About the Authors

Dirk S. Paul

dp5@sanger.ac.uk (DSP); panos@sanger.ac.uk (PD)

Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom

James P. Nisbet

Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom

Tsun-Po Yang

Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom

Stuart Meacham

Affiliations Wellcome Trust Sanger Institute, Hinxton, United Kingdom, Department of Haematology, University of Cambridge, Cambridge, United Kingdom, National Health Service Blood and Transplant (NHSBT), Cambridge, United Kingdom

Augusto Rendon

Affiliations Department of Haematology, University of Cambridge, Cambridge, United Kingdom, National Health Service Blood and Transplant (NHSBT), Cambridge, United Kingdom, Biostatistics Unit, Medical Research Council, Cambridge, United Kingdom

Katta Hautaviita

Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom

Jonna Tallila

Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom

Jacqui White

Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom

Marloes R. Tijssen

Affiliations Department of Haematology, University of Cambridge, Cambridge, United Kingdom, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom

Suthesh Sivapalaratnam

Affiliation Department of Vascular Medicine, Academic Medical Centre Amsterdam, Amsterdam, The Netherlands

Hanneke Basart

Affiliation Department of Vascular Medicine, Academic Medical Centre Amsterdam, Amsterdam, The Netherlands

Mieke D. Trip

Affiliation Department of Vascular Medicine, Academic Medical Centre Amsterdam, Amsterdam, The Netherlands

Consortium Cardiogenics

Memberships of the Cardiogenics and MuTHER Consortia are provided in the Acknowledgments.

Consortium MuTHER

Memberships of the Cardiogenics and MuTHER Consortia are provided in the Acknowledgments.

Berthold Göttgens

Affiliations Department of Haematology, University of Cambridge, Cambridge, United Kingdom, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom

Nicole Soranzo

Affiliations Wellcome Trust Sanger Institute, Hinxton, United Kingdom, Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

Willem H. Ouwehand

Affiliations Wellcome Trust Sanger Institute, Hinxton, United Kingdom, Department of Haematology, University of Cambridge, Cambridge, United Kingdom, National Health Service Blood and Transplant (NHSBT), Cambridge, United Kingdom

Panos Deloukas

dp5@sanger.ac.uk (DSP); panos@sanger.ac.uk (PD)

Affiliation Wellcome Trust Sanger Institute, Hinxton, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DSP PD. Performed the experiments: DSP JPN. Analyzed the data: DSP T-PY SM. Contributed reagents/materials/analysis tools: AR SS HB MDT Cardiogenics Consortium, MuTHER Consortium. Wrote the paper: DSP WHO PD. Made significant contributions to editing the paper: AR NS. Performed animal experiments: KH JT JW. Performed ChIP-seq experiments: MRT BG.