December 2016

Respiratory epithelial A549 cells inoculated with respiratory syncytial virus (RSV) for 24 hours are stained for RSV F protein (green) and cellular F-actin (red); nuclei have been counterstained with DAPI (blue). This image shows the cell on the left is infected and has extensive RSV-induced filopodia that contact the uninfected cell on the right. Filamentous RSV particles can be seen on the infected cell surface and at filopodia tips. Mehedi et al.

Image Credit: Sundar Ganesan, Margery Smelkinson, and Juraj Kabat, Biological Imaging Section, National Institute of Allergy and Infectious Diseases (NIAID) and Masfique Mehedi, Laboratory of Infectious Diseases, NIAID, National Institutes of Health, Bethesda, MD.

Opinion

Gene Editing Approaches against Viral Infections and Strategy to Prevent Occurrence of Viral Escape

Martyn K. White, Wenhui Hu, Kamel Khalili

PLOS Pathogens: published December 8, 2016 | https://doi.org/10.1371/journal.ppat.1005953

Pearls

Protein ADP-Ribosylation Takes Control in Plant–Bacterium Interactions

Baomin Feng, Chenglong Liu, Libo Shan, Ping He

PLOS Pathogens: published December 1, 2016 | https://doi.org/10.1371/journal.ppat.1005941

Evolutionary Paradigms from Ancient and Ongoing Conflicts between the Lentiviral Vif Protein and Mammalian APOBEC3 Enzymes

Reuben S. Harris, Brett D. Anderson

PLOS Pathogens: published December 1, 2016 | https://doi.org/10.1371/journal.ppat.1005958

Exploitation of the Host Cell Membrane Fusion Machinery by Leishmania Is Part of the Infection Process

Christine Matte, Albert Descoteaux

PLOS Pathogens: published December 8, 2016 | https://doi.org/10.1371/journal.ppat.1005962

Molecular Parasitic Plant–Host Interactions

Simon B. Saucet, Ken Shirasu

PLOS Pathogens: published December 15, 2016 | https://doi.org/10.1371/journal.ppat.1005978

Aspartyl Proteinases of Eukaryotic Microbial Pathogens: From Eating to Heating

Antonio Cassone, Anna Vecchiarelli, Bernhard Hube

PLOS Pathogens: published December 22, 2016 | https://doi.org/10.1371/journal.ppat.1005992

The Impact of the Gut Microbiota on Humoral Immunity to Pathogens and Vaccination in Early Infancy

Quang N. Nguyen, Jonathon E. Himes, David R. Martinez, Sallie R. Permar

PLOS Pathogens: published December 22, 2016 | https://doi.org/10.1371/journal.ppat.1005997

Convergence of Staphylococcus aureus Persister and Biofilm Research: Can Biofilms Be Defined as Communities of Adherent Persister Cells?

Elaine M. Waters, Sarah E. Rowe, James P. O'Gara, Brian P. Conlon

PLOS Pathogens: published December 29, 2016 | https://doi.org/10.1371/journal.ppat.1006012

Reviews

Interaction between Salmonella and Schistosomiasis: A Review

Amber Hsiao, Trevor Toy, Hye Jin Seo, Florian Marks

PLOS Pathogens: published December 1, 2016 | https://doi.org/10.1371/journal.ppat.1005928

IL-1β/IL-6/CRP and IL-18/ferritin: Distinct Inflammatory Programs in Infections

Jeroen Slaats, Jaap ten Oever, Frank L. van de Veerdonk, Mihai G. Netea

PLOS Pathogens: published December 15, 2016 | https://doi.org/10.1371/journal.ppat.1005973

PIWIs Go Viral: Arbovirus-Derived piRNAs in Vector Mosquitoes

Pascal Miesen, Joep Joosten, Ronald P. van Rij

PLOS Pathogens: published December 29, 2016 | https://doi.org/10.1371/journal.ppat.1006017

Research Articles

Vaccinia Virus Protein C6 Inhibits Type I IFN Signalling in the Nucleus and Binds to the Transactivation Domain of STAT2

Jennifer H. Stuart, Rebecca P. Sumner, Yongxu Lu, Joseph S. Snowden, Geoffrey L. Smith

PLOS Pathogens: published December 1, 2016 | https://doi.org/10.1371/journal.ppat.1005955

Pheromone Recognition and Selectivity by ComR Proteins among Streptococcus Species

Erin Shanker, Donald A. Morrison, Antoine Talagas, Sylvie Nessler, Michael J. Federle, Gerd Prehna

PLOS Pathogens: published December 1, 2016 | https://doi.org/10.1371/journal.ppat.1005979

Structural Insights into Streptococcal Competence Regulation by the Cell-to-Cell Communication System ComRS

Antoine Talagas, Laetitia Fontaine, Laura Ledesma-Garca, Johann Mignolet, Inès Li de la Sierra-Gallay, Noureddine Lazar, Magali Aumont-Nicaise, Michael J. Federle, Gerd Prehna, Pascal Hols, Sylvie Nessler

PLOS Pathogens: published December 1, 2016 | https://doi.org/10.1371/journal.ppat.1005980

Activation of Innate and Adaptive Immunity by a Recombinant Human Cytomegalovirus Strain Expressing an NKG2D Ligand

Adriana Tomić, Pavankumar R. Varanasi, Mijo Golemac, Suzana Malić, Peggy Riese, Eva M. Borst, Eva Mischak-Weissinger, Carlos A. Guzmán, Astrid Krmpotić, Stipan Jonjić, Martin Messerle

PLOS Pathogens: published December 1, 2016 | https://doi.org/10.1371/journal.ppat.1006015

Characterization in Helicobacter pylori of a Nickel Transporter Essential for Colonization That Was Acquired during Evolution by Gastric Helicobacter Species

Frédéric Fischer, Marie Robbe-Saule, Evelyne Turlin, Francesco Mancuso, Valérie Michel, Pierre Richaud, Frédéric J. Veyrier, Hilde De Reuse, Daniel Vinella

PLOS Pathogens: published December 6, 2016 | https://doi.org/10.1371/journal.ppat.1006018

CD8⁺ T Cells Induce Fatal Brainstem Pathology during Cerebral Malaria via Luminal Antigen-Specific Engagement of Brain Vasculature

Phillip A. Swanson II, Geoffrey T. Hart, Matthew V. Russo, Debasis Nayak, Takele Yazew, Mirna Peña, Shahid M. Khan, Chris J. Janse, Susan K. Pierce, Dorian B. McGavern

PLOS Pathogens: published December 1, 2016 | https://doi.org/10.1371/journal.ppat.1006022

The Ebola Interferon Inhibiting Domains Attenuate and Dysregulate Cell-Mediated Immune Responses

Ndongala Michel Lubaki, Patrick Younan, Rodrigo I. Santos, Michelle Meyer, Mathieu Iampietro, Richard A. Koup, Alexander Bukreyev

PLOS Pathogens: published December 8, 2016 | https://doi.org/10.1371/journal.ppat.1006031

The Influence of Programmed Cell Death in Myeloid Cells on Host Resilience to Infection with Legionella pneumophila or Streptococcus pyogenes

Pia Gamradt, Yun Xu, Nina Gratz, Kellyanne Duncan, Lester Kobzik, Sandra Högler, Pavel Kovarik, Thomas Decker, Amanda M. Jamieson

PLOS Pathogens: published December 14, 2016 | https://doi.org/10.1371/journal.ppat.1006032

The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation

Dmitry Ratner, M. Pontus A. Orning, Megan K. Proulx, Donghai Wang, Mikhail A. Gavrilin, Mark D. Wewers, Emad S. Alnemri, Peter F. Johnson, Bettina Lee, Joan Mecsas, Nobuhiko Kayagaki, Jon D. Goguen, Egil Lien

PLOS Pathogens: published December 2, 2016 | https://doi.org/10.1371/journal.ppat.1006035

An Interactome-Centered Protein Discovery Approach Reveals Novel Components Involved in Mitosome Function and Homeostasis in Giardia lamblia

Samuel Rout, Jon Paulin Zumthor, Elisabeth M. Schraner, Carmen Faso, Adrian B. Hehl

PLOS Pathogens: published December 7, 2016 | https://doi.org/10.1371/journal.ppat.1006036

C-type Lectin Mincle Recognizes Glucosyl-diacylglycerol of Streptococcus pneumoniae and Plays a Protective Role in Pneumococcal Pneumonia

Friederike Behler-Janbeck, Tomotsugu Takano, Regina Maus, Jennifer Stolper, Danny Jonigk, Meritxell Tort Tarrés, Thomas Fuehner, Antje Prasse, Tobias Welte, Mattie S. M. Timmer, Bridget L. Stocker, Yoichi Nakanishi, Tomofumi Miyamoto, Sho Yamasaki, Ulrich A. Maus

PLOS Pathogens: published December 6, 2016 | https://doi.org/10.1371/journal.ppat.1006038

The CXCL12/CXCR4 Signaling Pathway: A New Susceptibility Factor in Human Papillomavirus Pathogenesis

Floriane Meuris, Laetitia Carthagena, Agnieszka Jaracz-Ros, Françoise Gaudin, Pasquale Cutolo, Claire Deback, Yuezhen Xue, Françoise Thierry, John Doorbar, Françoise Bachelerie

PLOS Pathogens: published December 5, 2016 | https://doi.org/10.1371/journal.ppat.1006039

Large-Scale Phylogenomic Analysis Reveals the Complex Evolutionary History of Rabies Virus in Multiple Carnivore Hosts

Cécile Troupin, Laurent Dacheux, Marion Tanguy, Claude Sabeta, Hervé Blanc, Christiane Bouchier, Marco Vignuzzi, Sebastián Duchene, Edward C. Holmes, Hervé Bourhy

PLOS Pathogens: published December 15, 2016 | https://doi.org/10.1371/journal.ppat.1006041

Trehalose-6-Phosphate-Mediated Toxicity Determines Essentiality of OtsB2 in Mycobacterium tuberculosis In Vitro and in Mice

Jan Korte, Marina Alber, Carolina M. Trujillo, Karl Syson, Hendrik Koliwer-Brandl, René Deenen, Karl Köhrer, Michael A. DeJesus, Travis Hartman, William R. Jacobs Jr., Stephen Bornemann, Thomas R. Ioerger, Sabine Ehrt, Rainer Kalscheuer

PLOS Pathogens: published December 9, 2016 | https://doi.org/10.1371/journal.ppat.1006043

Enhanced in planta Fitness through Adaptive Mutations in EfpR, a Dual Regulator of Virulence and Metabolic Functions in the Plant Pathogen Ralstonia solanacearum

Anthony Perrier, Rémi Peyraud, David Rengel, Xavier Barlet, Emmanuel Lucasson, Jérôme Gouzy, Nemo Peeters, Stéphane Genin, Alice Guidot

PLOS Pathogens: published December 2, 2016 | https://doi.org/10.1371/journal.ppat.1006044

A Single Subcutaneous Injection of Cellulose Ethers Administered Long before Infection Confers Sustained Protection against Prion Diseases in Rodents

Kenta Teruya, Ayumi Oguma, Keiko Nishizawa, Maki Kawata, Yuji Sakasegawa, Hiroshi Kamitakahara, Katsumi Doh-ura

PLOS Pathogens: published December 14, 2016 | https://doi.org/10.1371/journal.ppat.1006045

Macrophage Colony Stimulating Factor Derived from CD4⁺ T Cells Contributes to Control of a Blood-Borne Infection

Mary F. Fontana, Gabrielly L. de Melo, Chioma Anidi, Rebecca Hamburger, Chris Y. Kim, So Youn Lee, Jennifer Pham, Charles C. Kim

PLOS Pathogens: published December 6, 2016 | https://doi.org/10.1371/journal.ppat.1006046

Microbial Translocation and Inflammation Occur in Hyperacute Immunodeficiency Virus Infection and Compromise Host Control of Virus Replication

Adam J. Ericsen, Michael Lauck, Mariel S. Mohns, Sarah R. DiNapoli, James P. Mutschler, Justin M. Greene, Jason T. Weinfurter, Gabrielle Lehrer-Brey, Trent M. Prall, Samantha M. Gieger, Connor R. Buechler, Kristin A. Crosno, Eric J. Peterson, Matthew R. Reynolds, Roger W. Wiseman, Benjamin J. Burwitz, Jacob D. Estes, Jonah B. Sacha, Thomas C. Friedrich, Jason M. Brenchley, David H. O’Connor

PLOS Pathogens: published December 7, 2016 | https://doi.org/10.1371/journal.ppat.1006048

Cytomegalovirus-Specific IL-10-Producing CD4⁺ T Cells Are Governed by Type-I IFN-Induced IL-27 and Promote Virus Persistence

Mathew Clement, Morgan Marsden, Maria A. Stacey, Juneid Abdul-Karim, Silvia Gimeno Brias, Diana Costa Bento, Martin J. Scurr, Peter Ghazal, Casey T. Weaver, Gianluca Carlesso, Simon Clare, Simon A. Jones, Andrew Godkin, Gareth W. Jones, Ian R. Humphreys

PLOS Pathogens: published December 7, 2016 | https://doi.org/10.1371/journal.ppat.1006050

Integrated Activity and Genetic Profiling of Secreted Peptidases in Cryptococcus neoformans Reveals an Aspartyl Peptidase Required for Low pH Survival and Virulence

Starlynn C. Clarke, Phillip A. Dumesic, Christina M. Homer, Anthony J. O’Donoghue, Florencia La Greca, Lenka Pallova, Pavel Majer, Hiten D. Madhani, Charles S. Craik

PLOS Pathogens: published December 15, 2016 | https://doi.org/10.1371/journal.ppat.1006051

Functional and Evolutionary Analyses Identify Proteolysis as a General Mechanism for NLRP1 Inflammasome Activation

Joseph Chavarría-Smith, Patrick S. Mitchell, Alvin M. Ho, Matthew D. Daugherty, Russell E. Vance

PLOS Pathogens: published December 7, 2016 | https://doi.org/10.1371/journal.ppat.1006052

Targeting Neutrophils to Prevent Malaria-Associated Acute Lung Injury/Acute Respiratory Distress Syndrome in Mice

Michelle K. Sercundes, Luana S. Ortolan, Daniela Debone, Paulo V. Soeiro-Pereira, Eliane Gomes, Elizabeth H. Aitken, Antonio Condino Neto, Momtchilo Russo, Maria R. D' Império Lima, José M. Alvarez, Silvia Portugal, Claudio R. F. Marinho, Sabrina Epiphanio

PLOS Pathogens: published December 7, 2016 | https://doi.org/10.1371/journal.ppat.1006054

The Mouse Cytomegalovirus Gene m42 Targets Surface Expression of the Protein Tyrosine Phosphatase CD45 in Infected Macrophages

Nadine Thiel, Kirsten A. Keyser, Niels A. W. Lemmermann, Jennifer D. Oduro, Karen Wagner, Carina Elsner, Anne Halenius, Tihana Lenac Roviš, Melanie M. Brinkmann, Stipan Jonjić, Luka Cicin-Sain, Martin Messerle

PLOS Pathogens: published December 7, 2016 | https://doi.org/10.1371/journal.ppat.1006057

Modulation of Re-initiation of Measles Virus Transcription at Intergenic Regions by P_XD to N_TAIL Binding Strength

Louis-Marie Bloyet, Joanna Brunel, Marion Dosnon, Véronique Hamon, Jenny Erales, Antoine Gruet, Carine Lazert, Christophe Bignon, Philippe Roche, Sonia Longhi, Denis Gerlier

PLOS Pathogens: published December 9, 2016 | https://doi.org/10.1371/journal.ppat.1006058

Inflammasome-Independent NLRP3 Restriction of a Protective Early Neutrophil Response to Pulmonary Tularemia

Sivakumar Periasamy, Hongnga T. Le, Ellen B. Duffy, Heather Chin, Jonathan A. Harton

PLOS Pathogens: published December 7, 2016 | https://doi.org/10.1371/journal.ppat.1006059

Disrupting Mosquito Reproduction and Parasite Development for Malaria Control

Lauren M. Childs, Francisco Y. Cai, Evdoxia G. Kakani, Sara N. Mitchell, Doug Paton, Paolo Gabrieli, Caroline O. Buckee, Flaminia Catteruccia

PLOS Pathogens: published December 15, 2016 | https://doi.org/10.1371/journal.ppat.1006060

Intercellular Extensions Are Induced by the Alphavirus Structural Proteins and Mediate Virus Transmission

Maria Guadalupe Martinez, Margaret Kielian

PLOS Pathogens: published December 15, 2016 | https://doi.org/10.1371/journal.ppat.1006061

Actin-Related Protein 2 (ARP2) and Virus-Induced Filopodia Facilitate Human Respiratory Syncytial Virus Spread

Masfique Mehedi, Thomas McCarty, Scott E. Martin, Cyril Le Nouën, Eugen Buehler, Yu-Chi Chen, Margery Smelkinson, Sundar Ganesan, Elizabeth R. Fischer, Linda G. Brock, Bo Liang, Shirin Munir, Peter L. Collins, Ursula J. Buchholz

PLOS Pathogens: published December 7, 2016 | https://doi.org/10.1371/journal.ppat.1006062

Effective Respiratory CD8 T-Cell Immunity to Influenza Virus Induced by Intranasal Carbomer-Lecithin-Adjuvanted Non-replicating Vaccines

David J. Gasper, Brandon Neldner, Erin H. Plisch, Hani Rustom, Emily Carrow, Hirotaka Imai, Yoshihiro Kawaoka, M. Suresh

PLOS Pathogens: published December 20, 2016 | https://doi.org/10.1371/journal.ppat.1006064

Non-human Primate Schlafen11 Inhibits Production of Both Host and Viral Proteins

Alex C. Stabell, John Hawkins, Manqing Li, Xia Gao, Michael David, William H. Press, Sara L. Sawyer

PLOS Pathogens: published December 27, 2016 | https://doi.org/10.1371/journal.ppat.1006066

Structure and Mechanism of Staphylococcus aureus TarS, the Wall Teichoic Acid β-glycosyltransferase Involved in Methicillin Resistance

Solmaz Sobhanifar, Liam J. Worrall, Dustin T. King, Gregory A. Wasney, Lars Baumann, Robert T. Gale, Michael Nosella, Eric D. Brown, Stephen G. Withers, Natalie C. J. Strynadka

PLOS Pathogens: published December 14, 2016 | https://doi.org/10.1371/journal.ppat.1006067

Elimination of Pseudomonas aeruginosa through Efferocytosis upon Binding to Apoptotic Cells

Darío Capasso, María Victoria Pepe, Jéssica Rossello, Paola Lepanto, Paula Arias, Valentina Salzman, Arlinet Kierbel

PLOS Pathogens: published December 15, 2016 | https://doi.org/10.1371/journal.ppat.1006068

Type 1 Interferons and NK Cells Limit Murine Cytomegalovirus Escape from the Lymph Node Subcapsular Sinus

Helen E. Farrell, Kimberley Bruce, Clara Lawler, Rhonda D. Cardin, Nicholas J. Davis-Poynter, Philip G. Stevenson

PLOS Pathogens: published December 7, 2016 | https://doi.org/10.1371/journal.ppat.1006069

Clostridium difficile Toxin A Undergoes Clathrin-Independent, PACSIN2-Dependent Endocytosis

Ramyavardhanee Chandrasekaran, Anne K. Kenworthy, D. Borden Lacy

PLOS Pathogens: published December 12, 2016 | https://doi.org/10.1371/journal.ppat.1006070

Structural and Functional Characterization of the Bacterial Type III Secretion Export Apparatus

Tobias Dietsche, Mehari Tesfazgi Mebrhatu, Matthias J. Brunner, Patrizia Abrusci, Jun Yan, Mirita Franz-Wachtel, Charlotta Schärfe, Susann Zilkenat, Iwan Grin, Jorge E. Galán, Oliver Kohlbacher, Susan Lea, Boris Macek, Thomas C. Marlovits, Carol V. Robinson, Samuel Wagner

PLOS Pathogens: published December 15, 2016 | https://doi.org/10.1371/journal.ppat.1006071

Peptide Processing Is Critical for T-Cell Memory Inflation and May Be Optimized to Improve Immune Protection by CMV-Based Vaccine Vectors

Iryna Dekhtiarenko, Robert B. Ratts, Renata Blatnik, Lian N. Lee, Sonja Fischer, Lisa Borkner, Jennifer D. Oduro, Thomas F. Marandu, Stephanie Hoppe, Zsolt Ruzsics, Julia K. Sonnemann, Mandana Mansouri, Christine Meyer, Niels A. W. Lemmermann, Rafaela Holtappels, Ramon Arens, Paul Klenerman, Klaus Früh, Matthias J. Reddehase, Angelika B. Riemer, Luka Cicin-Sain

PLOS Pathogens: published December 15, 2016 | https://doi.org/10.1371/journal.ppat.1006072

Increased Abundance of M Cells in the Gut Epithelium Dramatically Enhances Oral Prion Disease Susceptibility

David S. Donaldson, Anuj Sehgal, Daniel Rios, Ifor R. Williams, Neil A. Mabbott

PLOS Pathogens: published December 14, 2016 | https://doi.org/10.1371/journal.ppat.1006075

Using a Novel Partitivirus in Pseudogymnoascus destructans to Understand the Epidemiology of White-Nose Syndrome

Vaskar Thapa, Gregory G. Turner, Susan Hafenstein, Barrie E. Overton, Karen J. Vanderwolf, Marilyn J. Roossinck

PLOS Pathogens: published December 27, 2016 | https://doi.org/10.1371/journal.ppat.1006076

Vaccinia Virus Immunomodulator A46: A Lipid and Protein-Binding Scaffold for Sequestering Host TIR-Domain Proteins

Sofiya Fedosyuk, Gustavo Arruda Bezerra, Katharina Radakovics, Terry K. Smith, Massimo Sammito, Nina Bobik, Adam Round, Lynn F. Ten Eyck, Kristina Djinović-Carugo, Isabel Usón, Tim Skern

PLOS Pathogens: published December 14, 2016 | https://doi.org/10.1371/journal.ppat.1006079

Plasmodium falciparum Nucleosomes Exhibit Reduced Stability and Lost Sequence Dependent Nucleosome Positioning

Elisabeth Silberhorn, Uwe Schwartz, Patrick Löffler, Samuel Schmitz, Anne Symelka, Tania de Koning-Ward, Rainer Merkl, Gernot Längst

PLOS Pathogens: published December 29, 2016 | https://doi.org/10.1371/journal.ppat.1006080

Gene Expression Correlates with the Number of Herpes Viral Genomes Initiating Infection in Single Cells

Efrat M. Cohen, Oren Kobiler

PLOS Pathogens: published December 6, 2016 | https://doi.org/10.1371/journal.ppat.1006082

Role of Occult and Post-acute Phase Replication in Protective Immunity Induced with a Novel Live Attenuated SIV Vaccine

Neil Berry, Maria Manoussaka, Claire Ham, Deborah Ferguson, Hannah Tudor, Giada Mattiuzzo, Bep Klaver, Mark Page, Richard Stebbings, Atze T. Das, Ben Berkhout, Neil Almond, Martin P. Cranage

PLOS Pathogens: published December 21, 2016 | https://doi.org/10.1371/journal.ppat.1006083

Microbial Community Composition Impacts Pathogen Iron Availability during Polymicrobial Infection

Apollo Stacy, Nader Abraham, Peter Jorth, Marvin Whiteley

PLOS Pathogens: published December 14, 2016 | https://doi.org/10.1371/journal.ppat.1006084

Phosphorylation of Eukaryotic Initiation Factor-2α during Stress and Encystation in Entamoeba Species

Holland M. Hendrick, Brenda H. Welter, Matthew A. Hapstack, Steven E. Sykes, William J. Sullivan Jr., Lesly A. Temesvari

PLOS Pathogens: published December 8, 2016 | https://doi.org/10.1371/journal.ppat.1006085

MTOR-Driven Metabolic Reprogramming Regulates Legionella pneumophila Intracellular Niche Homeostasis

Camille F. Abshire, Ana-Maria Dragoi, Craig R. Roy, Stanimir S. Ivanov

PLOS Pathogens: published December 12, 2016 | https://doi.org/10.1371/journal.ppat.1006088

EhNPC1 and EhNPC2 Proteins Participate in Trafficking of Exogenous Cholesterol in Entamoeba histolytica Trophozoites: Relevance for Phagocytosis

Jeni Bolaños, Abigail Betanzos, Rosario Javier-Reyna, Guillermina García- Rivera, Miriam Huerta, Jonnatan Pais-Morales, Arturo González-Robles, Mario A. Rodríguez, Michael Schnoor, Esther Orozco

PLOS Pathogens: published December 21, 2016 | https://doi.org/10.1371/journal.ppat.1006089

A Precise Temperature-Responsive Bistable Switch Controlling Yersinia Virulence

Aaron Mischa Nuss, Franziska Schuster, Louisa Roselius, Johannes Klein, René Bücker, Katharina Herbst, Ann Kathrin Heroven, Fabio Pisano, Christoph Wittmann, Richard Münch, Johannes Müller, Dieter Jahn, Petra Dersch

PLOS Pathogens: published December 22, 2016 | https://doi.org/10.1371/journal.ppat.1006091

A Large Collection of Novel Nematode-Infecting Microsporidia and Their Diverse Interactions with Caenorhabditis elegans and Other Related Nematodes

Gaotian Zhang, Martin Sachse, Marie-Christine Prevost, Robert J. Luallen, Emily R. Troemel, Marie-Anne Félix

PLOS Pathogens: published December 12, 2016 | https://doi.org/10.1371/journal.ppat.1006093

Stage-Specific Changes in Plasmodium Metabolism Required for Differentiation and Adaptation to Different Host and Vector Environments

Anubhav Srivastava, Nisha Philip, Katie R. Hughes, Konstantina Georgiou, James I. MacRae, Michael P. Barrett, Darren J. Creek, Malcolm J. McConville, Andrew P. Waters

PLOS Pathogens: published December 27, 2016 | https://doi.org/10.1371/journal.ppat.1006094

Gene Expression and Silencing Studies in Phytophthora infestans Reveal Infection-Specific Nutrient Transporters and a Role for the Nitrate Reductase Pathway in Plant Pathogenesis

Melania Abrahamian, Audrey M. V. Ah-Fong, Carol Davis, Kalina Andreeva, Howard S. Judelson

PLOS Pathogens: published December 9, 2016 | https://doi.org/10.1371/journal.ppat.1006097

Receptor Activation of HIV-1 Env Leads to Asymmetric Exposure of the gp41 Trimer

Mukta D. Khasnis, Konstantine Halkidis, Anshul Bhardwaj, Michael J. Root

PLOS Pathogens: published December 19, 2016 | https://doi.org/10.1371/journal.ppat.1006098

The Effector Cig57 Hijacks FCHO-Mediated Vesicular Trafficking to Facilitate Intracellular Replication of Coxiella burnetii

Eleanor A. Latomanski, Patrice Newton, Chen Ai Khoo, Hayley J. Newton

PLOS Pathogens: published December 21, 2016 | https://doi.org/10.1371/journal.ppat.1006101

Cell-Based Screen Identifies Human Interferon-Stimulated Regulators of Listeria monocytogenes Infection

Sofya S. Perelman, Michael E. Abrams, Jennifer L. Eitson, Didi Chen, Alyssa Jimenez, Marcel Mettlen, John W. Schoggins, Neal M. Alto

PLOS Pathogens: published December 21, 2016 | https://doi.org/10.1371/journal.ppat.1006102

Persistent Low-Level Replication of SIVΔnef Drives Maturation of Antibody and CD8 T Cell Responses to Induce Protective Immunity against Vaginal SIV Infection

Sama Adnan, R. Keith Reeves, Jacqueline Gillis, Fay E. Wong, Yi Yu, Jeremy V. Camp, Qingsheng Li, Michelle Connole, Yuan Li, Michael Piatak Jr, Jeffrey D. Lifson, Wenjun Li, Brandon F. Keele, Pamela A. Kozlowski, Ronald C. Desrosiers, Ashley T. Haase, R. Paul Johnson

PLOS Pathogens: published December 13, 2016 | https://doi.org/10.1371/journal.ppat.1006104

The Vibrio cholerae Minor Pilin TcpB Initiates Assembly and Retraction of the Toxin-Coregulated Pilus

Dixon Ng, Tony Harn, Tuba Altindal, Subramania Kolappan, Jarrad M. Marles, Rajan Lala, Ingrid Spielman, Yang Gao, Caitlyn A. Hauke, Gabriela Kovacikova, Zia Verjee, Ronald K. Taylor, Nicolas Biais, Lisa Craig

PLOS Pathogens: published December 19, 2016 | https://doi.org/10.1371/journal.ppat.1006109

Within Host Evolution Selects for a Dominant Genotype of Mycobacterium tuberculosis while T Cells Increase Pathogen Genetic Diversity

Richard Copin, Xueying Wang, Eddie Louie, Vincent Escuyer, Mireia Coscolla, Sebastien Gagneux, Guy H. Palmer, Joel D. Ernst

PLOS Pathogens: published December 14, 2016 | https://doi.org/10.1371/journal.ppat.1006111

Experimental Estimation of the Effects of All Amino-Acid Mutations to HIV’s Envelope Protein on Viral Replication in Cell Culture

Hugh K. Haddox, Adam S. Dingens, Jesse D. Bloom

PLOS Pathogens: published December 13, 2016 | https://doi.org/10.1371/journal.ppat.1006114

Tolerogenic Plasmacytoid Dendritic Cells Control Paracoccidioides brasiliensis Infection by Inducting Regulatory T Cells in an IDO-Dependent Manner

Eliseu Frank de Araújo, Daniella Helena Medeiros, Nayane Alves de Lima Galdino, Antônio Condino-Neto, Vera Lúcia Garcia Calich, Flávio Vieira Loures

PLOS Pathogens: published December 19, 2016 | https://doi.org/10.1371/journal.ppat.1006115

Streptococcal Immunity Is Constrained by Lack of Immunological Memory following a Single Episode of Pyoderma

Manisha Pandey, Victoria Ozberk, Ainslie Calcutt, Emma Langshaw, Jessica Powell, Tania Rivera-Hernandez, Mei-Fong Ho, Zachary Philips, Michael R. Batzloff, Michael F. Good

PLOS Pathogens: published December 27, 2016 | https://doi.org/10.1371/journal.ppat.1006122

Scavenger Receptor C Mediates Phagocytosis of White Spot Syndrome Virus and Restricts Virus Proliferation in Shrimp

Ming-Chong Yang, Xiu-Zhen Shi, Hui-Ting Yang, Jie-Jie Sun, Ling Xu, Xian-Wei Wang, Xiao-Fan Zhao, Jin-Xing Wang

PLOS Pathogens: published December 27, 2016 | https://doi.org/10.1371/journal.ppat.1006127

Two-Component Signaling System VgrRS Directly Senses Extracytoplasmic and Intracellular Iron to Control Bacterial Adaptation under Iron Depleted Stress

Li Wang, Yue Pan, Zhi-Hui Yuan, Huan Zhang, Bao-Yu Peng, Fang-Fang Wang, Wei Qian

PLOS Pathogens: published December 30, 2016 | https://doi.org/10.1371/journal.ppat.1006133

Collapse of Cytolytic Potential in SIV-Specific CD8+ T Cells Following Acute SIV Infection in Rhesus Macaques

Emily R. Roberts, Diane G. Carnathan, Hui Li, George M. Shaw, Guido Silvestri, Michael R. Betts

PLOS Pathogens: published December 30, 2016 | https://doi.org/10.1371/journal.ppat.1006135

Fcγ-receptor IIa-mediated Src Signaling Pathway Is Essential for the Antibody-Dependent Enhancement of Ebola Virus Infection

Wakako Furuyama, Andrea Marzi, Aaron B. Carmody, Junki Maruyama, Makoto Kuroda, Hiroko Miyamoto, Asuka Nanbo, Rashid Manzoor, Reiko Yoshida, Manabu Igarashi, Heinz Feldmann, Ayato Takada

PLOS Pathogens: published December 30, 2016 | https://doi.org/10.1371/journal.ppat.1006139

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Cell-associated respiratory syncytial virus spread via filopodia.

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