About the Authors

Gyungah Jun

Contributed equally to this work with: Gyungah Jun, Hong Guo

Affiliation Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

Hong Guo

Contributed equally to this work with: Gyungah Jun, Hong Guo

Affiliation Rammelkamp Center for Research, Department of Pharmacology and Ireland Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

Barbara E. K. Klein

Affiliation Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America

Ronald Klein

Affiliation Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America

Jie Jin Wang

Affiliations Centre for Vision Research, Westmead Millennium Institute, Westmead Hospital, Department of Ophthalmology, University of Sydney, Sydney, Australia, Centre for Eye Research Australia and Department of Ophthalmology, University of Melbourne, Melbourne, Australia

Paul Mitchell

Affiliation Centre for Vision Research, Westmead Millennium Institute, Westmead Hospital, Department of Ophthalmology, University of Sydney, Sydney, Australia

Hui Miao

Affiliation Rammelkamp Center for Research, Department of Pharmacology and Ireland Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

Kristine E. Lee

Affiliation Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America

Tripti Joshi

Affiliation Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

Matthias Buck

Affiliation Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

Preeti Chugha

Affiliation Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

David Bardenstein

Affiliation Ocular Oncology Service, Department of Ophthalmology and Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

Alison P. Klein

Affiliation Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Joan E. Bailey-Wilson

Affiliation Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, Maryland, United States of America

Xiaohua Gong

Affiliation School of Optometry and Vision Science Program, University of California Berkeley/University of California San Francisco Joint Bioengineering Graduate Program, University of California Berkeley, Berkeley, California, United States of America

Tim D. Spector

Affiliation King's College London, St Thomas' Hospital Campus, Twin Research and Genetic Epidemiology Unit, London, United Kingdom

Toby Andrew

Affiliation King's College London, St Thomas' Hospital Campus, Twin Research and Genetic Epidemiology Unit, London, United Kingdom

Christopher J. Hammond

Affiliation King's College London, St Thomas' Hospital Campus, Twin Research and Genetic Epidemiology Unit, London, United Kingdom

Robert C. Elston

Affiliation Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

Sudha K. Iyengar

ski@case.edu (SKI); bxw14@case.edu (BW)

Affiliations Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America, Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America, Department of Ophthalmology, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

Bingcheng Wang

ski@case.edu (SKI); bxw14@case.edu (BW)

Affiliation Rammelkamp Center for Research, Department of Pharmacology and Ireland Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GJ HG SKI BW. Performed the experiments: GJ HG HM TJ PC DB SKI BW. Analyzed the data: GJ HG BEKK RK JJW PM HM KEL TJ MB RCE SKI BW. Contributed reagents/materials/analysis tools: BEKK RK JJW PM KEL MB PC AK JEBW XG TDS TA CJH RCE. Wrote the paper: GJ HG AK JEBW XG TDS TA CJH RCE SKI BW.