About the Authors

Montserrat Garcia-Closas

montse@nih.gov

Affiliation Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Marylan, United States of America

Per Hall

Affiliation Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden

Heli Nevanlinna

Affiliation Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Helsinki, Finland

Karen Pooley

Affiliation Department of Oncology, University of Cambridge, Cambridge, United Kingdom

Jonathan Morrison

Affiliation Department of Oncology, University of Cambridge, Cambridge, United Kingdom

Douglas A. Richesson

Affiliation Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Marylan, United States of America

Stig E. Bojesen

Affiliations Department of Clinical Biochemistry, Herlev and Bispebjerg University Hospitals, University of Copenhagen, Denmark, Department of Bispebjerg University Hospitals, University of Copenhagen, Denmark

Børge G. Nordestgaard

Affiliation Department of Clinical Biochemistry, Herlev and Bispebjerg University Hospitals, University of Copenhagen, Denmark

Christen K. Axelsson

Affiliation Department of Breast Surgery, Herlev University Hospital, University of Copenhagen, Denmark

Jose I. Arias

Affiliations Spanish National Cancer Centre, Madrid, Spain, Monte Naranco Hospital, Oviedo, Spain

Roger L. Milne

Affiliation Spanish National Cancer Centre, Madrid, Spain

Gloria Ribas

Affiliation Spanish National Cancer Centre, Madrid, Spain

Anna González-Neira

Affiliation Spanish National Cancer Centre, Madrid, Spain

Javier Benítez

Affiliation Spanish National Cancer Centre, Madrid, Spain

Pilar Zamora

Affiliation La Paz Hospital, Madrid, Spain

Hiltrud Brauch

Affiliation Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and University of Tübingen, Tübingen, Germany

Christina Justenhoven

Affiliation Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and University of Tübingen, Tübingen, Germany

Ute Hamann

Affiliation Deutsches Krebsforschungszentrum Heidelberg, Heidelberg, Germany

Yon-Dschun Ko

Affiliation Evangelische Kliniken Bonn gGmhH Johanniter Krankenhaus, Bonn, Germany

Thomas Bruening

Affiliation Berufsgenossenschaftliches Forschungsinstitut für Arbeitsmedizin, Ruhr University Bochum, Germany

Susanne Haas

Affiliation Institute für Pathology, University Bonn, Bonn, Germany

Thilo Dörk

Affiliation Department of Gynecology and Obstetrics, Hannover Medical School, Hannover, Germany

Peter Schürmann

Affiliation Department of Gynecology and Obstetrics, Hannover Medical School, Hannover, Germany

Peter Hillemanns

Affiliation Department of Gynecology and Obstetrics, Hannover Medical School, Hannover, Germany

Natalia Bogdanova

Affiliations Department of Gynecology and Obstetrics, Hannover Medical School, Hannover, Germany, Department of Radiation Oncology, Hannover Medical School, Hannover, Germany

Michael Bremer

Affiliation Department of Radiation Oncology, Hannover Medical School, Hannover, Germany

Johann Hinrich Karstens

Affiliation Department of Radiation Oncology, Hannover Medical School, Hannover, Germany

Rainer Fagerholm

Affiliation Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Helsinki, Finland

Kirsimari Aaltonen

Affiliations Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Helsinki, Finland, Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland

Kristiina Aittomäki

Affiliation Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki, Finland

Karl von Smitten

Affiliation Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland

Carl Blomqvist

Affiliation Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland

Arto Mannermaa

Affiliations Institute of Clinical Medicine, Pathology and Forensic Medicine, Biocenter Kuopio, University of Kuopio, Kuopio, Finland, Department of Pathology, Kuopio University Hospital, Kuopio, Finland

Matti Uusitupa

Affiliation Department of Public Health and Clinical Nutrition, Biocenter Kuopio, University of Kuopio, Kuopio, Finland

Matti Eskelinen

Affiliation Department of Surgery, Kuopio University Hospital, Kuopio, Finland

Maria Tengström

Affiliations Department of Oncology, Kuopio University Hospital, Kuopio, Finland, Department of Oncology, Vaasa Central Hospital, Vaasa, Finland

Veli-Matti Kosma

Affiliations Institute of Clinical Medicine, Pathology and Forensic Medicine, Biocenter Kuopio, University of Kuopio, Kuopio, Finland, Department of Pathology, Kuopio University Hospital, Kuopio, Finland

Vesa Kataja

Affiliations Department of Oncology, Kuopio University Hospital, Kuopio, Finland, Department of Oncology, Vaasa Central Hospital, Vaasa, Finland

Georgia Chenevix-Trench

Affiliation The Queensland Institute of Medical Research Post Office, Royal Brisbane Hospital, Herston, Queensland, Australia

Amanda B. Spurdle

Affiliation The Queensland Institute of Medical Research Post Office, Royal Brisbane Hospital, Herston, Queensland, Australia

Jonathan Beesley

Affiliation The Queensland Institute of Medical Research Post Office, Royal Brisbane Hospital, Herston, Queensland, Australia

Xiaoqing Chen

Affiliation The Queensland Institute of Medical Research Post Office, Royal Brisbane Hospital, Herston, Queensland, Australia

Australian Ovarian Cancer Management Group

Affiliations The Queensland Institute of Medical Research Post Office, Royal Brisbane Hospital, Herston, Queensland, Australia, Peter MacCallum Cancer Institute, East Melbourne, Victoria, Australia

The Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer

Affiliation Peter MacCallum Cancer Institute, East Melbourne, Victoria, Australia

Peter Devilee

Affiliation Departments of Human Genetics and Pathology, Leiden University Medical Center, Leiden, The Netherlands

Christi J. van Asperen

Affiliation Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands

Catharina E. Jacobi

Affiliation Department of Medical Decision Making, Leiden University Medical Center, Leiden, The Netherlands

Rob A. E. M. Tollenaar

Affiliation Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands

Petra E.A. Huijts

Affiliation Department of Medical Oncology, Family Cancer Clinic, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam, The Netherlands

Jan G. M. Klijn

Affiliation Department of Medical Oncology, Family Cancer Clinic, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam, The Netherlands

Jenny Chang-Claude

Affiliation Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany

Silke Kropp

Affiliation Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany

Tracy Slanger

Affiliation Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany

Dieter Flesch-Janys

Affiliation Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany

Elke Mutschelknauss

Affiliation Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany

Ramona Salazar

Affiliation Bioglobe GmbH, Hamburg, Germany

Shan Wang-Gohrke

Affiliation Molecular Biology Laboratory, Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany

Fergus Couch

Affiliation Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America

Ellen L. Goode

Affiliation Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America

Janet E. Olson

Affiliation Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America

Celine Vachon

Affiliation Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America

Zachary S. Fredericksen

Affiliation Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America

Graham G. Giles

Affiliation Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Victoria, Australia

Laura Baglietto

Affiliation Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Victoria, Australia

Gianluca Severi

Affiliation Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Victoria, Australia

John L. Hopper

Affiliation Centre for MEGA Epidemiology, The University of Melbourne, Melbourne, Victoria, Australia

Dallas R. English

Affiliation Centre for MEGA Epidemiology, The University of Melbourne, Melbourne, Victoria, Australia

Melissa C. Southey

Affiliation Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Melbourne, Victoria, Australia

Christopher A. Haiman

Affiliation Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

Brian E. Henderson

Affiliation Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

Laurence N. Kolonel

Affiliation Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii, United States of America

Loic Le Marchand

Affiliation Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii, United States of America

Daniel O. Stram

Affiliation Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

David J. Hunter

Affiliations Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America, Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Susan E. Hankinson

Affiliation Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

David G. Cox

Affiliations Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America

Rulla Tamimi

Affiliation Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Peter Kraft

Affiliation Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America

Mark E. Sherman

Affiliation Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Marylan, United States of America

Stephen J. Chanock

Affiliation Advanced Technology Center, National Cancer Institute, Gaithersburg, Maryland, United States of America

Jolanta Lissowska

Affiliation Department of Cancer Epidemiology and Prevention, Cancer Center and M. Sklodowska-Curie Institute of Oncology, Warsaw, Poland

Louise A. Brinton

Affiliation Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Marylan, United States of America

Beata Peplonska

Affiliation Nofer Institute of Occupational Medicine, Lodz, Poland

Jan G. M. Klijn

Affiliation Daniel den Hoed Cancer Center, Erasmus Medical Center, Department of Medical Oncology, Rotterdam, The Netherlands

Maartje J. Hooning

Affiliation Daniel den Hoed Cancer Center, Erasmus Medical Center, Department of Medical Oncology, Rotterdam, The Netherlands

Han Meijers-Heijboer

Affiliation Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands

J. Margriet Collee

Affiliation Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands

Ans van den Ouweland

Affiliation Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands

Andre G. Uitterlinden

Affiliation Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

Jianjun Liu

Affiliation Human Genetics, Genome Institute of Singapore, Singapore

Low Yen Lin

Affiliation Human Genetics, Genome Institute of Singapore, Singapore

Li Yuqing

Affiliation Human Genetics, Genome Institute of Singapore, Singapore

Keith Humphreys

Affiliation Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden

Kamila Czene

Affiliation Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden

Angela Cox

Affiliation Institute for Cancer Studies, Sheffield University Medical School, Sheffield, United Kingdom

Sabapathy P. Balasubramanian

Affiliation Academic Unit of Surgical Oncology, Sheffield University Medical School, Sheffield, United Kingdom

Simon S. Cross

Affiliation Academic Unit of Pathology, Sheffield University Medical School, Sheffield, United Kingdom

Malcolm W. R. Reed

Affiliation Academic Unit of Surgical Oncology, Sheffield University Medical School, Sheffield, United Kingdom

Fiona Blows

Affiliation Department of Oncology, University of Cambridge, Cambridge, United Kingdom

Kristy Driver

Affiliation Department of Oncology, University of Cambridge, Cambridge, United Kingdom

Alison Dunning

Affiliation Department of Oncology, University of Cambridge, Cambridge, United Kingdom

Jonathan Tyrer

Affiliation Department of Oncology, University of Cambridge, Cambridge, United Kingdom

Bruce A. J. Ponder

Affiliation Cancer Research UK, Cambridge Research Institute, Cambridge, United Kingdom

Suleeporn Sangrajrang

Affiliation Molecular Epidemiology Unit, National Cancer Institute, Ratchathewi, Bangkok, Thailand

Paul Brennan

Affiliation International Agency for Research on Cancer, Lyon, France

James McKay

Affiliation International Agency for Research on Cancer, Lyon, France

Fabrice Odefrey

Affiliation International Agency for Research on Cancer, Lyon, France

Valerie Gabrieau

Affiliation International Agency for Research on Cancer, Lyon, France

Alice Sigurdson

Affiliation Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Marylan, United States of America

Michele Doody

Affiliation Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Marylan, United States of America

Jeffrey P. Struewing

Affiliation Office of Population Genomics, National Human Genome Research Institute, Bethesda, Maryland, United Stated of America

Bruce Alexander

Affiliation Environmental Health Sciences, University of Minnesota, Minneapolis, Minnesota, United States of America

Douglas F. Easton

Affiliation Department of Oncology, University of Cambridge, Cambridge, United Kingdom

Paul D. Pharoah

Affiliation Department of Oncology, University of Cambridge, Cambridge, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: M. Garcia-Closas, P. Hall, S. Bojesen, B. Nordestgaard, C. Axelsson, T. Dörk, J. Chang-Claude, D. Flesch-Janys, D. Hunter, S. Hankinson, D. Cox, R. Tamimi, P. Kraft, P. Brennan, J. McKay, D. Easton, P. Pharoah. Performed the experiments: K. Pooley, R. Milne, G. Ribas, A. González-Neira, J. Benítez, H. Brauch, C. Justenhoven, T. Dörk, P. Schürmann, N. Bogdanova, A. Mannermaa, J. Beesley, X. Chen, J. Chang-Claude, R. Salazar, S. Wang-Gohrke, F. Couch, M. Southey, D. Hunter, D. Cox, S. Chanock, J. Liu, A. Dunning, F. Odefrey, J. Struewing. Analyzed the data: M. Garcia-Closas, D. Richesson, T. Dörk, M. Tengström, V. Kataja, P. Huijts, S. Kropp, D. Flesch-Janys, P. Kraft, J. Tyrer, V. Gabrieau. Contributed reagents/materials/analysis tools: M. Garcia-Closas, P. Hall, H. Nevanlinna, K. Pooley, J. Morrison, S. Bojesen, B. Nordestgaard, C. Axelsson, H. Brauch, P. Hillemanns, M. Bremer, J. Karstens, R. Fagerholm, K. Aaltonen, K. Aittomäki, K. von Smitten, C. Blomqvist, M. Uusitupa, M. Eskelinen, V. Kosma, G. Chenevix-Trench, A. Spurdle, Australian Ovarian Cancer Management Group, The Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer, P. Devilee, C. van Asperen, R. Tollenaar, J. Chang-Claude, D. Flesch-Janys, F. Couch, J. Olson, G. Giles, C. Haiman, B. Henderson, L. Kolonel, L. Le Marchand, D. Stram, A. Uitterlinden, J. Liu, K. Humphreys, K. Czene, J. Struewing. Wrote the paper: M. Garcia-Closas, P. Hall, H. Nevanlinna, P. Pharoah. Study design/data collection: M. Garcia-Closas, P. Hall, H. Nevanlinna, J. Morrison, J. Arias, P. Zamora, H. Brauch, C. Justenhoven, U. Hamann, Y. Ko, T. Bruening, S. Haas, R. Fagerholm, K. Aaltonen, A. Mannermaa, M. Uusitupa, M. Eskelinen, M. Tengström, V. Kosma, V. Kataja, G. Chenevix-Trench, A. Spurdle, C. van Asperen, C. Jacobi, R. Tollenaar, J. Klijn, T. Slanger, E. Mutschelknauss, F. Couch, E. Goode, J. Olson, C. Vachon, Z. Fredericksen, G. Giles, L. Baglietto, G. Severi, J. Hopper, D. English, M. Southey, C. Haiman, B. Henderson, L. Kolonel, L. Le Marchand, D. Stram, D. Hunter, S. Hankinson, R. Tamimi, M. Sherman, J. Lissowska, L. Brinton, B. Peplonska, J. Klijn, M. Hooning, H. Meijers-Heijboer, J. Collee, A. Ouweland, J. Liu, L. Lin, L. Yuqing, A. Cox, S. Balasubramanian, M. Reed, F. Blows, K. Driver, A. Dunning, B. Ponder, S. Sangrajrang, A. Sigurdson, M. Doody, B. Alexander, D. Easton, P. Pharoah. Pathology review: J. Arias, P. Zamora, S. Haas, M. Bremer, V. Kosma, M. Sherman, S. Cross, F. Blows, K. Driver.