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Table of Contents

October 2018

Cover

The cellular phenotype of cytoplasmic incompatibility in Culex pipiens in the light of cidB diversity
Issue Image

Development of embryos resulting from various Culex pipiens incompatible crosses was monitored to study CI cellular mechanism. Embryonic mortality due to Wolbachia-induced cytoplasmic incompatibility always resulted from defects of paternal chromatin segregation at the first nuclear division. However, these defects varied in terms of intensity putatively under the influence of cidB gene diversification. In the present image, embryos from infected father and uninfected mother did not display any visible development under microscope 48 hours post-oviposition resulting from an early arrest of embryogenesis. On the contrary, some embryos from incompatible infected parents exhibited further haploid development. See Figure 3 of Bonneau et al. Mathieu Sicard et al.

Image Credit: Bonneau M, et al.

Editorial

Horsepox: Framing a dual use research of concern debate

Carolyn B. Coyne

PLOS Pathogens: published October 4, 2018 | https://doi.org/10.1371/journal.ppat.1007344

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Opinions

Synthetic viruses—Anything new?

Volker Thiel

PLOS Pathogens: published October 4, 2018 | https://doi.org/10.1371/journal.ppat.1007019

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Synthetic horsepox viruses and the continuing debate about dual use research

Ryan S. Noyce, David H. Evans

PLOS Pathogens: published October 4, 2018 | https://doi.org/10.1371/journal.ppat.1007025

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Horsepox and the need for a new norm, more transparency, and stronger oversight for experiments that pose pandemic risks

Tom Inglesby

PLOS Pathogens: published October 4, 2018 | https://doi.org/10.1371/journal.ppat.1007129

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Inoculating science against potential pandemics and information hazards

Kevin M. Esvelt

PLOS Pathogens: published October 4, 2018 | https://doi.org/10.1371/journal.ppat.1007286

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Pearls

Toward the “unravelling” of HIV: Host cell factors involved in HIV-1 core uncoating

Daniel J. Rawle, David Harrich

PLOS Pathogens: published October 4, 2018 | https://doi.org/10.1371/journal.ppat.1007270

Detection of fungal and bacterial carbohydrates: Do the similar structures of chitin and peptidoglycan play a role in immune dysfunction?

Jonathan Dworkin

PLOS Pathogens: published October 11, 2018 | https://doi.org/10.1371/journal.ppat.1007271

Pathogen-based precision medicine for drug-resistant tuberculosis

Matthias I. Gröschel, Timothy M. Walker, Tjip S. van der Werf, Christoph Lange, Stefan Niemann, Matthias Merker

PLOS Pathogens: published October 18, 2018 | https://doi.org/10.1371/journal.ppat.1007297

"APP"reciating the complexity of HIV-induced neurodegenerative diseases

Mojgan H. Naghavi

PLOS Pathogens: published October 25, 2018 | https://doi.org/10.1371/journal.ppat.1007309

Bacteriophages shift the focus of the mammalian microbiota

Breck A. Duerkop

PLOS Pathogens: published October 25, 2018 | https://doi.org/10.1371/journal.ppat.1007310

Reviews

Secreted venom allergen-like proteins of helminths: Conserved modulators of host responses in animals and plants

Ruud H. P. Wilbers, Roger Schneiter, Martijn H. M. Holterman, Claire Drurey, Geert Smant, Oluwatoyin A. Asojo, Rick M. Maizels, Jose L. Lozano-Torres

PLOS Pathogens: published October 18, 2018 | https://doi.org/10.1371/journal.ppat.1007300

Fungal persister cells: The basis for recalcitrant infections?

Jurgen Wuyts, Patrick Van Dijck, Michelle Holtappels

PLOS Pathogens: published October 18, 2018 | https://doi.org/10.1371/journal.ppat.1007301

Research Articles

A bispecific immunotweezer prevents soluble PrP oligomers and abolishes prion toxicity

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PLOS Pathogens: published October 1, 2018 | https://doi.org/10.1371/journal.ppat.1007335

Klebsiella pneumoniae infection of murine neutrophils impairs their efferocytic clearance by modulating cell death machinery

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PLOS Pathogens: published October 1, 2018 | https://doi.org/10.1371/journal.ppat.1007338

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Weijian Ye, Marvin Chew, Jue Hou, Fritz Lai, Stije J. Leopold, Hooi Linn Loo, Aniruddha Ghose, Ashok K. Dutta, Qingfeng Chen, Eng Eong Ooi, Nicholas J. White, Arjen M. Dondorp, Peter Preiser, Jianzhu Chen

PLOS Pathogens: published October 4, 2018 | https://doi.org/10.1371/journal.ppat.1007298

Scavenger receptor-C acts as a receptor for Bacillus thuringiensis vegetative insecticidal protein Vip3Aa and mediates the internalization of Vip3Aa via endocytosis

Kun Jiang, Xiao-yue Hou, Tong-tong Tan, Zhang-lei Cao, Si-qi Mei, Bing Yan, Jin Chang, Lu Han, Dan Zhao, Jun Cai

PLOS Pathogens: published October 4, 2018 | https://doi.org/10.1371/journal.ppat.1007347

Potent neutralizing antibodies in humans infected with zoonotic simian foamy viruses target conserved epitopes located in the dimorphic domain of the surface envelope protein

Caroline Lambert, Mathilde Couteaudier, Julie Gouzil, Léa Richard, Thomas Montange, Edouard Betsem, Réjane Rua, Joelle Tobaly-Tapiero, Dirk Lindemann, Richard Njouom, Augustin Mouinga-Ondémé, Antoine Gessain, Florence Buseyne

PLOS Pathogens: published October 8, 2018 | https://doi.org/10.1371/journal.ppat.1007293

IFN-γ immune priming of macrophages in vivo induces prolonged STAT1 binding and protection against Cryptococcus neoformans

Chrissy M. Leopold Wager, Camaron R. Hole, Althea Campuzano, Natalia Castro-Lopez, Hong Cai, Marley C. Caballero Van Dyke, Karen L. Wozniak, Yufeng Wang, Floyd L. Wormley Jr.

PLOS Pathogens: published October 10, 2018 | https://doi.org/10.1371/journal.ppat.1007358

Escherichia coli mediated resistance of Entamoeba histolytica to oxidative stress is triggered by oxaloacetate

Yana Shaulov, Chikako Shimokawa, Meirav Trebicz-Geffen, Shruti Nagaraja, Karen Methling, Michael Lalk, Lea Weiss-Cerem, Ayelet T. Lamm, Hajime Hisaeda, Serge Ankri

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A polymorphic residue that attenuates the antiviral potential of interferon lambda 4 in hominid lineages

Connor G. G. Bamford, Elihu Aranday-Cortes, Ines Cordeiro Filipe, Swathi Sukumar, Daniel Mair, Ana da Silva Filipe, Juan L. Mendoza, K. Christopher Garcia, Shaohua Fan, Sarah A. Tishkoff, John McLauchlan

PLOS Pathogens: published October 11, 2018 | https://doi.org/10.1371/journal.ppat.1007307

Function of BriC peptide in the pneumococcal competence and virulence portfolio

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PLOS Pathogens: published October 11, 2018 | https://doi.org/10.1371/journal.ppat.1007328

CD8+ lymphocyte control of SIV infection during antiretroviral therapy

Youfang Cao, Emily K. Cartwright, Guido Silvestri, Alan S. Perelson

PLOS Pathogens: published October 11, 2018 | https://doi.org/10.1371/journal.ppat.1007350

Concurrent infection with Mycobacterium tuberculosis confers robust protection against secondary infection in macaques

Anthony M. Cadena, Forrest F. Hopkins, Pauline Maiello, Allison F. Carey, Eileen A. Wong, Constance J. Martin, Hannah P. Gideon, Robert M. DiFazio, Peter Andersen, Philana Ling Lin, Sarah M. Fortune, JoAnne L. Flynn

PLOS Pathogens: published October 12, 2018 | https://doi.org/10.1371/journal.ppat.1007305

SETD2-dependent H3K36me3 plays a critical role in epigenetic regulation of the HPV31 life cycle

Dipendra Gautam, Bryan A. Johnson, Michelle Mac, Cary A. Moody

PLOS Pathogens: published October 12, 2018 | https://doi.org/10.1371/journal.ppat.1007367

SNX8 modulates innate immune response to DNA virus by mediating trafficking and activation of MITA

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Streptococcal Lancefield polysaccharides are critical cell wall determinants for human Group IIA secreted phospholipase A2 to exert its bactericidal effects

Vincent P. van Hensbergen, Elin Movert, Vincent de Maat, Christian Lüchtenborg, Yoann Le Breton, Gérard Lambeau, Christine Payré, Anna Henningham, Victor Nizet, Jos A. G. van Strijp, Britta Brügger, Fredric Carlsson, Kevin S. McIver, Nina M. van Sorge

PLOS Pathogens: published October 15, 2018 | https://doi.org/10.1371/journal.ppat.1007348

The cellular phenotype of cytoplasmic incompatibility in Culex pipiens in the light of cidB diversity

Manon Bonneau, Frédéric Landmann, Pierrick Labbé, Fabienne Justy, Mylène Weill, Mathieu Sicard

PLOS Pathogens: published October 15, 2018 | https://doi.org/10.1371/journal.ppat.1007364

Microevolution in response to transient heme-iron restriction enhances intracellular bacterial community development and persistence

Rachael L. Hardison, Alistair Harrison, Rachel M. Wallace, Derek R. Heimlich, Meghan E. O’Bryan, Robert P. Sebra, Heather W. Pinkett, Sheryl S. Justice, Kevin M. Mason

PLOS Pathogens: published October 17, 2018 | https://doi.org/10.1371/journal.ppat.1007355

Adult plant resistance in maize to northern leaf spot is a feature of partial loss-of-function alleles of Hm1

Sandeep R. Marla, Kevin Chu, Satya Chintamanani, Dilbag S. Multani, Antje Klempien, Alyssa DeLeon, Kim Bong-suk, Larry D. Dunkle, Brian P. Dilkes, Gurmukh S. Johal

PLOS Pathogens: published October 17, 2018 | https://doi.org/10.1371/journal.ppat.1007356

Independent amplification of co-infected long incubation period low conversion efficiency prion strains

Thomas E. Eckland, Ronald A. Shikiya, Jason C. Bartz

PLOS Pathogens: published October 18, 2018 | https://doi.org/10.1371/journal.ppat.1007323

An unusually high substitution rate in transplant-associated BK polyomavirus in vivo is further concentrated in HLA-C-bound viral peptides

Pilar Domingo-Calap, Benjamin Schubert, Mélanie Joly, Morgane Solis, Meiggie Untrau, Raphael Carapito, Philippe Georgel, Sophie Caillard, Samira Fafi-Kremer, Nicodème Paul, Oliver Kohlbacher, Fernando González-Candelas, Seiamak Bahram

PLOS Pathogens: published October 18, 2018 | https://doi.org/10.1371/journal.ppat.1007368

Changes in temperature alter the potential outcomes of virus host shifts

Katherine E. Roberts, Jarrod D. Hadfield, Manmohan D. Sharma, Ben Longdon

PLOS Pathogens: published October 19, 2018 | https://doi.org/10.1371/journal.ppat.1007185

Nucleolin mediates the internalization of rabbit hemorrhagic disease virus through clathrin-dependent endocytosis

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PLOS Pathogens: published October 19, 2018 | https://doi.org/10.1371/journal.ppat.1007383

Branched late-steps of the cytosolic iron-sulphur cluster assembly machinery of Trypanosoma brucei

Maiko Luis Tonini, Priscila Peña-Diaz, Alexander C. Haindrich, Somsuvro Basu, Eva Kriegová, Antonio J. Pierik, Roland Lill, Stuart A. MacNeill, Terry K. Smith, Julius Lukeš

PLOS Pathogens: published October 22, 2018 | https://doi.org/10.1371/journal.ppat.1007326

Structure-guided disruption of the pseudopilus tip complex inhibits the Type II secretion in Pseudomonas aeruginosa

Yichen Zhang, Frédérick Faucher, Wenwen Zhang, Shu Wang, Nolan Neville, Keith Poole, Jun Zheng, Zongchao Jia

PLOS Pathogens: published October 22, 2018 | https://doi.org/10.1371/journal.ppat.1007343

CD11c-expressing Ly6C+CCR2+ monocytes constitute a reservoir for efficient Leishmania proliferation and cell-to-cell transmission

Sandrina Heyde, Lars Philipsen, Pauline Formaglio, Yan Fu, Iris Baars, Guido Höbbel, Corinna L. Kleinholz, Elena A. Seiß, Juliane Stettin, Patricia Gintschel, Anne Dudeck, Philippe Bousso, Burkhart Schraven, Andreas J. Müller

PLOS Pathogens: published October 22, 2018 | https://doi.org/10.1371/journal.ppat.1007374

Transcription apparatus of the yeast virus-like elements: Architecture, function, and evolutionary origin

Michal Sýkora, Martin Pospíšek, Josef Novák, Silvia Mrvová, Libor Krásný, Václav Vopálenský

PLOS Pathogens: published October 22, 2018 | https://doi.org/10.1371/journal.ppat.1007377

C-terminal processing of GlyGly-CTERM containing proteins by rhombosortase in Vibrio cholerae

Shilpa Gadwal, Tanya L. Johnson, Henriette Remmer, Maria Sandkvist

PLOS Pathogens: published October 23, 2018 | https://doi.org/10.1371/journal.ppat.1007341

Mononuclear cell dynamics in M. tuberculosis infection provide opportunities for therapeutic intervention

Brian A. Norris, Joel D. Ernst

PLOS Pathogens: published October 26, 2018 | https://doi.org/10.1371/journal.ppat.1007154

Integrin but not CEACAM receptors are dispensable for Helicobacter pylori CagA translocation

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PLOS Pathogens: published October 26, 2018 | https://doi.org/10.1371/journal.ppat.1007359

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Correction

Correction: Treatment with native heterodimeric IL-15 increases cytotoxic lymphocytes and reduces SHIV RNA in lymph nodes

Dionysios C. Watson, Eirini Moysi, Antonio Valentin, Cristina Bergamaschi, Santhi Devasundaram, Sotirios P. Fortis, Jenifer Bear, Elena Chertova, Julian Bess Jr., Ray Sowder, David J. Venzon, Claire Deleage, Jacob D. Estes, Jeffrey D. Lifson, Constantinos Petrovas, Barbara K. Felber, George N. Pavlakis

PLOS Pathogens: published October 11, 2018 | https://doi.org/10.1371/journal.ppat.1007345

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