A New Testing Strategy to Identify Rare Variants with Either Risk or Protective Effect on Disease

Iuliana Ionita-Laza; Joseph D. Buxbaum; Nan M. Laird; Christoph Lange

doi:10.1371/journal.pgen.1001289

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Open Access

Peer-reviewed

Research Article

A New Testing Strategy to Identify Rare Variants with Either Risk or Protective Effect on Disease

Iuliana Ionita-Laza ,

* E-mail: ii2135@columbia.edu

Affiliation Department of Biostatistics, Columbia University, New York, New York, United States of America
⨯
Joseph D. Buxbaum,

Affiliation Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, United States of America
⨯
Nan M. Laird ,

Contributed equally to this work with: Nan M. Laird, Christoph Lange

Affiliation Department of Biostatistics, Harvard University, Boston, Massachusetts, United States of America
⨯
Christoph Lange

Contributed equally to this work with: Nan M. Laird, Christoph Lange

Affiliations Department of Biostatistics, Harvard University, Boston, Massachusetts, United States of America, Institute for Genomic Mathematics, University of Bonn, Bonn, Germany, German Center for Neurodegenerative Diseases, Bonn, Germany
⨯

A New Testing Strategy to Identify Rare Variants with Either Risk or Protective Effect on Disease

Iuliana Ionita-Laza,
Joseph D. Buxbaum,
Nan M. Laird,
Christoph Lange

Published: February 3, 2011
https://doi.org/10.1371/journal.pgen.1001289

About the Authors

Iuliana Ionita-Laza

* E-mail: ii2135@columbia.edu

Affiliation Department of Biostatistics, Columbia University, New York, New York, United States of America

Joseph D. Buxbaum

Affiliation Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, United States of America

Nan M. Laird

Contributed equally to this work with: Nan M. Laird, Christoph Lange

Affiliation Department of Biostatistics, Harvard University, Boston, Massachusetts, United States of America

Christoph Lange

Contributed equally to this work with: Nan M. Laird, Christoph Lange

Affiliations Department of Biostatistics, Harvard University, Boston, Massachusetts, United States of America, Institute for Genomic Mathematics, University of Bonn, Bonn, Germany, German Center for Neurodegenerative Diseases, Bonn, Germany

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: IIL NML CL. Performed the experiments: IIL. Analyzed the data: IIL. Contributed reagents/materials/analysis tools: IIL JDB. Wrote the paper: IIL NML CL.

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