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Alternative poly-adenylation modulates α1-antitrypsin expression in chronic obstructive pulmonary disease
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Lela Lackey ,
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing
* E-mail: lelal@clemson.edu (LL); alain@unc.edu (AL)
Affiliation Department of Genetics and Biochemistry, Center for Human Genetics, Clemson University, Greenwood, South Carolina, United States of America
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Aaztli Coria,
Roles Formal analysis, Investigation, Visualization, Writing – review & editing
Affiliations Department of Biology, University of North Carolina, Chapel Hill, North Carolina, United States of America, Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina, United States of America
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Auyon J. Ghosh,
Roles Data curation, Investigation, Writing – review & editing
Affiliations Channing Division of Network Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
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Phil Grayeski,
Roles Formal analysis, Investigation, Visualization, Writing – review & editing
Affiliation Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, North Carolina, United States of America
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Abigail Hatfield,
Roles Formal analysis, Investigation, Writing – review & editing
Affiliation Department of Genetics and Biochemistry, Center for Human Genetics, Clemson University, Greenwood, South Carolina, United States of America
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Vijay Shankar,
Roles Conceptualization, Formal analysis, Investigation, Visualization, Writing – review & editing
Affiliation Department of Genetics and Biochemistry, Center for Human Genetics, Clemson University, Greenwood, South Carolina, United States of America
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John Platig,
Roles Data curation, Formal analysis, Investigation, Visualization, Writing – review & editing
Affiliation Channing Division of Network Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
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Zhonghui Xu,
Roles Data curation, Formal analysis, Visualization, Writing – review & editing
Affiliation Channing Division of Network Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
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Silvia B. V. Ramos,
Roles Conceptualization, Writing – review & editing
Affiliation Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina, United States of America
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Edwin K. Silverman,
Roles Conceptualization, Writing – review & editing
Affiliations Channing Division of Network Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
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Victor E. Ortega,
Roles Conceptualization, Writing – review & editing
Affiliation Department of Internal Medicine, Division of Respiratory Medicine, Center for Individualized Medicine, Mayo Clinic, Scottsdale, Arizona, United States of America
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Michael H. Cho,
Roles Conceptualization, Writing – review & editing
Affiliations Channing Division of Network Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
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Craig P. Hersh,
Roles Conceptualization, Writing – review & editing
Affiliations Channing Division of Network Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
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Brian D. Hobbs,
Roles Conceptualization, Writing – review & editing
Affiliations Channing Division of Network Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
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Peter Castaldi,
Roles Conceptualization, Data curation, Supervision, Writing – review & editing
Affiliations Channing Division of Network Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Division of Internal Medicine and Primary Care, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
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Alain Laederach
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing
* E-mail: lelal@clemson.edu (LL); alain@unc.edu (AL)
Affiliation Department of Biology, University of North Carolina, Chapel Hill, North Carolina, United States of America
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https://orcid.org/0000-0003-2163-4005
Alternative poly-adenylation modulates α1-antitrypsin expression in chronic obstructive pulmonary disease
- Lela Lackey,
- Aaztli Coria,
- Auyon J. Ghosh,
- Phil Grayeski,
- Abigail Hatfield,
- Vijay Shankar,
- John Platig,
- Zhonghui Xu,
- Silvia B. V. Ramos,
- Edwin K. Silverman
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- Published: November 16, 2021
- https://doi.org/10.1371/journal.pgen.1009912