Confocal image of systemically infected zebrafish larva with the espH mutant at 4 days post infection. The mCherry-expressing bacteria show extensive outgrowth in or near the blood vessels (green) and in the absence of L-plastin-labelled phagocytic cells (cyan). Bitter et al.
Image Credit: Lisanne M. van Leeuwen
Pearls
The devil is in the details: Genomics of transmissible cancers in Tasmanian devils
PLOS Pathogens: published August 2, 2018 | https://doi.org/10.1371/journal.ppat.1007098
Bat pathogens hit the road: But which one?
PLOS Pathogens: published August 9, 2018 | https://doi.org/10.1371/journal.ppat.1007134
cGAS and STING: At the intersection of DNA and RNA virus-sensing networks
PLOS Pathogens: published August 16, 2018 | https://doi.org/10.1371/journal.ppat.1007148
Five pillars of centromeric chromatin in fungal pathogens
PLOS Pathogens: published August 23, 2018 | https://doi.org/10.1371/journal.ppat.1007150
Research Matters
From chemistry to fruit flies: An unpredictable series of fortunate conversations
PLOS Pathogens: published August 9, 2018 | https://doi.org/10.1371/journal.ppat.1007077
Research Articles
S‐acylation mediates Mungbean yellow mosaic virus AC4 localization to the plasma membrane and in turns gene silencing suppression
PLOS Pathogens: published August 1, 2018 | https://doi.org/10.1371/journal.ppat.1007207
Alcohol enhances type 1 interferon-α production and mortality in young mice infected with Mycobacterium tuberculosis
PLOS Pathogens: published August 2, 2018 | https://doi.org/10.1371/journal.ppat.1007174
The Sec1/Munc18 (SM) protein Vps45 is involved in iron uptake, mitochondrial function and virulence in the pathogenic fungus Cryptococcus neoformans
PLOS Pathogens: published August 2, 2018 | https://doi.org/10.1371/journal.ppat.1007220
Macrophages inhibit Aspergillus fumigatus germination and neutrophil-mediated fungal killing
PLOS Pathogens: published August 2, 2018 | https://doi.org/10.1371/journal.ppat.1007229
A VP1 mutation acquired during an enterovirus 71 disseminated infection confers heparan sulfate binding ability and modulates ex vivo tropism
PLOS Pathogens: published August 3, 2018 | https://doi.org/10.1371/journal.ppat.1007190
Inhibition of murine herpesvirus-68 replication by IFN-gamma in macrophages is counteracted by the induction of SOCS1 expression
PLOS Pathogens: published August 3, 2018 | https://doi.org/10.1371/journal.ppat.1007202
RNA decay is an antiviral defense in plants that is counteracted by viral RNA silencing suppressors
PLOS Pathogens: published August 3, 2018 | https://doi.org/10.1371/journal.ppat.1007228
Interferon-beta expression and type I interferon receptor signaling of hepatocytes prevent hepatic necrosis and virus dissemination in Coxsackievirus B3-infected mice
PLOS Pathogens: published August 3, 2018 | https://doi.org/10.1371/journal.ppat.1007235
Reconstruction of the cell entry pathway of an extinct virus
PLOS Pathogens: published August 6, 2018 | https://doi.org/10.1371/journal.ppat.1007123
Cellular N-myristoyltransferases play a crucial picornavirus genus-specific role in viral assembly, virion maturation, and infectivity
PLOS Pathogens: published August 6, 2018 | https://doi.org/10.1371/journal.ppat.1007203
The Epstein Barr virus circRNAome
PLOS Pathogens: published August 6, 2018 | https://doi.org/10.1371/journal.ppat.1007206
A fully-virulent retargeted oncolytic HSV armed with IL-12 elicits local immunity and vaccine therapy towards distant tumors
PLOS Pathogens: published August 6, 2018 | https://doi.org/10.1371/journal.ppat.1007209
Type I IFNs drive hematopoietic stem and progenitor cell collapse via impaired proliferation and increased RIPK1-dependent cell death during shock-like ehrlichial infection
PLOS Pathogens: published August 6, 2018 | https://doi.org/10.1371/journal.ppat.1007234
Human papillomavirus type 16 antagonizes IRF6 regulation of IL-1β
PLOS Pathogens: published August 8, 2018 | https://doi.org/10.1371/journal.ppat.1007158
Clostridium difficile exosporium cysteine-rich proteins are essential for the morphogenesis of the exosporium layer, spore resistance, and affect C. difficile pathogenesis
PLOS Pathogens: published August 8, 2018 | https://doi.org/10.1371/journal.ppat.1007199
Prion acute synaptotoxicity is largely driven by protease-resistant PrPSc species
PLOS Pathogens: published August 8, 2018 | https://doi.org/10.1371/journal.ppat.1007214
The crystal structure of KSHV ORF57 reveals dimeric active sites important for protein stability and function
PLOS Pathogens: published August 10, 2018 | https://doi.org/10.1371/journal.ppat.1007232
Kinetic analysis of the influenza A virus HA/NA balance reveals contribution of NA to virus-receptor binding and NA-dependent rolling on receptor-containing surfaces
PLOS Pathogens: published August 13, 2018 | https://doi.org/10.1371/journal.ppat.1007233
Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cell receptor ACE2
PLOS Pathogens: published August 13, 2018 | https://doi.org/10.1371/journal.ppat.1007236
Macrophage-derived LTB4 promotes abscess formation and clearance of Staphylococcus aureus skin infection in mice
PLOS Pathogens: published August 13, 2018 | https://doi.org/10.1371/journal.ppat.1007244
EspH is a hypervirulence factor for Mycobacterium marinum and essential for the secretion of the ESX-1 substrates EspE and EspF
PLOS Pathogens: published August 13, 2018 | https://doi.org/10.1371/journal.ppat.1007247
Salmonella Typhimurium effector SseI inhibits chemotaxis and increases host cell survival by deamidation of heterotrimeric Gi proteins
PLOS Pathogens: published August 13, 2018 | https://doi.org/10.1371/journal.ppat.1007248
Wolbachia and host germline components compete for kinesin-mediated transport to the posterior pole of the Drosophila oocyte
PLOS Pathogens: published August 15, 2018 | https://doi.org/10.1371/journal.ppat.1007216
Related Articles
Immobility in the sedentary plant-parasitic nematode H. glycines is associated with remodeling of neuromuscular tissue
PLOS Pathogens: published August 16, 2018 | https://doi.org/10.1371/journal.ppat.1007198
Molecular basis for CesT recognition of type III secretion effectors in enteropathogenic Escherichia coli
PLOS Pathogens: published August 17, 2018 | https://doi.org/10.1371/journal.ppat.1007224
Stearoly-CoA desaturase 1 differentiates early and advanced dengue virus infections and determines virus particle infectivity
PLOS Pathogens: published August 17, 2018 | https://doi.org/10.1371/journal.ppat.1007261
Humoral immune response to adenovirus induce tolerogenic bystander dendritic cells that promote generation of regulatory T cells
PLOS Pathogens: published August 20, 2018 | https://doi.org/10.1371/journal.ppat.1007127
The C. difficile clnRAB operon initiates adaptations to the host environment in response to LL-37
PLOS Pathogens: published August 20, 2018 | https://doi.org/10.1371/journal.ppat.1007153
An EBNA3C-deleted Epstein-Barr virus (EBV) mutant causes B-cell lymphomas with delayed onset in a cord blood-humanized mouse model
PLOS Pathogens: published August 20, 2018 | https://doi.org/10.1371/journal.ppat.1007221
Diverse pathways of escape from all well-characterized VRC01-class broadly neutralizing HIV-1 antibodies
PLOS Pathogens: published August 20, 2018 | https://doi.org/10.1371/journal.ppat.1007238
A pathogen-derived effector modulates host glucose metabolism by arginine GlcNAcylation of HIF-1α protein
PLOS Pathogens: published August 20, 2018 | https://doi.org/10.1371/journal.ppat.1007259
SIVcol Nef counteracts SERINC5 by promoting its proteasomal degradation but does not efficiently enhance HIV-1 replication in human CD4+ T cells and lymphoid tissue
PLOS Pathogens: published August 20, 2018 | https://doi.org/10.1371/journal.ppat.1007269
A seven-helix protein constitutes stress granules crucial for regulating translation during human-to-mosquito transmission of Plasmodium falciparum
PLOS Pathogens: published August 22, 2018 | https://doi.org/10.1371/journal.ppat.1007249
NLRC3 negatively regulates CD4+ T cells and impacts protective immunity during Mycobacterium tuberculosis infection
PLOS Pathogens: published August 22, 2018 | https://doi.org/10.1371/journal.ppat.1007266
Asymmetric antiviral effects of ebolavirus antibodies targeting glycoprotein stem and glycan cap
PLOS Pathogens: published August 23, 2018 | https://doi.org/10.1371/journal.ppat.1007204
Pulmonary influenza A virus infection leads to suppression of the innate immune response to dermal injury
PLOS Pathogens: published August 23, 2018 | https://doi.org/10.1371/journal.ppat.1007212
Dysregulated hemolysin liberates bacterial outer membrane vesicles for cytosolic lipopolysaccharide sensing
PLOS Pathogens: published August 23, 2018 | https://doi.org/10.1371/journal.ppat.1007240
Active-site mTOR inhibitors augment HSV1-dICP0 infection in cancer cells via dysregulated eIF4E/4E-BP axis
PLOS Pathogens: published August 23, 2018 | https://doi.org/10.1371/journal.ppat.1007264
Type I IFN signaling blockade by a PASylated antagonist during chronic SIV infection suppresses specific inflammatory pathways but does not alter T cell activation or virus replication
PLOS Pathogens: published August 24, 2018 | https://doi.org/10.1371/journal.ppat.1007246
Protective antigenic sites in respiratory syncytial virus G attachment protein outside the central conserved and cysteine noose domains
PLOS Pathogens: published August 24, 2018 | https://doi.org/10.1371/journal.ppat.1007262
Exploitation of nuclear functions by human rhinovirus, a cytoplasmic RNA virus
PLOS Pathogens: published August 24, 2018 | https://doi.org/10.1371/journal.ppat.1007277
Interferon-stimulated TRIM69 interrupts dengue virus replication by ubiquitinating viral nonstructural protein 3
PLOS Pathogens: published August 24, 2018 | https://doi.org/10.1371/journal.ppat.1007287
Structure of the Cladosporium fulvum Avr4 effector in complex with (GlcNAc)6 reveals the ligand-binding mechanism and uncouples its intrinsic function from recognition by the Cf-4 resistance protein
PLOS Pathogens: published August 27, 2018 | https://doi.org/10.1371/journal.ppat.1007263
Phospholipid synthesis fueled by lipid droplets drives the structural development of poliovirus replication organelles
PLOS Pathogens: published August 27, 2018 | https://doi.org/10.1371/journal.ppat.1007280
Control of primary mouse cytomegalovirus infection in lung nodular inflammatory foci by cooperation of interferon-gamma expressing CD4 and CD8 T cells
PLOS Pathogens: published August 28, 2018 | https://doi.org/10.1371/journal.ppat.1007252
Trichuris muris whey acidic protein induces type 2 protective immunity against whipworm
PLOS Pathogens: published August 28, 2018 | https://doi.org/10.1371/journal.ppat.1007273
Select gp120 V2 domain specific antibodies derived from HIV and SIV infection and vaccination inhibit gp120 binding to α4β7
PLOS Pathogens: published August 28, 2018 | https://doi.org/10.1371/journal.ppat.1007278
Corrections
Correction: Correction: AIG1 affects in vitro and in vivo virulence in clinical isolates of Entamoeba histolytica
PLOS Pathogens: published August 17, 2018 | https://doi.org/10.1371/journal.ppat.1007258
Related Articles
Correction: The replication initiator protein of a geminivirus interacts with host monoubiquitination machinery and stimulates transcription of the viral genome
PLOS Pathogens: published August 29, 2018 | https://doi.org/10.1371/journal.ppat.1007281