August 2016

A striking image of the chlorovirus system, ranging in biology and size scale. We have studied this system at all of these levels for the past 35+ years to develop an evermore comprehensive understanding the viruses and their roles in biological systems. Van Etten et al,

Image Credit: Kit Lee

Opinion

Genome Skimming: A Rapid Approach to Gaining Diverse Biological Insights into Multicellular Pathogens

Dee R. Denver, Amanda M. V. Brown, Dana K. Howe, Amy B. Peetz, Inga A. Zasada

PLOS Pathogens: published August 4, 2016 | https://doi.org/10.1371/journal.ppat.1005713

Pearls

Standing on the Shoulders of Giant Viruses: Five Lessons Learned about Large Viruses Infecting Small Eukaryotes and the Opportunities They Create

Steven W. Wilhelm, Samantha R. Coy, Eric R. Gann, Mohammad Moniruzzaman, Joshua M. A. Stough

PLOS Pathogens: published August 25, 2016 | https://doi.org/10.1371/journal.ppat.1005752

Giant Chloroviruses: Five Easy Questions

James L. Van Etten, David D. Dunigan

PLOS Pathogens: published August 18, 2016 | https://doi.org/10.1371/journal.ppat.1005751

The Buzz about Honey Bee Viruses

Laura M. Brutscher, Alexander J. McMenamin, Michelle L. Flenniken

PLOS Pathogens: published August 18, 2016 | https://doi.org/10.1371/journal.ppat.1005757

Nudix Effectors: A Common Weapon in the Arsenal of Plant Pathogens

Suomeng Dong, Yuanchao Wang

PLOS Pathogens: published August 11, 2016 | https://doi.org/10.1371/journal.ppat.1005704

Posttranslational Modifications of NPR1: A Single Protein Playing Multiple Roles in Plant Immunity and Physiology

John Withers, Xinnian Dong

PLOS Pathogens: published August 11, 2016 | https://doi.org/10.1371/journal.ppat.1005707

Expanding Host Range and Cross-Species Infection of Hepatitis E Virus

Xiang-Jin Meng

PLOS Pathogens: published August 4, 2016 | https://doi.org/10.1371/journal.ppat.1005695

Research Matters

Discovering Protein Receptors for Signaling Nucleotides

Vincent T. Lee

PLOS Pathogens: published August 25, 2016 | https://doi.org/10.1371/journal.ppat.1005569

Life with Bacterial Secretion Systems

Tomoko Kubori

PLOS Pathogens: published August 11, 2016 | https://doi.org/10.1371/journal.ppat.1005562

Research Articles

Antibody-Mediated Internalization of Infectious HIV-1 Virions Differs among Antibody Isotypes and Subclasses

Matthew Zirui Tay, Pinghuang Liu, LaTonya D. Williams, Michael D McRaven, Sheetal Sawant, Thaddeus C Gurley, Thomas T. Xu, S. Moses Dennison, Hua-Xin Liao, Agnès-Laurence Chenine, S. Munir Alam, M. Anthony Moody, Thomas J. Hope, Barton F. Haynes, Georgia D. Tomaras

PLOS Pathogens: published August 31, 2016 | https://doi.org/10.1371/journal.ppat.1005817

Interactions of Prototype Foamy Virus Capsids with Host Cell Polo-Like Kinases Are Important for Efficient Viral DNA Integration

Irena Zurnic, Sylvia Hütter, Ute Rzeha, Nicole Stanke, Juliane Reh, Erik Müllers, Martin V. Hamann, Tobias Kern, Gesche K. Gerresheim, Fabian Lindel, Erik Serrao, Paul Lesbats, Alan N. Engelman, Peter Cherepanov, Dirk Lindemann

PLOS Pathogens: published August 31, 2016 | https://doi.org/10.1371/journal.ppat.1005860

Type I IFN Signaling Is Dispensable during Secondary Viral Infection

Martin P. Hosking, Claudia T. Flynn, J. Lindsay Whitton

PLOS Pathogens: published August 31, 2016 | https://doi.org/10.1371/journal.ppat.1005861

Natural Killer Cell Evasion Is Essential for Infection by Rhesus Cytomegalovirus

Elizabeth R. Sturgill, Daniel Malouli, Scott G. Hansen, Benjamin J. Burwitz, Seongkyung Seo, Christine L. Schneider, Jennie L. Womack, Marieke C. Verweij, Abigail B. Ventura, Amruta Bhusari, Krystal M. Jeffries, Alfred W. Legasse, Michael K. Axthelm, Amy W. Hudson, Jonah B. Sacha, Louis J. Picker, Klaus Früh

PLOS Pathogens: published August 31, 2016 | https://doi.org/10.1371/journal.ppat.1005868

The Dengue Virus NS5 Protein Intrudes in the Cellular Spliceosome and Modulates Splicing

Federico A. De Maio, Guillermo Risso, Nestor G. Iglesias, Priya Shah, Berta Pozzi, Leopoldo G. Gebhard, Pablo Mammi, Estefania Mancini, Marcelo J. Yanovsky, Raul Andino, Nevan Krogan, Anabella Srebrow, Andrea V. Gamarnik

PLOS Pathogens: published August 30, 2016 | https://doi.org/10.1371/journal.ppat.1005841

An Essential Viral Transcription Activator Modulates Chromatin Dynamics

Rebecca L. Gibeault, Kristen L. Conn, Michael D. Bildersheim, Luis M. Schang

PLOS Pathogens: published August 30, 2016 | https://doi.org/10.1371/journal.ppat.1005842

Overexpression of Differentially Expressed Genes Identified in Non-pathogenic and Pathogenic Entamoeba histolytica Clones Allow Identification of New Pathogenicity Factors Involved in Amoebic Liver Abscess Formation

Martin Meyer, Helena Fehling, Jenny Matthiesen, Stephan Lorenzen, Kathrin Schuldt, Hannah Bernin, Mareen Zaruba, Corinna Lender, Thomas Ernst, Harald Ittrich, Thomas Roeder, Egbert Tannich, Hannelore Lotter, Iris Bruchhaus

PLOS Pathogens: published August 30, 2016 | https://doi.org/10.1371/journal.ppat.1005853

The Mutational Robustness of Influenza A Virus

Elisa Visher, Shawn E. Whitefield, John T. McCrone, William Fitzsimmons, Adam S. Lauring

PLOS Pathogens: published August 29, 2016 | https://doi.org/10.1371/journal.ppat.1005856

Consecutive Inhibition of ISG15 Expression and ISGylation by Cytomegalovirus Regulators

Ye Ji Kim, Eui Tae Kim, Young-Eui Kim, Myoung Kyu Lee, Ki Mun Kwon, Keun Il Kim, Thomas Stamminger, Jin-Hyun Ahn

PLOS Pathogens: published August 26, 2016 | https://doi.org/10.1371/journal.ppat.1005850

Thermoregulation of Meningococcal fHbp, an Important Virulence Factor and Vaccine Antigen, Is Mediated by Anti-ribosomal Binding Site Sequences in the Open Reading Frame

Edmund Loh, Hayley Lavender, Felicia Tan, Alexander Tracy, Christoph M. Tang

PLOS Pathogens: published August 25, 2016 | https://doi.org/10.1371/journal.ppat.1005794

Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design

Joseph G. Jardine, Devin Sok, Jean-Philippe Julien, Bryan Briney, Anita Sarkar, Chi-Hui Liang, Erin A. Scherer, Carole J. Henry Dunand, Yumiko Adachi, Devan Diwanji, Jessica Hsueh, Meaghan Jones, Oleksandr Kalyuzhniy, Michael Kubitz, Skye Spencer, Matthias Pauthner, Karen L. Saye-Francisco, Fabian Sesterhenn, Patrick C. Wilson, Denise M. Galloway, Robyn L. Stanfield, Ian A. Wilson, Dennis R. Burton, William R. Schief

PLOS Pathogens: published August 25, 2016 | https://doi.org/10.1371/journal.ppat.1005815

MoDnm1 Dynamin Mediating Peroxisomal and Mitochondrial Fission in Complex with MoFis1 and MoMdv1 Is Important for Development of Functional Appressorium in Magnaporthe oryzae

Kaili Zhong, Xiao Li, Xinyi Le, Xiangyi Kong, Haifeng Zhang, Xiaobo Zheng, Ping Wang, Zhengguang Zhang

PLOS Pathogens: published August 24, 2016 | https://doi.org/10.1371/journal.ppat.1005823

The Prolyl Isomerase Pin1 Promotes the Herpesvirus-Induced Phosphorylation-Dependent Disassembly of the Nuclear Lamina Required for Nucleocytoplasmic Egress

Jens Milbradt, Corina Hutterer, Hanife Bahsi, Sabrina Wagner, Eric Sonntag, Anselm H. C. Horn, Benedikt B. Kaufer, Yasuko Mori, Heinrich Sticht, Torgils Fossen, Manfred Marschall

PLOS Pathogens: published August 24, 2016 | https://doi.org/10.1371/journal.ppat.1005825

Placental Sequestration of Plasmodium falciparum Malaria Parasites Is Mediated by the Interaction Between VAR2CSA and Chondroitin Sulfate A on Syndecan-1

Marina Ayres Pereira, Thomas Mandel Clausen, Caroline Pehrson, Yang Mao, Mafalda Resende, Mads Daugaard, Anders Riis Kristensen, Charlotte Spliid, Line Mathiesen, Lisbeth E. Knudsen, Peter Damm, Thor G. Theander, Stefan R. Hansson, Morten A. Nielsen, Ali Salanti

PLOS Pathogens: published August 24, 2016 | https://doi.org/10.1371/journal.ppat.1005831

Single-Molecule FISH Reveals Non-selective Packaging of Rift Valley Fever Virus Genome Segments

Paul J. Wichgers Schreur, Jeroen Kortekaas

PLOS Pathogens: published August 22, 2016 | https://doi.org/10.1371/journal.ppat.1005800

EBV Nuclear Antigen 3C Mediates Regulation of E2F6 to Inhibit E2F1 Transcription and Promote Cell Proliferation

Yonggang Pei, Shuvomoy Banerjee, Zhiguo Sun, Hem Chandra Jha, Abhik Saha, Erle S. Robertson

PLOS Pathogens: published August 22, 2016 | https://doi.org/10.1371/journal.ppat.1005844

Evidence and Role for Bacterial Mucin Degradation in Cystic Fibrosis Airway Disease

Jeffrey M. Flynn, David Niccum, Jordan M. Dunitz, Ryan C. Hunter

PLOS Pathogens: published August 22, 2016 | https://doi.org/10.1371/journal.ppat.1005846

MyD88 Shapes Vaccine Immunity by Extrinsically Regulating Survival of CD4⁺ T Cells during the Contraction Phase

Huafeng Wang, Mengyi Li, Chiung Yu Hung, Meenal Sinha, Linda M. Lee, Darin L. Wiesner, Vanessa LeBert, Tassanee Lerksuthirat, Kevin Galles, Marulasiddappa Suresh, Anthony L. DeFranco, Clifford A. Lowell, Bruce S. Klein, Marcel Wüthrich

PLOS Pathogens: published August 19, 2016 | https://doi.org/10.1371/journal.ppat.1005787

Compartmentalization of Total and Virus-Specific Tissue-Resident Memory CD8+ T Cells in Human Lymphoid Organs

Heng Giap Woon, Asolina Braun, Jane Li, Corey Smith, Jarem Edwards, Frederic Sierro, Carl G. Feng, Rajiv Khanna, Michael Elliot, Andrew Bell, Andrew D. Hislop, Stuart G. Tangye, Alan B. Rickinson, Thomas Gebhardt, Warwick J. Britton, Umaimainthan Palendira

PLOS Pathogens: published August 19, 2016 | https://doi.org/10.1371/journal.ppat.1005799

The G1/S Specific Cyclin D2 Is a Regulator of HIV-1 Restriction in Non-proliferating Cells

Roger Badia, Maria Pujantell, Eva Riveira-Muñoz, Teresa Puig, Javier Torres-Torronteras, Ramón Martí, Bonaventura Clotet, Rosa M. Ampudia, Marta Vives-Pi, José A. Esté, Ester Ballana

PLOS Pathogens: published August 19, 2016 | https://doi.org/10.1371/journal.ppat.1005829

The RNA Binding Specificity of Human APOBEC3 Proteins Resembles That of HIV-1 Nucleocapsid

Ashley York, Sebla B. Kutluay, Manel Errando, Paul D. Bieniasz

PLOS Pathogens: published August 19, 2016 | https://doi.org/10.1371/journal.ppat.1005833

A Drosophila Model of HPV E6-Induced Malignancy Reveals Essential Roles for Magi and the Insulin Receptor

Mojgan Padash Barmchi, Mary Gilbert, Miranda Thomas, Lawrence Banks, Bing Zhang, Vanessa J. Auld

PLOS Pathogens: published August 18, 2016 | https://doi.org/10.1371/journal.ppat.1005789

Antibodies with ‘Original Antigenic Sin’ Properties Are Valuable Components of Secondary Immune Responses to Influenza Viruses

Susanne L. Linderman, Scott E. Hensley

PLOS Pathogens: published August 18, 2016 | https://doi.org/10.1371/journal.ppat.1005806

Jagged1 Instructs Macrophage Differentiation in Leprosy

Jon Kibbie, Rosane M. B. Teles, Zhiming Wang, Patrick Hong, Dennis Montoya, Stephan Krutzik, Seung Lee, Ohyun Kwon, Robert L. Modlin, Daniel Cruz

PLOS Pathogens: published August 17, 2016 | https://doi.org/10.1371/journal.ppat.1005808

MUSASHI-Mediated Expression of JMJD3, a H3K27me3 Demethylase, Is Involved in Foamy Macrophage Generation during Mycobacterial Infection

Sahana Holla, Praveen Prakhar, Vikas Singh, Anupama Karnam, Tanushree Mukherjee, Kasturi Mahadik, Pankti Parikh, Amit Singh, R. S. Rajmani, Subbaraya G. Ramachandra, Kithiganahalli Narayanaswamy Balaji

PLOS Pathogens: published August 17, 2016 | https://doi.org/10.1371/journal.ppat.1005814

Histone Deacetylase Inhibitors Enhance CD4 T Cell Susceptibility to NK Cell Killing but Reduce NK Cell Function

Matthew Pace, James Williams, Ayako Kurioka, Andrew B. Gerry, Bent Jakobsen, Paul Klenerman, Nneka Nwokolo, Julie Fox, Sarah Fidler, John Frater, CHERUB Investigators

PLOS Pathogens: published August 16, 2016 | https://doi.org/10.1371/journal.ppat.1005782

Two Different Virulence-Related Regulatory Pathways in Borrelia burgdorferi Are Directly Affected by Osmotic Fluxes in the Blood Meal of Feeding Ixodes Ticks

Sébastien Bontemps-Gallo, Kevin Lawrence, Frank C. Gherardini

PLOS Pathogens: published August 15, 2016 | https://doi.org/10.1371/journal.ppat.1005791

Live-Cell Imaging of Vaccinia Virus Recombination

Patrick Paszkowski, Ryan S. Noyce, David H. Evans

PLOS Pathogens: published August 15, 2016 | https://doi.org/10.1371/journal.ppat.1005824

The Invertebrate Lysozyme Effector ILYS-3 Is Systemically Activated in Response to Danger Signals and Confers Antimicrobial Protection in C. elegans

Maria João Gravato-Nobre, Filipa Vaz, Sergio Filipe, Ronald Chalmers, Jonathan Hodgkin

PLOS Pathogens: published August 15, 2016 | https://doi.org/10.1371/journal.ppat.1005826

Exaptation of Bornavirus-Like Nucleoprotein Elements in Afrotherians

Yuki Kobayashi, Masayuki Horie, Ayumi Nakano, Koichi Murata, Takuya Itou, Yoshiyuki Suzuki

PLOS Pathogens: published August 12, 2016 | https://doi.org/10.1371/journal.ppat.1005785

Importin β Can Bind Hepatitis B Virus Core Protein and Empty Core-Like Particles and Induce Structural Changes

Chao Chen, Joseph Che-Yen Wang, Elizabeth E. Pierson, David Z. Keifer, Mildred Delaleau, Lara Gallucci, Christian Cazenave, Michael Kann, Martin F. Jarrold, Adam Zlotnick

PLOS Pathogens: published August 12, 2016 | https://doi.org/10.1371/journal.ppat.1005802

Metabolic Network for the Biosynthesis of Intra- and Extracellular α-Glucans Required for Virulence of Mycobacterium tuberculosis

Hendrik Koliwer-Brandl, Karl Syson, Robert van de Weerd, Govind Chandra, Ben Appelmelk, Marina Alber, Thomas R. Ioerger, William R. Jacobs Jr., Jeroen Geurtsen, Stephen Bornemann, Rainer Kalscheuer

PLOS Pathogens: published August 11, 2016 | https://doi.org/10.1371/journal.ppat.1005768

Virus Infection of Plants Alters Pollinator Preference: A Payback for Susceptible Hosts?

Simon C. Groen, Sanjie Jiang, Alex M. Murphy, Nik J. Cunniffe, Jack H. Westwood, Matthew P. Davey, Toby J. A. Bruce, John C. Caulfield, Oliver J. Furzer, Alison Reed, Sophie I. Robinson, Elizabeth Miller, Christopher N. Davis, John A. Pickett, Heather M. Whitney, Beverley J. Glover, John P. Carr

PLOS Pathogens: published August 11, 2016 | https://doi.org/10.1371/journal.ppat.1005790

Elevated Basal Pre-infection CXCL10 in Plasma and in the Small Intestine after Infection Are Associated with More Rapid HIV/SIV Disease Onset

Mickaël J. Ploquin, Yoann Madec, Armanda Casrouge, Nicolas Huot, Caroline Passaes, Camille Lécuroux, Asma Essat, Faroudy Boufassa, Béatrice Jacquelin, Simon P. Jochems, Gaël Petitjean, Mathieu Angin, Kathleen Gärtner, Thalía Garcia-Tellez, Nicolas Noël, Thijs Booiman, Brigitte D. Boeser-Nunnink, Pierre Roques, Asier Saez-Cirion, Bruno Vaslin, Nathalie Dereudre-Bosquet, Françoise Barré-Sinoussi, Mathilde Ghislain, Christine Rouzioux, Olivier Lambotte, Matthew L. Albert, Cécile Goujard, Neeltje Kootstra, Laurence Meyer, Michaela C. Müller-Trutwin

PLOS Pathogens: published August 10, 2016 | https://doi.org/10.1371/journal.ppat.1005774

New World and Old World Alphaviruses Have Evolved to Exploit Different Components of Stress Granules, FXR and G3BP Proteins, for Assembly of Viral Replication Complexes

Dal Young Kim, Josephine M. Reynaud, Aliaksandra Rasalouskaya, Ivan Akhrymuk, James A. Mobley, Ilya Frolov, Elena I. Frolova

PLOS Pathogens: published August 10, 2016 | https://doi.org/10.1371/journal.ppat.1005810

Structural Insights into the PorK and PorN Components of the Porphyromonas gingivalis Type IX Secretion System

Dhana G. Gorasia, Paul D. Veith, Eric G. Hanssen, Michelle D. Glew, Keiko Sato, Hideharu Yukitake, Koji Nakayama, Eric C. Reynolds

PLOS Pathogens: published August 10, 2016 | https://doi.org/10.1371/journal.ppat.1005820

An Epithelial Integrin Regulates the Amplitude of Protective Lung Interferon Responses against Multiple Respiratory Pathogens

Victoria A. Meliopoulos, Lee-Ann Van de Velde, Nicholas C. Van de Velde, Erik A. Karlsson, Geoff Neale, Peter Vogel, Cliff Guy, Shalini Sharma, Susu Duan, Sherri L. Surman, Bart G. Jones, Michael D. L. Johnson, Catharine Bosio, Lisa Jolly, R. Gisli Jenkins, Julia L. Hurwitz, Jason W. Rosch, Dean Sheppard, Paul G. Thomas, Peter J. Murray, Stacey Schultz-Cherry

PLOS Pathogens: published August 9, 2016 | https://doi.org/10.1371/journal.ppat.1005804

Polarized Cell Division of Chlamydia trachomatis

Yasser Abdelrahman, Scot P. Ouellette, Robert J. Belland, John V. Cox

PLOS Pathogens: published August 9, 2016 | https://doi.org/10.1371/journal.ppat.1005822

Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling

Siew Pheng Lim, Christian Guy Noble, Cheah Chen Seh, Tingjin Sherryl Soh, Abbas El Sahili, Grace Kar Yarn Chan, Julien Lescar, Rishi Arora, Timothy Benson, Shahul Nilar, Ujjini Manjunatha, Kah Fei Wan, Hongping Dong, Xuping Xie, Pei-Yong Shi, Fumiaki Yokokawa

PLOS Pathogens: published August 8, 2016 | https://doi.org/10.1371/journal.ppat.1005737

The Mechanism for Type I Interferon Induction by Mycobacterium tuberculosis is Bacterial Strain-Dependent

Kirsten E. Wiens, Joel D. Ernst

PLOS Pathogens: published August 8, 2016 | https://doi.org/10.1371/journal.ppat.1005809

Evaluating Clonal Expansion of HIV-Infected Cells: Optimization of PCR Strategies to Predict Clonality

Sarah B. Laskey, Christopher W. Pohlmeyer, Katherine M. Bruner, Robert F. Siliciano

PLOS Pathogens: published August 5, 2016 | https://doi.org/10.1371/journal.ppat.1005689

Ecological Contexts of Index Cases and Spillover Events of Different Ebolaviruses

Seth D. Judson, Robert Fischer, Andrew Judson, Vincent J. Munster

PLOS Pathogens: published August 5, 2016 | https://doi.org/10.1371/journal.ppat.1005780

The Arabidopsis Protein Phosphatase PP2C38 Negatively Regulates the Central Immune Kinase BIK1

Daniel Couto, Roda Niebergall, Xiangxiu Liang, Christoph A. Bücherl, Jan Sklenar, Alberto P. Macho, Vardis Ntoukakis, Paul Derbyshire, Denise Altenbach, Dan Maclean, Silke Robatzek, Joachim Uhrig, Frank Menke, Jian-Min Zhou, Cyril Zipfel

PLOS Pathogens: published August 5, 2016 | https://doi.org/10.1371/journal.ppat.1005811

Apicoplast-Localized Lysophosphatidic Acid Precursor Assembly Is Required for Bulk Phospholipid Synthesis in Toxoplasma gondii and Relies on an Algal/Plant-Like Glycerol 3-Phosphate Acyltransferase

Souad Amiar, James I. MacRae, Damien L. Callahan, David Dubois, Giel G. van Dooren, Melanie J. Shears, Marie-France Cesbron-Delauw, Eric Maréchal, Malcolm J. McConville, Geoffrey I. McFadden, Yoshiki Yamaryo-Botté, Cyrille Y. Botté

PLOS Pathogens: published August 4, 2016 | https://doi.org/10.1371/journal.ppat.1005765

Plant-Mediated Effects on Mosquito Capacity to Transmit Human Malaria

Domonbabele F. d. S. Hien, Kounbobr R. Dabiré, Benjamin Roche, Abdoulaye Diabaté, Rakiswende S. Yerbanga, Anna Cohuet, Bienvenue K. Yameogo, Louis-Clément Gouagna, Richard J. Hopkins, Georges A. Ouedraogo, Frédéric Simard, Jean-Bosco Ouedraogo, Rickard Ignell, Thierry Lefevre

PLOS Pathogens: published August 4, 2016 | https://doi.org/10.1371/journal.ppat.1005773

High Frequency and Diversity of Antimicrobial Activities Produced by Nasal Staphylococcus Strains against Bacterial Competitors

Daniela Janek, Alexander Zipperer, Andreas Kulik, Bernhard Krismer, Andreas Peschel

PLOS Pathogens: published August 4, 2016 | https://doi.org/10.1371/journal.ppat.1005812

Thermostability of Well-Ordered HIV Spikes Correlates with the Elicitation of Autologous Tier 2 Neutralizing Antibodies

Yu Feng, Karen Tran, Shridhar Bale, Shailendra Kumar, Javier Guenaga, Richard Wilson, Natalia de Val, Heather Arendt, Joanne DeStefano, Andrew B. Ward, Richard T. Wyatt

PLOS Pathogens: published August 3, 2016 | https://doi.org/10.1371/journal.ppat.1005767

TPL-2 Regulates Macrophage Lipid Metabolism and M2 Differentiation to Control T_H2-Mediated Immunopathology

Yashaswini Kannan, Jimena Perez-Lloret, Yanda Li, Lewis J. Entwistle, Hania Khoury, Stamatia Papoutsopoulou, Radma Mahmood, Nuha R. Mansour, Stanley Ching-Cheng Huang, Edward J. Pearce, Luiz Pedro S. de Carvalho, Steven C. Ley, Mark S. Wilson

PLOS Pathogens: published August 3, 2016 | https://doi.org/10.1371/journal.ppat.1005783

Interferon Alpha Induces Sustained Changes in NK Cell Responsiveness to Hepatitis B Viral Load Suppression In Vivo

Upkar S. Gill, Dimitra Peppa, Lorenzo Micco, Harsimran D. Singh, Ivana Carey, Graham R. Foster, Mala K. Maini, Patrick T. F. Kennedy

PLOS Pathogens: published August 3, 2016 | https://doi.org/10.1371/journal.ppat.1005788

Temporal Dynamics of CD8⁺ T Cell Effector Responses during Primary HIV Infection

Korey R. Demers, George Makedonas, Marcus Buggert, Michael A. Eller, Sarah J. Ratcliffe, Nilu Goonetilleke, Chris K. Li, Leigh Anne Eller, Kathleen Rono, Lucas Maganga, Sorachai Nitayaphan, Hannah Kibuuka, Jean-Pierre Routy, Mark K. Slifka, Barton F. Haynes, Andrew J. McMichael, Nicole F. Bernard, Merlin L. Robb, Michael R. Betts

PLOS Pathogens: published August 3, 2016 | https://doi.org/10.1371/journal.ppat.1005805

Analysis of Multiple HPV E6 PDZ Interactions Defines Type-Specific PDZ Fingerprints That Predict Oncogenic Potential

Miranda Thomas, Michael P. Myers, Paola Massimi, Corrado Guarnaccia, Lawrence Banks

PLOS Pathogens: published August 2, 2016 | https://doi.org/10.1371/journal.ppat.1005766

How Quorum Sensing Connects Sporulation to Necrotrophism in Bacillus thuringiensis

Stéphane Perchat, Antoine Talagas, Sandrine Poncet, Noureddine Lazar, Inès Li de la Sierra-Gallay, Michel Gohar, Didier Lereclus, Sylvie Nessler

PLOS Pathogens: published August 2, 2016 | https://doi.org/10.1371/journal.ppat.1005779

The Prostaglandin E₂-EP3 Receptor Axis Regulates Anaplasma phagocytophilum-Mediated NLRC4 Inflammasome Activation

Xiaowei Wang, Dana K. Shaw, Holly L. Hammond, Fayyaz S. Sutterwala, Manira Rayamajhi, Kari Ann Shirey, Darren J. Perkins, Joseph V. Bonventre, Thangam S. Velayutham, Sean M. Evans, Kyle G. Rodino, Lauren VieBrock, Karen M. Scanlon, Nicholas H. Carbonetti, Jason A. Carlyon, Edward A. Miao, Jere W. McBride, Michail Kotsyfakis, Joao H. F. Pedra

PLOS Pathogens: published August 2, 2016 | https://doi.org/10.1371/journal.ppat.1005803

Formal Comments

Insufficient Evidence for Rare Activation of Latent HIV in the Absence of Reservoir-Reducing Interventions

Alison L. Hill, Daniel I. S. Rosenbloom, Janet D. Siliciano, Robert F. Siliciano

PLOS Pathogens: published August 25, 2016 | https://doi.org/10.1371/journal.ppat.1005679

Modeling of Experimental Data Supports HIV Reactivation from Latency after Treatment Interruption on Average Once Every 5–8 Days

Mykola Pinkevych, Stephen J. Kent, Martin Tolstrup, Sharon R. Lewin, David A. Cooper, Ole S. Søgaard, Thomas A. Rasmussen, Anthony D. Kelleher, Deborah Cromer, Miles P. Davenport

PLOS Pathogens: published August 25, 2016 | https://doi.org/10.1371/journal.ppat.1005740

Cover

A single green alga (genus Chlorella) with multiple chlorovirus particles bound to the surface (gold)

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