About the Authors

Motoko Iwashita

Affiliations RIKEN Center for Developmental Biology, Kobe, Japan, Department of Biological Sciences, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Japan

Masakatsu Watanabe

Affiliation Department of Biological Sciences, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Japan

Masaru Ishii

Affiliation Department of Pharmacology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

Tim Chen

Affiliation Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America

Stephen L Johnson

Affiliation Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America

Yoshihisa Kurachi

Affiliation Department of Pharmacology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

Norihiro Okada

Affiliation Department of Biological Sciences, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Japan

Shigeru Kondo

To whom correspondence should be addressed. E-mail: skondo@bio.nagoya-u.ac.jp

Affiliations RIKEN Center for Developmental Biology, Kobe, Japan, Department of Biological Science, Graduate School of Science, Nagoya University, Nagoya, Japan

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

M. Iwashita and S. Kondo conceived and designed the experiments. M. Iwashita performed the experiments. M. Iwashita, M. Watanabe, N. Okada, and S. Kondo analyzed the data. M. Ishii and Y. Kurachi contributed to the electrophysiology experiments. T. Chen and S. L. Johnson contributed to the mapping of the jagb230 allele. M. Iwashita, M. Watanabe, and S. Kondo wrote the paper.