Reining in the CD8+ T cell: Respiratory virus infection and PD-1-mediated T-cell impairment

Meredith C. Rogers, John V. Williams

PLOS Pathogens: published January 3, 2019 | https://doi.org/10.1371/journal.ppat.1007387

To B₁₂ or not to B₁₂: Five questions on the role of cobalamin in host-microbial interactions

Carol A. Rowley, Melissa M. Kendall

PLOS Pathogens: published January 3, 2019 | https://doi.org/10.1371/journal.ppat.1007479

Good to the last drop: The emergence of coffee ringspot virus

Michael Goodin, Antonia Dos Reis Figueira

PLOS Pathogens: published January 10, 2019 | https://doi.org/10.1371/journal.ppat.1007462

Is the unique camouflage strategy of Pneumocystis associated with its particular niche within host lungs?

Philippe M. Hauser

PLOS Pathogens: published January 24, 2019 | https://doi.org/10.1371/journal.ppat.1007480

Finding the needle in a haystack: Mapping antifungal drug resistance in fungal pathogen by genomic approaches

Dominique Sanglard

PLOS Pathogens: published January 31, 2019 | https://doi.org/10.1371/journal.ppat.1007478

Roles, function and relevance of LAG3 in HIV infection

Colin G. Graydon, Allison L. Balasko, Keith R. Fowke

PLOS Pathogens: published January 17, 2019 | https://doi.org/10.1371/journal.ppat.1007429

Unexpected lessons from the neglected: How defective viral genomes became important again

Carolina B. López

PLOS Pathogens: published January 10, 2019 | https://doi.org/10.1371/journal.ppat.1007450

IgA tetramerization improves target breadth but not peak potency of functionality of anti-influenza virus broadly neutralizing antibody

Shinji Saito, Kaori Sano, Tadaki Suzuki, Akira Ainai, Yuki Taga, Tomonori Ueno, Koshiro Tabata, Kumpei Saito, Yuji Wada, Yuki Ohara, Haruko Takeyama, Takato Odagiri, Tsutomu Kageyama, Kiyoko Ogawa-Goto, Pretty Multihartina, Vivi Setiawaty, Krisna Nur Andriana Pangesti, Hideki Hasegawa

PLOS Pathogens: published January 3, 2019 | https://doi.org/10.1371/journal.ppat.1007427

Thymic expression of IL-4 and IL-15 after systemic inflammatory or infectious Th1 disease processes induce the acquisition of "innate" characteristics during CD8⁺ T cell development

Natalia S. Baez, Fabio Cerbán, Constanza Savid-Frontera, Deborah L. Hodge, Jimena Tosello, Eva Acosta-Rodriguez, Laura Almada, Adriana Gruppi, Maria Estefania Viano, Howard A. Young, Maria Cecilia Rodriguez-Galan

PLOS Pathogens: published January 4, 2019 | https://doi.org/10.1371/journal.ppat.1007456

GPI-anchor signal sequence influences PrP^C sorting, shedding and signalling, and impacts on different pathomechanistic aspects of prion disease in mice

Berta Puig, Hermann C. Altmeppen, Luise Linsenmeier, Karima Chakroun, Florian Wegwitz, Ulrike K. Piontek, Jörg Tatzelt, Clive Bate, Tim Magnus, Markus Glatzel

PLOS Pathogens: published January 4, 2019 | https://doi.org/10.1371/journal.ppat.1007520

Urease is an essential component of the acid response network of Staphylococcus aureus and is required for a persistent murine kidney infection

Chunyi Zhou, Fatema Bhinderwala, McKenzie K. Lehman, Vinai C. Thomas, Sujata S. Chaudhari, Kelsey J. Yamada, Kirk W. Foster, Robert Powers, Tammy Kielian, Paul D. Fey

PLOS Pathogens: published January 4, 2019 | https://doi.org/10.1371/journal.ppat.1007538

The Vaccinia virion: Filling the gap between atomic and ultrastructure

Yeva Mirzakhanyan, Paul Gershon

PLOS Pathogens: published January 7, 2019 | https://doi.org/10.1371/journal.ppat.1007508

EBNA3C facilitates RASSF1A downregulation through ubiquitin-mediated degradation and promoter hypermethylation to drive B-cell proliferation

Shengwei Zhang, Yonggang Pei, Fengchao Lang, Kunfeng Sun, Rajnish Kumar Singh, Zachary L. Lamplugh, Abhik Saha, Erle S. Robertson

PLOS Pathogens: published January 7, 2019 | https://doi.org/10.1371/journal.ppat.1007514

Epstein-Barr virus microRNAs regulate B cell receptor signal transduction and lytic reactivation

Yan Chen, Devin Fachko, Nikita S. Ivanov, Camille M. Skinner, Rebecca L. Skalsky

PLOS Pathogens: published January 7, 2019 | https://doi.org/10.1371/journal.ppat.1007535

Human polyomavirus BKV infection of endothelial cells results in interferon pathway induction and persistence

Ping An, Maria Teresa Sáenz Robles, Alexis M. Duray, Paul G. Cantalupo, James M. Pipas

PLOS Pathogens: published January 8, 2019 | https://doi.org/10.1371/journal.ppat.1007505

Recruitment of Vps34 PI3K and enrichment of PI3P phosphoinositide in the viral replication compartment is crucial for replication of a positive-strand RNA virus

Zhike Feng, Kai Xu, Nikolay Kovalev, Peter D. Nagy

PLOS Pathogens: published January 9, 2019 | https://doi.org/10.1371/journal.ppat.1007530

Prophage induction, but not production of phage particles, is required for lethal disease in a microbiome-replete murine model of enterohemorrhagic E. coli infection

Sowmya Balasubramanian, Marcia S. Osburne, Haley BrinJones, Albert K. Tai, John M. Leong

PLOS Pathogens: published January 10, 2019 | https://doi.org/10.1371/journal.ppat.1007494

Probing the impact of nairovirus genomic diversity on viral ovarian tumor domain protease (vOTU) structure and deubiquitinase activity

John V. Dzimianski, Brianna S. Beldon, Courtney M. Daczkowski, Octavia Y. Goodwin, Florine E. M. Scholte, Éric Bergeron, Scott D. Pegan

PLOS Pathogens: published January 10, 2019 | https://doi.org/10.1371/journal.ppat.1007515

Immune-inducible non-coding RNA molecule lincRNA-IBIN connects immunity and metabolism in Drosophila melanogaster

Susanna Valanne, Tiina S. Salminen, Mirva Järvelä-Stölting, Laura Vesala, Mika Rämet

PLOS Pathogens: published January 11, 2019 | https://doi.org/10.1371/journal.ppat.1007504

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Exclusive dependence of IL-10Rα signalling on intestinal microbiota homeostasis and control of whipworm infection

María A. Duque-Correa, Natasha A. Karp, Catherine McCarthy, Simon Forman, David Goulding, Geetha Sankaranarayanan, Timothy P. Jenkins, Adam J. Reid, Emma L. Cambridge, Carmen Ballesteros Reviriego, The Sanger Mouse Genetics Project, The 3i consortium, Werner Müller, Cinzia Cantacessi, Gordon Dougan, Richard K. Grencis, Matthew Berriman

PLOS Pathogens: published January 14, 2019 | https://doi.org/10.1371/journal.ppat.1007265

Antagonistic paralogs control a switch between growth and pathogen resistance in C. elegans

Kirthi C. Reddy, Tal Dror, Ryan S. Underwood, Guled A. Osman, Corrina R. Elder, Christopher A. Desjardins, Christina A. Cuomo, Michalis Barkoulas, Emily R. Troemel

PLOS Pathogens: published January 14, 2019 | https://doi.org/10.1371/journal.ppat.1007528

Interferon-induced transmembrane protein 3 blocks fusion of sensitive but not resistant viruses by partitioning into virus-carrying endosomes

Krishna C. Suddala, Christine C. Lee, Paul Meraner, Mariana Marin, Ruben M. Markosyan, Tanay M. Desai, Fredric S. Cohen, Abraham L. Brass, Gregory B. Melikyan

PLOS Pathogens: published January 14, 2019 | https://doi.org/10.1371/journal.ppat.1007532

Reiterative Enrichment and Authentication of CRISPRi Targets (REACT) identifies the proteasome as a key contributor to HIV-1 latency

Zichong Li, Jun Wu, Leonard Chavez, Rebecca Hoh, Steven G. Deeks, Satish K. Pillai, Qiang Zhou

PLOS Pathogens: published January 15, 2019 | https://doi.org/10.1371/journal.ppat.1007498

Fibrillar structures induced by a plant reovirus target mitochondria to activate typical apoptotic response and promote viral infection in insect vectors

Qian Chen, Limin Zheng, Qianzhuo Mao, Jiejie Liu, Haitao Wang, Dongsheng Jia, Hongyan Chen, Wei Wu, Taiyun Wei

PLOS Pathogens: published January 17, 2019 | https://doi.org/10.1371/journal.ppat.1007510

Zika virus infection at mid-gestation results in fetal cerebral cortical injury and fetal death in the olive baboon

Sunam Gurung, Nicole Reuter, Alisha Preno, Jamie Dubaut, Hugh Nadeau, Kimberly Hyatt, Krista Singleton, Ashley Martin, W. Tony Parks, James F. Papin, Dean A. Myers

PLOS Pathogens: published January 18, 2019 | https://doi.org/10.1371/journal.ppat.1007507

Identification of a short, highly conserved, motif required for picornavirus capsid precursor processing at distal sites

Thea Kristensen, Graham J. Belsham

PLOS Pathogens: published January 18, 2019 | https://doi.org/10.1371/journal.ppat.1007509

Multiple roles of the non-structural protein 3 (nsP3) alphavirus unique domain (AUD) during Chikungunya virus genome replication and transcription

Yanni Gao, Niluka Goonawardane, Joseph Ward, Andrew Tuplin, Mark Harris

PLOS Pathogens: published January 22, 2019 | https://doi.org/10.1371/journal.ppat.1007239

Tomato yellow leaf curl virus intergenic siRNAs target a host long noncoding RNA to modulate disease symptoms

Yuwen Yang, Tingli Liu, Danyu Shen, Jinyan Wang, Xitie Ling, Zhongze Hu, Tianzi Chen, Jieli Hu, Junyu Huang, Wengui Yu, Daolong Dou, Ming-Bo Wang, Baolong Zhang

PLOS Pathogens: published January 22, 2019 | https://doi.org/10.1371/journal.ppat.1007534

Inhibition of the Staphylococcus aureus c-di-AMP cyclase DacA by direct interaction with the phosphoglucosamine mutase GlmM

Tommaso Tosi, Fumiya Hoshiga, Charlotte Millership, Rahul Singh, Charles Eldrid, Delphine Patin, Dominique Mengin-Lecreulx, Konstantinos Thalassinos, Paul Freemont, Angelika Gründling

PLOS Pathogens: published January 22, 2019 | https://doi.org/10.1371/journal.ppat.1007537

Seroprevalence, cross antigenicity and circulation sphere of bat-borne hantaviruses revealed by serological and antigenic analyses

Lin Xu, Jianmin Wu, Qi Li, Yamei Wei, Zhizhou Tan, Jianqiu Cai, Huancheng Guo, Ling’en Yang, Xiaohong Huang, Jing Chen, Fuqiang Zhang, Biao He, Changchun Tu

PLOS Pathogens: published January 22, 2019 | https://doi.org/10.1371/journal.ppat.1007545

Role of SpaO in the assembly of the sorting platform of a Salmonella type III secretion system

Maria Lara-Tejero, Zhuan Qin, Bo Hu, Carmen Butan, Jun Liu, Jorge E. Galán

PLOS Pathogens: published January 22, 2019 | https://doi.org/10.1371/journal.ppat.1007565

Whole-genome sequence of the bovine blood fluke Schistosoma bovis supports interspecific hybridization with S. haematobium

Harald Oey, Martha Zakrzewski, Kerstin Gravermann, Neil D. Young, Pasi K. Korhonen, Geoffrey N. Gobert, Sujeevi Nawaratna, Shihab Hasan, David M. Martínez, Hong You, Martin Lavin, Malcolm K. Jones, Mark A. Ragan, Jens Stoye, Ana Oleaga, Aidan M. Emery, Bonnie L. Webster, David Rollinson, Robin B. Gasser, Donald P. McManus, Lutz Krause

PLOS Pathogens: published January 23, 2019 | https://doi.org/10.1371/journal.ppat.1007513

Comprehensive profiling of translation initiation in influenza virus infected cells

Heather M. Machkovech, Jesse D. Bloom, Arvind R. Subramaniam

PLOS Pathogens: published January 23, 2019 | https://doi.org/10.1371/journal.ppat.1007518

CD4⁺ T cells promote humoral immunity and viral control during Zika virus infection

Annie Elong Ngono, Matthew P. Young, Maximilian Bunz, Zhigang Xu, Sararat Hattakam, Edward Vizcarra, Jose Angel Regla-Nava, William W. Tang, Montarop Yamabhai, Jinsheng Wen, Sujan Shresta

PLOS Pathogens: published January 24, 2019 | https://doi.org/10.1371/journal.ppat.1007474

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INDETERMINATE-DOMAIN 4 (IDD4) coordinates immune responses with plant-growth in Arabidopsis thaliana

Ronny Völz, Soon-Kap Kim, Jianing Mi, Anamika A. Rawat, Alaguraj Veluchamy, Kiruthiga G. Mariappan, Naganand Rayapuram, Jean-Michel Daviere, Patrick Achard, Ikram Blilou, Salim Al-Babili, Moussa Benhamed, Heribert Hirt

PLOS Pathogens: published January 24, 2019 | https://doi.org/10.1371/journal.ppat.1007499

The Human Cytomegalovirus U_L38 protein drives mTOR-independent metabolic flux reprogramming by inhibiting TSC2

Irene Rodríguez-Sánchez, Xenia L. Schafer, Morgan Monaghan, Joshua Munger

PLOS Pathogens: published January 24, 2019 | https://doi.org/10.1371/journal.ppat.1007569

LANA oligomeric architecture is essential for KSHV nuclear body formation and viral genome maintenance during latency

Alessandra De Leo, Zhong Deng, Olga Vladimirova, Horng-Shen Chen, Jayaraju Dheekollu, Abram Calderon, Kenneth A. Myers, James Hayden, Frederick Keeney, Benedikt B. Kaufer, Yan Yuan, Erle Robertson, Paul M. Lieberman

PLOS Pathogens: published January 25, 2019 | https://doi.org/10.1371/journal.ppat.1007489

Bclaf1 critically regulates the type I interferon response and is degraded by alphaherpesvirus US3

Chao Qin, Rui Zhang, Yue Lang, Anwen Shao, Aotian Xu, Wenhai Feng, Jun Han, Mengdong Wang, Wanwei He, Cuilian Yu, Jun Tang

PLOS Pathogens: published January 25, 2019 | https://doi.org/10.1371/journal.ppat.1007559

Influenza-induced immune suppression to methicillin-resistant Staphylococcus aureus is mediated by TLR9

Giovanny J. Martínez-Colón, Helen Warheit-Niemi, Stephen J. Gurczynski, Quincy M. Taylor, Carol A. Wilke, Amy B. Podsiad, Joel Crespo, Urvashi Bhan, Bethany B. Moore

PLOS Pathogens: published January 25, 2019 | https://doi.org/10.1371/journal.ppat.1007560

Merkel cell polyomavirus Tumor antigens expressed in Merkel cell carcinoma function independently of the ubiquitin ligases Fbw7 and β-TrCP

Kristine N. Dye, Markus Welcker, Bruce E. Clurman, Ann Roman, Denise A. Galloway

PLOS Pathogens: published January 28, 2019 | https://doi.org/10.1371/journal.ppat.1007543

GluClR-mediated inhibitory postsynaptic currents reveal targets for ivermectin and potential mechanisms of ivermectin resistance

Mohammed Atif, Jennifer J. Smith, Argel Estrada-Mondragon, Xue Xiao, Angela A. Salim, Robert J. Capon, Joseph W. Lynch, Angelo Keramidas

PLOS Pathogens: published January 29, 2019 | https://doi.org/10.1371/journal.ppat.1007570

Oncogenic KSHV-encoded interferon regulatory factor upregulates HMGB2 and CMPK1 expression to promote cell invasion by disrupting a complex lncRNA-OIP5-AS1/miR-218-5p network

Wan Li, Qingxia Wang, Qi Feng, Fei Wang, Qin Yan, Shou-Jiang Gao, Chun Lu

PLOS Pathogens: published January 30, 2019 | https://doi.org/10.1371/journal.ppat.1007578

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Plasmodium male gametocyte development and transmission are critically regulated by the two putative deadenylases of the CAF1/CCR4/NOT complex

Kevin J. Hart, Jenna Oberstaller, Michael P. Walker, Allen M. Minns, Mark F. Kennedy, Ian Padykula, John H. Adams, Scott E. Lindner

PLOS Pathogens: published January 31, 2019 | https://doi.org/10.1371/journal.ppat.1007164

Increased Programmed Death-Ligand 1 is an Early Epithelial Cell Response to Helicobacter pylori Infection

Loryn Holokai, Jayati Chakrabarti, Taylor Broda, Julie Chang, Jennifer A. Hawkins, Nambirajan Sundaram, Lydia E. Wroblewski, Richard M. Peek Jr., Jiang Wang, Michael Helmrath, James M. Wells, Yana Zavros

PLOS Pathogens: published January 31, 2019 | https://doi.org/10.1371/journal.ppat.1007468

Correction: Wolbachia and host germline components compete for kinesin-mediated transport to the posterior pole of the Drosophila oocyte

Shelbi L. Russell, Nassim Lemseffer, William T. Sullivan

PLOS Pathogens: published January 30, 2019 | https://doi.org/10.1371/journal.ppat.1007557

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Correction: Small-Molecule Inhibitors of Dengue-Virus Entry

Aaron G. Schmidt, Kyungae Lee, Priscilla L. Yang, Stephen C. Harrison

PLOS Pathogens: published January 31, 2019 | https://doi.org/10.1371/journal.ppat.1007553

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