April 2019

"Fig3. The Fusarium graminearum FGRRES_16221 receptor and specific receptor sub-domains are important to virulence on wheat. Complementation of the receptor null mutants with the native FGRES_16221 gene restores full virulence. This non-classical receptor physically interacts with intracellular G-proteins. The absence of the receptor dysregulates virulence traits, which amounts to an enhanced wheat defensive response that restricts the progression of infection." Dilks et al.

Image Credit: Dilks T and Brown NA (2019)

Pearls

A call to arms: Mustering secondary metabolites for success and survival of an opportunistic pathogen

Nicholas Raffa, Nancy P. Keller

PLOS Pathogens: published April 4, 2019 | https://doi.org/10.1371/journal.ppat.1007606

Candida auris: An emerging pathogen “incognito”?

Jeniel E. Nett

PLOS Pathogens: published April 8, 2019 | https://doi.org/10.1371/journal.ppat.1007638

Pepper mild mottle virus: Agricultural menace turned effective tool for microbial water quality monitoring and assessing (waste)water treatment technologies

Erin M. Symonds, Karyna Rosario, Mya Breitbart

PLOS Pathogens: published April 18, 2019 | https://doi.org/10.1371/journal.ppat.1007639

The ABCs of wheeze: Asthma and bacterial communities

Naomi G. Wilson, Ariel Hernandez-Leyva, Andrew L. Kau

PLOS Pathogens: published April 25, 2019 | https://doi.org/10.1371/journal.ppat.1007645

Review

The possible role of cross-reactive dengue virus antibodies in Zika virus pathogenesis

Thomas Langerak, Noreen Mumtaz, Vera I. Tolk, Eric C. M. van Gorp, Byron E. Martina, Barry Rockx, Marion P. G. Koopmans

PLOS Pathogens: published April 18, 2019 | https://doi.org/10.1371/journal.ppat.1007640

Research Articles

Non-canonical fungal G-protein coupled receptors promote Fusarium head blight on wheat

Tess Dilks, Kirstie Halsey, Rebecca P. De Vos, Kim E. Hammond-Kosack, Neil Andrew Brown

PLOS Pathogens: published April 1, 2019 | https://doi.org/10.1371/journal.ppat.1007666

Mutational pathway maps and founder effects define the within-host spectrum of hepatitis C virus mutants resistant to drugs

Rubesh Raja, Aditya Pareek, Kapil Newar, Narendra M. Dixit

PLOS Pathogens: published April 1, 2019 | https://doi.org/10.1371/journal.ppat.1007701

Rational design and in vivo selection of SHIVs encoding transmitted/founder subtype C HIV-1 envelopes

Sean P. O’Brien, Adrienne E. Swanstrom, Amarendra Pegu, Sung-Youl Ko, Taina T. Immonen, Gregory Q. Del Prete, Christine M. Fennessey, Jason Gorman, Kathryn E. Foulds, Stephen D. Schmidt, Nicole Doria-Rose, Carolyn Williamson, Theodora Hatziioannou, Paul D. Bieniasz, Hui Li, George M. Shaw, John R. Mascola, Richard A. Koup, Peter D. Kwong, Jeffrey D. Lifson, Mario Roederer, Brandon F. Keele

PLOS Pathogens: published April 3, 2019 | https://doi.org/10.1371/journal.ppat.1007632

USP49 negatively regulates cellular antiviral responses via deconjugating K63-linked ubiquitination of MITA

Liya Ye, Qiang Zhang, Tianzi Liuyu, Zhigao Xu, Meng-Xin Zhang, Min-Hua Luo, Wen-Bo Zeng, Qiyun Zhu, Dandan Lin, Bo Zhong

PLOS Pathogens: published April 3, 2019 | https://doi.org/10.1371/journal.ppat.1007680

The requirement for co-germinants during Clostridium difficile spore germination is influenced by mutations in yabG and cspA

Ritu Shrestha, Alicia M. Cochran, Joseph A. Sorg

PLOS Pathogens: published April 3, 2019 | https://doi.org/10.1371/journal.ppat.1007681

Proximity-dependent proteomics of the Chlamydia trachomatis inclusion membrane reveals functional interactions with endoplasmic reticulum exit sites

Mary S. Dickinson, Lindsey N. Anderson, Bobbie-Jo M. Webb-Robertson, Joshua R. Hansen, Richard D. Smith, Aaron T. Wright, Kevin Hybiske

PLOS Pathogens: published April 3, 2019 | https://doi.org/10.1371/journal.ppat.1007698

A unique dynamin-related protein is essential for mitochondrial fission in Toxoplasma gondii

Carmen Melatti, Manuela Pieperhoff, Leandro Lemgruber, Ehmke Pohl, Lilach Sheiner, Markus Meissner

PLOS Pathogens: published April 4, 2019 | https://doi.org/10.1371/journal.ppat.1007512

Viral RNA-dependent RNA polymerase mutants display an altered mutation spectrum resulting in attenuation in both mosquito and vertebrate hosts

K. Lane Warmbrod, Edward I. Patterson, Tiffany F. Kautz, Adam Stanton, Dedeke Rockx-Brouwer, Birte K. Kalveram, Kamil Khanipov, Saravanan Thangamani, Yuriy Fofanov, Naomi L. Forrester

PLOS Pathogens: published April 4, 2019 | https://doi.org/10.1371/journal.ppat.1007610

Gut microbiota from high-risk men who have sex with men drive immune activation in gnotobiotic mice and in vitro HIV infection

Sam X. Li, Sharon Sen, Jennifer M. Schneider, Ka-Na Xiong, Nichole M. Nusbacher, Nancy Moreno-Huizar, Michael Shaffer, Abigail J. S. Armstrong, Erin Severs, Kristine Kuhn, Charles P. Neff, Martin McCarter, Thomas Campbell, Catherine A. Lozupone, Brent E. Palmer

PLOS Pathogens: published April 4, 2019 | https://doi.org/10.1371/journal.ppat.1007611

Subversion of natural killer cell responses by a cytomegalovirus-encoded soluble CD48 decoy receptor

Pablo Martínez-Vicente, Domènec Farré, Carolina Sánchez, Antonio Alcamí, Pablo Engel, Ana Angulo

PLOS Pathogens: published April 4, 2019 | https://doi.org/10.1371/journal.ppat.1007658

Supramolecular arrangement of the full-length Zika virus NS5

Diego S. Ferrero, Victor M. Ruiz-Arroyo, Nicolas Soler, Isabel Usón, Alba Guarné, Núria Verdaguer

PLOS Pathogens: published April 5, 2019 | https://doi.org/10.1371/journal.ppat.1007656

Unique features in the intracellular transport of typhoid toxin revealed by a genome-wide screen

Shu-Jung Chang, Sheng Chih Jin, Xuyao Jiao, Jorge E. Galán

PLOS Pathogens: published April 5, 2019 | https://doi.org/10.1371/journal.ppat.1007704

Biphasic and cardiomyocyte-specific IFIT activity protects cardiomyocytes from enteroviral infection

Taishi Kimura, Claudia T. Flynn, Mehrdad Alirezaei, Ganes C. Sen, J. Lindsay Whitton

PLOS Pathogens: published April 8, 2019 | https://doi.org/10.1371/journal.ppat.1007674

Human metapneumovirus activates NOD-like receptor protein 3 inflammasome via its small hydrophobic protein which plays a detrimental role during infection in mice

Vuong B. Lê, Julia Dubois, Christian Couture, Marie-Hélène Cavanagh, Olus Uyar, Andres Pizzorno, Manuel Rosa-Calatrava, Marie-Ève Hamelin, Guy Boivin

PLOS Pathogens: published April 9, 2019 | https://doi.org/10.1371/journal.ppat.1007689

A model of chronic, transmissible Otitis Media in mice

Kalyan K. Dewan, Dawn L. Taylor-Mulneix, Laura L. Campos, Amanda L. Skarlupka, Shannon M. Wagner, Valerie E. Ryman, Monica C. Gestal, Longhua Ma, Uriel Blas-Machado, Brian T. Faddis, Eric T. Harvill

PLOS Pathogens: published April 10, 2019 | https://doi.org/10.1371/journal.ppat.1007696

Early existence and biochemical evolution characterise acutely synaptotoxic PrP^Sc

Simote Totauhelotu Foliaki, Victoria Lewis, Abu Mohammed Taufiqual Islam, Laura Jane Ellett, Matteo Senesi, David Isaac Finkelstein, Blaine Roberts, Victoria A. Lawson, Paul Anthony Adlard, Steven John Collins

PLOS Pathogens: published April 10, 2019 | https://doi.org/10.1371/journal.ppat.1007712

Increased mucosal neutrophil survival is associated with altered microbiota in HIV infection

Tiffany Hensley-McBain, Michael C. Wu, Jennifer A. Manuzak, Ryan K. Cheu, Andrew Gustin, Connor B. Driscoll, Alexander S. Zevin, Charlene J. Miller, Ernesto Coronado, Elise Smith, Jean Chang, Michael Gale Jr., Ma Somsouk, Adam D. Burgener, Peter W. Hunt, Thomas J. Hope, Ann C. Collier, Nichole R. Klatt

PLOS Pathogens: published April 11, 2019 | https://doi.org/10.1371/journal.ppat.1007672

T-cell derived acetylcholine aids host defenses during enteric bacterial infection with Citrobacter rodentium

Valerie T. Ramirez, Dayn R. Godinez, Ingrid Brust-Mascher, Eric B. Nonnecke, Patricia A. Castillo, Mariana Barboza Gardner, Diane Tu, Jessica A. Sladek, Elaine N. Miller, Carlito B. Lebrilla, Charles L. Bevins, Melanie G. Gareau, Colin Reardon

PLOS Pathogens: published April 11, 2019 | https://doi.org/10.1371/journal.ppat.1007719

Cathelicidin is a “fire alarm”, generating protective NLRP3-dependent airway epithelial cell inflammatory responses during infection with Pseudomonas aeruginosa

Brian J. McHugh, Rongling Wang, Hsin-Ni Li, Paula E. Beaumont, Rebekah Kells, Holly Stevens, Lisa Young, Adriano G. Rossi, Robert D. Gray, Julia R. Dorin, Emily L. Gwyer Findlay, David Brough, Donald J. Davidson

PLOS Pathogens: published April 12, 2019 | https://doi.org/10.1371/journal.ppat.1007694

The potato cyst nematode effector RHA1B is a ubiquitin ligase and uses two distinct mechanisms to suppress plant immune signaling

Joanna Kud, Wenjie Wang, Rachel Gross, Youhong Fan, Li Huang, Yulin Yuan, Amanda Gray, Aida Duarte, Joseph C. Kuhl, Allan Caplan, Aska Goverse, Yongsheng Liu, Louise-Marie Dandurand, Fangming Xiao

PLOS Pathogens: published April 12, 2019 | https://doi.org/10.1371/journal.ppat.1007720

MyD88 and IL-1R signaling drive antibacterial immunity and osteoclast-driven bone loss during Staphylococcus aureus osteomyelitis

Nicole E. Putnam, Laura E. Fulbright, Jacob M. Curry, Caleb A. Ford, Jenna R. Petronglo, Andrew S. Hendrix, James E. Cassat

PLOS Pathogens: published April 12, 2019 | https://doi.org/10.1371/journal.ppat.1007744

RNA recombination at Chikungunya virus 3'UTR as an evolutionary mechanism that provides adaptability

Claudia V. Filomatori, Eugenia S. Bardossy, Fernando Merwaiss, Yasutsugu Suzuki, Annabelle Henrion, María Carla Saleh, Diego E. Alvarez

PLOS Pathogens: published April 15, 2019 | https://doi.org/10.1371/journal.ppat.1007706

A specific sequence in the genome of respiratory syncytial virus regulates the generation of copy-back defective viral genomes

Yan Sun, Eun Ji Kim, Sébastien A. Felt, Louis J. Taylor, Divyansh Agarwal, Gregory R. Grant, Carolina B. López

PLOS Pathogens: published April 17, 2019 | https://doi.org/10.1371/journal.ppat.1007707

NK cells negatively regulate CD8 T cells via natural cytotoxicity receptor (NCR) 1 during LCMV infection

Katharina Pallmer, Isabel Barnstorf, Nicolas S. Baumann, Mariana Borsa, Stipan Jonjic, Annette Oxenius

PLOS Pathogens: published April 17, 2019 | https://doi.org/10.1371/journal.ppat.1007725

TGFβ-activation by dendritic cells drives Th17 induction and intestinal contractility and augments the expulsion of the parasite Trichinella spiralis in mice

Nicola Steel, Aduragbemi A. Faniyi, Sayema Rahman, Stefanie Swietlik, Beata I. Czajkowska, Bethany T. Chan, Alexander Hardgrave, Anthony Steel, Tim D. Sparwasser, Mushref B. Assas, Richard K. Grencis, Mark A. Travis, John J. Worthington

PLOS Pathogens: published April 18, 2019 | https://doi.org/10.1371/journal.ppat.1007657

Two components of the rhpPC operon coordinately regulate the type III secretion system and bacterial fitness in Pseudomonas savastanoi pv. phaseolicola

Kun Li, Yanan Zhu, Wei Yan, Xin Deng, Yanmei Xiao, Liyang Song, Rongxiang Fang, Yantao Jia, Xiaoyan Tang

PLOS Pathogens: published April 18, 2019 | https://doi.org/10.1371/journal.ppat.1007673

Hepatitis B e antigen induces the expansion of monocytic myeloid-derived suppressor cells to dampen T-cell function in chronic hepatitis B virus infection

Feifei Yang, Xueping Yu, Chenliang Zhou, Richeng Mao, Mengqi Zhu, Haoxiang Zhu, Zhenxuan Ma, Bidisha Mitra, Gan Zhao, Yuxian Huang, Haitao Guo, Bin Wang, Jiming Zhang

PLOS Pathogens: published April 18, 2019 | https://doi.org/10.1371/journal.ppat.1007690

Distinct phenotype and function of circulating Vδ1⁺ and Vδ2⁺ γδT-cells in acute and chronic hepatitis B

Kyong-Mi Chang, Daniel Traum, Jang-June Park, Suzanne Ho, Keisuke Ojiro, David K. Wong, Abdus S. Wahed, Norah A. Terrault, Mandana Khalili, Richard K. Sterling, Harry L. A. Janssen, Margaret C. Shuhart, Daryl T. Lau, Lewis R. Roberts, Geoffrey S. Johnson, David E. Kaplan, Michael R. Betts, William M. Lee, Anna S. F. Lok, for the Hepatitis B Research Network (HBRN)

PLOS Pathogens: published April 18, 2019 | https://doi.org/10.1371/journal.ppat.1007715

Oxidized low-density lipoprotein (oxLDL) supports Mycobacterium tuberculosis survival in macrophages by inducing lysosomal dysfunction

Frank Vrieling, Louis Wilson, Patrick C. N. Rensen, Gerhard Walzl, Tom H. M. Ottenhoff, Simone A. Joosten

PLOS Pathogens: published April 18, 2019 | https://doi.org/10.1371/journal.ppat.1007724

βC1 protein encoded in geminivirus satellite concertedly targets MKK2 and MPK4 to counter host defense

Tao Hu, Changjun Huang, Yuting He, Claudia Castillo-González, Xiaojian Gui, Yaqin Wang, Xiuren Zhang, Xueping Zhou

PLOS Pathogens: published April 18, 2019 | https://doi.org/10.1371/journal.ppat.1007728

Signal peptide peptidase activity connects the unfolded protein response to plant defense suppression by Ustilago maydis

Niko Pinter, Christina Andrea Hach, Martin Hampel, Dmitrij Rekhter, Krzysztof Zienkiewicz, Ivo Feussner, Anja Poehlein, Rolf Daniel, Florian Finkernagel, Kai Heimel

PLOS Pathogens: published April 18, 2019 | https://doi.org/10.1371/journal.ppat.1007734

E6 proteins from high-risk HPV, low-risk HPV, and animal papillomaviruses activate the Wnt/β-catenin pathway through E6AP-dependent degradation of NHERF1

Camille M. Drews, Samuel Case, Scott B. Vande Pol

PLOS Pathogens: published April 19, 2019 | https://doi.org/10.1371/journal.ppat.1007575

Structure and mechanism of TagA, a novel membrane-associated glycosyltransferase that produces wall teichoic acids in pathogenic bacteria

Michele D. Kattke, Jason E. Gosschalk, Orlando E. Martinez, Garima Kumar, Robert T. Gale, Duilio Cascio, Michael R. Sawaya, Martin Philips, Eric D. Brown, Robert T. Clubb

PLOS Pathogens: published April 19, 2019 | https://doi.org/10.1371/journal.ppat.1007723

Niche-specific metabolic adaptation in biotrophic and necrotrophic oomycetes is manifested in differential use of nutrients, variation in gene content, and enzyme evolution

Audrey M. V. Ah-Fong, Meenakshi S. Kagda, Melania Abrahamian, Howard S. Judelson

PLOS Pathogens: published April 19, 2019 | https://doi.org/10.1371/journal.ppat.1007729

Dengue virus nonstructural protein 1 activates platelets via Toll-like receptor 4, leading to thrombocytopenia and hemorrhage

Chiao-Hsuan Chao, Wei-Chueh Wu, Yen-Chung Lai, Pei-Jane Tsai, Guey-Chuen Perng, Yee-Shin Lin, Trai-Ming Yeh

PLOS Pathogens: published April 22, 2019 | https://doi.org/10.1371/journal.ppat.1007625

Twin arginine translocation, ammonia incorporation, and polyamine biosynthesis are crucial for Proteus mirabilis fitness during bloodstream infection

Chelsie E. Armbruster, Valerie S. Forsyth, Alexandra O. Johnson, Sara N. Smith, Ashley N. White, Aimee L. Brauer, Brian S. Learman, Lili Zhao, Weisheng Wu, Mark T. Anderson, Michael A. Bachman, Harry L. T. Mobley

PLOS Pathogens: published April 22, 2019 | https://doi.org/10.1371/journal.ppat.1007653

Clumping factor B is an important virulence factor during Staphylococcus aureus skin infection and a promising vaccine target

Keenan A. Lacey, Michelle E. Mulcahy, Aisling M. Towell, Joan A. Geoghegan, Rachel M. McLoughlin

PLOS Pathogens: published April 22, 2019 | https://doi.org/10.1371/journal.ppat.1007713

Candida albicans induces mucosal bacterial dysbiosis that promotes invasive infection

Martinna Bertolini, Amit Ranjan, Angela Thompson, Patricia I. Diaz, Takanori Sobue, Kendra Maas, Anna Dongari-Bagtzoglou

PLOS Pathogens: published April 22, 2019 | https://doi.org/10.1371/journal.ppat.1007717

Detection of post-vaccination enhanced dengue virus infection in macaques: An improved model for early assessment of dengue vaccines

Maria Beatriz Borges, Renato Sergio Marchevsky, Renata Carvalho Pereira, Ygara da Silva Mendes, Luiz Gustavo Almeida Mendes, Leonardo Diniz-Mendes, Michael A. Cruz, Ouafaâ Tahmaoui, Sébastien Baudart, Marcos Freire, Akira Homma, Kirsten Schneider-Ohrum, David W. Vaughn, Yannick Vanloubbeeck, Clarisse Lorin, Marie-Pierre Malice, Elena Caride, Lucile Warter

PLOS Pathogens: published April 22, 2019 | https://doi.org/10.1371/journal.ppat.1007721

Proteomics of intracellular Salmonella enterica reveals roles of Salmonella pathogenicity island 2 in metabolism and antioxidant defense

Janina Noster, Tzu-Chiao Chao, Nathalie Sander, Marc Schulte, Tatjana Reuter, Nicole Hansmeier, Michael Hensel

PLOS Pathogens: published April 22, 2019 | https://doi.org/10.1371/journal.ppat.1007741

STAT2 dependent Type I Interferon response promotes dysbiosis and luminal expansion of the enteric pathogen Salmonella Typhimurium

R. Paul Wilson, Sarah A. Tursi, Glenn J. Rapsinski, Nicole J. Medeiros, Long S. Le, Kevin P. Kotredes, Sajan Patel, Elisabetta Liverani, Shuang Sun, Wenhan Zhu, Laurie Kilpatrick, Sebastian E. Winter, Ana M. Gamero, Çagla Tükel

PLOS Pathogens: published April 22, 2019 | https://doi.org/10.1371/journal.ppat.1007745

p62-mediated Selective autophagy endows virus-transformed cells with insusceptibility to DNA damage under oxidative stress

Ling Wang, Mary E. A. Howell, Ayrianna Sparks-Wallace, Caroline Hawkins, Camri A. Nicksic, Carissa Kohne, Kenton H. Hall, Jonathan P. Moorman, Zhi Q. Yao, Shunbin Ning

PLOS Pathogens: published April 24, 2019 | https://doi.org/10.1371/journal.ppat.1007541

Salmonella invasion is controlled through the secondary structure of the hilD transcript

Chien-Che Hung, Colleen R. Eade, Michael I. Betteken, Paulina D. Pavinski Bitar, Elaine M. Handley, Staci L. Nugent, Rimi Chowdhury, Craig Altier

PLOS Pathogens: published April 24, 2019 | https://doi.org/10.1371/journal.ppat.1007700

Unmasking cellular response of a bloom-forming alga to viral infection by resolving expression profiles at a single-cell level

Shilo Rosenwasser, Uri Sheyn, Miguel J. Frada, David Pilzer, Ron Rotkopf, Assaf Vardi

PLOS Pathogens: published April 24, 2019 | https://doi.org/10.1371/journal.ppat.1007708

Nlrp3 inflammasome activation and Gasdermin D-driven pyroptosis are immunopathogenic upon gastrointestinal norovirus infection

Hanne Dubois, Frederic Sorgeloos, Soroush T. Sarvestani, Liesbet Martens, Yvan Saeys, Jason M. Mackenzie, Mohamed Lamkanfi, Geert van Loo, Ian Goodfellow, Andy Wullaert

PLOS Pathogens: published April 24, 2019 | https://doi.org/10.1371/journal.ppat.1007709

Corrections

Correction: Colonization of the tsetse fly midgut with commensal Kosakonia cowanii Zambiae inhibits trypanosome infection establishment

Brian L. Weiss, Michele A. Maltz, Aurélien Vigneron, Yineng Wu, Katharine S. Walter, Michelle B. O’Neill, Jingwen Wang, Serap Aksoy

PLOS Pathogens: published April 8, 2019 | https://doi.org/10.1371/journal.ppat.1007688

Correction: Shugoshin 1 is dislocated by KSHV-encoded LANA inducing aneuploidy

Fengchao Lang, Zhiguo Sun, Yonggang Pei, Rajnish Kumar Singh, Hem Chandra Jha, Erle S. Robertson

PLOS Pathogens: published April 9, 2019 | https://doi.org/10.1371/journal.ppat.1007732

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"Non-canonical fungal G-protein coupled receptors promote Fusarium head blight on wheat"

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