March 2014

A 3D rendering generated using Imaris software (from Bitplane) of an MDCK cell infected with influenza A/WSN/1933 (H1N1) virus with four influenza viral RNA segments identified by fluorescent in situ hybridization: PB2 (red spots), PB1 (green spots), PA (orange spots), and NP (yellow spots). The nucleus is labeled in blue based on DAPI staining. Lakdawala et al.

Image Credit: Seema S. Lakdawala and Juraj Kabat, NIAID, NIH.

Opinions

Viral OTU Deubiquitinases: A Structural and Functional Comparison

Ben A. Bailey-Elkin, Puck B. van Kasteren, Eric J. Snijder, Marjolein Kikkert, Brian L. Mark

PLOS Pathogens: published March 27, 2014 | https://doi.org/10.1371/journal.ppat.1003894

A Missing Dimension in Measures of Vaccination Impacts

M. Gabriela M. Gomes, Marc Lipsitch, Andrew R. Wargo, Gael Kurath, Carlota Rebelo, Graham F. Medley, Antonio Coutinho

PLOS Pathogens: published March 6, 2014 | https://doi.org/10.1371/journal.ppat.1003849

Pearls

Oral Bacteria and Cancer

Sarah E. Whitmore, Richard J. Lamont

PLOS Pathogens: published March 27, 2014 | https://doi.org/10.1371/journal.ppat.1003933

Mycobacteriophages: Windows into Tuberculosis

Graham F. Hatfull

PLOS Pathogens: published March 20, 2014 | https://doi.org/10.1371/journal.ppat.1003953

Conflicting Interests in the Pathogen–Host Tug of War: Fungal Micronutrient Scavenging Versus Mammalian Nutritional Immunity

Joanna Potrykus, Elizabeth R. Ballou, Delma S. Childers, Alistair J. P. Brown

PLOS Pathogens: published March 13, 2014 | https://doi.org/10.1371/journal.ppat.1003910

Putting Fungi to Work: Harvesting a Cornucopia of Drugs, Toxins, and Antibiotics

Ulrich Kück, Sandra Bloemendal, Ines Teichert

PLOS Pathogens: published March 13, 2014 | https://doi.org/10.1371/journal.ppat.1003950

Five Things to Know about Genetically Modified (GM) Insects for Vector Control

Luke Alphey, Nina Alphey

PLOS Pathogens: published March 6, 2014 | https://doi.org/10.1371/journal.ppat.1003909

Review

Plasmodium falciparum Erythrocyte Invasion: Combining Function with Immune Evasion

Gavin J. Wright, Julian C. Rayner

PLOS Pathogens: published March 20, 2014 | https://doi.org/10.1371/journal.ppat.1003943

Research Articles

Rotavirus Activates Lymphocytes from Non-Obese Diabetic Mice by Triggering Toll-Like Receptor 7 Signaling and Interferon Production in Plasmacytoid Dendritic Cells

Jessica A. Pane, Nicole L. Webster, Barbara S. Coulson

PLOS Pathogens: published March 27, 2014 | https://doi.org/10.1371/journal.ppat.1003998

Interferon Regulatory Factor-1 Protects from Fatal Neurotropic Infection with Vesicular Stomatitis Virus by Specific Inhibition of Viral Replication in Neurons

Sharmila Nair, Kristin Michaelsen-Preusse, Katja Finsterbusch, Sabine Stegemann-Koniszewski, Dunja Bruder, Martina Grashoff, Martin Korte, Mario Köster, Ulrich Kalinke, Hansjörg Hauser, Andrea Kröger

PLOS Pathogens: published March 27, 2014 | https://doi.org/10.1371/journal.ppat.1003999

A Cytosolic Chaperone Complexes with Dynamic Membrane J-Proteins and Mobilizes a Nonenveloped Virus out of the Endoplasmic Reticulum

Christopher Paul Walczak, Madhu Sudhan Ravindran, Takamasa Inoue, Billy Tsai

PLOS Pathogens: published March 27, 2014 | https://doi.org/10.1371/journal.ppat.1004007

Broadly Reactive Human CD8 T Cells that Recognize an Epitope Conserved between VZV, HSV and EBV

Christopher Chiu, Megan McCausland, John Sidney, Fuh-Mei Duh, Nadine Rouphael, Aneesh Mehta, Mark Mulligan, Mary Carrington, Andreas Wieland, Nicole L. Sullivan, Adriana Weinberg, Myron J. Levin, Bali Pulendran, Bjoern Peters, Alessandro Sette, Rafi Ahmed

PLOS Pathogens: published March 27, 2014 | https://doi.org/10.1371/journal.ppat.1004008

Crk Adaptors Negatively Regulate Actin Polymerization in Pedestals Formed by Enteropathogenic Escherichia coli (EPEC) by Binding to Tir Effector

Elvira Nieto-Pelegrin, Eugenia Meiler, José Manuel Martín-Villa, María Benito-León, Narcisa Martinez-Quiles

PLOS Pathogens: published March 27, 2014 | https://doi.org/10.1371/journal.ppat.1004022

New Insights into How Yersinia pestis Adapts to Its Mammalian Host during Bubonic Plague

Elizabeth Pradel, Nadine Lemaître, Maud Merchez, Isabelle Ricard, Angéline Reboul, Amélie Dewitte, Florent Sebbane

PLOS Pathogens: published March 27, 2014 | https://doi.org/10.1371/journal.ppat.1004029

An Immunomics Approach to Schistosome Antigen Discovery: Antibody Signatures of Naturally Resistant and Chronically Infected Individuals from Endemic Areas

Soraya Gaze, Patrick Driguez, Mark S. Pearson, Tiago Mendes, Denise L. Doolan, Angela Trieu, Donald P. McManus, Geoffrey N. Gobert, Maria Victoria Periago, Rodrigo Correa Oliveira, Fernanda C. Cardoso, Guilherme Oliveira, Rie Nakajima, Al Jasinskas, Chris Hung, Li Liang, Jozelyn Pablo, Jeffrey M. Bethony, Philip L. Felgner, Alex Loukas

PLOS Pathogens: published March 27, 2014 | https://doi.org/10.1371/journal.ppat.1004033

Structural and Functional Characterization of a Complex between the Acidic Transactivation Domain of EBNA2 and the Tfb1/p62 Subunit of TFIIH

Philippe R. Chabot, Luca Raiola, Mathieu Lussier-Price, Thomas Morse, Genevieve Arseneault, Jacques Archambault, James G. Omichinski

PLOS Pathogens: published March 27, 2014 | https://doi.org/10.1371/journal.ppat.1004042

Two-Component System Cross-Regulation Integrates Bacillus anthracis Response to Heme and Cell Envelope Stress

Laura A. Mike, Jacob E. Choby, Paul R. Brinkman, Lorenzo Q. Olive, Brendan F. Dutter, Samuel J. Ivan, Christopher M. Gibbs, Gary A. Sulikowski, Devin L. Stauff, Eric P. Skaar

PLOS Pathogens: published March 27, 2014 | https://doi.org/10.1371/journal.ppat.1004044

Heterogeneity and Breadth of Host Antibody Response to KSHV Infection Demonstrated by Systematic Analysis of the KSHV Proteome

Nazzarena Labo, Wendell Miley, Vickie Marshall, William Gillette, Dominic Esposito, Matthew Bess, Alexandra Turano, Thomas Uldrick, Mark N. Polizzotto, Kathleen M. Wyvill, Rachel Bagni, Robert Yarchoan, Denise Whitby

PLOS Pathogens: published March 27, 2014 | https://doi.org/10.1371/journal.ppat.1004046

Production, Fate and Pathogenicity of Plasma Microparticles in Murine Cerebral Malaria

Fatima El-Assaad, Julie Wheway, Nicholas H. Hunt, Georges E. R. Grau, Valery Combes

PLOS Pathogens: published March 20, 2014 | https://doi.org/10.1371/journal.ppat.1003839

Infection of Adult Thymus with Murine Retrovirus Induces Virus-Specific Central Tolerance That Prevents Functional Memory CD8⁺ T Cell Differentiation

Shiki Takamura, Eiji Kajiwara, Sachiyo Tsuji-Kawahara, Tomoko Masumoto, Makoto Fujisawa, Maiko Kato, Tomomi Chikaishi, Yuri Kawasaki, Saori Kinoshita, Manami Itoi, Nobuo Sakaguchi, Masaaki Miyazawa

PLOS Pathogens: published March 20, 2014 | https://doi.org/10.1371/journal.ppat.1003937

A Non-Coding RNA Promotes Bacterial Persistence and Decreases Virulence by Regulating a Regulator in Staphylococcus aureus

Cédric Romilly, Claire Lays, Arnaud Tomasini, Isabelle Caldelari, Yvonne Benito, Philippe Hammann, Thomas Geissmann, Sandrine Boisset, Pascale Romby, François Vandenesch

PLOS Pathogens: published March 20, 2014 | https://doi.org/10.1371/journal.ppat.1003979

Activation of HIV-1 from Latent Infection via Synergy of RUNX1 Inhibitor Ro5-3335 and SAHA

Zachary Klase, Venkat S. R. K. Yedavalli, Laurent Houzet, Molly Perkins, Frank Maldarelli, Jason Brenchley, Klaus Strebel, Paul Liu, Kuan-Teh Jeang

PLOS Pathogens: published March 20, 2014 | https://doi.org/10.1371/journal.ppat.1003997

Lack of Detectable HIV-1 Molecular Evolution during Suppressive Antiretroviral Therapy

Mary F. Kearney, Jonathan Spindler, Wei Shao, Sloane Yu, Elizabeth M. Anderson, Angeline O'Shea, Catherine Rehm, Carry Poethke, Nicholas Kovacs, John W. Mellors, John M. Coffin, Frank Maldarelli

PLOS Pathogens: published March 20, 2014 | https://doi.org/10.1371/journal.ppat.1004010

HMGB1-Promoted and TLR2/4-Dependent NK Cell Maturation and Activation Take Part in Rotavirus-Induced Murine Biliary Atresia

Yinrong Qiu, Jixin Yang, Wenmei Wang, Wentao Zhao, Fei Peng, Ying Xiang, Gang Chen, Tao Chen, Chengwei Chai, Shuaiyu Zheng, Daniel J. Watkins, Jiexiong Feng

PLOS Pathogens: published March 20, 2014 | https://doi.org/10.1371/journal.ppat.1004011

DHX36 Enhances RIG-I Signaling by Facilitating PKR-Mediated Antiviral Stress Granule Formation

Ji-Seung Yoo, Kiyohiro Takahasi, Chen Seng Ng, Ryota Ouda, Koji Onomoto, Mitsutoshi Yoneyama, Janice Ching Lai, Simon Lattmann, Yoshikuni Nagamine, Tadashi Matsui, Kuniyoshi Iwabuchi, Hiroki Kato, Takashi Fujita

PLOS Pathogens: published March 20, 2014 | https://doi.org/10.1371/journal.ppat.1004012

Identification of OmpA, a Coxiella burnetii Protein Involved in Host Cell Invasion, by Multi-Phenotypic High-Content Screening

Eric Martinez, Franck Cantet, Laura Fava, Isobel Norville, Matteo Bonazzi

PLOS Pathogens: published March 20, 2014 | https://doi.org/10.1371/journal.ppat.1004013

MAVS-MKK7-JNK2 Defines a Novel Apoptotic Signaling Pathway during Viral Infection

Yuefeng Huang, Heng Liu, Senlin Li, Yijun Tang, Bo Wei, Huansha Yu, Chen Wang

PLOS Pathogens: published March 20, 2014 | https://doi.org/10.1371/journal.ppat.1004020

De novo Fatty Acid Biosynthesis Contributes Significantly to Establishment of a Bioenergetically Favorable Environment for Vaccinia Virus Infection

Matthew D. Greseth, Paula Traktman

PLOS Pathogens: published March 20, 2014 | https://doi.org/10.1371/journal.ppat.1004021

A Compact, Multifunctional Fusion Module Directs Cholesterol-Dependent Homomultimerization and Syncytiogenic Efficiency of Reovirus p10 FAST Proteins

Tim Key, Roy Duncan

PLOS Pathogens: published March 20, 2014 | https://doi.org/10.1371/journal.ppat.1004023

Different Mutagenic Potential of HIV-1 Restriction Factors APOBEC3G and APOBEC3F Is Determined by Distinct Single-Stranded DNA Scanning Mechanisms

Anjuman Ara, Robin P. Love, Linda Chelico

PLOS Pathogens: published March 20, 2014 | https://doi.org/10.1371/journal.ppat.1004024

RON5 Is Critical for Organization and Function of the Toxoplasma Moving Junction Complex

Josh R. Beck, Allan L. Chen, Elliot W. Kim, Peter J. Bradley

PLOS Pathogens: published March 20, 2014 | https://doi.org/10.1371/journal.ppat.1004025

The Role of Host and Microbial Factors in the Pathogenesis of Pneumococcal Bacteraemia Arising from a Single Bacterial Cell Bottleneck

Alice Gerlini, Leonarda Colomba, Leonardo Furi, Tiziana Braccini, Ana Sousa Manso, Andrea Pammolli, Bo Wang, Antonio Vivi, Maria Tassini, Nico van Rooijen, Gianni Pozzi, Susanna Ricci, Peter W. Andrew, Uwe Koedel, E. Richard Moxon, Marco R. Oggioni

PLOS Pathogens: published March 20, 2014 | https://doi.org/10.1371/journal.ppat.1004026

Hepatitis B Virus Infection and Immunopathogenesis in a Humanized Mouse Model: Induction of Human-Specific Liver Fibrosis and M2-Like Macrophages

Moses T. Bility, Liang Cheng, Zheng Zhang, Yan Luan, Feng Li, Liqun Chi, Liguo Zhang, Zhengkun Tu, Yanhang Gao, Yangxin Fu, Junqi Niu, Fusheng Wang, Lishan Su

PLOS Pathogens: published March 20, 2014 | https://doi.org/10.1371/journal.ppat.1004032

IL-1α and Complement Cooperate in Triggering Local Neutrophilic Inflammation in Response to Adenovirus and Eliminating Virus-Containing Cells

Nelson C. Di Paolo, Lisa K. Baldwin, Eric E. Irons, Thalia Papayannopoulou, Stephen Tomlinson, Dmitry M. Shayakhmetov

PLOS Pathogens: published March 20, 2014 | https://doi.org/10.1371/journal.ppat.1004035

Inflammasome Sensor NLRP1 Controls Rat Macrophage Susceptibility to Toxoplasma gondii

Kimberly M. Cirelli, Gezahegn Gorfu, Musa A. Hassan, Morton Printz, Devorah Crown, Stephen H. Leppla, Michael E. Grigg, Jeroen P. J. Saeij, Mahtab Moayeri

PLOS Pathogens: published March 13, 2014 | https://doi.org/10.1371/journal.ppat.1003927

VE-Cadherin Cleavage by LasB Protease from Pseudomonas aeruginosa Facilitates Type III Secretion System Toxicity in Endothelial Cells

Guillaume Golovkine, Eric Faudry, Stéphanie Bouillot, Romé Voulhoux, Ina Attrée, Philippe Huber

PLOS Pathogens: published March 13, 2014 | https://doi.org/10.1371/journal.ppat.1003939

Dimerization of VirD2 Binding Protein Is Essential for Agrobacterium Induced Tumor Formation in Plants

Abhilash Padavannil, Chacko Jobichen, Yang Qinghua, Jayaraman Seetharaman, Adrian Velazquez-Campoy, Liu Yang, Shen Q. Pan, J. Sivaraman

PLOS Pathogens: published March 13, 2014 | https://doi.org/10.1371/journal.ppat.1003948

Caspase-1-Dependent and -Independent Cell Death Pathways in Burkholderia pseudomallei Infection of Macrophages

Antje Bast, Kathrin Krause, Imke H. E. Schmidt, Matsayapan Pudla, Stefanie Brakopp, Verena Hopf, Katrin Breitbach, Ivo Steinmetz

PLOS Pathogens: published March 13, 2014 | https://doi.org/10.1371/journal.ppat.1003986

Eosinophils Are Important for Protection, Immunoregulation and Pathology during Infection with Nematode Microfilariae

Emma T. Cadman, Katherine A. Thysse, Siobhan Bearder, Anita Y. N. Cheung, Ashleigh C. Johnston, James J. Lee, Rachel A. Lawrence

PLOS Pathogens: published March 13, 2014 | https://doi.org/10.1371/journal.ppat.1003988

Fha Interaction with Phosphothreonine of TssL Activates Type VI Secretion in Agrobacterium tumefaciens

Jer-Sheng Lin, Hsin-Hui Wu, Pang-Hung Hsu, Lay-Sun Ma, Yin-Yuin Pang, Ming-Daw Tsai, Erh-Min Lai

PLOS Pathogens: published March 13, 2014 | https://doi.org/10.1371/journal.ppat.1003991

Immune Suppression by Neutrophils in HIV-1 Infection: Role of PD-L1/PD-1 Pathway

Nathan L. Bowers, E. Scott Helton, Richard P. H. Huijbregts, Paul A. Goepfert, Sonya L. Heath, Zdenek Hel

PLOS Pathogens: published March 13, 2014 | https://doi.org/10.1371/journal.ppat.1003993

Modulation of Phagosomal pH by Candida albicans Promotes Hyphal Morphogenesis and Requires Stp2p, a Regulator of Amino Acid Transport

Slavena Vylkova, Michael C. Lorenz

PLOS Pathogens: published March 13, 2014 | https://doi.org/10.1371/journal.ppat.1003995

Oral Mycobiome Analysis of HIV-Infected Patients: Identification of Pichia as an Antagonist of Opportunistic Fungi

Pranab K. Mukherjee, Jyotsna Chandra, Mauricio Retuerto, Masoumeh Sikaroodi, Robert E. Brown, Richard Jurevic, Robert A. Salata, Michael M. Lederman, Patrick M. Gillevet, Mahmoud A. Ghannoum

PLOS Pathogens: published March 13, 2014 | https://doi.org/10.1371/journal.ppat.1003996

Cytomegalovirus m154 Hinders CD48 Cell-Surface Expression and Promotes Viral Escape from Host Natural Killer Cell Control

Angela Zarama, Natàlia Pérez-Carmona, Domènec Farré, Adriana Tomic, Eva Maria Borst, Martin Messerle, Stipan Jonjic, Pablo Engel, Ana Angulo

PLOS Pathogens: published March 13, 2014 | https://doi.org/10.1371/journal.ppat.1004000

Foodborne Transmission of Nipah Virus in Syrian Hamsters

Emmie de Wit, Joseph Prescott, Darryl Falzarano, Trenton Bushmaker, Dana Scott, Heinz Feldmann, Vincent J. Munster

PLOS Pathogens: published March 13, 2014 | https://doi.org/10.1371/journal.ppat.1004001

Adaptive Gene Amplification As an Intermediate Step in the Expansion of Virus Host Range

Greg Brennan, Jacob O. Kitzman, Stefan Rothenburg, Jay Shendure, Adam P. Geballe

PLOS Pathogens: published March 13, 2014 | https://doi.org/10.1371/journal.ppat.1004002

Intracellular Theileria annulata Promote Invasive Cell Motility through Kinase Regulation of the Host Actin Cytoskeleton

Min Ma, Martin Baumgartner

PLOS Pathogens: published March 13, 2014 | https://doi.org/10.1371/journal.ppat.1004003

A Model System for Studying the Transcriptomic and Physiological Changes Associated with Mammalian Host-Adaptation by Leptospira interrogans Serovar Copenhageni

Melissa J. Caimano, Sathesh K. Sivasankaran, Anna Allard, Daniel Hurley, Karsten Hokamp, André A. Grassmann, Jay C. D. Hinton, Jarlath E. Nally

PLOS Pathogens: published March 13, 2014 | https://doi.org/10.1371/journal.ppat.1004004

Clonality of HTLV-2 in Natural Infection

Anat Melamed, Aviva D. Witkover, Daniel J. Laydon, Rachael Brown, Kristin Ladell, Kelly Miners, Aileen G. Rowan, Niall Gormley, David A. Price, Graham P. Taylor, Edward L. Murphy, Charles R. M. Bangham

PLOS Pathogens: published March 13, 2014 | https://doi.org/10.1371/journal.ppat.1004006

Genetic Dissection of Anopheles gambiae Gut Epithelial Responses to Serratia marcescens

Stavros Stathopoulos, Daniel E. Neafsey, Mara K. N. Lawniczak, Marc A. T. Muskavitch, George K. Christophides

PLOS Pathogens: published March 6, 2014 | https://doi.org/10.1371/journal.ppat.1003897

Group B Streptococcal Infection of the Choriodecidua Induces Dysfunction of the Cytokeratin Network in Amniotic Epithelium: A Pathway to Membrane Weakening

Jeroen P. Vanderhoeven, Craig J. Bierle, Raj P. Kapur, Ryan M. McAdams, Richard P. Beyer, Theo K. Bammler, Federico M. Farin, Aasthaa Bansal, Min Spencer, Mei Deng, Michael G. Gravett, Craig E. Rubens, Lakshmi Rajagopal, Kristina M. Adams Waldorf

PLOS Pathogens: published March 6, 2014 | https://doi.org/10.1371/journal.ppat.1003920

In Vivo Administration of a JAK3 Inhibitor during Acute SIV Infection Leads to Significant Increases in Viral Load during Chronic Infection

Yoshiaki Takahashi, Siddappa N. Byrareddy, Christina Albrecht, Markus Brameier, Lutz Walter, Ann E. Mayne, Paul Dunbar, Robert Russo, Dawn M. Little, Tara Villinger, Ladawan Khowawisetsut, Kovit Pattanapanyasat, Francois Villinger, Aftab A. Ansari

PLOS Pathogens: published March 6, 2014 | https://doi.org/10.1371/journal.ppat.1003929

A Polysaccharide Virulence Factor from Aspergillus fumigatus Elicits Anti-inflammatory Effects through Induction of Interleukin-1 Receptor Antagonist

Mark S. Gresnigt, Silvia Bozza, Katharina L. Becker, Leo A. B. Joosten, Shahla Abdollahi-Roodsaz, Wim B. van der Berg, Charles A. Dinarello, Mihai G. Netea, Thierry Fontaine, Antonella De Luca, Silvia Moretti, Luigina Romani, Jean-Paul Latge, Frank L. van de Veerdonk

PLOS Pathogens: published March 6, 2014 | https://doi.org/10.1371/journal.ppat.1003936

Gambiense Human African Trypanosomiasis and Immunological Memory: Effect on Phenotypic Lymphocyte Profiles and Humoral Immunity

Veerle Lejon, Dieudonné Mumba Ngoyi, Luc Kestens, Luc Boel, Barbara Barbé, Victor Kande Betu, Johan van Griensven, Emmanuel Bottieau, Jean-Jacques Muyembe Tamfum, Jan Jacobs, Philippe Büscher

PLOS Pathogens: published March 6, 2014 | https://doi.org/10.1371/journal.ppat.1003947

Transovarial Transmission of a Plant Virus Is Mediated by Vitellogenin of Its Insect Vector

Yan Huo, Wenwen Liu, Fujie Zhang, Xiaoying Chen, Li Li, Qifei Liu, Yijun Zhou, Taiyun Wei, Rongxiang Fang, Xifeng Wang

PLOS Pathogens: published March 6, 2014 | https://doi.org/10.1371/journal.ppat.1003949

Porphyromonas gingivalis and Treponema denticola Exhibit Metabolic Symbioses

Kheng H. Tan, Christine A. Seers, Stuart G. Dashper, Helen L. Mitchell, James S. Pyke, Vincent Meuric, Nada Slakeski, Steven M. Cleal, Jenny L. Chambers, Malcolm J. McConville, Eric C. Reynolds

PLOS Pathogens: published March 6, 2014 | https://doi.org/10.1371/journal.ppat.1003955

Oncogenic Human Papillomaviruses Activate the Tumor-Associated Lens Epithelial-Derived Growth Factor (LEDGF) Gene

Jenny Leitz, Miriam Reuschenbach, Claudia Lohrey, Anja Honegger, Rosita Accardi, Massimo Tommasino, Manuel Llano, Magnus von Knebel Doeberitz, Karin Hoppe-Seyler, Felix Hoppe-Seyler

PLOS Pathogens: published March 6, 2014 | https://doi.org/10.1371/journal.ppat.1003957

Target Cell Availability, Rather than Breast Milk Factors, Dictates Mother-to-Infant Transmission of SIV in Sooty Mangabeys and Rhesus Macaques

Ann Chahroudi, Emily Cartwright, S. Thera Lee, Maud Mavigner, Diane G. Carnathan, Benton Lawson, Paul M. Carnathan, Tayebeh Hashempoor, Megan K. Murphy, Tracy Meeker, Stephanie Ehnert, Christopher Souder, James G. Else, Joyce Cohen, Ronald G. Collman, Thomas H. Vanderford, Sallie R. Permar, Cynthia A. Derdeyn, Francois Villinger, Guido Silvestri

PLOS Pathogens: published March 6, 2014 | https://doi.org/10.1371/journal.ppat.1003958

The Herpes Virus Fc Receptor gE-gI Mediates Antibody Bipolar Bridging to Clear Viral Antigens from the Cell Surface

Blaise Ndjamen, Alexander H. Farley, Terri Lee, Scott E. Fraser, Pamela J. Bjorkman

PLOS Pathogens: published March 6, 2014 | https://doi.org/10.1371/journal.ppat.1003961

Evolution of the Retroviral Restriction Gene Fv1: Inhibition of Non-MLV Retroviruses

Melvyn W. Yap, Emily Colbeck, Scott A. Ellis, Jonathan P. Stoye

PLOS Pathogens: published March 6, 2014 | https://doi.org/10.1371/journal.ppat.1003968

Influenza A Virus Assembly Intermediates Fuse in the Cytoplasm

Seema S. Lakdawala, Yicong Wu, Peter Wawrzusin, Juraj Kabat, Andrew J. Broadbent, Elaine W. Lamirande, Ervin Fodor, Nihal Altan-Bonnet, Hari Shroff, Kanta Subbarao

PLOS Pathogens: published March 6, 2014 | https://doi.org/10.1371/journal.ppat.1003971

Chronic Exposure to Type-I IFN under Lymphopenic Conditions Alters CD4 T Cell Homeostasis

Cecile Le Saout, Rebecca B. Hasley, Hiromi Imamichi, Lueng Tcheung, Zonghui Hu, Megan A. Luckey, Jung-Hyun Park, Scott K. Durum, Mindy Smith, Adam W. Rupert, Michael C. Sneller, H. Clifford Lane, Marta Catalfamo

PLOS Pathogens: published March 6, 2014 | https://doi.org/10.1371/journal.ppat.1003976

Crystal Structure of the Vaccinia Virus DNA Polymerase Holoenzyme Subunit D4 in Complex with the A20 N-Terminal Domain

Céline Contesto-Richefeu, Nicolas Tarbouriech, Xavier Brazzolotto, Stéphane Betzi, Xavier Morelli, Wim P. Burmeister, Frédéric Iseni

PLOS Pathogens: published March 6, 2014 | https://doi.org/10.1371/journal.ppat.1003978

PPARγ Agonists Improve Survival and Neurocognitive Outcomes in Experimental Cerebral Malaria and Induce Neuroprotective Pathways in Human Malaria

Lena Serghides, Chloe R. McDonald, Ziyue Lu, Miriam Friedel, Cheryl Cui, Keith T. Ho, Howard T. J. Mount, John G. Sled, Kevin C. Kain

PLOS Pathogens: published March 6, 2014 | https://doi.org/10.1371/journal.ppat.1003980

ChIP-Seq and RNA-Seq Reveal an AmrZ-Mediated Mechanism for Cyclic di-GMP Synthesis and Biofilm Development by Pseudomonas aeruginosa

Christopher J. Jones, David Newsom, Benjamin Kelly, Yasuhiko Irie, Laura K. Jennings, Binjie Xu, Dominique H. Limoli, Joe J. Harrison, Matthew R. Parsek, Peter White, Daniel J. Wozniak

PLOS Pathogens: published March 6, 2014 | https://doi.org/10.1371/journal.ppat.1003984

Corrections

Correction: The Chlamydia trachomatis Type III Secretion Chaperone Slc1 Engages Multiple Early Effectors, Including TepP, a Tyrosine-phosphorylated Protein Required for the Recruitment of CrkI-II to Nascent Inclusions and Innate Immune Signaling

The PLOS Pathogens Staff

PLOS Pathogens: published March 26, 2014 | https://doi.org/10.1371/journal.ppat.1004094

Correction: Human Genome-Wide RNAi Screen Identifies an Essential Role for Inositol Pyrophosphates in Type-I Interferon Response

The PLOS Pathogens Staff

PLOS Pathogens: published March 26, 2014 | https://doi.org/10.1371/journal.ppat.1004095

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Visualization of four distinct influenza viral RNA segments within a single cell.

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