Macrophage (white) hosting Leishmania amazonensis (red, parasite nuclei and kinetoplasts in orange) that multiply in spacious, large parasitophorous vacuoles (PVs). The volumetric expansion of PVs is controlled by different host cell factors, among which the d2 variant of V-ATPase subunit d (ATP6V0d2). Picture obtained from confocal images of immunostained samples (for host macrophage lysosomes using anti-Lamp-1 antibody and parasite surface using 2A3-26 antibody) and reconstructed in three-dimensional image. Pessoa et al.
Pearls
Herpes simplex virus replication compartments: From naked release to recombining together
PLOS Pathogens: published June 3, 2019 | https://doi.org/10.1371/journal.ppat.1007714
Heteroresistance: A cause of unexplained antibiotic treatment failure?
PLOS Pathogens: published June 6, 2019 | https://doi.org/10.1371/journal.ppat.1007726
Vitamin A at the interface of host–commensal–pathogen interactions
PLOS Pathogens: published June 6, 2019 | https://doi.org/10.1371/journal.ppat.1007750
Plastid–endomembrane connections in apicomplexan parasites
PLOS Pathogens: published June 13, 2019 | https://doi.org/10.1371/journal.ppat.1007661
Microbiota-mediated disease resistance in plants
PLOS Pathogens: published June 13, 2019 | https://doi.org/10.1371/journal.ppat.1007740
Born to sweet delight: Using natural models of malaria protection to understand and neutralize P. falciparum pathogenesis
PLOS Pathogens: published June 20, 2019 | https://doi.org/10.1371/journal.ppat.1007770
Blood brain barrier disruption in cerebral malaria: Beyond endothelial cell activation
PLOS Pathogens: published June 27, 2019 | https://doi.org/10.1371/journal.ppat.1007786
Research Articles
Schistosoma japonicum extracellular vesicle miRNA cargo regulates host macrophage functions facilitating parasitism
PLOS Pathogens: published June 4, 2019 | https://doi.org/10.1371/journal.ppat.1007817
Multidimensional analysis of Gammaherpesvirus RNA expression reveals unexpected heterogeneity of gene expression
PLOS Pathogens: published June 5, 2019 | https://doi.org/10.1371/journal.ppat.1007849
Potent neutralizing antibodies elicited by dengue vaccine in rhesus macaque target diverse epitopes
PLOS Pathogens: published June 6, 2019 | https://doi.org/10.1371/journal.ppat.1007716
Covalent Plasmodium falciparum-selective proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents
PLOS Pathogens: published June 6, 2019 | https://doi.org/10.1371/journal.ppat.1007722
An ortholog of Plasmodium falciparum chloroquine resistance transporter (PfCRT) plays a key role in maintaining the integrity of the endolysosomal system in Toxoplasma gondii to facilitate host invasion
PLOS Pathogens: published June 6, 2019 | https://doi.org/10.1371/journal.ppat.1007775
An NLRP3 inflammasome-triggered cytokine storm contributes to Streptococcal toxic shock-like syndrome (STSLS)
PLOS Pathogens: published June 6, 2019 | https://doi.org/10.1371/journal.ppat.1007795
A bacterial secreted translocator hijacks riboregulators to control type III secretion in response to host cell contact
PLOS Pathogens: published June 7, 2019 | https://doi.org/10.1371/journal.ppat.1007813
Natural Immunity to HIV is associated with Low BLyS/BAFF levels and low frequencies of innate marginal zone like CD1c+ B-cells in the genital tract
PLOS Pathogens: published June 7, 2019 | https://doi.org/10.1371/journal.ppat.1007840
In cultured cells the baculovirus P10 protein forms two independent intracellular structures that play separate roles in occlusion body maturation and their release by nuclear disintegration
PLOS Pathogens: published June 10, 2019 | https://doi.org/10.1371/journal.ppat.1007827
The Group B Streptococcal surface antigen I/II protein, BspC, interacts with host vimentin to promote adherence to brain endothelium and inflammation during the pathogenesis of meningitis
PLOS Pathogens: published June 10, 2019 | https://doi.org/10.1371/journal.ppat.1007848
The 2nd sialic acid-binding site of influenza A virus neuraminidase is an important determinant of the hemagglutinin-neuraminidase-receptor balance
PLOS Pathogens: published June 10, 2019 | https://doi.org/10.1371/journal.ppat.1007860
Fimbriae reprogram host gene expression – Divergent effects of P and type 1 fimbriae
PLOS Pathogens: published June 10, 2019 | https://doi.org/10.1371/journal.ppat.1007671
Divergent roles for the RH5 complex components, CyRPA and RIPR in human-infective malaria parasites
PLOS Pathogens: published June 11, 2019 | https://doi.org/10.1371/journal.ppat.1007809
The landscape of transcription initiation across latent and lytic KSHV genomes
PLOS Pathogens: published June 12, 2019 | https://doi.org/10.1371/journal.ppat.1007852
BATF3-dependent dendritic cells drive both effector and regulatory T-cell responses in bacterially infected tissues
PLOS Pathogens: published June 12, 2019 | https://doi.org/10.1371/journal.ppat.1007866
Regulation of arginine transport by GCN2 eIF2 kinase is important for replication of the intracellular parasite Toxoplasma gondii
PLOS Pathogens: published June 13, 2019 | https://doi.org/10.1371/journal.ppat.1007746
Functional paralysis of human natural killer cells by alphaherpesviruses
PLOS Pathogens: published June 13, 2019 | https://doi.org/10.1371/journal.ppat.1007784
Therapeutic efficacy of favipiravir against Bourbon virus in mice
PLOS Pathogens: published June 13, 2019 | https://doi.org/10.1371/journal.ppat.1007790
Broadly resistant HIV-1 against CD4-binding site neutralizing antibodies
PLOS Pathogens: published June 13, 2019 | https://doi.org/10.1371/journal.ppat.1007819
An autoinducer-independent RhlR quorum-sensing receptor enables analysis of RhlR regulation
PLOS Pathogens: published June 13, 2019 | https://doi.org/10.1371/journal.ppat.1007820
TLR11-independent inflammasome activation is critical for CD4+ T cell-derived IFN-γ production and host resistance to Toxoplasma gondii
PLOS Pathogens: published June 13, 2019 | https://doi.org/10.1371/journal.ppat.1007872
ATP6V0d2 controls Leishmania parasitophorous vacuole biogenesis via cholesterol homeostasis
PLOS Pathogens: published June 14, 2019 | https://doi.org/10.1371/journal.ppat.1007834
Separate domains of G3BP promote efficient clustering of alphavirus replication complexes and recruitment of the translation initiation machinery
PLOS Pathogens: published June 14, 2019 | https://doi.org/10.1371/journal.ppat.1007842
Rab32 GTPase, as a direct target of miR-30b/c, controls the intracellular survival of Burkholderia pseudomallei by regulating phagosome maturation
PLOS Pathogens: published June 14, 2019 | https://doi.org/10.1371/journal.ppat.1007879
DNA methylation from a Type I restriction modification system influences gene expression and virulence in Streptococcus pyogenes
PLOS Pathogens: published June 17, 2019 | https://doi.org/10.1371/journal.ppat.1007841
Hidden regulation of herpes simplex virus 1 pre-mRNA splicing and polyadenylation by virally encoded immediate early gene ICP27
PLOS Pathogens: published June 17, 2019 | https://doi.org/10.1371/journal.ppat.1007884
The fatty acid oleate is required for innate immune activation and pathogen defense in Caenorhabditis elegans
PLOS Pathogens: published June 17, 2019 | https://doi.org/10.1371/journal.ppat.1007893
The Orthotospovirus nonstructural protein NSs suppresses plant MYC-regulated jasmonate signaling leading to enhanced vector attraction and performance
PLOS Pathogens: published June 17, 2019 | https://doi.org/10.1371/journal.ppat.1007897
Systems analysis of subjects acutely infected with the Chikungunya virus
PLOS Pathogens: published June 18, 2019 | https://doi.org/10.1371/journal.ppat.1007880
Host-specialized fibrinogen-binding by a bacterial surface protein promotes biofilm formation and innate immune evasion
PLOS Pathogens: published June 19, 2019 | https://doi.org/10.1371/journal.ppat.1007816
Structural mechanism for guanylate-binding proteins (GBPs) targeting by the Shigella E3 ligase IpaH9.8
PLOS Pathogens: published June 19, 2019 | https://doi.org/10.1371/journal.ppat.1007876
NK cell–intrinsic FcεRIγ limits CD8+ T-cell expansion and thereby turns an acute into a chronic viral infection
PLOS Pathogens: published June 20, 2019 | https://doi.org/10.1371/journal.ppat.1007797
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Comparison of intra- and inter-host genetic diversity in rabies virus during experimental cross-species transmission
PLOS Pathogens: published June 20, 2019 | https://doi.org/10.1371/journal.ppat.1007799
Killing from the inside: Intracellular role of T3SS in the fate of Pseudomonas aeruginosa within macrophages revealed by mgtC and oprF mutants
PLOS Pathogens: published June 20, 2019 | https://doi.org/10.1371/journal.ppat.1007812
Blowing epithelial cell bubbles with GumB: ShlA-family pore-forming toxins induce blebbing and rapid cellular death in corneal epithelial cells
PLOS Pathogens: published June 20, 2019 | https://doi.org/10.1371/journal.ppat.1007825
Vaccinia viral A26 protein is a fusion suppressor of mature virus and triggers membrane fusion through conformational change at low pH
PLOS Pathogens: published June 20, 2019 | https://doi.org/10.1371/journal.ppat.1007826
Neutrophil and macrophage influx into the central nervous system are inflammatory components of lethal Rift Valley fever encephalitis in rats
PLOS Pathogens: published June 20, 2019 | https://doi.org/10.1371/journal.ppat.1007833
Proliferative memory SAMHD1low CD4+ T cells harbour high levels of HIV-1 with compartmentalized viral populations
PLOS Pathogens: published June 20, 2019 | https://doi.org/10.1371/journal.ppat.1007868
Life-long control of cytomegalovirus (CMV) by T resident memory cells in the adipose tissue results in inflammation and hyperglycemia
PLOS Pathogens: published June 20, 2019 | https://doi.org/10.1371/journal.ppat.1007890
EBV epitranscriptome reprogramming by METTL14 is critical for viral-associated tumorigenesis
PLOS Pathogens: published June 21, 2019 | https://doi.org/10.1371/journal.ppat.1007796
Autocrine STAT3 activation in HPV positive cervical cancer through a virus-driven Rac1—NFκB—IL-6 signalling axis
PLOS Pathogens: published June 21, 2019 | https://doi.org/10.1371/journal.ppat.1007835
Unraveling the role of the secretor antigen in human rotavirus attachment to histo-blood group antigens
PLOS Pathogens: published June 21, 2019 | https://doi.org/10.1371/journal.ppat.1007865
The lectin-specific activity of Toxoplasma gondii microneme proteins 1 and 4 binds Toll-like receptor 2 and 4 N-glycans to regulate innate immune priming
PLOS Pathogens: published June 21, 2019 | https://doi.org/10.1371/journal.ppat.1007871
Global analysis of polysome-associated mRNA in vesicular stomatitis virus infected cells
PLOS Pathogens: published June 21, 2019 | https://doi.org/10.1371/journal.ppat.1007875
The YIN and YANG of lipoproteins in developing and preventing infectious arthritis by Staphylococcus aureus
PLOS Pathogens: published June 21, 2019 | https://doi.org/10.1371/journal.ppat.1007877
Non-canonical NLRP3 inflammasome activation and IL-1β signaling are necessary to L. amazonensis control mediated by P2X7 receptor and leukotriene B4
PLOS Pathogens: published June 24, 2019 | https://doi.org/10.1371/journal.ppat.1007887
Recognition of specific sialoglycan structures by oral streptococci impacts the severity of endocardial infection
PLOS Pathogens: published June 24, 2019 | https://doi.org/10.1371/journal.ppat.1007896
Genetic dissection of a Leishmania flagellar proteome demonstrates requirement for directional motility in sand fly infections
PLOS Pathogens: published June 26, 2019 | https://doi.org/10.1371/journal.ppat.1007828
A broadly neutralizing germline-like human monoclonal antibody against dengue virus envelope domain III
PLOS Pathogens: published June 26, 2019 | https://doi.org/10.1371/journal.ppat.1007836
The protective effect of inflammatory monocytes during systemic C. albicans infection is dependent on collaboration between C-type lectin-like receptors
PLOS Pathogens: published June 26, 2019 | https://doi.org/10.1371/journal.ppat.1007850
Enteropathogenic Escherichia coli remodels host endosomes to promote endocytic turnover and breakdown of surface polarity
PLOS Pathogens: published June 26, 2019 | https://doi.org/10.1371/journal.ppat.1007851
Infectious particle identity determines dissemination and disease outcome for the inhaled human fungal pathogen Cryptococcus
PLOS Pathogens: published June 27, 2019 | https://doi.org/10.1371/journal.ppat.1007777
Gasdermin-D and Caspase-7 are the key Caspase-1/8 substrates downstream of the NAIP5/NLRC4 inflammasome required for restriction of Legionella pneumophila
PLOS Pathogens: published June 28, 2019 | https://doi.org/10.1371/journal.ppat.1007886
EspF is crucial for Citrobacter rodentium-induced tight junction disruption and lethality in immunocompromised animals
PLOS Pathogens: published June 28, 2019 | https://doi.org/10.1371/journal.ppat.1007898
HTLV-1 basic leucine zipper factor protects cells from oxidative stress by upregulating expression of Heme Oxygenase I
PLOS Pathogens: published June 28, 2019 | https://doi.org/10.1371/journal.ppat.1007922
Corrections
Correction: TnSeq of Mycobacterium tuberculosis clinical isolates reveals strain-specific antibiotic liabilities
PLOS Pathogens: published June 4, 2019 | https://doi.org/10.1371/journal.ppat.1007846
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Correction: Additive Function of Vibrio vulnificus MARTX Vv and VvhA Cytolysins Promotes Rapid Growth and Epithelial Tissue Necrosis During Intestinal Infection
PLOS Pathogens: published June 19, 2019 | https://doi.org/10.1371/journal.ppat.1007895
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Correction: A model of chronic, transmissible Otitis Media in mice
PLOS Pathogens: published June 28, 2019 | https://doi.org/10.1371/journal.ppat.1007916