio Lunardi
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Affiliation Department of Medicine, Policlinico GB Rossi, University of Verona, Italy
- Benedicte A. Lie
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Affiliation Institute of Immunology, Oslo University Hospital Rikshospitalet, Oslo, Norway
- Anna-Maria Hoffmann-Vold
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Affiliation Department of Rheumatology, Rikshospitalet, Oslo University Hospital, Oslo, Norway
- Øyvind Palm
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Affiliation Department of Rheumatology, Rikshospitalet, Oslo University Hospital, Oslo, Norway
- Paloma García de la Peña
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Affiliation Servicio de Reumatología, Hospital Ramón y Cajal, Madrid, Spain
- Patricia Carreira
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Affiliation Hospital 12 de Octubre, Madrid, Spain
- Spanish Scleroderma Group
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Contributed equally to this work with: Olga Gorlova, Jose-Ezequiel Martin, Blanca Rueda, Bobby P. C. Koeleman, Spanish Scleroderma Group
Affiliation For membership of the Spanish Scleroderma Group, please see Text S1.
- John Varga
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Affiliation Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America
- Monique Hinchcliff
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Affiliation Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America
- Annette T. Lee
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Affiliation Feinstein Institute of Medical Research, Manhasset, New York, United States of America
- Pravitt Gourh
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Affiliation The University of Texas Health Science Center–Houston, Houston, Texas, United States of America
- Christopher I. Amos
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Affiliation Department of Epidemiology, M. D. Anderson Cancer Center, Houston, Texas, United States of America
- Frederick M. Wigley
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Affiliation The Johns Hopkins University Medical Center, Baltimore, Maryland, United States of America
- Laura K. Hummers
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Affiliation Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
- J. Hummers
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Affiliation The Johns Hopkins University Medical Center, Baltimore, Maryland, United States of America
- J. Lee Nelson
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Affiliation Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
- Gabriella Riemekasten
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Affiliation Department of Rheumatology and Clinical Immunology, Charité University Hospital, Berlin, Germany
- Ariane Herrick
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Affiliation Department of Rheumatology and Epidemiology, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom
- Lorenzo Beretta
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Affiliation Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico and University of Milan, Milan, Italy
- Carmen Fonseca
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Affiliation Centre for Rheumatology, Royal Free and University College School, London, United Kingdom
- Christopher P. Denton
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Affiliation Centre for Rheumatology, Royal Free and University College School, London, United Kingdom
- Peter K. Gregersen
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Affiliation Feinstein Institute of Medical Research, Manhasset, New York, United States of America
- Sandeep Agarwal
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Affiliation The University of Texas Health Science Center–Houston, Houston, Texas, United States of America
- Shervin Assassi
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Affiliation The University of Texas Health Science Center–Houston, Houston, Texas, United States of America
- Filemon K. Tan
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Affiliation The University of Texas Health Science Center–Houston, Houston, Texas, United States of America
- Frank C. Arnett
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¶These authors also contributed equally to this work.
Affiliation The University of Texas Health Science Center–Houston, Houston, Texas, United States of America
- Timothy R. D. J. Radstake
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¶These authors also contributed equally to this work.
Affiliation Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
- Maureen D. Mayes
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¶These authors also contributed equally to this work.
Affiliation The University of Texas Health Science Center–Houston, Houston, Texas, United States of America
- Javier Martin
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* E-mail: oygorlov@mdanderson.org (O Gorlova); martin@ipb.csic.es (J Martin)
¶These authors also contributed equally to this work.
Affiliation Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas, Granada, Spain
Competing Interests
The authors have declared that no competing interests exist.
Author Contributions
Conceived and designed the experiments: O Gorlova, J-E Martin, B Rueda, BPC Koeleman, FC Arnett, TRDJ Radstake, MD Mayes, J Martin. Performed the experiments: O Gorlova, J-E Martin, B Rueda, M Teruel, L-M Diaz-Gallo, JC Broen, P Gourh, S Agarwal, S Assassi. Analyzed the data: O Gorlova, J-E Martin, B Rueda, BPC Koeleman, BZ Alizadeh. Contributed reagents/materials/analysis tools: J Ying, MC Vonk, CP Simeon, MJH Coenen, AE Voskuyl, AJ Schuerwegh, PLCM van Riel, M Vanthuyne, R van 't Slot, A Italiaander, RA Ophoff, N Hunzelmann, V Fonollosa, N Ortego-Centeno, MA González-Gay, FJ García-Hernández, MF González-Escribano, P Airo, J van Laar, J Worthington, R Hesselstrand, V Smith, F de Keyser, F Houssiau, MM Chee, R Madhok, PG Shiels, R Westhovens, A Kreuter, E de Baere, T Witte, L Padyukov, A Nordin, R Scorza, C Lunardi, BA Lie A-M Hoffmann-Vold, Ø Palm, P García de la Peña, P Carreira, Spanish Scleroderma Group, J Varga, M Hinchcliff, AT Lee, P Gourh, CI Amos, FM Wigley, LK Hummers, JL Nelson, G Riemekasten, A Herrick, L Beretta, C Fonseca, CP Denton, S Agarwal, S Assassi, FK Tan, FC Arnett, TRDJ Radstake, MD Mayes, J Martin. Wrote the paper: O Gorlova, J-E Martin, B Rueda, BPC Koeleman, PK Gregersen, FC Arnett, TRDJ Radstake, MD Mayes, J Martin.