About the Authors

Daniel I. Chasman

dchasman@rics.bwh.harvard.edu

Affiliations Donald W. Reynolds Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

Guillaume Paré

Affiliations Donald W. Reynolds Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

Samia Mora

Affiliations Donald W. Reynolds Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Division of Cardiology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

Jemma C. Hopewell

Affiliations PROCARDIS Consortium, Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom

Gina Peloso

Affiliation Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

Robert Clarke

Affiliations PROCARDIS Consortium, Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom

L. Adrienne Cupples

Affiliations Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America, Framingham Heart Study, Boston University School of Medicine, Boston, Massachusetts, United States of America

Anders Hamsten

Affiliations PROCARDIS Consortium, Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden

Sekar Kathiresan

Affiliation Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, United States of America

Anders Mälarstig

Affiliations PROCARDIS Consortium, Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden

José M. Ordovas

Affiliation USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, United States of America

Samuli Ripatti

Affiliation Institute for Molecular Medicine Finland, FIMM, Helsinki, Finland

Alex N. Parker

Affiliation Amgen, Inc., Cambridge, Massachusetts, United States of America

Joseph P. Miletich

Affiliation Amgen, Inc., Thousand Oaks, California, United States of America

Paul M. Ridker

Affiliations Donald W. Reynolds Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Division of Cardiology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

Competing Interests

Alex Parker and Joseph Miletich are employees of Amgen.

Author Contributions

Conceived and designed the experiments: DI Chasman, G Paré, S Mora. Performed the experiments: AN Parker. Analyzed the data: DI Chasman, G Paré, JC Hopewell, Gina Peloso, S Ripatti. Contributed reagents/materials/analysis tools: DI Chasman, G Paré, JC Hopewell, R Clarke, LA Cupples. A Hamsten, S Kathiresan, A Mälarstig, JM Ordovas, S Ripatti, AN Parker, JP Miletich, PM Ridker. Wrote the paper: DI Chasman, S Mora, JC Hopewell, G Peloso, R Clarke, LA Cupples, A Hamsten, S Kathiresan, A Mälarstig, JM Ordovas, S Ripatti, AN Parker, JP Miletich, PM Ridker. Made comments on the manuscript: A Hamsten.