Preexisting and inducible endotoxemia as crucial contributors to the severity of COVID-19 outcomes

Ilja L. Kruglikov, Philipp E. Scherer

PLOS Pathogens: published February 18, 2021 | https://doi.org/10.1371/journal.ppat.1009306

Five key aspects of metaproteomics as a tool to understand functional interactions in host-associated microbiomes

Fernanda Salvato, Robert L. Hettich, Manuel Kleiner

PLOS Pathogens: published February 25, 2021 | https://doi.org/10.1371/journal.ppat.1009245

Three-dimensional chromatin in infectious disease—A role for gene regulation and pathogenicity?

Sage Z. Davis, Thomas Hollin, Todd Lenz, Karine G. Le Roch

PLOS Pathogens: published February 4, 2021 | https://doi.org/10.1371/journal.ppat.1009207

SARS-CoV-2 tropism, entry, replication, and propagation: Considerations for drug discovery and development

Nicholas Murgolo, Alex G. Therien, Bonnie Howell, Daniel Klein, Kenneth Koeplinger, Linda A. Lieberman, Gregory C. Adam, Jessica Flynn, Philip McKenna, Gokul Swaminathan, Daria J. Hazuda, David B. Olsen

PLOS Pathogens: published February 17, 2021 | https://doi.org/10.1371/journal.ppat.1009225

Current understanding of the interplays between host hormones and plant viral infections

Shanshan Zhao, Yi Li

PLOS Pathogens: published February 25, 2021 | https://doi.org/10.1371/journal.ppat.1009242

Nonimmune antibody interactions of Group A Streptococcus M and M-like proteins

Jori O. Mills, Partho Ghosh

PLOS Pathogens: published February 25, 2021 | https://doi.org/10.1371/journal.ppat.1009248

New insights into the interactions between Blastocystis, the gut microbiota, and host immunity

Lei Deng, Lukasz Wojciech, Nicholas R. J. Gascoigne, Guangneng Peng, Kevin S. W. Tan

PLOS Pathogens: published February 25, 2021 | https://doi.org/10.1371/journal.ppat.1009253

Inhibition of anti-viral stress granule formation by coronavirus endoribonuclease nsp15 ensures efficient virus replication

Bo Gao, Xiaoqian Gong, Shouguo Fang, Wenlian Weng, Huan Wang, Hongyan Chu, Yingjie Sun, Chunchun Meng, Lei Tan, Cuiping Song, Xusheng Qiu, Weiwei Liu, Maria Forlenza, Chan Ding, Ying Liao

PLOS Pathogens: published February 26, 2021 | https://doi.org/10.1371/journal.ppat.1008690

Actin and an unconventional myosin motor, TgMyoF, control the organization and dynamics of the endomembrane network in Toxoplasma gondii

Romain Carmeille, Porfirio Schiano Lomoriello, Parvathi M. Devarakonda, Jacob A. Kellermeier, Aoife T. Heaslip

PLOS Pathogens: published February 2, 2021 | https://doi.org/10.1371/journal.ppat.1008787

A highly attenuated vaccinia virus strain LC16m8-based vaccine for severe fever with thrombocytopenia syndrome

Tomoki Yoshikawa, Satoshi Taniguchi, Hirofumi Kato, Naoko Iwata-Yoshikawa, Hideki Tani, Takeshi Kurosu, Hikaru Fujii, Natsumi Omura, Miho Shibamura, Shumpei Watanabe, Kazutaka Egawa, Takuya Inagaki, Satoko Sugimoto, Supranee Phanthanawiboon, Shizuko Harada, Souichi Yamada, Shuetsu Fukushi, Shigeru Morikawa, Noriyo Nagata, Masayuki Shimojima, Masayuki Saijo

PLOS Pathogens: published February 3, 2021 | https://doi.org/10.1371/journal.ppat.1008859

The molecular targets of ivermectin and lotilaner in the human louse Pediculus humanus humanus: New prospects for the treatment of pediculosis

Nicolas Lamassiaude, Berthine Toubate, Cédric Neveu, Pierre Charnet, Catherine Dupuy, Françoise Debierre-Grockiego, Isabelle Dimier-Poisson, Claude L. Charvet

PLOS Pathogens: published February 18, 2021 | https://doi.org/10.1371/journal.ppat.1008863

Eukaryotic translation initiation factor 5A and its posttranslational modifications play an important role in proliferation and potentially in differentiation of the human enteric protozoan parasite Entamoeba histolytica

Ghulam Jeelani, Tomoyoshi Nozaki

PLOS Pathogens: published February 16, 2021 | https://doi.org/10.1371/journal.ppat.1008909

The narrow-spectrum anthelmintic oxantel is a potent agonist of a novel acetylcholine receptor subtype in whipworms

Tina V. A. Hansen, Susanna Cirera, Cédric Neveu, Elise Courtot, Claude L. Charvet, Kirstine Calloe, Dan A. Klaerke, Richard J. Martin

PLOS Pathogens: published February 5, 2021 | https://doi.org/10.1371/journal.ppat.1008982

CVB3 VP1 interacts with MAT1 to inhibit cell proliferation by interfering with Cdk-activating kinase complex activity in CVB3-induced acute pancreatitis

Hongxia Zhang, Lingbing Zeng, Qiong Liu, Guilin Jin, Jieyu Zhang, Zengbin Li, Yilian Xu, Huizhen Tian, Shanshan Deng, Qiaofa Shi, Xiaotian Huang

PLOS Pathogens: published February 8, 2021 | https://doi.org/10.1371/journal.ppat.1008992

Non-permissive human conventional CD1c⁺ dendritic cells enable trans-infection of human primary renal tubular epithelial cells and protect BK polyomavirus from neutralization

Mathieu Sikorski, Flora Coulon, Cécile Peltier, Cécile Braudeau, Alexandra Garcia, Matthieu Giraud, Karine Renaudin, Christine Kandel-Aznar, Steven Nedellec, Philippe Hulin, Julien Branchereau, Joëlle Véziers, Pauline Gaboriaud, Antoine Touzé, Julien Burlaud-Gaillard, Régis Josien, Dorian McIlroy, Céline Bressollette-Bodin, Franck Halary

PLOS Pathogens: published February 16, 2021 | https://doi.org/10.1371/journal.ppat.1009042

DksA-dependent regulation of RpoS contributes to Borrelia burgdorferi tick-borne transmission and mammalian infectivity

William K. Boyle, Crystal L. Richards, Daniel P. Dulebohn, Amanda K. Zalud, Jeff A. Shaw, Sándor Lovas, Frank C. Gherardini, Travis J. Bourret

PLOS Pathogens: published February 18, 2021 | https://doi.org/10.1371/journal.ppat.1009072

Genome-wide dissection reveals diverse pathogenic roles of bacterial Tc toxins

Nan Song, Lihong Chen, Zhemin Zhou, Xingmei Ren, Bo Liu, Siyu Zhou, Caihong Wang, Yun Wu, Nicholas R. Waterfield, Jian Yang, Guowei Yang

PLOS Pathogens: published February 4, 2021 | https://doi.org/10.1371/journal.ppat.1009102

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Defective viral genomes from chikungunya virus are broad-spectrum antivirals and prevent virus dissemination in mosquitoes

Laura I. Levi, Veronica V. Rezelj, Annabelle Henrion-Lacritick, Diana Erazo, J Boussier, Thomas Vallet, Veronika Bernhauerová, Yasutsugu Suzuki, Lucia Carrau, James Weger-Lucarelli, Maria-Carla Saleh, Marco Vignuzzi

PLOS Pathogens: published February 8, 2021 | https://doi.org/10.1371/journal.ppat.1009110

A lysine ring in HIV capsid pores coordinates IP6 to drive mature capsid assembly

Nadine Renner, Donna L. Mallery, K. M. Rifat Faysal, Wang Peng, David A. Jacques, Till Böcking, Leo C. James

PLOS Pathogens: published February 1, 2021 | https://doi.org/10.1371/journal.ppat.1009164

Multi-clonal SARS-CoV-2 neutralization by antibodies isolated from severe COVID-19 convalescent donors

Michael Mor, Michal Werbner, Joel Alter, Modi Safra, Elad Chomsky, Jamie C. Lee, Smadar Hada-Neeman, Ksenia Polonsky, Cameron J. Nowell, Alex E. Clark, Anna Roitburd-Berman, Noam Ben-Shalom, Michal Navon, Dor Rafael, Hila Sharim, Evgeny Kiner, Eric R. Griffis, Jonathan M. Gershoni, Oren Kobiler, Sandra Lawrynowicz Leibel, Oren Zimhony, Aaron F. Carlin, Gur Yaari, Moshe Dessau, Meital Gal-Tanamy, David Hagin, Ben A. Croker, Natalia T. Freund

PLOS Pathogens: published February 11, 2021 | https://doi.org/10.1371/journal.ppat.1009165

Ephrin receptor A2, the epithelial receptor for Epstein-Barr virus entry, is not available for efficient infection in human gastric organoids

Nina Wallaschek, Saskia Reuter, Sabrina Silkenat, Katharina Wolf, Carolin Niklas, Özge Kayisoglu, Carmen Aguilar, Armin Wiegering, Christoph-Thomas Germer, Stefan Kircher, Andreas Rosenwald, Claire Shannon-Lowe, Sina Bartfeld

PLOS Pathogens: published February 17, 2021 | https://doi.org/10.1371/journal.ppat.1009210

Divergent features of the coenzyme Q:cytochrome c oxidoreductase complex in Toxoplasma gondii parasites

Jenni A. Hayward, Esther Rajendran, Soraya M. Zwahlen, Pierre Faou, Giel G. van Dooren

PLOS Pathogens: published February 1, 2021 | https://doi.org/10.1371/journal.ppat.1009211

The leucine-rich repeats in allelic barley MLA immune receptors define specificity towards sequence-unrelated powdery mildew avirulence effectors with a predicted common RNase-like fold

Saskia Bauer, Dongli Yu, Aaron W. Lawson, Isabel M. L. Saur, Lamprinos Frantzeskakis, Barbara Kracher, Elke Logemann, Jijie Chai, Takaki Maekawa, Paul Schulze-Lefert

PLOS Pathogens: published February 3, 2021 | https://doi.org/10.1371/journal.ppat.1009223

Site-specific analysis of N-glycans from different sheep prion strains

Natali Nakić, Thanh Hoa Tran, Mislav Novokmet, Olivier Andreoletti, Gordan Lauc, Giuseppe Legname

PLOS Pathogens: published February 18, 2021 | https://doi.org/10.1371/journal.ppat.1009232

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Winter is coming–Temperature affects immune defenses and susceptibility to Batrachochytrium salamandrivorans

Edward Davis Carter, Molly C. Bletz, Mitchell Le Sage, Brandon LaBumbard, Louise A. Rollins-Smith, Douglas C. Woodhams, Debra L. Miller, Matthew J. Gray

PLOS Pathogens: published February 18, 2021 | https://doi.org/10.1371/journal.ppat.1009234

Metabolomic/lipidomic profiling of COVID-19 and individual response to tocilizumab

Gaia Meoni, Veronica Ghini, Laura Maggi, Alessia Vignoli, Alessio Mazzoni, Lorenzo Salvati, Manuela Capone, Anna Vanni, Leonardo Tenori, Paolo Fontanari, Federico Lavorini, Adriano Peris, Alessandro Bartoloni, Francesco Liotta, Lorenzo Cosmi, Claudio Luchinat, Francesco Annunziato, Paola Turano

PLOS Pathogens: published February 1, 2021 | https://doi.org/10.1371/journal.ppat.1009243

N-Glycans and sulfated glycosaminoglycans contribute to the action of diverse Tc toxins on mammalian cells

Nan Song, Lihong Chen, Xingmei Ren, Nicholas R. Waterfield, Jian Yang, Guowei Yang

PLOS Pathogens: published February 4, 2021 | https://doi.org/10.1371/journal.ppat.1009244

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Antibiotics modulate attractive interactions in bacterial colonies affecting survivability under combined treatment

Tom Cronenberg, Marc Hennes, Isabelle Wielert, Berenike Maier

PLOS Pathogens: published February 1, 2021 | https://doi.org/10.1371/journal.ppat.1009251

A murine model of Lyme disease demonstrates that Borrelia burgdorferi colonizes the dura mater and induces inflammation in the central nervous system

Timothy Casselli, Ali Divan, Emilie E. Vomhof-DeKrey, Yvonne Tourand, Heidi L. Pecoraro, Catherine A. Brissette

PLOS Pathogens: published February 1, 2021 | https://doi.org/10.1371/journal.ppat.1009256

The C3/465 glycan hole cluster in BG505 HIV-1 envelope is the major neutralizing target involved in preventing mucosal SHIV infection

Tysheena P. Charles, Samantha L. Burton, Prabhu S. Arunachalam, Christopher A. Cottrell, Leigh M. Sewall, Venkata S. Bollimpelli, Sailaja Gangadhara, Antu K. Dey, Andrew B. Ward, George M. Shaw, Eric Hunter, Rama R. Amara, Bali Pulendran, Marit J. van Gils, Cynthia A. Derdeyn

PLOS Pathogens: published February 8, 2021 | https://doi.org/10.1371/journal.ppat.1009257

First complete-genome documentation of HIV-1 intersubtype superinfection with transmissions of diverse recombinants over time to five recipients

Yang Gao, Shan He, Wen Tian, Dan Li, Minghui An, Bin Zhao, Haibo Ding, Junjie Xu, Zhenxing Chu, Hong Shang, Xiaoxu Han

PLOS Pathogens: published February 12, 2021 | https://doi.org/10.1371/journal.ppat.1009258

Breakdown in membrane asymmetry regulation leads to monocyte recognition of P. falciparum-infected red blood cells

Merryn Fraser, Weidong Jing, Stefan Bröer, Florian Kurth, Leif-Erik Sander, Kai Matuschewski, Alexander G. Maier

PLOS Pathogens: published February 18, 2021 | https://doi.org/10.1371/journal.ppat.1009259

Maternal schistosomiasis impairs offspring Interleukin-4 production and B cell expansion

Diana Cortés-Selva, Lisa Gibbs, Andrew Ready, H. Atakan Ekiz, Ryan O’Connell, Bartek Rajwa, Keke C. Fairfax

PLOS Pathogens: published February 1, 2021 | https://doi.org/10.1371/journal.ppat.1009260

Capture and visualization of live Mycobacterium tuberculosis bacilli from tuberculosis patient bioaerosols

Ryan Dinkele, Sophia Gessner, Andrea McKerry, Bryan Leonard, Ronnett Seldon, Anastasia S. Koch, Carl Morrow, Melitta Gqada, Mireille Kamariza, Carolyn R. Bertozzi, Brian Smith, Courtney McLoud, Andrew Kamholz, Wayne Bryden, Charles Call, Gilla Kaplan, Valerie Mizrahi, Robin Wood, Digby F. Warner

PLOS Pathogens: published February 1, 2021 | https://doi.org/10.1371/journal.ppat.1009262

Endoribonuclease-mediated control of hns mRNA stability constitutes a key regulatory pathway for Salmonella Typhimurium pathogenicity island 1 expression

Minho Lee, Minkyung Ryu, Minju Joo, Young-Jin Seo, Jaejin Lee, Hong-Man Kim, Eunkyoung Shin, Ji-Hyun Yeom, Yong-Hak Kim, Jeehyeon Bae, Kangseok Lee

PLOS Pathogens: published February 1, 2021 | https://doi.org/10.1371/journal.ppat.1009263

Transferrin-mediated iron sequestration suggests a novel therapeutic strategy for controlling Nosema disease in the honey bee, Apis mellifera

Cristina Rodríguez-García, Matthew C. Heerman, Steven C. Cook, Jay D. Evans, Gloria DeGrandi-Hoffman, Olubukola Banmeke, Yi Zhang, Shaokang Huang, Michele Hamilton, Yan Ping Chen

PLOS Pathogens: published February 18, 2021 | https://doi.org/10.1371/journal.ppat.1009270

In vivo dynamics and adaptation of HTLV-1-infected clones under different clinical conditions

Mikiko Izaki, Jun-ichirou Yasunaga, Kisato Nosaka, Kenji Sugata, Hayato Utsunomiya, Youko Suehiro, Takafumi Shichijo, Asami Yamada, Yasuhiko Sugawara, Taizo Hibi, Yukihiro Inomata, Hirofumi Akari, Anat Melamed, Charles Bangham, Masao Matsuoka

PLOS Pathogens: published February 1, 2021 | https://doi.org/10.1371/journal.ppat.1009271

Pre-existing heterosubtypic immunity provides a barrier to airborne transmission of influenza viruses

Valerie Le Sage, Jennifer E. Jones, Karen A. Kormuth, William J. Fitzsimmons, Eric Nturibi, Gabriella H. Padovani, Claudia P. Arevalo, Andrea J. French, Annika J. Avery, Richard Manivanh, Elizabeth E. McGrady, Amar R. Bhagwat, Adam S. Lauring, Scott E. Hensley, Seema S. Lakdawala

PLOS Pathogens: published February 18, 2021 | https://doi.org/10.1371/journal.ppat.1009273

Preclinical transmission of prions by blood transfusion is influenced by donor genotype and route of infection

M. Khalid F. Salamat, A. Richard Alejo Blanco, Sandra McCutcheon, Kyle B. C. Tan, Paula Stewart, Helen Brown, Allister Smith, Christopher de Wolf, Martin H. Groschup, Dietmar Becher, Olivier Andréoletti, Marc Turner, Jean C. Manson, E. Fiona Houston

PLOS Pathogens: published February 18, 2021 | https://doi.org/10.1371/journal.ppat.1009276

Tripartite Motif 22 (TRIM22) protein restricts herpes simplex virus 1 by epigenetic silencing of viral immediate-early genes

Tejaswini S. Reddi, Philipp E. Merkl, So-Yon Lim, Norman L. Letvin, David M. Knipe

PLOS Pathogens: published February 1, 2021 | https://doi.org/10.1371/journal.ppat.1009281

Multimerization- and glycosylation-dependent receptor binding of SARS-CoV-2 spike proteins

Kim M. Bouwman, Ilhan Tomris, Hannah L. Turner, Roosmarijn van der Woude, Tatiana M. Shamorkina, Gerlof P. Bosman, Barry Rockx, Sander Herfst, Joost Snijder, Bart L. Haagmans, Andrew B. Ward, Geert-Jan Boons, Robert P. de Vries

PLOS Pathogens: published February 8, 2021 | https://doi.org/10.1371/journal.ppat.1009282

MeV-Stealth: A CD46-specific oncolytic measles virus resistant to neutralization by measles-immune human serum

Miguel Ángel Muñoz-Alía, Rebecca A. Nace, Alexander Tischer, Lianwen Zhang, Eugene S. Bah, Matthew Auton, Stephen J. Russell

PLOS Pathogens: published February 3, 2021 | https://doi.org/10.1371/journal.ppat.1009283

ASC-dependent inflammasomes contribute to immunopathology and mortality in herpes simplex encephalitis

Cooper K. Hayes, Douglas R. Wilcox, Yuchen Yang, Grace K. Coleman, Melissa A. Brown, Richard Longnecker

PLOS Pathogens: published February 1, 2021 | https://doi.org/10.1371/journal.ppat.1009285

Extrafollicular CD4 T cell-derived IL-10 functions rapidly and transiently to support anti-Plasmodium humoral immunity

Fionna A. Surette, Jenna J. Guthmiller, Lei Li, Alexandria J. Sturtz, Rahul Vijay, Rosemary L. Pope, Brandon L. McClellan, Angela D. Pack, Ryan A. Zander, Peng Shao, Linda Yu-Ling Lan, Daniel Fernandez-Ruiz, William R. Heath, Patrick C. Wilson, Noah S. Butler

PLOS Pathogens: published February 2, 2021 | https://doi.org/10.1371/journal.ppat.1009288

PspC domain-containing protein (PCP) determines Streptococcus mutans biofilm formation through bacterial extracellular DNA release and platelet adhesion in experimental endocarditis

Chiau-Jing Jung, Chih-Chieh Hsu, Jeng-Wei Chen, Hung-Wei Cheng, Chang-Tsu Yuan, Yu-Min Kuo, Ron-Bin Hsu, Jean-San Chia

PLOS Pathogens: published February 12, 2021 | https://doi.org/10.1371/journal.ppat.1009289

Shiga toxin remodels the intestinal epithelial transcriptional response to Enterohemorrhagic Escherichia coli

Alyson R. Warr, Carole J. Kuehl, Matthew K. Waldor

PLOS Pathogens: published February 2, 2021 | https://doi.org/10.1371/journal.ppat.1009290

Capsule carbohydrate structure determines virulence in Acinetobacter baumannii

Yuli Talyansky, Travis B. Nielsen, Jun Yan, Ulrike Carlino-Macdonald, Gisela Di Venanzio, Somnath Chakravorty, Amber Ulhaq, Mario F. Feldman, Thomas A. Russo, Evgeny Vinogradov, Brian Luna, Meredith S. Wright, Mark D. Adams, Brad Spellberg

PLOS Pathogens: published February 2, 2021 | https://doi.org/10.1371/journal.ppat.1009291

A redox-active crosslinker reveals an essential and inhibitable oxidative folding network in the endoplasmic reticulum of malaria parasites

David W. Cobb, Heather M. Kudyba, Alejandra Villegas, Michael R. Hoopmann, Rodrigo P. Baptista, Baylee Bruton, Michelle Krakowiak, Robert L. Moritz, Vasant Muralidharan

PLOS Pathogens: published February 3, 2021 | https://doi.org/10.1371/journal.ppat.1009293

CircRNA ARFGEF1 functions as a ceRNA to promote oncogenic KSHV-encoded viral interferon regulatory factor induction of cell invasion and angiogenesis by upregulating glutaredoxin 3

Shuihong Yao, Xuemei Jia, Fei Wang, Liuxue Sheng, Pengxia Song, Yanhui Cao, Hongjuan Shi, Weifei Fan, Xiangya Ding, Shou-Jiang Gao, Chun Lu

PLOS Pathogens: published February 4, 2021 | https://doi.org/10.1371/journal.ppat.1009294

SND1 promotes Th1/17 immunity against chlamydial lung infection through enhancing dendritic cell function

Xinting Wang, Chunyan Zhang, Shuhe Wang, Rasheduzzaman Rashu, Rony Thomas, Jie Yang, Xi Yang

PLOS Pathogens: published February 26, 2021 | https://doi.org/10.1371/journal.ppat.1009295

Type IV pilus retraction enables sustained bacteremia and plays a key role in the outcome of meningococcal sepsis in a humanized mouse model

Jean-Philippe Barnier, Daniel Euphrasie, Olivier Join-Lambert, Mathilde Audry, Sophia Schonherr-Hellec, Taliah Schmitt, Sandrine Bourdoulous, Mathieu Coureuil, Xavier Nassif, Mohamed El Behi

PLOS Pathogens: published February 16, 2021 | https://doi.org/10.1371/journal.ppat.1009299

The PB1 protein of influenza A virus inhibits the innate immune response by targeting MAVS for NBR1-mediated selective autophagic degradation

Yan Zeng, Shuai Xu, Yanli Wei, Xuegang Zhang, Qian Wang, Yane Jia, Wanbing Wang, Lu Han, Zhaoshan Chen, Zhengxiang Wang, Bo Zhang, Hualan Chen, Cao-Qi Lei, Qiyun Zhu

PLOS Pathogens: published February 12, 2021 | https://doi.org/10.1371/journal.ppat.1009300

Viral growth factor- and STAT3 signaling-dependent elevation of the TCA cycle intermediate levels during vaccinia virus infection

Anil Pant, Lara Dsouza, Shuai Cao, Chen Peng, Zhilong Yang

PLOS Pathogens: published February 2, 2021 | https://doi.org/10.1371/journal.ppat.1009303

Distinct clonal lineages and within-host diversification shape invasive Staphylococcus epidermidis populations

Anna Both, Jiabin Huang, Minyue Qi, Christian Lausmann, Samira Weißelberg, Henning Büttner, Susanne Lezius, Antonio Virgilio Failla, Martin Christner, Marc Stegger, Thorsten Gehrke, Sharmin Baig, Mustafa Citak, Malik Alawi, Martin Aepfelbacher, Holger Rohde

PLOS Pathogens: published February 5, 2021 | https://doi.org/10.1371/journal.ppat.1009304

Response of human macrophages to gamma radiation is mediated via expression of endogenous retroviruses

Natallia Mikhalkevich, Ina P. O’Carroll, Rok Tkavc, Kateryna Lund, Gauthaman Sukumar, Clifton L. Dalgard, Kory R. Johnson, Wenxue Li, Tongguang Wang, Avindra Nath, Sergey Iordanskiy

PLOS Pathogens: published February 8, 2021 | https://doi.org/10.1371/journal.ppat.1009305

Marek’s disease virus U_S3 protein kinase phosphorylates chicken HDAC 1 and 2 and regulates viral replication and pathogenesis

Yifei Liao, Blanca Lupiani, Mohammad AI-Mahmood, Sanjay M. Reddy

PLOS Pathogens: published February 17, 2021 | https://doi.org/10.1371/journal.ppat.1009307

Physiological and immunological changes in the brain associated with lethal eastern equine encephalitis virus in macaques

Joseph R. Albe, Henry Ma, Theron H. Gilliland, Cynthia M. McMillen, Christina L. Gardner, Devin A. Boyles, Emily L. Cottle, Matthew D. Dunn, Jeneveve D. Lundy, Katherine J. O’Malley, Noah Salama, Aaron W. Walters, Ivona Pandrea, Tobias Teichert, William B. Klimstra, Douglas S. Reed, Amy L. Hartman

PLOS Pathogens: published February 3, 2021 | https://doi.org/10.1371/journal.ppat.1009308

TAM mediates adaptation of carbapenem-resistant Klebsiella pneumoniae to antimicrobial stress during host colonization and infection

Hea-Jin Jung, Matthew T. Sorbara, Eric G. Pamer

PLOS Pathogens: published February 8, 2021 | https://doi.org/10.1371/journal.ppat.1009309

Uropathogenic E. coli induces DNA damage in the bladder

Camille V. Chagneau, Clémence Massip, Nadège Bossuet-Greif, Christophe Fremez, Jean-Paul Motta, Ayaka Shima, Céline Besson, Pauline Le Faouder, Nicolas Cénac, Marie-Paule Roth, Hélène Coppin, Maxime Fontanié, Patricia Martin, Jean-Philippe Nougayrède, Eric Oswald

PLOS Pathogens: published February 25, 2021 | https://doi.org/10.1371/journal.ppat.1009310

Evidence for distinct mechanisms of small molecule inhibitors of filovirus entry

Adam Schafer, Rui Xiong, Laura Cooper, Raghad Nowar, Hyun Lee, Yangfeng Li, Benjamin E. Ramirez, Norton P. Peet, Michael Caffrey, Gregory R. J. Thatcher, Erica Ollmann Saphire, Han Cheng, Lijun Rong

PLOS Pathogens: published February 4, 2021 | https://doi.org/10.1371/journal.ppat.1009312

Diverging patterns of introgression from Schistosoma bovis across S. haematobium African lineages

Olivier Rey, Eve Toulza, Cristian Chaparro, Jean-François Allienne, Julien Kincaid-Smith, Eglantine Mathieu-Begné, Fiona Allan, David Rollinson, Bonnie L. Webster, Jérôme Boissier

PLOS Pathogens: published February 5, 2021 | https://doi.org/10.1371/journal.ppat.1009313

A novel role of Zebrafish TMEM33 in negative regulation of interferon production by two distinct mechanisms

Long-Feng Lu, Can Zhang, Zhuo-Cong Li, Xiao-Yu Zhou, Jing-Yu Jiang, Dan-Dan Chen, Yong-An Zhang, Feng Xiong, Fang Zhou, Shun Li

PLOS Pathogens: published February 18, 2021 | https://doi.org/10.1371/journal.ppat.1009317

Protein kinase TgCDPK7 regulates vesicular trafficking and phospholipid synthesis in Toxoplasma gondii

Priyanka Bansal, Neelam Antil, Manish Kumar, Yoshiki Yamaryo-Botté, Rahul Singh Rawat, Sneha Pinto, Keshava K. Datta, Nicholas J. Katris, Cyrille Y. Botté, T. S. Keshava Prasad, Pushkar Sharma

PLOS Pathogens: published February 26, 2021 | https://doi.org/10.1371/journal.ppat.1009325

Antibody affinity versus dengue morphology influences neutralization

Guntur Fibriansah, Elisa X. Y. Lim, Jan K. Marzinek, Thiam-Seng Ng, Joanne L. Tan, Roland G. Huber, Xin-Ni Lim, Valerie S. Y. Chew, Victor A. Kostyuchenko, Jian Shi, Ganesh S. Anand, Peter J. Bond, James E. Crowe Jr., Shee-Mei Lok

PLOS Pathogens: published February 23, 2021 | https://doi.org/10.1371/journal.ppat.1009331

Viral RNA-binding ability conferred by SUMOylation at PB1 K612 of influenza A virus is essential for viral pathogenesis and transmission

Junping Li, Libin Liang, Li Jiang, Qian Wang, Xia Wen, Yuhui Zhao, Pengfei Cui, Yaping Zhang, Guangwen Wang, Qibing Li, Guohua Deng, Jianzhong Shi, Guobin Tian, Xianying Zeng, Yongping Jiang, Liling Liu, Hualan Chen, Chengjun Li

PLOS Pathogens: published February 11, 2021 | https://doi.org/10.1371/journal.ppat.1009336

TLR7 agonist, N6-LS and PGT121 delayed viral rebound in SHIV-infected macaques after antiretroviral therapy interruption

Denise C. Hsu, Alexandra Schuetz, Rawiwan Imerbsin, Decha Silsorn, Amarendra Pegu, Dutsadee Inthawong, Jumpol Sopanaporn, Pornsuk Visudhiphan, Weerawan Chuenarom, Boot Keawboon, Wei Shi, Merlin L. Robb, John R. Mascola, Romas Geleziunas, Richard A. Koup, Dan H. Barouch, Nelson L. Michael, Sandhya Vasan

PLOS Pathogens: published February 18, 2021 | https://doi.org/10.1371/journal.ppat.1009339

Mitochondrial morphodynamics alteration induced by influenza virus infection as a new antiviral strategy

Irene Pila-Castellanos, Diana Molino, Joe McKellar, Laetitia Lines, Juliane Da Graca, Marine Tauziet, Laurent Chanteloup, Ivan Mikaelian, Laurène Meyniel-Schicklin, Patrice Codogno, Jacky Vonderscher, Cédric Delevoye, Olivier Moncorgé, Eric Meldrum, Caroline Goujon, Etienne Morel, Benoit de Chassey

PLOS Pathogens: published February 17, 2021 | https://doi.org/10.1371/journal.ppat.1009340

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Super enhancer-mediated transcription of miR146a-5p drives M2 polarization during Leishmania donovani infection

Sonali Das, Sohitri Mukherjee, Nahid Ali

PLOS Pathogens: published February 25, 2021 | https://doi.org/10.1371/journal.ppat.1009343

Epigenomic characterization of latent HIV infection identifies latency regulating transcription factors

Stuart R. Jefferys, Samuel D. Burgos, Jackson J. Peterson, Sara R. Selitsky, Anne-Marie W. Turner, Lindsey I. James, Yi-Hsuan Tsai, Alisha R. Coffey, David M. Margolis, Joel Parker, Edward P. Browne

PLOS Pathogens: published February 26, 2021 | https://doi.org/10.1371/journal.ppat.1009346

Breadth and function of antibody response to acute SARS-CoV-2 infection in humans

Kuan-Ying A. Huang, Tiong Kit Tan, Ting-Hua Chen, Chung-Guei Huang, Ruth Harvey, Saira Hussain, Cheng-Pin Chen, Adam Harding, Javier Gilbert-Jaramillo, Xu Liu, Michael Knight, Lisa Schimanski, Shin-Ru Shih, Yi-Chun Lin, Chien-Yu Cheng, Shu-Hsing Cheng, Yhu-Chering Huang, Tzou-Yien Lin, Jia-Tsrong Jan, Che Ma, William James, Rodney S. Daniels, John W. McCauley, Pramila Rijal, Alain R. Townsend

PLOS Pathogens: published February 26, 2021 | https://doi.org/10.1371/journal.ppat.1009352

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Rapamycin inhibits pathogen transmission in mosquitoes by promoting immune activation

Yuebiao Feng, Lu Chen, Li Gao, Li Dong, Han Wen, Xiumei Song, Fang Luo, Gong Cheng, Jingwen Wang

PLOS Pathogens: published February 24, 2021 | https://doi.org/10.1371/journal.ppat.1009353

An aspartyl protease-mediated cleavage regulates structure and function of a flavodoxin-like protein and aids oxidative stress survival

Anamika Battu, Rajaram Purushotham, Partha Dey, S. Surya Vamshi, Rupinder Kaur

PLOS Pathogens: published February 25, 2021 | https://doi.org/10.1371/journal.ppat.1009355

A diffusible signal factor of the intestine dictates Salmonella invasion through its direct control of the virulence activator HilD

Rimi Chowdhury, Paulina D. Pavinski Bitar, Ivan Keresztes, Anthony M. Condo Jr., Craig Altier

PLOS Pathogens: published February 22, 2021 | https://doi.org/10.1371/journal.ppat.1009357

ZBTB2 represses HIV-1 transcription and is regulated by HIV-1 Vpr and cellular DNA damage responses

James W. Bruce, Megan Bracken, Edward Evans, Nathan Sherer, Paul Ahlquist

PLOS Pathogens: published February 26, 2021 | https://doi.org/10.1371/journal.ppat.1009364

Effector memory CD8 T cell response elicits Hepatitis E Virus genotype 3 pathogenesis in the elderly

Hicham El Costa, Jordi Gouilly, Florence Abravanel, Elmostafa Bahraoui, Jean-Marie Peron, Nassim Kamar, Nabila Jabrane-Ferrat, Jacques Izopet

PLOS Pathogens: published February 22, 2021 | https://doi.org/10.1371/journal.ppat.1009367

Bacterial virulence plays a crucial role in MRSA sepsis

Gordon Y. C. Cheung, Justin S. Bae, Ryan Liu, Rachelle L. Hunt, Yue Zheng, Michael Otto

PLOS Pathogens: published February 25, 2021 | https://doi.org/10.1371/journal.ppat.1009369

Therapeutic targeting of measles virus polymerase with ERDRP-0519 suppresses all RNA synthesis activity

Robert M. Cox, Julien Sourimant, Mugunthan Govindarajan, Michael G. Natchus, Richard K. Plemper

PLOS Pathogens: published February 23, 2021 | https://doi.org/10.1371/journal.ppat.1009371

Transmission of SARS-CoV-2 in domestic cats imposes a narrow bottleneck

Katarina M. Braun, Gage K. Moreno, Peter J. Halfmann, Emma B. Hodcroft, David A. Baker, Emma C. Boehm, Andrea M. Weiler, Amelia K. Haj, Masato Hatta, Shiho Chiba, Tadashi Maemura, Yoshihiro Kawaoka, Katia Koelle, David H. O’Connor, Thomas C. Friedrich

PLOS Pathogens: published February 26, 2021 | https://doi.org/10.1371/journal.ppat.1009373

Correction: Histone demethylase LSD1 restricts influenza A virus infection by erasing IFITM3-K88 monomethylation

Jiaoyu Shan, Binbin Zhao, Zhao Shan, Jia Nie, Rong Deng, Rui Xiong, Andy Tsun, Weiqi Pan, Hanzhi Zhao, Ling Chen, Ying Jin, Zhikang Qian, Kawing Lui, Rui Liang, Dan Li, Bing Sun, Dimitri Lavillette, Ke Xu, Bin Li

PLOS Pathogens: published February 22, 2021 | https://doi.org/10.1371/journal.ppat.1009359

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