Characterising and Predicting Haploinsufficiency in the Human Genome

Ni Huang; Insuk Lee; Edward M. Marcotte; Matthew E. Hurles

doi:10.1371/journal.pgen.1001154

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Open Access

Peer-reviewed

Research Article

Characterising and Predicting Haploinsufficiency in the Human Genome

Ni Huang,

Affiliation Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom
⨯
Insuk Lee,

Affiliations Center for Systems and Synthetic Biology, Department of Chemistry and Biochemistry, Institute for Cellular and Molecular Biology, University of Texas, Austin, Texas, United States of America, Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea
⨯
Edward M. Marcotte,

Affiliation Center for Systems and Synthetic Biology, Department of Chemistry and Biochemistry, Institute for Cellular and Molecular Biology, University of Texas, Austin, Texas, United States of America
⨯
Matthew E. Hurles

* E-mail: meh@sanger.ac.uk

Affiliation Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom
⨯

Characterising and Predicting Haploinsufficiency in the Human Genome

Ni Huang,
Insuk Lee,
Edward M. Marcotte,
Matthew E. Hurles

Published: October 14, 2010
https://doi.org/10.1371/journal.pgen.1001154

About the Authors

Ni Huang

Affiliation Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom

Insuk Lee

Affiliations Center for Systems and Synthetic Biology, Department of Chemistry and Biochemistry, Institute for Cellular and Molecular Biology, University of Texas, Austin, Texas, United States of America, Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea

Edward M. Marcotte

Affiliation Center for Systems and Synthetic Biology, Department of Chemistry and Biochemistry, Institute for Cellular and Molecular Biology, University of Texas, Austin, Texas, United States of America

Matthew E. Hurles

* E-mail: meh@sanger.ac.uk

Affiliation Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NH MEH. Analyzed the data: NH. Contributed reagents/materials/analysis tools: IL EMM. Wrote the paper: NH MEH.

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Haploinsufficiency
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Forecasting
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Genomics
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Gene prediction
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Evolutionary genetics
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Mammalian genomics
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Heterozygosity
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Genome-wide association studies
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