On the Use of Variance per Genotype as a Tool to Identify Quantitative Trait Interaction Effects: A Report from the Women's Genome Health Study

Guillaume Paré; Nancy R. Cook; Paul M. Ridker; Daniel I. Chasman

doi:10.1371/journal.pgen.1000981

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Open Access

Peer-reviewed

Research Article

On the Use of Variance per Genotype as a Tool to Identify Quantitative Trait Interaction Effects: A Report from the Women's Genome Health Study

Guillaume Paré ,

* E-mail: pareg@mcmaster.ca

Affiliations Department of Pathology and Molecular Medicine, Population Genomics Program, McMaster University, Hamilton, Canada, Department of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America
⨯
Nancy R. Cook,

Affiliation Department of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America
⨯
Paul M. Ridker,

Affiliation Department of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America
⨯
Daniel I. Chasman

Affiliation Department of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America
⨯

On the Use of Variance per Genotype as a Tool to Identify Quantitative Trait Interaction Effects: A Report from the Women's Genome Health Study

Guillaume Paré,
Nancy R. Cook,
Paul M. Ridker,
Daniel I. Chasman

Published: June 17, 2010
https://doi.org/10.1371/journal.pgen.1000981

About the Authors

Guillaume Paré

* E-mail: pareg@mcmaster.ca

Affiliations Department of Pathology and Molecular Medicine, Population Genomics Program, McMaster University, Hamilton, Canada, Department of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

Nancy R. Cook

Affiliation Department of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

Paul M. Ridker

Affiliation Department of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

Daniel I. Chasman

Affiliation Department of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GP. Performed the experiments: GP. Analyzed the data: GP. Contributed reagents/materials/analysis tools: GP PMR DIC. Wrote the paper: GP NRC PMR DIC.

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Single nucleotide polymorphisms
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Quantitative traits
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Variant genotypes
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Genetics
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Linear regression analysis
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C-reactive proteins
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Drug interactions
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Protein interactions
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