Chemical tools for decoding redox signaling at the host–microbe interface

Elizabeth M. Gordon, Stavroula K. Hatzios

PLOS Pathogens: published December 17, 2020 | https://doi.org/10.1371/journal.ppat.1009070

On invariant T cells and measles: A theory of “innate immune amnesia”

S. M. Mansour Haeryfar

PLOS Pathogens: published December 17, 2020 | https://doi.org/10.1371/journal.ppat.1009071

Is Candida auris sexual?

Zoe K. Ross, Alexander Lorenz

PLOS Pathogens: published December 17, 2020 | https://doi.org/10.1371/journal.ppat.1009094

Joining forces: Leveraging novel combination therapies to combat infections with eukaryotic pathogens

Rachel E. Ham, Lesly A. Temesvari

PLOS Pathogens: published December 31, 2020 | https://doi.org/10.1371/journal.ppat.1009081

Host RAB11FIP5 protein inhibits the release of Kaposi’s sarcoma-associated herpesvirus particles by promoting lysosomal degradation of ORF45

Xiaoqin Wei, Jiazhen Dong, Chin-Chen Cheng, Mingjun Ji, Lei Yu, Shengqiu Luo, Shuwen Wu, Lei Bai, Ke Lan

PLOS Pathogens: published December 14, 2020 | https://doi.org/10.1371/journal.ppat.1009099

The CH1α domain of mucosal gp41 IgA contributes to antibody specificity and antiviral functions in HIV-1 highly exposed Sero-Negative individuals

Marwa Khamassi, Lin Xu, Julien Rey, Maxence Duchemin, Tahar Bouceba, Pierre Tuffery, Daniela Tudor, Morgane Bomsel

PLOS Pathogens: published December 14, 2020 | https://doi.org/10.1371/journal.ppat.1009103

Bacterial persisters in long-term infection: Emergence and fitness in a complex host environment

Jennifer A. Bartell, David R. Cameron, Biljana Mojsoska, Janus Anders Juul Haagensen, Tacjana Pressler, Lea M. Sommer, Kim Lewis, Søren Molin, Helle Krogh Johansen

PLOS Pathogens: published December 14, 2020 | https://doi.org/10.1371/journal.ppat.1009112

Emergence of artemisinin-resistant Plasmodium falciparum with kelch13 C580Y mutations on the island of New Guinea

Olivo Miotto, Makoto Sekihara, Shin-Ichiro Tachibana, Masato Yamauchi, Richard D. Pearson, Roberto Amato, Sonia Gonçalves, Somya Mehra, Rintis Noviyanti, Jutta Marfurt, Sarah Auburn, Ric N. Price, Ivo Mueller, Mie Ikeda, Toshiyuki Mori, Makoto Hirai, Livingstone Tavul, Manuel W. Hetzel, Moses Laman, Alyssa E. Barry, Pascal Ringwald, Jun Ohashi, Francis Hombhanje, Dominic P. Kwiatkowski, Toshihiro Mita

PLOS Pathogens: published December 15, 2020 | https://doi.org/10.1371/journal.ppat.1009133

Bacterial behavior in human blood reveals complement evaders with some persister-like features

Stéphane Pont, Nathan Fraikin, Yvan Caspar, Laurence Van Melderen, Ina Attrée, François Cretin

PLOS Pathogens: published December 16, 2020 | https://doi.org/10.1371/journal.ppat.1008893

Lipid droplets fuel SARS-CoV-2 replication and production of inflammatory mediators

Suelen Silva Gomes Dias, Vinicius Cardoso Soares, André C. Ferreira, Carolina Q. Sacramento, Natalia Fintelman-Rodrigues, Jairo R. Temerozo, Lívia Teixeira, Marcos Alexandre Nunes da Silva, Ester Barreto, Mayara Mattos, Caroline S. de Freitas, Isaclaudia G. Azevedo-Quintanilha, Pedro Paulo A. Manso, Milene D. Miranda, Marilda Mendonça Siqueira, Eugenio D. Hottz, Camila R. R. Pão, Dumith C. Bou-Habib, Debora F. Barreto-Vieira, Fernando A. Bozza, Thiago M. L. Souza, Patricia T. Bozza

PLOS Pathogens: published December 16, 2020 | https://doi.org/10.1371/journal.ppat.1009127

mRNA induced expression of human angiotensin-converting enzyme 2 in mice for the study of the adaptive immune response to severe acute respiratory syndrome coronavirus 2

Mariah Hassert, Elizabeth Geerling, E. Taylor Stone, Tara L. Steffen, Madi S. Feldman, Alexandria L. Dickson, Jacob Class, Justin M. Richner, James D. Brien, Amelia K. Pinto

PLOS Pathogens: published December 16, 2020 | https://doi.org/10.1371/journal.ppat.1009163

Mycolactone toxin induces an inflammatory response by targeting the IL-1β pathway: Mechanistic insight into Buruli ulcer pathophysiology

M. Foulon, M. Robbe-Saule, J. Manry, L. Esnault, Y. Boucaud, A. Alcaïs, M. Malloci, M. Fanton d’Andon, T. Beauvais, N. Labarriere, P. Jeannin, L. Abel, J. P. Saint-André, A. Croué, Y. Delneste, I. G. Boneca, L. Marsollier, E. Marion

PLOS Pathogens: published December 18, 2020 | https://doi.org/10.1371/journal.ppat.1009107

A mating-induced reproductive gene promotes Anopheles tolerance to Plasmodium falciparum infection

Perrine Marcenac, W. Robert Shaw, Evdoxia G. Kakani, Sara N. Mitchell, Adam South, Kristine Werling, Eryney Marrogi, Daniel G. Abernathy, Rakiswendé Serge Yerbanga, Roch K. Dabiré, Abdoulaye Diabaté, Thierry Lefèvre, Flaminia Catteruccia

PLOS Pathogens: published December 21, 2020 | https://doi.org/10.1371/journal.ppat.1008908

Independent genomic polymorphisms in the PknH serine threonine kinase locus during evolution of the Mycobacterium tuberculosis Complex affect virulence and host preference

Elena Mata, Damien Farrell, Ruoyao Ma, Santiago Uranga, Ana Belen Gomez, Marta Monzon, Juan Badiola, Alberto Anel, Jesús Gonzalo-Asensio, Carlos Martin, Stephen V. Gordon, Nacho Aguilo

PLOS Pathogens: published December 21, 2020 | https://doi.org/10.1371/journal.ppat.1009061

GAS6 signaling tempers Th17 development in patients with multiple sclerosis and helminth infection

Juan M. Ortiz Wilczyñski, Cinthia M. Olexen, Andrea E. Errasti, Mirta Schattner, Carla V. Rothlin, Jorge Correale, Eugenio A. Carrera Silva

PLOS Pathogens: published December 21, 2020 | https://doi.org/10.1371/journal.ppat.1009176

IL-33 facilitates rapid expulsion of the parasitic nematode Strongyloides ratti from the intestine via ILC2- and IL-9-driven mast cell activation

Jana Meiners, Martina Reitz, Nikolas Rüdiger, Jan-Eric Turner, Lennart Heepmann, Lena Rudolf, Wiebke Hartmann, Henry J. McSorley, Minka Breloer

PLOS Pathogens: published December 22, 2020 | https://doi.org/10.1371/journal.ppat.1009121

Targeting bioenergetics is key to counteracting the drug-tolerant state of biofilm-grown bacteria

Monique Donnert, Sarah Elsheikh, Alejandro Arce-Rodriguez, Vinay Pawar, Peter Braubach, Danny Jonigk, Axel Haverich, Siegfried Weiss, Mathias Müsken, Susanne Häussler

PLOS Pathogens: published December 22, 2020 | https://doi.org/10.1371/journal.ppat.1009126

The SUMOylation pathway suppresses arbovirus replication in Aedes aegypti cells

Samuel Stokes, Floriane Almire, Michael H. Tatham, Steven McFarlane, Peter Mertens, Emilie Pondeville, Chris Boutell

PLOS Pathogens: published December 22, 2020 | https://doi.org/10.1371/journal.ppat.1009134

Biased Pol II fidelity contributes to conservation of functional domains in the Potato spindle tuber viroid genome

Jian Wu, David M. Bisaro

PLOS Pathogens: published December 22, 2020 | https://doi.org/10.1371/journal.ppat.1009144

Mutations altering acetylated residues in the CTD of HIV-1 integrase cause defects in proviral transcription at early times after integration of viral DNA

Shelby Winans, Stephen P. Goff

PLOS Pathogens: published December 22, 2020 | https://doi.org/10.1371/journal.ppat.1009147

The E3/E4 ubiquitin conjugation factor UBE4B interacts with and ubiquitinates the HTLV-1 Tax oncoprotein to promote NF-κB activation

Suchitra Mohanty, Teng Han, Young Bong Choi, Alfonso Lavorgna, Jiawen Zhang, Edward William Harhaj

PLOS Pathogens: published December 23, 2020 | https://doi.org/10.1371/journal.ppat.1008504

Vaginal microbiome-hormonal contraceptive interactions associate with the mucosal proteome and HIV acquisition

Laura Noël-Romas, Michelle Perner, Refilwe Molatlhegi, Christina Farr Zuend, Amanda Mabhula, Sarah Hoger, Alana Lamont, Kenzie Birse, Alicia Berard, Stuart McCorrister, Garett Westmacott, Al Leslie, Vanessa Poliquin, Renee Heffron, Lyle R. McKinnon, Adam D. Burgener

PLOS Pathogens: published December 23, 2020 | https://doi.org/10.1371/journal.ppat.1009097

Directed evolution reveals the mechanism of HitRS signaling transduction in Bacillus anthracis

Hualiang Pi, Michelle L. Chu, Samuel J. Ivan, Casey J. Latario, Allen M. Toth, Sophia M. Carlin, Gideon H. Hillebrand, Hannah K. Lin, Jared D. Reppart, Devin L. Stauff, Eric P. Skaar

PLOS Pathogens: published December 23, 2020 | https://doi.org/10.1371/journal.ppat.1009148

Helicobacter pylori diversification during chronic infection within a single host generates sub-populations with distinct phenotypes

Laura K. Jackson, Barney Potter, Sean Schneider, Matthew Fitzgibbon, Kris Blair, Hajirah Farah, Uma Krishna, Trevor Bedford, Richard M. Peek Jr, Nina R. Salama

PLOS Pathogens: published December 28, 2020 | https://doi.org/10.1371/journal.ppat.1008686

Toxoplasma gondii PPM3C, a secreted protein phosphatase, affects parasitophorous vacuole effector export

Joshua Mayoral, Tadakimi Tomita, Vincent Tu, Jennifer T. Aguilan, Simone Sidoli, Louis M. Weiss

PLOS Pathogens: published December 28, 2020 | https://doi.org/10.1371/journal.ppat.1008771

The axonal sorting activity of pseudorabies virus Us9 protein depends on the state of neuronal maturation

Nikhila S. Tanneti, Joel D. Federspiel, Ileana M. Cristea, Lynn W. Enquist

PLOS Pathogens: published December 28, 2020 | https://doi.org/10.1371/journal.ppat.1008861

Key interplay between the co-opted sorting nexin-BAR proteins and PI3P phosphoinositide in the formation of the tombusvirus replicase

Zhike Feng, Nikolay Kovalev, Peter D. Nagy

PLOS Pathogens: published December 28, 2020 | https://doi.org/10.1371/journal.ppat.1009120

Memory like NK cells display stem cell like properties after Zika virus infection

Weshely Kujur, Oscar Murillo, Raju S. R. Adduri, Ramakrishna Vankayalapati, Nagarjun V. Konduru, Sachin Mulik

PLOS Pathogens: published December 28, 2020 | https://doi.org/10.1371/journal.ppat.1009132

Runx proteins mediate protective immunity against Leishmania donovani infection by promoting CD40 expression on dendritic cells

Md. Naushad Akhtar, Manish Mishra, Vinod Yadav, Manisha Yadav, Ravindra Gujar, Sunaina Lal, Raj Kumar, Neeraj Khatri, Pradip Sen

PLOS Pathogens: published December 28, 2020 | https://doi.org/10.1371/journal.ppat.1009136

Assembly of infectious enteroviruses depends on multiple, conserved genomic RNA-coat protein contacts

Rebecca Chandler-Bostock, Carlos P. Mata, Richard J. Bingham, Eric C. Dykeman, Bo Meng, Tobias J. Tuthill, David J. Rowlands, Neil A. Ranson, Reidun Twarock, Peter G. Stockley

PLOS Pathogens: published December 28, 2020 | https://doi.org/10.1371/journal.ppat.1009146

Role of astroglial Connexin 43 in pneumolysin cytotoxicity and during pneumococcal meningitis

Chakir Bello, Yasmine Smail, Vincent Sainte-Rose, Isabelle Podglajen, Alice Gilbert, Vanessa Moreira, Fabrice Chrétien, Martine Cohen Salmon, Guy Tran Van Nhieu

PLOS Pathogens: published December 28, 2020 | https://doi.org/10.1371/journal.ppat.1009152

The latency-associated transcript locus of herpes simplex virus 1 is a virulence determinant in human skin

Emilia A. H. Vanni, Joseph W. Foley, Andrew J. Davison, Marvin Sommer, Dongmei Liu, Phillip Sung, Jennifer Moffat, Leigh Zerboni, Ann M. Arvin

PLOS Pathogens: published December 28, 2020 | https://doi.org/10.1371/journal.ppat.1009166

Rationally designed Human Cytomegalovirus gB nanoparticle vaccine with improved immunogenicity

Michela Perotti, Jessica Marcandalli, Davide Demurtas, Federica Sallusto, Laurent Perez

PLOS Pathogens: published December 28, 2020 | https://doi.org/10.1371/journal.ppat.1009169

T-cell responses to sequentially emerging viral escape mutants shape long-term HIV-1 population dynamics

Tomohiro Akahoshi, Hiroyuki Gatanaga, Nozomi Kuse, Takayuki Chikata, Madoka Koyanagi, Naoki Ishizuka, Chanson J. Brumme, Hayato Murakoshi, Zabrina L. Brumme, Shinichi Oka, Masafumi Takiguchi

PLOS Pathogens: published December 28, 2020 | https://doi.org/10.1371/journal.ppat.1009177

Phylogenomics of 8,839 Clostridioides difficile genomes reveals recombination-driven evolution and diversification of toxin A and B

Michael J. Mansfield, Benjamin J-M Tremblay, Ji Zeng, Xin Wei, Harold Hodgins, Jay Worley, Lynn Bry, Min Dong, Andrew C. Doxey

PLOS Pathogens: published December 28, 2020 | https://doi.org/10.1371/journal.ppat.1009181

Signal peptide of HIV-1 envelope modulates glycosylation impacting exposure of V1V2 and other epitopes

Chitra Upadhyay, Roya Feyznezhad, Liwei Cao, Kun-Wei Chan, Kevin Liu, Weiming Yang, Hui Zhang, Jason Yolitz, James Arthos, Arthur Nadas, Xiang-Peng Kong, Susan Zolla-Pazner, Catarina E. Hioe

PLOS Pathogens: published December 28, 2020 | https://doi.org/10.1371/journal.ppat.1009185

A dual-therapy approach for the treatment of biofilm-mediated Salmonella gallbladder carriage

Jenna L. Sandala, Bradley W. Eichar, Laura G. Kuo, Mark M. Hahn, Akash K. Basak, William M. Huggins, Katherine Woolard, Christian Melander, John S. Gunn

PLOS Pathogens: published December 28, 2020 | https://doi.org/10.1371/journal.ppat.1009192

Epstein-Barr virus LMP1 manipulates the content and functions of extracellular vesicles to enhance metastatic potential of recipient cells

Dingani Nkosi, Li Sun, Leanne C. Duke, David G. Meckes Jr.

PLOS Pathogens: published December 31, 2020 | https://doi.org/10.1371/journal.ppat.1009023

A single Na⁺-P_i cotransporter in Toxoplasma plays key roles in phosphate import and control of parasite osmoregulation

Beejan Asady, Claudia F. Dick, Karen Ehrenman, Tejram Sahu, Julia D. Romano, Isabelle Coppens

PLOS Pathogens: published December 31, 2020 | https://doi.org/10.1371/journal.ppat.1009067

Modeling intra-mosquito dynamics of Zika virus and its dose-dependence confirms the low epidemic potential of Aedes albopictus

Sebastian Lequime, Jean-Sébastien Dehecq, Séverine Matheus, Franck de Laval, Lionel Almeras, Sébastien Briolant, Albin Fontaine

PLOS Pathogens: published December 31, 2020 | https://doi.org/10.1371/journal.ppat.1009068

Multiple blood feeding in mosquitoes shortens the Plasmodium falciparum incubation period and increases malaria transmission potential

W. Robert Shaw, Inga E. Holmdahl, Maurice A. Itoe, Kristine Werling, Meghan Marquette, Douglas G. Paton, Naresh Singh, Caroline O. Buckee, Lauren M. Childs, Flaminia Catteruccia

PLOS Pathogens: published December 31, 2020 | https://doi.org/10.1371/journal.ppat.1009131

Correction: Immunosuppressive FK506 treatment leads to more frequent EBV-associated lymphoproliferative disease in humanized mice

Nicole Caduff, Donal McHugh, Anita Murer, Patrick Rämer, Ana Raykova, Vanessa Landtwing, Lisa Rieble, Christian W. Keller, Michael Prummer, Laurent Hoffmann, Janice K. P. Lam, Alan K. S. Chiang, Friedrich Raulf, Tarik Azzi, Christoph Berger, Tina Rubic-Schneider, Elisabetta Traggiai, Jan D. Lünemann, Michael Kammüller, Christian Münz

PLOS Pathogens: published December 21, 2020 | https://doi.org/10.1371/journal.ppat.1009167

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Correction: Mutant prion proteins increase calcium permeability of AMPA receptors, exacerbating excitotoxicity

Elsa Ghirardini, Elena Restelli, Raffaella Morini, Ilaria Bertani, Davide Ortolan, Fabio Perrucci, Davide Pozzi, Michela Matteoli, Roberto Chiesa

PLOS Pathogens: published December 22, 2020 | https://doi.org/10.1371/journal.ppat.1009174

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Correction: Plant A20/AN1 protein serves as the important hub to mediate antiviral immunity

Li Chang, Ho-Hsiung Chang, Jui-Che Chang, Hsiang-Chia Lu, Tan-Tung Wang, Duen-Wei Hsu, Yuh Tzean, An-Po Cheng, Yi-Shu Chiu, Hsin-Hung Yeh

PLOS Pathogens: published December 22, 2020 | https://doi.org/10.1371/journal.ppat.1009178

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Correction: Leptospiral LPS escapes mouse TLR4 internalization and TRIF-associated antimicrobial responses through O antigen and associated lipoproteins

Delphine Bonhomme, Ignacio Santecchia, Frédérique Vernel-Pauillac, Martine Caroff, Pierre Germon, Gerald Murray, Ben Adler, Ivo G. Boneca, Catherine Werts

PLOS Pathogens: published December 23, 2020 | https://doi.org/10.1371/journal.ppat.1009173

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