About the Authors

Seung Hoan Choi

Contributed equally to this work with: Seung Hoan Choi, Daniela Ruggiero, Rossella Sorice

Affiliations Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America, Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America, National Heart, Lung and Blood Institute’s Framingham Heart Study, Framingham, Massachusetts, United States of America

Daniela Ruggiero

Contributed equally to this work with: Seung Hoan Choi, Daniela Ruggiero, Rossella Sorice

Affiliation Institute of Genetics and Biophysics, National Research Council of Italy, Naples, Italy

Rossella Sorice

Contributed equally to this work with: Seung Hoan Choi, Daniela Ruggiero, Rossella Sorice

Affiliation Institute of Genetics and Biophysics, National Research Council of Italy, Naples, Italy

Ci Song

Affiliations Population Sciences Branch, National Heart, Lung and Blood Institute’s Framingham Heart Study, Framingham, Massachusetts, United States of America, Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

Teresa Nutile

Affiliation Institute of Genetics and Biophysics, National Research Council of Italy, Naples, Italy

Albert Vernon Smith

Affiliations Icelandic Heart Association, Kopavogur, Iceland, University of Iceland, Reykjavik, Iceland

Maria Pina Concas

Affiliation Institute of Population Genetics, National Research Council of Italy, Sassari, Italy

Michela Traglia

Affiliation Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano, Italy

Caterina Barbieri

Affiliation Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano, Italy

Ndeye Coumba Ndiaye

Affiliation UMR INSERM U1122, IGE-PCV “Interactions Gène-Environnement en Physiopathologie Cardio-Vasculaire”, Faculté de Pharmacie, Université de Lorraine, Nancy, France

Maria G. Stathopoulou

Affiliation UMR INSERM U1122, IGE-PCV “Interactions Gène-Environnement en Physiopathologie Cardio-Vasculaire”, Faculté de Pharmacie, Université de Lorraine, Nancy, France

Vasiliki Lagou

Affiliations Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom

Giovanni Battista Maestrale

Affiliation Institute of Population Genetics, National Research Council of Italy, Sassari, Italy

Cinzia Sala

Affiliation Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano, Italy

Stephanie Debette

Affiliations Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America, Department of Neurology, Bordeaux University Hospital, Bordeaux, France, INSERM U897, Bordeaux, France

Peter Kovacs

Affiliation University of Leipzig, IFB Adiposity Diseases, Leipzig, Germany

Lars Lind

Affiliation Department of Medical Sciences, Uppsala University, Uppsala, Sweden

John Lamont

Affiliation Randox Laboratories, Crumlin, United Kingdom

Peter Fitzgerald

Affiliation Randox Laboratories, Crumlin, United Kingdom

Anke Tönjes

Affiliation University of Leipzig, Department of Medicine, Leipzig, Germany

Vilmundur Gudnason

Affiliations Icelandic Heart Association, Kopavogur, Iceland, University of Iceland, Reykjavik, Iceland

Daniela Toniolo

Affiliation Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano, Italy

Mario Pirastu

Affiliation Institute of Population Genetics, National Research Council of Italy, Sassari, Italy

Celine Bellenguez

Affiliations Institut Pasteur de Lille, Lille, France, INSEM U744, Lille, France, Université Lille-Nord de France, Lille, France

Ramachandran S. Vasan

Affiliations National Heart, Lung and Blood Institute’s Framingham Heart Study, Framingham, Massachusetts, United States of America, Section of Preventive Medicine and Epidemiology, Department of Medicine, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America

Erik Ingelsson

Affiliation Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden

Anne-Louise Leutenegger

Affiliations INSERM U946, Paris, France, Université Paris Diderot, Sorbonne Paris Cité, IUH, UMR-S 946, Paris, France

Andrew D. Johnson

Affiliation Population Sciences Branch, National Heart, Lung and Blood Institute’s Framingham Heart Study, Framingham, Massachusetts, United States of America

Anita L. DeStefano

Affiliations Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America, Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America, National Heart, Lung and Blood Institute’s Framingham Heart Study, Framingham, Massachusetts, United States of America

Sophie Visvikis-Siest

Affiliation UMR INSERM U1122, IGE-PCV “Interactions Gène-Environnement en Physiopathologie Cardio-Vasculaire”, Faculté de Pharmacie, Université de Lorraine, Nancy, France

Sudha Seshadri

suseshad@bu.edu (SS); ciullo@igb.cnr.it (MC)

‡ These authors are joint senior authors on this work.

Affiliations Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America, National Heart, Lung and Blood Institute’s Framingham Heart Study, Framingham, Massachusetts, United States of America

Marina Ciullo

suseshad@bu.edu (SS); ciullo@igb.cnr.it (MC)

‡ These authors are joint senior authors on this work.

Affiliation Institute of Genetics and Biophysics, National Research Council of Italy, Naples, Italy

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SHC DR RS TN CBe RSV EI ALL SVS SS MC. Performed the experiments: DR RS CSo AVS MT CBa GBM PK AT SVS SS. Analyzed the data: SHC DR RS CSo TN AVS MPC NCN MGS VL AT ADJ ALD. Contributed reagents/materials/analysis tools: TN CSa LL JL PF DT EI. Wrote the paper: SHC DR RS SD RSV ADJ ALD SS MC. Designed individual study: VG DT MP PK. Obtained funding: RSV SS MC. Interpretation of individual data: NCN MGS CBe ALL SVS. Review of the manuscript: NCN MGS LL JL PF CBe ALL SVS.