Virus–Host Interactions and the ARTD/PARP Family of Enzymes

Chad V. Kuny, Christopher S. Sullivan

PLOS Pathogens: published March 24, 2016 | https://doi.org/10.1371/journal.ppat.1005453

Cooperation and Conflict in the Plant Immune System

Eunyoung Chae, Diep T. N. Tran, Detlef Weigel

PLOS Pathogens: published March 17, 2016 | https://doi.org/10.1371/journal.ppat.1005452

The Herpes Simplex Virus Neurovirulence Factor γ34.5: Revealing Virus–Host Interactions

Douglas R. Wilcox, Richard Longnecker

PLOS Pathogens: published March 10, 2016 | https://doi.org/10.1371/journal.ppat.1005449

Beg, Borrow and Steal: Three Aspects of Horizontal Gene Transfer in the Protozoan Parasite, Cryptosporidium parvum

Adam Sateriale, Boris Striepen

PLOS Pathogens: published March 3, 2016 | https://doi.org/10.1371/journal.ppat.1005429

The Unifying Nature of Basic Science Research

Kirk W. Deitsch

PLOS Pathogens: published March 31, 2016 | https://doi.org/10.1371/journal.ppat.1005329

The Developmental Biology of Parasitic Nematodes

James B. Lok

PLOS Pathogens: published March 10, 2016 | https://doi.org/10.1371/journal.ppat.1005328

siRNA Screen Identifies Trafficking Host Factors that Modulate Alphavirus Infection

Sheli R. Radoshitzky, Gianluca Pegoraro, Xiǎolì Chī, Lián Dǒng, Chih-Yuan Chiang, Lucas Jozwick, Jeremiah C. Clester, Christopher L. Cooper, Duane Courier, David P. Langan, Knashka Underwood, Kathleen A. Kuehl, Mei G. Sun, Yíngyún Caì, Shuǐqìng Yú, Robin Burk, Rouzbeh Zamani, Krishna Kota, Jens H. Kuhn, Sina Bavari

PLOS Pathogens: published March 31, 2016 | https://doi.org/10.1371/journal.ppat.1005466

Endothelin-1 Mediates Brain Microvascular Dysfunction Leading to Long-Term Cognitive Impairment in a Model of Experimental Cerebral Malaria

Brandi D. Freeman, Yuri C. Martins, Oscar B. Akide-Ndunge, Fernando P. Bruno, Hua Wang, Herbert B. Tanowitz, David C. Spray, Mahalia S. Desruisseaux

PLOS Pathogens: published March 31, 2016 | https://doi.org/10.1371/journal.ppat.1005477

Cold-Adapted Viral Attenuation (CAVA): Highly Temperature Sensitive Polioviruses as Novel Vaccine Strains for a Next Generation Inactivated Poliovirus Vaccine

Barbara P. Sanders, Isabel de los Rios Oakes, Vladimir van Hoek, Viki Bockstal, Tobias Kamphuis, Taco G. Uil, Yutong Song, Gillian Cooper, Laura E. Crawt, Javier Martín, Roland Zahn, John Lewis, Eckard Wimmer, Jerome H. H. V. Custers, Hanneke Schuitemaker, Jeronimo Cello, Diana Edo-Matas

PLOS Pathogens: published March 31, 2016 | https://doi.org/10.1371/journal.ppat.1005483

PI3Kγ Is Critical for Dendritic Cell-Mediated CD8+ T Cell Priming and Viral Clearance during Influenza Virus Infection

Samuel Philip Nobs, Christoph Schneider, Alex Kaspar Heer, Jatta Huotari, Ari Helenius, Manfred Kopf

PLOS Pathogens: published March 31, 2016 | https://doi.org/10.1371/journal.ppat.1005508

Endosomal MR1 Trafficking Plays a Key Role in Presentation of Mycobacterium tuberculosis Ligands to MAIT Cells

Melanie J. Harriff, Elham Karamooz, Ansen Burr, Wilmon F. Grant, Elizabeth T. Canfield, Michelle L. Sorensen, Luis F. Moita, David M. Lewinsohn

PLOS Pathogens: published March 31, 2016 | https://doi.org/10.1371/journal.ppat.1005524

The E3 Ligase APIP10 Connects the Effector AvrPiz-t to the NLR Receptor Piz-t in Rice

Chan Ho Park, Gautam Shirsekar, Maria Bellizzi, Songbiao Chen, Pattavipha Songkumarn, Xin Xie, Xuetao Shi, Yuese Ning, Bo Zhou, Pavinee Suttiviriya, Mo Wang, Kenji Umemura, Guo-Liang Wang

PLOS Pathogens: published March 31, 2016 | https://doi.org/10.1371/journal.ppat.1005529

Optimal Combinations of Broadly Neutralizing Antibodies for Prevention and Treatment of HIV-1 Clade C Infection

Kshitij Wagh, Tanmoy Bhattacharya, Carolyn Williamson, Alex Robles, Madeleine Bayne, Jetta Garrity, Michael Rist, Cecilia Rademeyer, Hyejin Yoon, Alan Lapedes, Hongmei Gao, Kelli Greene, Mark K. Louder, Rui Kong, Salim Abdool Karim, Dennis R. Burton, Dan H. Barouch, Michel C. Nussenzweig, John R. Mascola, Lynn Morris, David C. Montefiori, Bette Korber, Michael S. Seaman

PLOS Pathogens: published March 30, 2016 | https://doi.org/10.1371/journal.ppat.1005520

Candida glabrata Binding to Candida albicans Hyphae Enables Its Development in Oropharyngeal Candidiasis

Swetha Tati, Peter Davidow, Andrew McCall, Elizabeth Hwang-Wong, Isolde G. Rojas, Brendan Cormack, Mira Edgerton

PLOS Pathogens: published March 30, 2016 | https://doi.org/10.1371/journal.ppat.1005522

Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease Inhibitor

Yunjeong Kim, Hongwei Liu, Anushka C. Galasiti Kankanamalage, Sahani Weerasekara, Duy H. Hua, William C. Groutas, Kyeong-Ok Chang, Niels C. Pedersen

PLOS Pathogens: published March 30, 2016 | https://doi.org/10.1371/journal.ppat.1005531

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Bacillus bombysepticus α-Toxin Binding to G Protein-Coupled Receptor Kinase 2 Regulates cAMP/PKA Signaling Pathway to Induce Host Death

Ping Lin, Tingcai Cheng, Sanyuan Ma, Junping Gao, Shengkai Jin, Liang Jiang, Qingyou Xia

PLOS Pathogens: published March 29, 2016 | https://doi.org/10.1371/journal.ppat.1005527

The Type III Secretion Translocation Pore Senses Host Cell Contact

Erin I. Armentrout, Arne Rietsch

PLOS Pathogens: published March 29, 2016 | https://doi.org/10.1371/journal.ppat.1005530

A Novel Toll-Like Receptor (TLR) Influences Compatibility between the Gastropod Biomphalaria glabrata, and the Digenean Trematode Schistosoma mansoni

Emmanuel A. Pila, Mahmoud Tarrabain, Alethe L. Kabore, Patrick C. Hanington

PLOS Pathogens: published March 25, 2016 | https://doi.org/10.1371/journal.ppat.1005513

An Immature Myeloid/Myeloid-Suppressor Cell Response Associated with Necrotizing Inflammation Mediates Lethal Pulmonary Tularemia

Sivakumar Periasamy, Dorina Avram, Amanda McCabe, Katherine C. MacNamara, Timothy J. Sellati, Jonathan A. Harton

PLOS Pathogens: published March 25, 2016 | https://doi.org/10.1371/journal.ppat.1005517

Genome-wide siRNA Screening at Biosafety Level 4 Reveals a Crucial Role for Fibrillarin in Henipavirus Infection

Celine Deffrasnes, Glenn A. Marsh, Chwan Hong Foo, Christina L. Rootes, Cathryn M. Gould, Julian Grusovin, Paul Monaghan, Michael K. Lo, S. Mark Tompkins, Timothy E. Adams, John W. Lowenthal, Kaylene J. Simpson, Cameron R. Stewart, Andrew G. D. Bean, Lin-Fa Wang

PLOS Pathogens: published March 24, 2016 | https://doi.org/10.1371/journal.ppat.1005478

The Lymphocytic Choriomeningitis Virus Matrix Protein PPXY Late Domain Drives the Production of Defective Interfering Particles

Christopher M. Ziegler, Philip Eisenhauer, Emily A. Bruce, Marion E. Weir, Benjamin R. King, Joseph P. Klaus, Dimitry N. Krementsov, David J. Shirley, Bryan A. Ballif, Jason Botten

PLOS Pathogens: published March 24, 2016 | https://doi.org/10.1371/journal.ppat.1005501

Multiple Lytic Origins of Replication Are Required for Optimal Gammaherpesvirus Fitness In Vitro and In Vivo

Christine Sattler, Beatrix Steer, Heiko Adler

PLOS Pathogens: published March 23, 2016 | https://doi.org/10.1371/journal.ppat.1005510

Activation of Plant Innate Immunity by Extracellular High Mobility Group Box 3 and Its Inhibition by Salicylic Acid

Hyong Woo Choi, Murli Manohar, Patricia Manosalva, Miaoying Tian, Magali Moreau, Daniel F. Klessig

PLOS Pathogens: published March 23, 2016 | https://doi.org/10.1371/journal.ppat.1005518

Regulating a Post-Transcriptional Regulator: Protein Phosphorylation, Degradation and Translational Blockage in Control of the Trypanosome Stress-Response RNA-Binding Protein ZC3H11

Igor Minia, Christine Clayton

PLOS Pathogens: published March 22, 2016 | https://doi.org/10.1371/journal.ppat.1005514

Locally Produced IL-10 Limits Cutaneous Vaccinia Virus Spread

Stephanie S. Cush, Glennys V. Reynoso, Olena Kamenyeva, Jack R. Bennink, Jonathan W. Yewdell, Heather D. Hickman

PLOS Pathogens: published March 18, 2016 | https://doi.org/10.1371/journal.ppat.1005493

Promotion of Expansion and Differentiation of Hematopoietic Stem Cells by Interleukin-27 into Myeloid Progenitors to Control Infection in Emergency Myelopoiesis

Jun-ichi Furusawa, Izuru Mizoguchi, Yukino Chiba, Masayuki Hisada, Fumie Kobayashi, Hiroki Yoshida, Susumu Nakae, Akihiko Tsuchida, Tetsuya Matsumoto, Hideo Ema, Junichiro Mizuguchi, Takayuki Yoshimoto

PLOS Pathogens: published March 18, 2016 | https://doi.org/10.1371/journal.ppat.1005507

In Vivo Molecular Dissection of the Effects of HIV-1 in Active Tuberculosis

Lucy C. K. Bell, Gabriele Pollara, Mellissa Pascoe, Gillian S. Tomlinson, Rannakoe J. Lehloenya, Jennifer Roe, Richard Meldau, Robert F. Miller, Alan Ramsay, Benjamin M. Chain, Keertan Dheda, Mahdad Noursadeghi

PLOS Pathogens: published March 17, 2016 | https://doi.org/10.1371/journal.ppat.1005469

Antigen-Specific Antibody Glycosylation Is Regulated via Vaccination

Alison E. Mahan, Madeleine F. Jennewein, Todd Suscovich, Kendall Dionne, Jacquelynne Tedesco, Amy W. Chung, Hendrik Streeck, Maria Pau, Hanneke Schuitemaker, Don Francis, Patricia Fast, Dagna Laufer, Bruce D. Walker, Lindsey Baden, Dan H. Barouch, Galit Alter

PLOS Pathogens: published March 16, 2016 | https://doi.org/10.1371/journal.ppat.1005456

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Cellular Tracking and Gene Profiling of Fusarium graminearum during Maize Stalk Rot Disease Development Elucidates Its Strategies in Confronting Phosphorus Limitation in the Host Apoplast

Yan Zhang, Juan He, Lei-Jie Jia, Ting-Lu Yuan, Dong Zhang, Yan Guo, Yufeng Wang, Wei-Hua Tang

PLOS Pathogens: published March 14, 2016 | https://doi.org/10.1371/journal.ppat.1005485

PSGL-1 on Leukocytes is a Critical Component of the Host Immune Response against Invasive Pneumococcal Disease

Elisa Ramos-Sevillano, Ana Urzainqui, Belén de Andrés, Rafael González-Tajuelo, Mirian Domenech, Fernando González-Camacho, Francisco Sánchez-Madrid, Jeremy S. Brown, Ernesto García, Jose Yuste

PLOS Pathogens: published March 14, 2016 | https://doi.org/10.1371/journal.ppat.1005500

TIM3 Mediates T Cell Exhaustion during Mycobacterium tuberculosis Infection

Pushpa Jayaraman, Miye K. Jacques, Chen Zhu, Katherine M. Steblenko, Britni L. Stowell, Asaf Madi, Ana C. Anderson, Vijay K. Kuchroo, Samuel M. Behar

PLOS Pathogens: published March 11, 2016 | https://doi.org/10.1371/journal.ppat.1005490

A Functional Bacterium-to-Plant DNA Transfer Machinery of Rhizobium etli

Benoît Lacroix, Vitaly Citovsky

PLOS Pathogens: published March 11, 2016 | https://doi.org/10.1371/journal.ppat.1005502

Experimental Cerebral Malaria Spreads along the Rostral Migratory Stream

Angelika Hoffmann, Johannes Pfeil, Julieta Alfonso, Felix T. Kurz, Felix Sahm, Sabine Heiland, Hannah Monyer, Martin Bendszus, Ann-Kristin Mueller, Xavier Helluy, Mirko Pham

PLOS Pathogens: published March 10, 2016 | https://doi.org/10.1371/journal.ppat.1005470

Quantitative Trait Locus Based Virulence Determinant Mapping of the HSV-1 Genome in Murine Ocular Infection: Genes Involved in Viral Regulatory and Innate Immune Networks Contribute to Virulence

Aaron W. Kolb, Kyubin Lee, Inna Larsen, Mark Craven, Curtis R. Brandt

PLOS Pathogens: published March 10, 2016 | https://doi.org/10.1371/journal.ppat.1005499

Cyclin-Dependent Kinase CRK9, Required for Spliced Leader trans Splicing of Pre-mRNA in Trypanosomes, Functions in a Complex with a New L-Type Cyclin and a Kinetoplastid-Specific Protein

Nitika Badjatia, Sung Hee Park, Daniela L. Ambrósio, Justin K. Kirkham, Arthur Günzl

PLOS Pathogens: published March 8, 2016 | https://doi.org/10.1371/journal.ppat.1005498

Acetylation of Lysine 201 Inhibits the DNA-Binding Ability of PhoP to Regulate Salmonella Virulence

Jie Ren, Yu Sang, Yongcong Tan, Jing Tao, Jinjing Ni, Shuting Liu, Xia Fan, Wei Zhao, Jie Lu, Wenjuan Wu, Yu-Feng Yao

PLOS Pathogens: published March 4, 2016 | https://doi.org/10.1371/journal.ppat.1005458

A Numerically Subdominant CD8 T Cell Response to Matrix Protein of Respiratory Syncytial Virus Controls Infection with Limited Immunopathology

Jie Liu, Elias K. Haddad, Joshua Marceau, Kaitlyn M. Morabito, Srinivas S. Rao, Ali Filali-Mouhim, Rafick-Pierre Sekaly, Barney S. Graham

PLOS Pathogens: published March 4, 2016 | https://doi.org/10.1371/journal.ppat.1005486

The Myeloid LSECtin Is a DAP12-Coupled Receptor That Is Crucial for Inflammatory Response Induced by Ebola Virus Glycoprotein

Dianyuan Zhao, Xintao Han, Xuexing Zheng, Hualei Wang, Zaopeng Yang, Di Liu, Ke Han, Jing Liu, Xiaowen Wang, Wenting Yang, Qingyang Dong, Songtao Yang, Xianzhu Xia, Li Tang, Fuchu He

PLOS Pathogens: published March 4, 2016 | https://doi.org/10.1371/journal.ppat.1005487

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The Bacterial Flagellar Type III Export Gate Complex Is a Dual Fuel Engine That Can Use Both H⁺ and Na⁺ for Flagellar Protein Export

Tohru Minamino, Yusuke V. Morimoto, Noritaka Hara, Phillip D. Aldridge, Keiichi Namba

PLOS Pathogens: published March 4, 2016 | https://doi.org/10.1371/journal.ppat.1005495

Structural Basis for Recognition of Human Enterovirus 71 by a Bivalent Broadly Neutralizing Monoclonal Antibody

Xiaohua Ye, Chen Fan, Zhiqiang Ku, Teng Zuo, Liangliang Kong, Chao Zhang, Jinping Shi, Qingwei Liu, Tan Chen, Yingyi Zhang, Wen Jiang, Linqi Zhang, Zhong Huang, Yao Cong

PLOS Pathogens: published March 3, 2016 | https://doi.org/10.1371/journal.ppat.1005454

When Parasites Are Good for Health: Cestode Parasitism Increases Resistance to Arsenic in Brine Shrimps

Marta I. Sánchez, Inès Pons, Mónica Martínez-Haro, Mark A. Taggart, Thomas Lenormand, Andy J. Green

PLOS Pathogens: published March 3, 2016 | https://doi.org/10.1371/journal.ppat.1005459

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NAD⁺-Glycohydrolase Promotes Intracellular Survival of Group A Streptococcus

Onkar Sharma, Maghnus O’Seaghdha, Jorge J. Velarde, Michael R. Wessels

PLOS Pathogens: published March 3, 2016 | https://doi.org/10.1371/journal.ppat.1005468

Integrated and Total HIV-1 DNA Predict Ex Vivo Viral Outgrowth

Maja Kiselinova, Ward De Spiegelaere, Maria Jose Buzon, Eva Malatinkova, Mathias Lichterfeld, Linos Vandekerckhove

PLOS Pathogens: published March 3, 2016 | https://doi.org/10.1371/journal.ppat.1005472

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Morphology and Molecular Composition of Purified Bovine Viral Diarrhea Virus Envelope

Nathalie Callens, Britta Brügger, Pierre Bonnafous, Hervé Drobecq, Mathias J. Gerl, Thomas Krey, Gleyder Roman-Sosa, Till Rümenapf, Olivier Lambert, Jean Dubuisson, Yves Rouillé

PLOS Pathogens: published March 3, 2016 | https://doi.org/10.1371/journal.ppat.1005476

PKR Transduces MDA5-Dependent Signals for Type I IFN Induction

Alissa M. Pham, Felicia Gilfoy Santa Maria, Tanaya Lahiri, Eugene Friedman, Isabelle J. Marié, David E. Levy

PLOS Pathogens: published March 3, 2016 | https://doi.org/10.1371/journal.ppat.1005489

Defensins Potentiate a Neutralizing Antibody Response to Enteric Viral Infection

Anshu P. Gounder, Nicolle D. Myers, Piper M. Treuting, Beth A. Bromme, Sarah S. Wilson, Mayim E. Wiens, Wuyuan Lu, André J. Ouellette, Katherine R. Spindler, William C. Parks, Jason G. Smith

PLOS Pathogens: published March 2, 2016 | https://doi.org/10.1371/journal.ppat.1005474

A Family of Salmonella Type III Secretion Effector Proteins Selectively Targets the NF-κB Signaling Pathway to Preserve Host Homeostasis

Hui Sun, Jana Kamanova, Maria Lara-Tejero, Jorge E. Galán

PLOS Pathogens: published March 2, 2016 | https://doi.org/10.1371/journal.ppat.1005484