Pearls collections: What we can learn about infectious disease and cancer

Laura J. Knoll, Deborah A. Hogan, John M. Leong, Joseph Heitman, Richard C. Condit

PLOS Pathogens: published March 29, 2018 | https://doi.org/10.1371/journal.ppat.1006915

PLOS Pathogens 2017 Reviewer and Editorial Board Thank You

PLOS Pathogens: published March 15, 2018 | https://doi.org/10.1371/journal.ppat.1006958

Single-sex schistosome infections of definitive hosts: Implications for epidemiology and disease control in a changing world

Da-Bing Lu, Yao Deng, Huan Ding, You-Sheng Liang, Joanne P. Webster

PLOS Pathogens: published March 1, 2018 | https://doi.org/10.1371/journal.ppat.1006817

Hostile intruder: Toxoplasma holds host organelles captive

Isabelle Coppens, Julia D. Romano

PLOS Pathogens: published March 29, 2018 | https://doi.org/10.1371/journal.ppat.1006893

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Macrodomain ADP-ribosylhydrolase and the pathogenesis of infectious diseases

Anthony K. L. Leung, Robert Lyle McPherson, Diane E. Griffin

PLOS Pathogens: published March 22, 2018 | https://doi.org/10.1371/journal.ppat.1006864

Mitogen-activated protein kinase signaling in plant pathogenic fungi

Cong Jiang, Xue Zhang, Huiquan Liu, Jin-Rong Xu

PLOS Pathogens: published March 15, 2018 | https://doi.org/10.1371/journal.ppat.1006875

Does the common sexually transmitted parasite Trichomonas vaginalis have sex?

Martina Bradic, Jane M. Carlton

PLOS Pathogens: published March 8, 2018 | https://doi.org/10.1371/journal.ppat.1006831

Wicked: The untold story of ciprofloxacin

Zachary C. Conley, Truston J. Bodine, Andrew Chou, Lynn Zechiedrich

PLOS Pathogens: published March 1, 2018 | https://doi.org/10.1371/journal.ppat.1006805

Viral manipulation of STAT3: Evade, exploit, and injure

Armando Andres Roca Suarez, Nicolaas Van Renne, Thomas F. Baumert, Joachim Lupberger

PLOS Pathogens: published March 15, 2018 | https://doi.org/10.1371/journal.ppat.1006839

The quest for good explanations

Benhur Lee

PLOS Pathogens: published March 8, 2018 | https://doi.org/10.1371/journal.ppat.1006818

The bacterial type III-secreted protein AvrRps4 is a bipartite effector

Morgan K. Halane, Sang Hee Kim, Benjamin J. Spears, Christopher M. Garner, Conner J. Rogan, Elizabeth C. Okafor, Jianbin Su, Saikat Bhattacharjee, Walter Gassmann

PLOS Pathogens: published March 30, 2018 | https://doi.org/10.1371/journal.ppat.1006984

Outer membrane vesicles from Neisseria gonorrhoeae target PorB to mitochondria and induce apoptosis

Pankaj Deo, Seong H. Chow, Iain D. Hay, Oded Kleifeld, Adam Costin, Kirstin D. Elgass, Jhih-Hang Jiang, Georg Ramm, Kipros Gabriel, Gordon Dougan, Trevor Lithgow, Eva Heinz, Thomas Naderer

PLOS Pathogens: published March 30, 2018 | https://doi.org/10.1371/journal.ppat.1006945

Molecularly barcoded Zika virus libraries to probe in vivo evolutionary dynamics

Matthew T. Aliota, Dawn M. Dudley, Christina M. Newman, James Weger-Lucarelli, Laurel M. Stewart, Michelle R. Koenig, Meghan E. Breitbach, Andrea M. Weiler, Matthew R. Semler, Gabrielle L. Barry, Katie R. Zarbock, Amelia K. Haj, Ryan V. Moriarty, Mariel S. Mohns, Emma L. Mohr, Vanessa Venturi, Nancy Schultz-Darken, Eric Peterson, Wendy Newton, Michele L. Schotzko, Heather A. Simmons, Andres Mejia, Jennifer M. Hayes, Saverio Capuano III, Miles P. Davenport, Thomas C. Friedrich, Gregory D. Ebel, Shelby L. O’Connor, David H. O’Connor

PLOS Pathogens: published March 28, 2018 | https://doi.org/10.1371/journal.ppat.1006964

Streptococcal M protein promotes IL-10 production by cGAS-independent activation of the STING signaling pathway

Elin Movert, Julia Lienard, Christine Valfridsson, Therése Nordström, Bengt Johansson-Lindbom, Fredric Carlsson

PLOS Pathogens: published March 26, 2018 | https://doi.org/10.1371/journal.ppat.1006969

HSV-1-induced disruption of transcription termination resembles a cellular stress response but selectively increases chromatin accessibility downstream of genes

Thomas Hennig, Marco Michalski, Andrzej J. Rutkowski, Lara Djakovic, Adam W. Whisnant, Marie-Sophie Friedl, Bhaskar Anand Jha, Marisa A. P. Baptista, Anne L’Hernault, Florian Erhard, Lars Dölken, Caroline C. Friedel

PLOS Pathogens: published March 26, 2018 | https://doi.org/10.1371/journal.ppat.1006954

miR-126-5p by direct targeting of JNK-interacting protein-2 (JIP-2) plays a key role in Theileria-infected macrophage virulence

Malak Haidar, Zineb Rchiad, Hifzur Rahman Ansari, Fathia Ben-Rached, Shahin Tajeri, Perle Latre De Late, Gordon Langsley, Arnab Pain

PLOS Pathogens: published March 23, 2018 | https://doi.org/10.1371/journal.ppat.1006942

PDZ domain-binding motif of Tax sustains T-cell proliferation in HTLV-1-infected humanized mice

Eléonore Pérès, Juliana Blin, Emiliano P. Ricci, Maria Artesi, Vincent Hahaut, Anne Van den Broeke, Antoine Corbin, Louis Gazzolo, Lee Ratner, Pierre Jalinot, Madeleine Duc Dodon

PLOS Pathogens: published March 22, 2018 | https://doi.org/10.1371/journal.ppat.1006933

A novel blood-feeding detoxification pathway in Nippostrongylus brasiliensis L3 reveals a potential checkpoint for arresting hookworm development

Tiffany Bouchery, Kara Filbey, Amy Shepherd, Jodie Chandler, Deepa Patel, Alfonso Schmidt, Mali Camberis, Adeline Peignier, Adam A. T. Smith, Karen Johnston, Gavin Painter, Mark Pearson, Paul Giacomin, Alex Loukas, Maria-Elena Bottazzi, Peter Hotez, Graham LeGros

PLOS Pathogens: published March 22, 2018 | https://doi.org/10.1371/journal.ppat.1006931

Down-regulation of microRNA-203-3p initiates type 2 pathology during schistosome infection via elevation of interleukin-33

Xing He, Jun Xie, Yange Wang, Xiaobin Fan, Qin Su, Yue Sun, Nanhang Lei, Dongmei Zhang, Guangping Gao, Weiqing Pan

PLOS Pathogens: published March 19, 2018 | https://doi.org/10.1371/journal.ppat.1006957

Deletion of transketolase triggers a stringent metabolic response in promastigotes and loss of virulence in amastigotes of Leishmania mexicana

Julie Kovářová, Andrew W. Pountain, David Wildridge, Stefan Weidt, Frédéric Bringaud, Richard J. S. Burchmore, Fiona Achcar, Michael P. Barrett

PLOS Pathogens: published March 19, 2018 | https://doi.org/10.1371/journal.ppat.1006953

Nuclear RNA surveillance complexes silence HIV-1 transcription

Xavier Contreras, Kader Salifou, Gabriel Sanchez, Marion Helsmoortel, Emmanuelle Beyne, Lisa Bluy, Stéphane Pelletier, Emilie Rousset, Sylvie Rouquier, Rosemary Kiernan

PLOS Pathogens: published March 19, 2018 | https://doi.org/10.1371/journal.ppat.1006950

Evolution of echovirus 11 in a chronically infected immunodeficient patient

Majid Laassri, Tatiana Zagorodnyaya, Sharon Hassin-Baer, Rachel Handsher, Danit Sofer, Merav Weil, Konstantinos Karagiannis, Vahan Simonyan, Konstantin Chumakov, Lester Shulman

PLOS Pathogens: published March 19, 2018 | https://doi.org/10.1371/journal.ppat.1006943

Genetic requirements for Staphylococcus aureus nitric oxide resistance and virulence

Melinda R. Grosser, Elyse Paluscio, Lance R. Thurlow, Marcus M. Dillon, Vaughn S. Cooper, Thomas H. Kawula, Anthony R. Richardson

PLOS Pathogens: published March 19, 2018 | https://doi.org/10.1371/journal.ppat.1006907

AIG1 affects in vitro and in vivo virulence in clinical isolates of Entamoeba histolytica

Kumiko Nakada-Tsukui, Tsuyoshi Sekizuka, Emi Sato-Ebine, Aleyla Escueta-de Cadiz, Dar-der Ji, Kentaro Tomii, Makoto Kuroda, Tomoyoshi Nozaki

PLOS Pathogens: published March 19, 2018 | https://doi.org/10.1371/journal.ppat.1006882

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1. AIG1 affects in vitro and in vivo virulence in clinical isolates of Entamoeba histolytica
2. Correction: Correction: AIG1 affects in vitro and in vivo virulence in clinical isolates of Entamoeba histolytica

Interleukin-4 activated macrophages mediate immunity to filarial helminth infection by sustaining CCR3-dependent eosinophilia

Joseph D. Turner, Nicolas Pionnier, Julio Furlong-Silva, Hanna Sjoberg, Stephen Cross, Alice Halliday, Ana F. Guimaraes, Darren A. N. Cook, Andrew Steven, Nico Van Rooijen, Judith E. Allen, Stephen J. Jenkins, Mark J. Taylor

PLOS Pathogens: published March 16, 2018 | https://doi.org/10.1371/journal.ppat.1006949

The root-knot nematode effector MiPFN3 disrupts plant actin filaments and promotes parasitism

Natthanon Leelarasamee, Lei Zhang, Cynthia Gleason

PLOS Pathogens: published March 15, 2018 | https://doi.org/10.1371/journal.ppat.1006947

SpdC, a novel virulence factor, controls histidine kinase activity in Staphylococcus aureus

Olivier Poupel, Caroline Proux, Bernd Jagla, Tarek Msadek, Sarah Dubrac

PLOS Pathogens: published March 15, 2018 | https://doi.org/10.1371/journal.ppat.1006917

Chlamydia trachomatis inclusion membrane protein MrcA interacts with the inositol 1,4,5-trisphosphate receptor type 3 (ITPR3) to regulate extrusion formation

Phu Hai Nguyen, Erika I. Lutter, Ted Hackstadt

PLOS Pathogens: published March 15, 2018 | https://doi.org/10.1371/journal.ppat.1006911

Oxidative stress and protein damage responses mediate artemisinin resistance in malaria parasites

Frances Rocamora, Lei Zhu, Kek Yee Liong, Arjen Dondorp, Olivo Miotto, Sachel Mok, Zbynek Bozdech

PLOS Pathogens: published March 14, 2018 | https://doi.org/10.1371/journal.ppat.1006930

Infection with hepatitis C virus depends on TACSTD2, a regulator of claudin-1 and occludin highly downregulated in hepatocellular carcinoma

Vandana Sekhar, Teresa Pollicino, Giacomo Diaz, Ronald E. Engle, Farah Alayli, Marta Melis, Juraj Kabat, Ashley Tice, Anna Pomerenke, Nihal Altan-Bonnet, Fausto Zamboni, Paolo Lusso, Suzanne U. Emerson, Patrizia Farci

PLOS Pathogens: published March 14, 2018 | https://doi.org/10.1371/journal.ppat.1006916

Pleiotropic roles of Clostridium difficile sin locus

Brintha Parasumanna Girinathan, Junjun Ou, Bruno Dupuy, Revathi Govind

PLOS Pathogens: published March 12, 2018 | https://doi.org/10.1371/journal.ppat.1006940

Minimal SPI1-T3SS effector requirement for Salmonella enterocyte invasion and intracellular proliferation in vivo

Kaiyi Zhang, Ambre Riba, Monika Nietschke, Natalia Torow, Urska Repnik, Andreas Pütz, Marcus Fulde, Aline Dupont, Michael Hensel, Mathias Hornef

PLOS Pathogens: published March 9, 2018 | https://doi.org/10.1371/journal.ppat.1006925

Lung macrophage scavenger receptor SR-A6 (MARCO) is an adenovirus type-specific virus entry receptor

Nicole Stichling, Maarit Suomalainen, Justin W. Flatt, Markus Schmid, Martin Pacesa, Silvio Hemmi, Wolfgang Jungraithmayr, Mareike D. Maler, Marina A. Freudenberg, Andreas Plückthun, Tobias May, Mario Köster, György Fejer, Urs F. Greber

PLOS Pathogens: published March 9, 2018 | https://doi.org/10.1371/journal.ppat.1006914

Inclusion bodies of human parainfluenza virus type 3 inhibit antiviral stress granule formation by shielding viral RNAs

Zhulong Hu, Yuang Wang, Qiaopeng Tang, Xiaodan Yang, Yali Qin, Mingzhou Chen

PLOS Pathogens: published March 8, 2018 | https://doi.org/10.1371/journal.ppat.1006948

Species-specific vulnerability of RanBP2 shaped the evolution of SIV as it transmitted in African apes

Nicholas R. Meyerson, Cody J. Warren, Daniel A. S. A. Vieira, Felipe Diaz-Griferro, Sara L. Sawyer

PLOS Pathogens: published March 8, 2018 | https://doi.org/10.1371/journal.ppat.1006906

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CRISPR/Cas9 -mediated gene knockout of Anopheles gambiae FREP1 suppresses malaria parasite infection

Yuemei Dong, Maria L. Simões, Eric Marois, George Dimopoulos

PLOS Pathogens: published March 8, 2018 | https://doi.org/10.1371/journal.ppat.1006898

COP1, a negative regulator of photomorphogenesis, positively regulates plant disease resistance via double-stranded RNA binding proteins

Gah-Hyun Lim, Timothy Hoey, Shifeng Zhu, Marion Clavel, Keshun Yu, Duroy Navarre, Aardra Kachroo, Jean-Marc Deragon, Pradeep Kachroo

PLOS Pathogens: published March 7, 2018 | https://doi.org/10.1371/journal.ppat.1006894

Structural basis for recognition of the central conserved region of RSV G by neutralizing human antibodies

Harrison G. Jones, Tina Ritschel, Gabriel Pascual, Just P. J. Brakenhoff, Elissa Keogh, Polina Furmanova-Hollenstein, Ellen Lanckacker, Jehangir S. Wadia, Morgan S. A. Gilman, R. Anthony Williamson, Dirk Roymans, Angélique B. van ‘t Wout, Johannes P. Langedijk, Jason S. McLellan

PLOS Pathogens: published March 6, 2018 | https://doi.org/10.1371/journal.ppat.1006935

TnSeq of Mycobacterium tuberculosis clinical isolates reveals strain-specific antibiotic liabilities

Allison F. Carey, Jeremy M. Rock, Inna V. Krieger, Michael R. Chase, Marta Fernandez-Suarez, Sebastien Gagneux, James C. Sacchettini, Thomas R. Ioerger, Sarah M. Fortune

PLOS Pathogens: published March 5, 2018 | https://doi.org/10.1371/journal.ppat.1006939

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A protein coevolution method uncovers critical features of the Hepatitis C Virus fusion mechanism

Florian Douam, Floriane Fusil, Margot Enguehard, Linda Dib, Francesca Nadalin, Loïc Schwaller, Gabriela Hrebikova, Jimmy Mancip, Laurent Mailly, Roland Montserret, Qiang Ding, Carine Maisse, Emilie Carlot, Ke Xu, Els Verhoeyen, Thomas F. Baumert, Alexander Ploss, Alessandra Carbone, François-Loïc Cosset, Dimitri Lavillette

PLOS Pathogens: published March 5, 2018 | https://doi.org/10.1371/journal.ppat.1006908

Potential of conventional & bispecific broadly neutralizing antibodies for prevention of HIV-1 subtype A, C & D infections

Kshitij Wagh, Michael S. Seaman, Marshall Zingg, Tomas Fitzsimons, Dan H. Barouch, Dennis R. Burton, Mark Connors, David D. Ho, John R. Mascola, Michel C. Nussenzweig, Jeffrey Ravetch, Rajeev Gautam, Malcolm A. Martin, David C. Montefiori, Bette Korber

PLOS Pathogens: published March 5, 2018 | https://doi.org/10.1371/journal.ppat.1006860

A20 upregulation during treated HIV disease is associated with intestinal epithelial cell recovery and function

Avantika S. Chitre, Michael G. Kattah, Yenny Y. Rosli, Montha Pao, Monika Deswal, Steven G. Deeks, Peter W. Hunt, Mohamed Abdel-Mohsen, Luis J. Montaner, Charles C. Kim, Averil Ma, Ma Somsouk, Joseph M. McCune

PLOS Pathogens: published March 5, 2018 | https://doi.org/10.1371/journal.ppat.1006806

The interferon-stimulated gene product oligoadenylate synthetase-like protein enhances replication of Kaposi’s sarcoma-associated herpesvirus (KSHV) and interacts with the KSHV ORF20 protein

Kendra A. Bussey, Ulrike Lau, Sophie Schumann, Antonio Gallo, Lisa Osbelt, Markus Stempel, Christine Arnold, Josef Wissing, Hans Henrik Gad, Rune Hartmann, Wolfram Brune, Lothar Jänsch, Adrian Whitehouse, Melanie M. Brinkmann

PLOS Pathogens: published March 2, 2018 | https://doi.org/10.1371/journal.ppat.1006937

Nubbin isoform antagonism governs Drosophila intestinal immune homeostasis

Bo G. Lindberg, Xiongzhuo Tang, Widad Dantoft, Priya Gohel, Shiva Seyedoleslami Esfahani, Jessica M. Lindvall, Ylva Engström

PLOS Pathogens: published March 2, 2018 | https://doi.org/10.1371/journal.ppat.1006936

Wolbachia-mediated virus blocking in mosquito cells is dependent on XRN1-mediated viral RNA degradation and influenced by viral replication rate

Saijo Thomas, Jiyoti Verma, Megan Woolfit, Scott L. O’Neill

PLOS Pathogens: published March 1, 2018 | https://doi.org/10.1371/journal.ppat.1006879

A new cell culture model to genetically dissect the complete human papillomavirus life cycle

Malgorzata Bienkowska-Haba, Wioleta Luszczek, Julia E. Myers, Timothy R. Keiffer, Stephen DiGiuseppe, Paula Polk, Jason M. Bodily, Rona S. Scott, Martin Sapp

PLOS Pathogens: published March 1, 2018 | https://doi.org/10.1371/journal.ppat.1006846