A paramyxovirus-like model for Ebola virus bipartite promoters

Irina Gutsche, Philippe le Mercier, Daniel Kolakofsky

PLOS Pathogens: published November 5, 2020 | https://doi.org/10.1371/journal.ppat.1008972

Infectious hypothesis of Alzheimer disease

Charles E. Seaks, Donna M. Wilcock

PLOS Pathogens: published November 12, 2020 | https://doi.org/10.1371/journal.ppat.1008596

Insights into malaria pathogenesis gained from host metabolomics

Heather N. Colvin, Regina Joice Cordy

PLOS Pathogens: published November 12, 2020 | https://doi.org/10.1371/journal.ppat.1008930

Entamoeba histolytica: Five facts about modeling a complex human disease in rodents

Carolina Mendoza Cavazos, Laura J. Knoll

PLOS Pathogens: published November 12, 2020 | https://doi.org/10.1371/journal.ppat.1008950

Staphylococcus epidermidis—Skin friend or foe?

Morgan M. Brown, Alexander R. Horswill

PLOS Pathogens: published November 12, 2020 | https://doi.org/10.1371/journal.ppat.1009026

Harnessing early life immunity to develop a pediatric HIV vaccine that can protect through adolescence

Ria Goswami, Stella J. Berendam, Shuk Hang Li, Ashley N. Nelson, Kristina De Paris, Koen K. A. Van Rompay, Sallie R. Permar, Genevieve G. Fouda

PLOS Pathogens: published November 12, 2020 | https://doi.org/10.1371/journal.ppat.1008983

The pathogenesis of cardiac microlesion formation during severe bacteremic infection

Armand O. Brown, Danielle A. Garsin

PLOS Pathogens: published November 19, 2020 | https://doi.org/10.1371/journal.ppat.1009021

Maternal antibody interference contributes to reduced rotavirus vaccine efficacy in developing countries

Claire E. Otero, Stephanie N. Langel, Maria Blasi, Sallie R. Permar

PLOS Pathogens: published November 19, 2020 | https://doi.org/10.1371/journal.ppat.1009010

The role of cysteine peptidases in coronavirus cell entry and replication: The therapeutic potential of cathepsin inhibitors

Anja Pišlar, Ana Mitrović, Jerica Sabotič, Urša Pečar Fonović, Milica Perišić Nanut, Tanja Jakoš, Emanuela Senjor, Janko Kos

PLOS Pathogens: published November 2, 2020 | https://doi.org/10.1371/journal.ppat.1009013

Convergent structural features of respiratory syncytial virus neutralizing antibodies and plasticity of the site V epitope on prefusion F

Wayne Harshbarger, Sai Tian, Newton Wahome, Ankita Balsaraf, Deep Bhattacharya, Desheng Jiang, Ratnesh Pandey, Kunal Tungare, Kristian Friedrich, Nurjahan Mehzabeen, Marco Biancucci, Diana Chinchilla-Olszar, Corey P. Mallett, Ying Huang, Zihao Wang, Matthew James Bottomley, Enrico Malito, Sumana Chandramouli

PLOS Pathogens: published November 2, 2020 | https://doi.org/10.1371/journal.ppat.1008943

The role of dermis resident macrophages and their interaction with neutrophils in the early establishment of Leishmania major infection transmitted by sand fly bite

Mariana M. Chaves, Sang Hun Lee, Olena Kamenyeva, Kashinath Ghosh, Nathan C. Peters, David Sacks

PLOS Pathogens: published November 2, 2020 | https://doi.org/10.1371/journal.ppat.1008674

Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs

Federica Giordani, Daniel Paape, Isabel M. Vincent, Andrew W. Pountain, Fernando Fernández-Cortés, Eva Rico, Ning Zhang, Liam J. Morrison, Yvonne Freund, Michael J. Witty, Rosemary Peter, Darren Y. Edwards, Jonathan M. Wilkes, Justin J. J. van der Hooft, Clément Regnault, Kevin D. Read, David Horn, Mark C. Field, Michael P. Barrett

PLOS Pathogens: published November 3, 2020 | https://doi.org/10.1371/journal.ppat.1008932

Drivers of within-host genetic diversity in acute infections of viruses

Maoz Gelbart, Sheri Harari, Ya’ara Ben-Ari, Talia Kustin, Dana Wolf, Michal Mandelboim, Orna Mor, Pleuni S. Pennings, Adi Stern

PLOS Pathogens: published November 4, 2020 | https://doi.org/10.1371/journal.ppat.1009029

Transcriptional analysis of immune response genes during pathogenesis of cytomegalovirus retinitis in mice with murine acquired immunodeficiency syndrome

Jessica J. Carter, Jesse M. Gardner, Brent P. Poling, Madeline M. Welch, Judee Grace E. Nemeno, John E. Houghton, Richard D. Dix

PLOS Pathogens: published November 6, 2020 | https://doi.org/10.1371/journal.ppat.1009032

A human secretome library screen reveals a role for Peptidoglycan Recognition Protein 1 in Lyme borreliosis

Akash Gupta, Gunjan Arora, Connor E. Rosen, Zachary Kloos, Yongguo Cao, Jiri Cerny, Andaleeb Sajid, Dieuwertje Hoornstra, Maryna Golovchenko, Natalie Rudenko, Ulrike Munderloh, Joppe W. Hovius, Carmen J. Booth, Christine Jacobs-Wagner, Noah W. Palm, Aaron M. Ring, Erol Fikrig

PLOS Pathogens: published November 11, 2020 | https://doi.org/10.1371/journal.ppat.1009030

Virulence and pathogenesis of SARS-CoV-2 infection in rhesus macaques: A nonhuman primate model of COVID-19 progression

Huiwen Zheng, Heng Li, Lei Guo, Yan Liang, Jing Li, Xi Wang, Yunguang Hu, Lichun Wang, Yun Liao, Fengmei Yang, Yanyan Li, Shengtao Fan, Dandan Li, Pingfang Cui, Qingling Wang, Haijing Shi, Yanli Chen, Zening Yang, Jinling Yang, Dong Shen, Wei Cun, Xiaofang Zhou, Xingqi Dong, Yunchuan Wang, Yong Chen, Qing Dai, Weihua Jin, Zhanlong He, Qihan Li, Longding Liu

PLOS Pathogens: published November 12, 2020 | https://doi.org/10.1371/journal.ppat.1008949

Hepatitis B virus Core protein nuclear interactome identifies SRSF10 as a host RNA-binding protein restricting HBV RNA production

Hélène Chabrolles, Héloïse Auclair, Serena Vegna, Thomas Lahlali, Caroline Pons, Maud Michelet, Yohann Couté, Lucid Belmudes, Gilliane Chadeuf, Yujin Kim, Ariel Di Bernardo, Pascal Jalaguier, François-Loïc Cosset, Floriane Fusil, Michel Rivoire, Lee D. Arnold, Uri Lopatin, Christophe Combet, Fabien Zoulim, David Grierson, Benoit Chabot, Julie Lucifora, David Durantel, Anna Salvetti

PLOS Pathogens: published November 12, 2020 | https://doi.org/10.1371/journal.ppat.1008593

Tick-transmitted thogotovirus gains high virulence by a single MxA escape mutation in the viral nucleoprotein

Jonas Fuchs, Alexander Oschwald, Laura Graf, Georg Kochs

PLOS Pathogens: published November 16, 2020 | https://doi.org/10.1371/journal.ppat.1009038

Characterising the epidemic spread of influenza A/H3N2 within a city through phylogenetics

Nicola F. Müller, Daniel Wüthrich, Nina Goldman, Nadine Sailer, Claudia Saalfrank, Myrta Brunner, Noémi Augustin, Helena MB Seth-Smith, Yvonne Hollenstein, Mohammedyaseen Syedbasha, Daniela Lang, Richard A. Neher, Olivier Dubuis, Michael Naegele, Andreas Buser, Christian H. Nickel, Nicole Ritz, Andreas Zeller, Brian M. Lang, James Hadfield, Trevor Bedford, Manuel Battegay, Rita Schneider-Sliwa, Adrian Egli, Tanja Stadler

PLOS Pathogens: published November 19, 2020 | https://doi.org/10.1371/journal.ppat.1008984

Calcineurin phosphatase activity regulates Varicella-Zoster Virus induced cell-cell fusion

Momei Zhou, Vivek Kamarshi, Ann M. Arvin, Stefan L. Oliver

PLOS Pathogens: published November 20, 2020 | https://doi.org/10.1371/journal.ppat.1009022

Structural insights into loss of function of a pore forming toxin and its role in pneumococcal adaptation to an intracellular lifestyle

Dilip C. Badgujar, Anjali Anil, Angharad E. Green, Manalee Vishnu Surve, Shilpa Madhavan, Alison Beckett, Ian A. Prior, Barsa K. Godsora, Sanket B. Patil, Prachi Kadam More, Shruti Guha Sarkar, Andrea Mitchell, Rinti Banerjee, Prashant S. Phale, Timothy J. Mitchell, Daniel R. Neill, Prasenjit Bhaumik, Anirban Banerjee

PLOS Pathogens: published November 20, 2020 | https://doi.org/10.1371/journal.ppat.1009016

In vitro and in vivo characterization of a recombinant rhesus cytomegalovirus containing a complete genome

Husam Taher, Eisa Mahyari, Craig Kreklywich, Luke S. Uebelhoer, Matthew R. McArdle, Matilda J. Moström, Amruta Bhusari, Michael Nekorchuk, Xiaofei E, Travis Whitmer, Elizabeth A. Scheef, Lesli M. Sprehe, Dawn L. Roberts, Colette M. Hughes, Kerianne A. Jackson, Andrea N. Selseth, Abigail B. Ventura, Hillary C. Cleveland-Rubeor, Yujuan Yue, Kimberli A. Schmidt, Jason Shao, Paul T. Edlefsen, Jeremy Smedley, Timothy F. Kowalik, Richard J. Stanton, Michael K. Axthelm, Jacob D. Estes, Scott G. Hansen, Amitinder Kaur, Peter A. Barry, Benjamin N. Bimber, Louis J. Picker, Daniel N. Streblow, Klaus Früh, Daniel Malouli

PLOS Pathogens: published November 24, 2020 | https://doi.org/10.1371/journal.ppat.1008666

Foot-and-mouth disease virus VP1 target the MAVS to inhibit type-I interferon signaling and VP1 E83K mutation results in virus attenuation

Pathum Ekanayaka, Seo-Yong Lee, Thilina U. B. Herath, Jae-Hoon Kim, Tae-Hwan Kim, Hyuncheol Lee, Kiramage Chathuranga, W. A. Gayan Chathuranga, Jong-Hyeon Park, Jong-Soo Lee

PLOS Pathogens: published November 24, 2020 | https://doi.org/10.1371/journal.ppat.1009057

Defensin-driven viral evolution

Karina Diaz, Ciara T. Hu, Youngmee Sul, Beth A. Bromme, Nicolle D. Myers, Ksenia V. Skorohodova, Anshu P. Gounder, Jason G. Smith

PLOS Pathogens: published November 24, 2020 | https://doi.org/10.1371/journal.ppat.1009018

Structural intermediates in the low pH-induced transition of influenza hemagglutinin

Jingjing Gao, Miao Gui, Ye Xiang

PLOS Pathogens: published November 30, 2020 | https://doi.org/10.1371/journal.ppat.1009062

Genomic analysis reveals an exogenous viral symbiont with dual functionality in parasitoid wasps and their hosts

Kelsey A. Coffman, Gaelen R. Burke

PLOS Pathogens: published November 30, 2020 | https://doi.org/10.1371/journal.ppat.1009069

TLR-9 agonist and CD40-targeting vaccination induces HIV-1 envelope-specific B cells with a diversified immunoglobulin repertoire in humanized mice

Véronique Godot, Colas Tcherakian, Laurine Gil, Iñaki Cervera-Marzal, Guangming Li, Liang Cheng, Nicolas Ortonne, Jean-Daniel Lelièvre, Giuseppe Pantaleo, Craig Fenwick, Mireille Centlivre, Hugo Mouquet, Sylvain Cardinaud, Sandra M. Zurawski, Gerard Zurawski, Pierre Milpied, Lishan Su, Yves Lévy

PLOS Pathogens: published November 30, 2020 | https://doi.org/10.1371/journal.ppat.1009025

Human splice factors contribute to latent HIV infection in primary cell models and blood CD4⁺ T cells from ART-treated individuals

Sara Moron-Lopez, Sushama Telwatte, Indra Sarabia, Emilie Battivelli, Mauricio Montano, Amanda B. Macedo, Dvir Aran, Atul J. Butte, R. Brad Jones, Alberto Bosque, Eric Verdin, Warner C. Greene, Joseph K. Wong, Steven A. Yukl

PLOS Pathogens: published November 30, 2020 | https://doi.org/10.1371/journal.ppat.1009060

Vesicular trafficking permits evasion of cGAS/STING surveillance during initial human papillomavirus infection

Brittany L. Uhlorn, Robert Jackson, Shuaizhi Li, Shauna M. Bratton, Koenraad Van Doorslaer, Samuel K. Campos

PLOS Pathogens: published November 30, 2020 | https://doi.org/10.1371/journal.ppat.1009028

Ifit2 deficiency restricts microglial activation and leukocyte migration following murine coronavirus (m-CoV) CNS infection

Jayasri Das Sarma, Amy Burrows, Patricia Rayman, Mi-Hyun Hwang, Soumya Kundu, Nikhil Sharma, Cornelia Bergmann, Ganes C. Sen

PLOS Pathogens: published November 30, 2020 | https://doi.org/10.1371/journal.ppat.1009034

Global discovery of human-infective RNA viruses: A modelling analysis

Feifei Zhang, Margo Chase-Topping, Chuan-Guo Guo, Bram A. D. van Bunnik, Liam Brierley, Mark E. J. Woolhouse

PLOS Pathogens: published November 30, 2020 | https://doi.org/10.1371/journal.ppat.1009079

Mutations in dnaA and a cryptic interaction site increase drug resistance in Mycobacterium tuberculosis

Nathan D. Hicks, Samantha R. Giffen, Peter H. Culviner, Michael C. Chao, Charles L. Dulberger, Qingyun Liu, Sydney Stanley, Jessica Brown, Jaimie Sixsmith, Ian D. Wolf, Sarah M. Fortune

PLOS Pathogens: published November 30, 2020 | https://doi.org/10.1371/journal.ppat.1009063

Correction: 15-keto-prostaglandin E₂ activates host peroxisome proliferator-activated receptor gamma (PPAR-γ) to promote Cryptococcus neoformans growth during infection

Robert J. Evans, Katherine Pline, Catherine A. Loynes, Sarah Needs, Maceler Aldrovandi, Jens Tiefenbach, Ewa Bielska, Rachel E. Rubino, Christopher J. Nicol, Robin C. May, Henry M. Krause, Valerie B. O’Donnell, Stephen A. Renshaw, Simon A. Johnston

PLOS Pathogens: published November 4, 2020 | https://doi.org/10.1371/journal.ppat.1009058

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1. 15-keto-prostaglandin E₂ activates host peroxisome proliferator-activated receptor gamma (PPAR-γ) to promote Cryptococcus neoformans growth during infection