HIV control: Is getting there the same as staying there?

Philip Goulder, Steven G. Deeks

PLOS Pathogens: published November 1, 2018 | https://doi.org/10.1371/journal.ppat.1007222

The calendar of epidemics: Seasonal cycles of infectious diseases

Micaela Elvira Martinez

PLOS Pathogens: published November 8, 2018 | https://doi.org/10.1371/journal.ppat.1007327

Infection of anopheline mosquitoes with Wolbachia: Implications for malaria control

Fabio M. Gomes, Carolina Barillas-Mury

PLOS Pathogens: published November 15, 2018 | https://doi.org/10.1371/journal.ppat.1007333

Mitochondrial protein import in trypanosomatids: Variations on a theme or fundamentally different?

André Schneider

PLOS Pathogens: published November 29, 2018 | https://doi.org/10.1371/journal.ppat.1007351

Evaluation of mechanisms that may generate DNA lesions triggering antigenic variation in African trypanosomes

Marcelo Santos da Silva, Galadriel A. Hovel-Miner, Emma M. Briggs, Maria Carolina Elias, Richard McCulloch

PLOS Pathogens: published November 15, 2018 | https://doi.org/10.1371/journal.ppat.1007321

A planarian nidovirus expands the limits of RNA genome size

Amir Saberi, Anastasia A. Gulyaeva, John L. Brubacher, Phillip A. Newmark, Alexander E. Gorbalenya

PLOS Pathogens: published November 1, 2018 | https://doi.org/10.1371/journal.ppat.1007314

Lymph nodes are sites of prolonged bacterial persistence during Mycobacterium tuberculosis infection in macaques

Sharie Keanne C. Ganchua, Anthony M. Cadena, Pauline Maiello, Hannah P. Gideon, Amy J. Myers, Beth F. Junecko, Edwin C. Klein, Philana Ling Lin, Joshua T. Mattila, JoAnne L. Flynn

PLOS Pathogens: published November 1, 2018 | https://doi.org/10.1371/journal.ppat.1007337

Niche adaptation and viral transmission of human papillomaviruses from archaic hominins to modern humans

Zigui Chen, Rob DeSalle, Mark Schiffman, Rolando Herrero, Charles E. Wood, Julio C. Ruiz, Gary M. Clifford, Paul K. S. Chan, Robert D. Burk

PLOS Pathogens: published November 1, 2018 | https://doi.org/10.1371/journal.ppat.1007352

Two herpesviral noncoding PAN RNAs are functionally homologous but do not associate with common chromatin loci

Johanna B. Withers, Eric S. Li, Tenaya K. Vallery, Therese A. Yario, Joan A. Steitz

PLOS Pathogens: published November 1, 2018 | https://doi.org/10.1371/journal.ppat.1007389

Glycerol supports growth of the Trypanosoma brucei bloodstream forms in the absence of glucose: Analysis of metabolic adaptations on glycerol-rich conditions

Erika Pineda, Magali Thonnus, Muriel Mazet, Arnaud Mourier, Edern Cahoreau, Hanna Kulyk, Jean-William Dupuy, Marc Biran, Cyril Masante, Stefan Allmann, Loïc Rivière, Brice Rotureau, Jean-Charles Portais, Frédéric Bringaud

PLOS Pathogens: published November 1, 2018 | https://doi.org/10.1371/journal.ppat.1007412

Unveiling the structural features that determine the dual methyltransferase activities of Streptococcus pneumoniae RlmCD

Yiyang Jiang, Hailong Yu, Fudong Li, Lin Cheng, Lingru Zhu, Yunyu Shi, Qingguo Gong

PLOS Pathogens: published November 2, 2018 | https://doi.org/10.1371/journal.ppat.1007379

The deubiquitinase CYLD is a specific checkpoint of the STING antiviral signaling pathway

Lele Zhang, Ning Wei, Ye Cui, Ze Hong, Xing Liu, Qiang Wang, Senlin Li, Heng Liu, Huansha Yu, Yanni Cai, Quanyi Wang, Juanjuan Zhu, Wei Meng, Zhengjun Chen, Chen Wang

PLOS Pathogens: published November 2, 2018 | https://doi.org/10.1371/journal.ppat.1007435

Mucosal immunoglobulins protect the olfactory organ of teleost fish against parasitic infection

Yong-Yao Yu, Weiguang Kong, Ya-Xing Yin, Fen Dong, Zhen-Yu Huang, Guang-Mei Yin, Shuai Dong, Irene Salinas, Yong-An Zhang, Zhen Xu

PLOS Pathogens: published November 5, 2018 | https://doi.org/10.1371/journal.ppat.1007251

Poly(ADP-ribose) polymerase 1 is necessary for coactivating hypoxia-inducible factor-1-dependent gene expression by Epstein-Barr virus latent membrane protein 1

Michael Hulse, Lisa B. Caruso, Jozef Madzo, Yinfei Tan, Sarah Johnson, Italo Tempera

PLOS Pathogens: published November 5, 2018 | https://doi.org/10.1371/journal.ppat.1007394

HEXIM1-Tat chimera inhibits HIV-1 replication

Marie Leoz, Petra Kukanja, Zeping Luo, Fang Huang, Daniele C. Cary, B. Matija Peterlin, Koh Fujinaga

PLOS Pathogens: published November 5, 2018 | https://doi.org/10.1371/journal.ppat.1007402

HIV-1 envelope glycan modifications that permit neutralization by germline-reverted VRC01-class broadly neutralizing antibodies

Celia C. LaBranche, Andrew T. McGuire, Matthew D. Gray, Shay Behrens, Tongqing Zhou, Quentin J. Sattentau, James Peacock, Amanda Eaton, Kelli Greene, Hongmei Gao, Haili Tang, Lautaro G. Perez, Kevin O. Saunders, John R. Mascola, Barton F. Haynes, Leonidas Stamatatos, David C. Montefiori

PLOS Pathogens: published November 5, 2018 | https://doi.org/10.1371/journal.ppat.1007431

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REM1.3's phospho-status defines its plasma membrane nanodomain organization and activity in restricting PVX cell-to-cell movement

Artemis Perraki, Julien Gronnier, Paul Gouguet, Marie Boudsocq, Anne-Flore Deroubaix, Vincent Simon, Sylvie German-Retana, Anthony Legrand, Birgit Habenstein, Cyril Zipfel, Emmanuelle Bayer, Sébastien Mongrand, Véronique Germain

PLOS Pathogens: published November 12, 2018 | https://doi.org/10.1371/journal.ppat.1007378

HIV-1 capsids from B27/B57⁺ elite controllers escape Mx2 but are targeted by TRIM5α, leading to the induction of an antiviral state

Natacha Merindol, Mohamed El-Far, Mohamed Sylla, Nasser Masroori, Caroline Dufour, Jia-xin Li, Pearl Cherry, Mélodie B. Plourde, Cécile Tremblay, Lionel Berthoux

PLOS Pathogens: published November 12, 2018 | https://doi.org/10.1371/journal.ppat.1007398

Highly competent, non-exhausted CD8+ T cells continue to tightly control pathogen load throughout chronic Trypanosoma cruzi infection

Angela D. Pack, Matthew H. Collins, Charles S. Rosenberg, Rick L. Tarleton

PLOS Pathogens: published November 12, 2018 | https://doi.org/10.1371/journal.ppat.1007410

Lassa virus activates myeloid dendritic cells but suppresses their ability to stimulate T cells

Justine Schaeffer, Xavier Carnec, Stéphanie Reynard, Mathieu Mateo, Caroline Picard, Natalia Pietrosemoli, Marie-Agnès Dillies, Sylvain Baize

PLOS Pathogens: published November 12, 2018 | https://doi.org/10.1371/journal.ppat.1007430

Delayed oseltamivir plus sirolimus treatment attenuates H1N1 virus-induced severe lung injury correlated with repressed NLRP3 inflammasome activation and inflammatory cell infiltration

Xuehong Jia, Bo Liu, Linlin Bao, Qi Lv, Fengdi Li, Hui Li, Yunqing An, Xulong Zhang, Bin Cao, Chen Wang

PLOS Pathogens: published November 13, 2018 | https://doi.org/10.1371/journal.ppat.1007428

Whole genome screen reveals a novel relationship between Wolbachia levels and Drosophila host translation

Yolande Grobler, Chi Y. Yun, David J. Kahler, Casey M. Bergman, Hangnoh Lee, Brian Oliver, Ruth Lehmann

PLOS Pathogens: published November 13, 2018 | https://doi.org/10.1371/journal.ppat.1007445

Adaptive plasticity in the gametocyte conversion rate of malaria parasites

Petra Schneider, Megan A. Greischar, Philip L. G. Birget, Charlotte Repton, Nicole Mideo, Sarah E. Reece

PLOS Pathogens: published November 14, 2018 | https://doi.org/10.1371/journal.ppat.1007371

Characterization of Haartman Institute snake virus-1 (HISV-1) and HISV-like viruses—The representatives of genus Hartmanivirus, family Arenaviridae

Jussi Hepojoki, Satu Hepojoki, Teemu Smura, Leonóra Szirovicza, Eva Dervas, Barbara Prähauser, Lisbeth Nufer, Elisabeth M. Schraner, Olli Vapalahti, Anja Kipar, Udo Hetzel

PLOS Pathogens: published November 14, 2018 | https://doi.org/10.1371/journal.ppat.1007415

Gut and blood differ in constitutive blocks to HIV transcription, suggesting tissue-specific differences in the mechanisms that govern HIV latency

Sushama Telwatte, Sulggi Lee, Ma Somsouk, Hiroyu Hatano, Christopher Baker, Philipp Kaiser, Peggy Kim, Tsui-Hua Chen, Jeffrey Milush, Peter W. Hunt, Steven G. Deeks, Joseph K. Wong, Steven A. Yukl

PLOS Pathogens: published November 15, 2018 | https://doi.org/10.1371/journal.ppat.1007357

An aromatic amino acid and associated helix in the C-terminus of the potato leafroll virus minor capsid protein regulate systemic infection and symptom expression

Yi Xu, Washington Luis Da Silva, Yajuan Qian, Stewart M. Gray

PLOS Pathogens: published November 15, 2018 | https://doi.org/10.1371/journal.ppat.1007451

Salmonella escapes adaptive immune response via SIRT2 mediated modulation of innate immune response in dendritic cells

Mayuri Gogoi, Kasturi Chandra, Mohsen Sarikhani, Ramya Ramani, Nagalingam Ravi Sundaresan, Dipshikha Chakravortty

PLOS Pathogens: published November 19, 2018 | https://doi.org/10.1371/journal.ppat.1007437

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Macrophage activation by IFN-γ triggers restriction of phagosomal copper from intracellular pathogens

Qian Shen, Matthew J. Beucler, Stephanie C. Ray, Chad A. Rappleye

PLOS Pathogens: published November 19, 2018 | https://doi.org/10.1371/journal.ppat.1007444

RNA virus evasion of nonsense-mediated decay

Jared P. May, Xuefeng Yuan, Erika Sawicki, Anne E. Simon

PLOS Pathogens: published November 19, 2018 | https://doi.org/10.1371/journal.ppat.1007459

Proteasome-associated HECT-type ubiquitin ligase activity is required for plant immunity

James J. Furniss, Heather Grey, Zhishuo Wang, Mika Nomoto, Lorna Jackson, Yasuomi Tada, Steven H. Spoel

PLOS Pathogens: published November 20, 2018 | https://doi.org/10.1371/journal.ppat.1007447

Neddylation contributes to CD4⁺ T cell-mediated protective immunity against blood-stage Plasmodium infection

Qianqian Cheng, Jian Liu, Yujun Pei, Yaolin Zhang, Dawang Zhou, Weiqing Pan, Jiyan Zhang

PLOS Pathogens: published November 21, 2018 | https://doi.org/10.1371/journal.ppat.1007440

Nuclear-cytoplasmic compartmentalization of the herpes simplex virus 1 infected cell transcriptome is co-ordinated by the viral endoribonuclease vhs and cofactors to facilitate the translation of late proteins

Kathleen Pheasant, Carla Sofia Möller-Levet, Juliet Jones, Daniel Depledge, Judith Breuer, Gillian Elliott

PLOS Pathogens: published November 26, 2018 | https://doi.org/10.1371/journal.ppat.1007331

The RNA helicase DDX3X is an essential mediator of innate antimicrobial immunity

Daniel Szappanos, Roland Tschismarov, Thomas Perlot, Sandra Westermayer, Katrin Fischer, Ekaterini Platanitis, Fabian Kallinger, Maria Novatchkova, Caroline Lassnig, Mathias Müller, Veronika Sexl, Keiryn L. Bennett, Michelle Foong-Sobis, Josef M. Penninger, Thomas Decker

PLOS Pathogens: published November 26, 2018 | https://doi.org/10.1371/journal.ppat.1007397

Global emergence and population dynamics of divergent serotype 3 CC180 pneumococci

Taj Azarian, Patrick K. Mitchell, Maria Georgieva, Claudette M. Thompson, Amel Ghouila, Andrew J. Pollard, Anne von Gottberg, Mignon du Plessis, Martin Antonio, Brenda A. Kwambana-Adams, Stuart C. Clarke, Dean Everett, Jennifer Cornick, Ewa Sadowy, Waleria Hryniewicz, Anna Skoczynska, Jennifer C. Moïsi, Lesley McGee, Bernard Beall, Benjamin J. Metcalf, Robert F. Breiman, PL Ho, Raymond Reid, Katherine L. O’Brien, Rebecca A. Gladstone, Stephen D. Bentley, William P. Hanage

PLOS Pathogens: published November 26, 2018 | https://doi.org/10.1371/journal.ppat.1007438

Differential induction of interferon stimulated genes between type I and type III interferons is independent of interferon receptor abundance

Kalliopi Pervolaraki, Soheil Rastgou Talemi, Dorothee Albrecht, Felix Bormann, Connor Bamford, Juan L. Mendoza, K. Christopher Garcia, John McLauchlan, Thomas Höfer, Megan L. Stanifer, Steeve Boulant

PLOS Pathogens: published November 28, 2018 | https://doi.org/10.1371/journal.ppat.1007420

Apolipoprotein E is an HIV-1-inducible inhibitor of viral production and infectivity in macrophages

Rokeya Siddiqui, Shinya Suzu, Mikinori Ueno, Hesham Nasser, Ryota Koba, Farzana Bhuyan, Osamu Noyori, Sofiane Hamidi, Guojun Sheng, Mariko Yasuda-Inoue, Takayuki Hishiki, Sayaka Sukegawa, Eri Miyagi, Klaus Strebel, Shuzo Matsushita, Kunitada Shimotohno, Yasuo Ariumi

PLOS Pathogens: published November 29, 2018 | https://doi.org/10.1371/journal.ppat.1007372

Multiple components of the nuclear pore complex interact with the amino-terminus of MX2 to facilitate HIV-1 restriction

Matthew D. J. Dicks, Gilberto Betancor, Jose M. Jimenez-Guardeño, Lucie Pessel-Vivares, Luis Apolonia, Caroline Goujon, Michael H. Malim

PLOS Pathogens: published November 29, 2018 | https://doi.org/10.1371/journal.ppat.1007408

Soil humic acids degrade CWD prions and reduce infectivity

Alsu Kuznetsova, Catherine Cullingham, Debbie McKenzie, Judd M. Aiken

PLOS Pathogens: published November 29, 2018 | https://doi.org/10.1371/journal.ppat.1007414

Inhibition of JNK signaling in the Asian malaria vector Anopheles stephensi extends mosquito longevity and improves resistance to Plasmodium falciparum infection

Lattha Souvannaseng, Lewis Vibul Hun, Heather Baker, John M. Klyver, Bo Wang, Nazzy Pakpour, Jordan M. Bridgewater, Eleonora Napoli, Cecilia Giulivi, Michael A. Riehle, Shirley Luckhart

PLOS Pathogens: published November 29, 2018 | https://doi.org/10.1371/journal.ppat.1007418

Prion pathogenesis is unaltered in a mouse strain with a permeable blood-brain barrier

Annika Keller, Mario Nuvolone, Irina Abakumova, Andra Chincisan, Regina Reimann, Merve Avar, Daniel Heinzer, Simone Hornemann, Josephin Wagner, Daniel Kirschenbaum, Fabian F. Voigt, Caihong Zhu, Luca Regli, Fritjof Helmchen, Adriano Aguzzi

PLOS Pathogens: published November 29, 2018 | https://doi.org/10.1371/journal.ppat.1007424

A forward genetic screen reveals a primary role for Plasmodium falciparum Reticulocyte Binding Protein Homologue 2a and 2b in determining alternative erythrocyte invasion pathways

Susana Campino, Alejandro Marin-Menendez, Alison Kemp, Nadia Cross, Laura Drought, Thomas D. Otto, Ernest Diez Benavente, Matt Ravenhall, Frank Schwach, Gareth Girling, Magnus Manske, Michel Theron, Kelda Gould, Eleanor Drury, Taane G. Clark, Dominic P. Kwiatkowski, Alena Pance, Julian C. Rayner

PLOS Pathogens: published November 29, 2018 | https://doi.org/10.1371/journal.ppat.1007436

Specificity and functional interplay between influenza virus PA-X and NS1 shutoff activity

Chutikarn Chaimayo, Megan Dunagan, Tsuyoshi Hayashi, Netty Santoso, Toru Takimoto

PLOS Pathogens: published November 29, 2018 | https://doi.org/10.1371/journal.ppat.1007465

Ym1 induces RELMα and rescues IL-4Rα deficiency in lung repair during nematode infection

Tara E. Sutherland, Dominik Rückerl, Nicola Logan, Sheelagh Duncan, Thomas A. Wynn, Judith E. Allen

PLOS Pathogens: published November 30, 2018 | https://doi.org/10.1371/journal.ppat.1007423

Defining cooperative roles for colonic microbiota and Muc2 mucin in mediating innate host defense against Entamoeba histolytica

Aralia Leon-Coria, Manish Kumar, France Moreau, Kris Chadee

PLOS Pathogens: published November 30, 2018 | https://doi.org/10.1371/journal.ppat.1007466

Correction: Hepatitis C virus NS4B induces the degradation of TRIF to inhibit TLR3-mediated interferon signaling pathway

Yisha Liang, Xuezhi Cao, Qiang Ding, Yanan Zhao, Zhenliang He, Jin Zhong

PLOS Pathogens: published November 16, 2018 | https://doi.org/10.1371/journal.ppat.1007455

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Correction: Syk Signaling in Dendritic Cells Orchestrates Innate Resistance to Systemic Fungal Infection

Paul G. Whitney, Eva Bär, Fabiola Osorio, Neil C. Rogers, Barbara U. Schraml, Safia Deddouche, Salomé LeibundGut-Landmann, Caetano Reis e Sousa

PLOS Pathogens: published November 21, 2018 | https://doi.org/10.1371/journal.ppat.1007366

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