Manipulating the plant mycobiome to enhance resilience: Ecological and evolutionary opportunities and challenges

Christine V. Hawkes, Xavious Allen, Peter Balint-Kurti, Christina Cowger

PLOS Pathogens: published December 14, 2023 | https://doi.org/10.1371/journal.ppat.1011816

New anticancer therapeutics impact fungal pathobiology, infection dynamics, and outcome

Julia R. Palmucci, Julia A. Messina, Jennifer L. Tenor, John R. Perfect

PLOS Pathogens: published December 21, 2023 | https://doi.org/10.1371/journal.ppat.1011845

Mechanisms of pathogenicity for the emerging fungus Candida auris

Mark V. Horton, Ashley M. Holt, Jeniel E. Nett

PLOS Pathogens: published December 21, 2023 | https://doi.org/10.1371/journal.ppat.1011843

A sticky situation: When trypanosomatids attach to insect tissues

Megan L. Povelones, Nikki A. Holmes, Michael Povelones

PLOS Pathogens: published December 21, 2023 | https://doi.org/10.1371/journal.ppat.1011854

The Herpes Simplex Virus pUL16 and pUL21 Proteins Prevent Capsids from Docking at Nuclear Pore Complexes

Ethan C. M. Thomas, Renée L. Finnen, Jeffrey D. Mewburn, Stephen L. Archer, Bruce W. Banfield

PLOS Pathogens: published December 1, 2023 | https://doi.org/10.1371/journal.ppat.1011832

The Kelch13 compartment contains highly divergent vesicle trafficking proteins in malaria parasites

Sabine Schmidt, Jan Stephan Wichers-Misterek, Hannah Michaela Behrens, Jakob Birnbaum, Isabelle G. Henshall, Jana Dröge, Ernst Jonscher, Sven Flemming, Carolina Castro-Peña, Paolo Mesén-Ramírez, Tobias Spielmann

PLOS Pathogens: published December 1, 2023 | https://doi.org/10.1371/journal.ppat.1011814

NSUN2-mediated m⁵C modification of HBV RNA positively regulates HBV replication

Jiangpeng Feng, Tianmo Xu, Miao He, Jiali Li, Peipei Yao, Chengbao Ma, Shimin Yang, Zaichao Xu, Kun Yan, Xianying Chen, Hongyun Wang, Jiejie Liu, Cong Zeng, Yuchen Xia, Huan Yan, Li Zhou, Yu Chen

PLOS Pathogens: published December 4, 2023 | https://doi.org/10.1371/journal.ppat.1011808

Plasmodium falciparum utilizes pyrophosphate to fuel an essential proton pump in the ring stage and the transition to trophozoite stage

Omobukola Solebo, Liqin Ling, Ikechukwu Nwankwo, Jing Zhou, Tian-Min Fu, Hangjun Ke

PLOS Pathogens: published December 4, 2023 | https://doi.org/10.1371/journal.ppat.1011818

Breakthrough infection elicits hypermutated IGHV3-53/3-66 public antibodies with broad and potent neutralizing activity against SARS-CoV-2 variants including the emerging EG.5 lineages

Ling Li, Xixian Chen, Zuowei Wang, Yunjian Li, Chen Wang, Liwei Jiang, Teng Zuo

PLOS Pathogens: published December 4, 2023 | https://doi.org/10.1371/journal.ppat.1011856

Experimental infection of pigs and ferrets with “pre-pandemic,” human-adapted, and swine-adapted variants of the H1N1pdm09 influenza A virus reveals significant differences in viral dynamics and pathological manifestations

Charlotte Kristensen, Helena A. Laybourn, Jeri-Carol Crumpton, Karen Martiny, Ashley Webb, Pia Ryt-Hansen, Ramona Trebbien, Henrik E. Jensen, Jakob N. Nissen, Kerstin Skovgaard, Richard J. Webby, Lars E. Larsen

PLOS Pathogens: published December 4, 2023 | https://doi.org/10.1371/journal.ppat.1011838

Disease phenotype of classical sheep scrapie is changed upon experimental passage through white-tailed deer

Robyn D. Kokemuller, S. Jo Moore, Jifeng Bian, M. Heather West Greenlee, Justin J. Greenlee

PLOS Pathogens: published December 4, 2023 | https://doi.org/10.1371/journal.ppat.1011815

The Gβ-like protein Bcgbl1 regulates development and pathogenicity of the gray mold Botrytis cinerea via modulating two MAP kinase signaling pathways

Jiejing Tang, Zhe Sui, Ronghui Li, Yuping Xu, Lixuan Xiang, Shiying Fu, Jinfeng Wei, Xuan Cai, Mingde Wu, Jing Zhang, Weidong Chen, Yangdou Wei, Guoqing Li, Long Yang

PLOS Pathogens: published December 4, 2023 | https://doi.org/10.1371/journal.ppat.1011839

A novel chimeric RNA originating from BmCPV S4 and Bombyx mori HDAC11 transcripts regulates virus proliferation

Jun Pan, Shulin Wei, Qunnan Qiu, Xinyu Tong, Zeen Shen, Min Zhu, Xiaolong Hu, Chengliang Gong

PLOS Pathogens: published December 4, 2023 | https://doi.org/10.1371/journal.ppat.1011184

Progeny counter mechanism in malaria parasites is linked to extracellular resources

Vanessa S. Stürmer, Sophie Stopper, Patrick Binder, Anja Klemmer, Nicolas P. Lichti, Nils B. Becker, Julien Guizetti

PLOS Pathogens: published December 5, 2023 | https://doi.org/10.1371/journal.ppat.1011807

Transient CD4⁺ T cell depletion during suppressive ART reduces the HIV reservoir in humanized mice

Lijun Ling, Chandrav De, Rae Ann Spagnuolo, Nurjahan Begum, Shane D. Falcinelli, Nancie M. Archin, Martina Kovarova, Guido Silvestri, Angela Wahl, David M. Margolis, J. Victor Garcia

PLOS Pathogens: published December 6, 2023 | https://doi.org/10.1371/journal.ppat.1011824

Evolution of HIV-1 envelope towards reduced neutralization sensitivity, as demonstrated by contemporary HIV-1 subtype B from the United States

Lindsay Wieczorek, Eric Sanders-Buell, Michelle Zemil, Eric Lewitus, Erin Kavusak, Jonah Heller, Sebastian Molnar, Mekhala Rao, Gabriel Smith, Meera Bose, Amy Nguyen, Adwitiya Dhungana, Katherine Okada, Kelly Parisi, Daniel Silas, Bonnie Slike, Anuradha Ganesan, Jason Okulicz, Tahaniyat Lalani, Brian K. Agan, Trevor A. Crowell, Janice Darden, Morgane Rolland, Sandhya Vasan, Julie Ake, Shelly J. Krebs, Sheila Peel, Sodsai Tovanabutra, Victoria R. Polonis

PLOS Pathogens: published December 6, 2023 | https://doi.org/10.1371/journal.ppat.1011780

Regulation of Ebola GP conformation and membrane binding by the chemical environment of the late endosome

Aastha Jain, Ramesh Govindan, Alex R. Berkman, Jeremy Luban, Marco A. Díaz-Salinas, Natasha D. Durham, James B. Munro

PLOS Pathogens: published December 6, 2023 | https://doi.org/10.1371/journal.ppat.1011848

Citrullination profile analysis reveals peptidylarginine deaminase 3 as an HSV-1 target to dampen the activity of candidate antiviral restriction factors

Selina Pasquero, Francesca Gugliesi, Matteo Biolatti, Valentina Dell’Oste, Camilla Albano, Greta Bajetto, Gloria Griffante, Linda Trifirò, Bianca Brugo, Stefano Raviola, Davide Lacarbonara, Qiao Yang, Sen Sudeshna, Leonard Barasa, Hafeez Haniff, Paul R. Thompson, Santo Landolfo, Marco De Andrea

PLOS Pathogens: published December 6, 2023 | https://doi.org/10.1371/journal.ppat.1011849

GARP and EARP are required for efficient BoHV-1 replication as identified by a genome wide CRISPR knockout screen

Wenfang S. Tan, Enguang Rong, Inga Dry, Simon G. Lillico, Andy Law, Paul Digard, Bruce Whitelaw, Robert G. Dalziel

PLOS Pathogens: published December 6, 2023 | https://doi.org/10.1371/journal.ppat.1011822

IL-17RA promotes pathologic epithelial inflammation in a mouse model of upper respiratory influenza infection

Zahrasadat Navaeiseddighi, Jitendra Kumar Tripathi, Kai Guo, Zhihan Wang, Taylor Schmit, Delano R. Brooks, Reese A. Allen, Junguk Hur, Ramkumar Mathur, Donald Jurivich, Nadeem Khan

PLOS Pathogens: published December 7, 2023 | https://doi.org/10.1371/journal.ppat.1011847

Developing novel antimicrobials by combining cancer chemotherapeutics with bacterial DNA repair inhibitors

Lorenzo Bernacchia, Arya Gupta, Antoine Paris, Alexandra A. Moores, Neil M. Kad

PLOS Pathogens: published December 7, 2023 | https://doi.org/10.1371/journal.ppat.1011875

G-quadruplex in the TMV Genome Regulates Viral Proliferation and Acts as Antiviral Target of Photodynamic Therapy

Congbao Xie, Xianpeng Zhang, Wenyue Pei, Ju Sun, Hongqi Shang, Zhiyuan Huang, Mengxi Wang, Daozhong Wang, Guiqian Wang, Zhikun Gui, Sisi Liu, Feng Li, Dengguo Wei

PLOS Pathogens: published December 7, 2023 | https://doi.org/10.1371/journal.ppat.1011796

Cross-talk between QseBC and PmrAB two-component systems is crucial for regulation of motility and colistin resistance in Enteropathogenic Escherichia coli

Blanca Fernandez-Ciruelos, Tasneemah Potmis, Vitalii Solomin, Jerry M. Wells

PLOS Pathogens: published December 7, 2023 | https://doi.org/10.1371/journal.ppat.1011345

Microsporidian Nosema bombycis hijacks host vitellogenin and restructures ovariole cells for transovarial transmission

Chunxia Wang, Bin Yu, Xianzhi Meng, Dan Xia, Boyan Pei, Xiangyou Tang, Guizheng Zhang, Junhong Wei, Mengxian Long, Jie Chen, Jialing Bao, Chunfeng Li, Guoqing Pan, Zeyang Zhou, Tian Li

PLOS Pathogens: published December 7, 2023 | https://doi.org/10.1371/journal.ppat.1011859

Deep analysis of CD4 T cells in the rhesus CNS during SIV infection

Sonny R. Elizaldi, Anil Verma, Zhong-Min Ma, Sean Ott, Dhivyaa Rajasundaram, Chase E. Hawes, Yashavanth Shaan Lakshmanappa, Mackenzie L. Cottrell, Angela D. M. Kashuba, Zandrea Ambrose, Jeffrey D. Lifson, John H. Morrison, Smita S. Iyer

PLOS Pathogens: published December 7, 2023 | https://doi.org/10.1371/journal.ppat.1011844

Dissecting the cytomegalovirus CC chemokine: Chemokine activity and gHgLchemokine-dependent cell tropism are independent players in CMV infection

Marwa Eletreby, Lena Thiessen, Adrian Prager, Ilija Brizic, Jelena Materljan, Lucie Kubic, Katharina Jäger, Križan Jurinović, Josipa Jerak, Karsten Krey, Barbara Adler

PLOS Pathogens: published December 8, 2023 | https://doi.org/10.1371/journal.ppat.1011793

The V2 domain of HIV gp120 mimics an interaction between CD4 and integrin ⍺₄β₇

Donald Van Ryk, Sinmanus Vimonpatranon, Joe Hiatt, Sundar Ganesan, Nathalie Chen, Jordan McMurry, Saadiq Garba, Susie Min, Livia R. Goes, Alexandre Girard, Jason Yolitz, Isabella Licavoli, Danlan Wei, Dawei Huang, Marcelo A. Soares, Elena Martinelli, Claudia Cicala, James Arthos

PLOS Pathogens: published December 8, 2023 | https://doi.org/10.1371/journal.ppat.1011860

Functional and biochemical characterization of the Toxoplasma gondii succinate dehydrogenase complex

Mariana F. Silva, Kiera Douglas, Sofia Sandalli, Andrew E. Maclean, Lilach Sheiner

PLOS Pathogens: published December 11, 2023 | https://doi.org/10.1371/journal.ppat.1011867

Hookworms dynamically respond to loss of Type 2 immune pressure

Annabel A. Ferguson, Juan M. Inclan-Rico, Dihong Lu, Sarah D. Bobardt, LiYin Hung, Quentin Gouil, Louise Baker, Matthew E. Ritchie, Aaron R. Jex, Erich M. Schwarz, Heather L. Rossi, Meera G. Nair, Adler R. Dillman, De’Broski R. Herbert

PLOS Pathogens: published December 11, 2023 | https://doi.org/10.1371/journal.ppat.1011797

Filamentation and biofilm formation are regulated by the phase-separation capacity of network transcription factors in Candida albicans

Collin Ganser, Mae I. Staples, Maureen Dowell, Corey Frazer, Joseph Dainis, Shabnam Sircaik, Richard J. Bennett

PLOS Pathogens: published December 13, 2023 | https://doi.org/10.1371/journal.ppat.1011833

Symbiotic bacteria confer insecticide resistance by metabolizing buprofezin in the brown planthopper, Nilaparvata lugens (Stål)

Bin Zeng, Fan Zhang, Ya-Ting Liu, Shun-Fan Wu, Chris Bass, Cong-Fen Gao

PLOS Pathogens: published December 13, 2023 | https://doi.org/10.1371/journal.ppat.1011828

The Toxoplasma protein phosphatase 6 catalytic subunit (TgPP6C) is essential for cell cycle progression and virulence

Qin-Li Liang, Lan-Bi Nie, Hany M. Elsheikha, Ting-Ting Li, Li-Xiu Sun, Zhi-Wei Zhang, Meng Wang, Bao-Quan Fu, Xing-Quan Zhu, Jin-Lei Wang

PLOS Pathogens: published December 13, 2023 | https://doi.org/10.1371/journal.ppat.1011831

Demonstrating the importance of porcine reproductive and respiratory syndrome virus papain-like protease 2 deubiquitinating activity in viral replication by structure-guided mutagenesis

Ben A. Bailey-Elkin, Robert C. M. Knaap, Anuradha De Silva, Ilse M. Boekhoud, Sandra Mous, Niek van Vught, Mazdak Khajehpour, Erwin van den Born, Marjolein Kikkert, Brian L. Mark

PLOS Pathogens: published December 14, 2023 | https://doi.org/10.1371/journal.ppat.1011872

Phylogenomic analysis of 343 Xanthomonas citri pv. citri strains unravels introduction history and dispersal paths

Jin Xu, Yanan Zhang, Jinyun Li, Doron Teper, Xiaoan Sun, Debra Jones, Yayu Wang, Jin Tao, Erica M. Goss, Jeffrey B. Jones, Nian Wang

PLOS Pathogens: published December 15, 2023 | https://doi.org/10.1371/journal.ppat.1011876

Chimeric antigen receptors enable superior control of HIV replication by rapidly killing infected cells

Yuqi Zhou, Julie Jadlowsky, Caitlin Baiduc, Alex W. Klattenhoff, Zhilin Chen, Alan D. Bennett, Nicholas J. Pumphrey, Bent K. Jakobsen, James L. Riley

PLOS Pathogens: published December 15, 2023 | https://doi.org/10.1371/journal.ppat.1011853

PIP₂ regulating calcium signal modulates actin cytoskeleton-dependent cytoadherence and cytolytic capacity in the protozoan parasite Trichomonas vaginalis

Yen-Ju Chen, Kuan-Yi Wu, Shu-Fan Lin, Sung-Hsi Huang, Heng-Cheng Hsu, Hong-Ming Hsu

PLOS Pathogens: published December 18, 2023 | https://doi.org/10.1371/journal.ppat.1011891

TRPV1 controls innate immunity during Citrobacter rodentium enteric infection

Michael Cremin, Emmy Xue Yun Tay, Valerie T. Ramirez, Kaitlin Murray, Rene K. Nichols, Ingrid Brust-Mascher, Colin Reardon

PLOS Pathogens: published December 18, 2023 | https://doi.org/10.1371/journal.ppat.1011576

Gene expression changes throughout the life cycle allow a bacterial plant pathogen to persist in diverse environmental habitats

Roger de Pedro-Jové, Jordi Corral, Mercedes Rocafort, Marina Puigvert, Fàtima Latif Azam, Agustina Vandecaveye, Alberto P. Macho, Carlos Balsalobre, Núria S. Coll, Elena Orellano, Marc Valls

PLOS Pathogens: published December 19, 2023 | https://doi.org/10.1371/journal.ppat.1011888

A distinct isoform of lymphoid enhancer binding factor 1 (LEF1) epigenetically restricts EBV reactivation to maintain viral latency

B. J. H. Ward, Kanchanjunga Prasai, Danielle L. Schaal, Jian Wang, Rona S. Scott

PLOS Pathogens: published December 19, 2023 | https://doi.org/10.1371/journal.ppat.1011873

Using viral sequence diversity to estimate time of HIV infection in infants

Magdalena L. Russell, Carolyn S. Fish, Sara Drescher, Noah A. J. Cassidy, Pritha Chanana, Sarah Benki-Nugent, Jennifer Slyker, Dorothy Mbori-Ngacha, Rose Bosire, Barbra Richardson, Dalton Wamalwa, Elizabeth Maleche-Obimbo, Julie Overbaugh, Grace John-Stewart, Frederick A. Matsen IV, Dara A. Lehman

PLOS Pathogens: published December 20, 2023 | https://doi.org/10.1371/journal.ppat.1011861

CNP blocks mitochondrial depolarization and inhibits SARS-CoV-2 replication in vitro and in vivo

James Logue, Victoria M. Melville, Jeremy Ardanuy, Matthew B. Frieman

PLOS Pathogens: published December 20, 2023 | https://doi.org/10.1371/journal.ppat.1011870

Convergent evolution of SARS-CoV-2 XBB lineages on receptor-binding domain 455–456 synergistically enhances antibody evasion and ACE2 binding

Fanchong Jian, Leilei Feng, Sijie Yang, Yuanling Yu, Lei Wang, Weiliang Song, Ayijiang Yisimayi, Xiaosu Chen, Yanli Xu, Peng Wang, Lingling Yu, Jing Wang, Lu Liu, Xiao Niu, Jing Wang, Tianhe Xiao, Ran An, Yao Wang, Qingqing Gu, Fei Shao, Ronghua Jin, Zhongyang Shen, Youchun Wang, Xiangxi Wang, Yunlong Cao

PLOS Pathogens: published December 20, 2023 | https://doi.org/10.1371/journal.ppat.1011868

A fungal RNA-dependent RNA polymerase is a novel player in plant infection and cross-kingdom RNA interference

An-Po Cheng, Bernhard Lederer, Lorenz Oberkofler, Lihong Huang, Nathan R. Johnson, Fabian Platten, Florian Dunker, Constance Tisserant, Arne Weiberg

PLOS Pathogens: published December 20, 2023 | https://doi.org/10.1371/journal.ppat.1011885

Brain tropism acquisition: The spatial dynamics and evolution of a measles virus collective infectious unit that drove lethal subacute sclerosing panencephalitis

Iris Yousaf, William W. Hannon, Ryan C. Donohue, Christian K. Pfaller, Kalpana Yadav, Ryan J. Dikdan, Sanjay Tyagi, Declan C. Schroeder, Wun-Ju Shieh, Paul A. Rota, Alison F. Feder, Roberto Cattaneo

PLOS Pathogens: published December 21, 2023 | https://doi.org/10.1371/journal.ppat.1011817

Regulation of human neutrophil IL-1β secretion induced by Escherichia coli O157:H7 responsible for hemolytic uremic syndrome

Florencia Sabbione, Irene Angelica Keitelman, Carolina Maiumi Shiromizu, Alexia Vereertbrugghen, Douglas Vera Aguilar, Paolo Nahuel Rubatto Birri, Manuela Pizzano, María Victoria Ramos, Federico Fuentes, Lucas Saposnik, Agostina Cernutto, Juliana Cassataro, Carolina Cristina Jancic, Jeremías Gaston Galletti, Marina Sandra Palermo, Analía Silvina Trevani

PLOS Pathogens: published December 21, 2023 | https://doi.org/10.1371/journal.ppat.1011877

FLAgellum Member 8 modulates extravascular distribution of African trypanosomes

Estefanía Calvo-Alvarez, Jean Marc Tsagmo Ngoune, Parul Sharma, Anneli Cooper, Aïssata Camara, Christelle Travaillé, Aline Crouzols, Annette MacLeod, Brice Rotureau

PLOS Pathogens: published December 21, 2023 | https://doi.org/10.1371/journal.ppat.1011220

Genes differentially expressed between pathogenic and non-pathogenic Entamoeba histolytica clones influence pathogenicity-associated phenotypes by multiple mechanisms

Juliett Anders, Constantin König, Corinna Lender, Arne Hellhund, Sarah Nehls, Ibrahim Shalabi, Barbara Honecker, Stephan Lorenzen, Martin Meyer, Jenny Matthiesen, Dániel Cadar, Thomas Roeder, Nahla Galal Metwally, Hannelore Lotter, Iris Bruchhaus

PLOS Pathogens: published December 22, 2023 | https://doi.org/10.1371/journal.ppat.1011745

Toll receptor ligand Spätzle 4 responses to the highly pathogenic Enterococcus faecalis from Varroa mites in honeybees

Wenhao Zhang, Cheng Sun, Haoyu Lang, Jieni Wang, Xinyu Li, Jun Guo, Zijing Zhang, Hao Zheng

PLOS Pathogens: published December 27, 2023 | https://doi.org/10.1371/journal.ppat.1011897

circMORC3-encoded novel protein negatively regulates antiviral immunity through synergizing with host gene MORC3

Linchao Wang, Weiwei Zheng, Xing Lv, Yanhong Song, Tianjun Xu

PLOS Pathogens: published December 27, 2023 | https://doi.org/10.1371/journal.ppat.1011894

Malaria parasite centrins can assemble by Ca²⁺-inducible condensation

Yannik Voß, Severina Klaus, Nicolas P. Lichti, Markus Ganter, Julien Guizetti

PLOS Pathogens: published December 27, 2023 | https://doi.org/10.1371/journal.ppat.1011899

Continued selection on cryptic SARS-CoV-2 observed in Missouri wastewater

Devon A. Gregory, Clayton Rushford, Torin Hunter, Chung-Ho Lin, Christie Darby, Nicole Niehues, Elizabeth Semkiw, Melissa Reynolds, Jeff Wenzel, Marc C. Johnson

PLOS Pathogens: published December 28, 2023 | https://doi.org/10.1371/journal.ppat.1011688

Pathogen-driven nucleotide overload triggers mitochondria-centered cell death in phagocytes

Nicoletta Schwermann, Rita Haller, Sebastian Koch, Guntram A. Grassl, Volker Winstel

PLOS Pathogens: published December 29, 2023 | https://doi.org/10.1371/journal.ppat.1011892

Roles of epidermal growth factor receptor, claudin-1 and occludin in multi-step entry of hepatitis C virus into polarized hepatoma spheroids

Chui-Wa So, Marion Sourisseau, Shamila Sarwar, Matthew J. Evans, Glenn Randall

PLOS Pathogens: published December 29, 2023 | https://doi.org/10.1371/journal.ppat.1011887

Deep mutational scans of XBB.1.5 and BQ.1.1 reveal ongoing epistatic drift during SARS-CoV-2 evolution

Ashley L. Taylor, Tyler N. Starr

PLOS Pathogens: published December 29, 2023 | https://doi.org/10.1371/journal.ppat.1011901

Borrelia burgdorferi initiates early transcriptional re-programming in macrophages that supports long-term suppression of inflammation

Tanja Petnicki-Ocwieja, Julie E. McCarthy, Urmila Powale, P. Kent Langston, Jennifer D. Helble, Linden T. Hu

PLOS Pathogens: published December 29, 2023 | https://doi.org/10.1371/journal.ppat.1011886

Correction: USP12 promotes antiviral responses by deubiquitinating and stabilizing IFI16

Yuling Fu, Xiaoxia Zhan, Xiaolong You, Dingnai Nie, Haiyan Mai, Yitian Chen, Shitong He, Junli Sheng, Zhijie Zeng, Hongwei Li, Jinlong Li, Shengfeng Hu

PLOS Pathogens: published December 1, 2023 | https://doi.org/10.1371/journal.ppat.1011827

Related Articles

1. USP12 promotes antiviral responses by deubiquitinating and stabilizing IFI16