About the Authors

Jacob M Zahn

Contributed equally to this work with: Jacob M Zahn, Suresh Poosala

Affiliation Department of Developmental Biology, Stanford University Medical Center, Stanford, California, United States of America

Suresh Poosala

Contributed equally to this work with: Jacob M Zahn, Suresh Poosala

Affiliation National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

Art B Owen

Affiliation Department of Statistics, Stanford University, Stanford, California, United States of America

Donald K Ingram

Affiliation National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

Ana Lustig

Affiliation National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

Arnell Carter

Affiliation National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

Ashani T Weeraratna

Affiliation National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

Dennis D Taub

Affiliation National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

Myriam Gorospe

Affiliation National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

Krystyna Mazan-Mamczarz

Affiliation National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

Edward G Lakatta

Affiliation National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

Kenneth R Boheler

Affiliation National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

Xiangru Xu

Affiliation National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

Mark P Mattson

Affiliation National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

Geppino Falco

Affiliation National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

Minoru S. H Ko

Affiliation National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

David Schlessinger

Affiliation National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

Jeffrey Firman

Affiliation National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

Sarah K Kummerfeld

Affiliation Department of Developmental Biology, Stanford University Medical Center, Stanford, California, United States of America

William H Wood III

Affiliation National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

Alan B Zonderman

Affiliation National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

Stuart K Kim

To whom correspondence should be addressed. E-mail: kim@cmgm.stanford.edu (SKK); beckerk@mail.nih.gov (KGB)

Affiliations Department of Developmental Biology, Stanford University Medical Center, Stanford, California, United States of America , Department of Genetics, Stanford University Medical Center, Stanford, California, United States of America

Kevin G Becker

To whom correspondence should be addressed. E-mail: kim@cmgm.stanford.edu (SKK); beckerk@mail.nih.gov (KGB)

Affiliation National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

All authors conceived and designed the experiments. JMZ, SP, DKI, AL, AC, ATW, DDT, KMM, EGL, KRB, XX, MPM, GF, MSHK, DS, JF, SKK, WHW, ABZ, and KGB performed the experiments. JMZ, ABO, MG, and SKK analyzed the data. SP, ABO, DKI, AL, AC, ATW, DDT, MG, KMM, EGL, KRB, XX, MPM, GF, MSHK, DS, JF, SKK, WHW, ABZ, SKK, and KGB contributed reagents/materials/analysis tools. JMZ, SP, ABO, SKK, and KGB wrote the paper.