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PLOS Genetics

October 9, 2026

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10/08/2026

Research Article

ZBED6 deficiency drives pathological cardiac hypertrophy through MEOX1–ERK1/2–dependent autophagy dysfunction

An enlarged heart may initially help the body cope with stress, but persistent enlargement can impair heart function and increase the risk of heart failure. We investigated whether a gene regulator called ZBED6 helps protect the heart from this harmful growth. We found that ZBED6 levels were reduced in heart tissue from people with cardiac hypertrophy. 

Image credit: Zhang et al.

ZBED6 deficiency drives pathological cardiac hypertrophy through MEOX1–ERK1/2–dependent autophagy dysfunction

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10/08/2026

Research Article

Chromatin stability safeguards mitochondrial homeostasis and restrains TORC1 signaling

The cellular nutrient environment regulates gene expression by signaling through the TORC1 kinase to control chromatin structure and function. However, whether chromatin signals back to regulate TORC1 is unknown. We find that a histone H3 lysine 37 to alanine (H3K37A) mutant promotes histone degradation, hyperactivates TORC1, and causes cell death when TORC1 is inhibited. 

Image credit: Sigamani et al.

Chromatin stability safeguards mitochondrial homeostasis and restrains TORC1 signaling

10/07/2026

Research Article

Heat stress promotes GTBP-1 association with perinuclear P-bodies in the C. elegans germline

Reproduction is particularly vulnerable to environmental stress, yet germ cells must remain functional to ensure fertility. How germ cells protect themselves under stressful conditions is still not well understood. In this study, we used the nematode Caenorhabditis elegans to examine how germ cells respond to heat stress, focusing on GTBP-1, a conserved protein involved in stress granule formation.

Image credit: Zang et al.

Heat stress promotes GTBP-1 association with perinuclear P-bodies in the C. elegans germline

10/06/2026

Research Article

GPC: An expressive and tractable deep generative model for genetic variation data

Human genetic data are essential for studying disease, but they are also deeply personal, and privacy rules often prevent researchers from sharing them. One way around this is to create artificial genomes: synthetic data that reproduce the statistical patterns of a real population without belonging to any real person.

GPC: An expressive and tractable deep generative model for genetic variation data

Image credit: Anand et al.

10/05/2026

Research Article

Decoupling metabolic defense: Mutational and recombinational chaos in Sod1-deficient cells

Sod1 is a primary antioxidant defense enzyme, yet its comprehensive role in preserving eukaryotic genome stability remains insufficiently mapped. Using a diploid yeast model, we demonstrate that Sod1 loss triggers global genomic chaos. Anaerobic growth and antioxidative agent abolish this instability, confirming...

Decoupling metabolic defense: Mutational and recombinational chaos in Sod1-deficient cells

Image credit: Sui, Zheng, et al.

PLOS Genetics | ISSN: 1553-7404 (online)