Rhinovirus C is a significant cause of respiratory illness world-wide, yet little remains known about the life cycle of this pathogen in human airway epithelial cells. Immunofluorescence detection of double-stranded RNA (magenta) in a well-differentiated model of human airway epithelium following rhinovirus-C15 infection reveals ongoing viral replication in Forkhead Box J1 (FoxJ1; gray) – positive ciliated cells. Motile cilia are visualized by acetylated α-tubulin staining (green).
Image Credit: Talita Bianca Gagliardi
Review
Advances and gaps in SARS-CoV-2 infection models
PLOS Pathogens: published January 13, 2022 | https://doi.org/10.1371/journal.ppat.1010161
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Corrections
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