April 2013

Helminths are very successful at regulating host immune responses to evade rejection and as a consequence may also protect the host from certain autoimmune diseases. Clinical trials are underway to determine if reintroducing helminths to patients may be a viable therapeutic strategy. In a Pearls article, Girgis et al. review features of the immune response against helminths, focusing in particular on immune regulation. The picture shows Trichuris trichiura eggs inside a female worm from an infected individual.

Image Credit: Kimberley Evason, UCSF School of Medicine, Department of Pathology

Opinion

p53 Protein Isoforms: Key Regulators in the Front Line of Pathogen Infections?

Olivier Terrier, Jean-Christophe Bourdon, Manuel Rosa-Calatrava

PLOS Pathogens: published April 4, 2013 | https://doi.org/10.1371/journal.ppat.1003246

Pearls

Have It Your Way: How Polymorphic, Injected Kinases and Pseudokinases Enable Toxoplasma to Subvert Host Defenses

John C. Boothroyd

PLOS Pathogens: published April 25, 2013 | https://doi.org/10.1371/journal.ppat.1003296

Immune Regulation during Helminth Infections

Natasha M. Girgis, Uma Mahesh Gundra, P'ng Loke

PLOS Pathogens: published April 18, 2013 | https://doi.org/10.1371/journal.ppat.1003250

A Disconnect between the Neurospirochetoses in Humans and Rodent Models of Disease

Juan C. Garcia-Monco, Jorge L. Benach

PLOS Pathogens: published April 11, 2013 | https://doi.org/10.1371/journal.ppat.1003288

Parasites FeS Up: Iron-Sulfur Cluster Biogenesis in Eukaryotic Pathogens

Teegan A. Dellibovi-Ragheb, Jolyn E. Gisselberg, Sean T. Prigge

PLOS Pathogens: published April 4, 2013 | https://doi.org/10.1371/journal.ppat.1003227

Review

Vaccination Strategies against Highly Pathogenic Arenaviruses: The Next Steps toward Clinical Trials

Stephan Ölschläger, Lukas Flatz

PLOS Pathogens: published April 11, 2013 | https://doi.org/10.1371/journal.ppat.1003212

Research Articles

HCV-Induced miR-21 Contributes to Evasion of Host Immune System by Targeting MyD88 and IRAK1

Yanni Chen, Junbo Chen, Hui Wang, Jingjing Shi, Kailang Wu, Shi Liu, Yingle Liu, Jianguo Wu

PLOS Pathogens: published April 25, 2013 | https://doi.org/10.1371/journal.ppat.1003248

The Mnn2 Mannosyltransferase Family Modulates Mannoprotein Fibril Length, Immune Recognition and Virulence of Candida albicans

Rebecca A. Hall, Steven Bates, Megan D. Lenardon, Donna M. MacCallum, Jeanette Wagener, Douglas W. Lowman, Michael D. Kruppa, David L. Williams, Frank C. Odds, Alistair J. P. Brown, Neil A. R. Gow

PLOS Pathogens: published April 25, 2013 | https://doi.org/10.1371/journal.ppat.1003276

Systems Analysis of a RIG-I Agonist Inducing Broad Spectrum Inhibition of Virus Infectivity

Marie-Line Goulet, David Olagnier, Zhengyun Xu, Suzanne Paz, S. Mehdi Belgnaoui, Erin I. Lafferty, Valérie Janelle, Meztli Arguello, Marilene Paquet, Khader Ghneim, Stephanie Richards, Andrew Smith, Peter Wilkinson, Mark Cameron, Ulrich Kalinke, Salman Qureshi, Alain Lamarre, Elias K. Haddad, Rafick Pierre Sekaly, Suraj Peri, Siddharth Balachandran, Rongtuan Lin, John Hiscott

PLOS Pathogens: published April 25, 2013 | https://doi.org/10.1371/journal.ppat.1003298

Vpu Binds Directly to Tetherin and Displaces It from Nascent Virions

Matthew W. McNatt, Trinity Zang, Paul D. Bieniasz

PLOS Pathogens: published April 25, 2013 | https://doi.org/10.1371/journal.ppat.1003299

Parallel Exploitation of Diverse Host Nutrients Enhances Salmonella Virulence

Benjamin Steeb, Beatrice Claudi, Neil A. Burton, Petra Tienz, Alexander Schmidt, Hesso Farhan, Alain Mazé, Dirk Bumann

PLOS Pathogens: published April 25, 2013 | https://doi.org/10.1371/journal.ppat.1003301

A Refined Model of the Prototypical Salmonella SPI-1 T3SS Basal Body Reveals the Molecular Basis for Its Assembly

Julien R. C. Bergeron, Liam J. Worrall, Nikolaos G. Sgourakis, Frank DiMaio, Richard A. Pfuetzner, Heather B. Felise, Marija Vuckovic, Angel C. Yu, Samuel I. Miller, David Baker, Natalie C. J. Strynadka

PLOS Pathogens: published April 25, 2013 | https://doi.org/10.1371/journal.ppat.1003307

Regulatory T Cells Negatively Affect IL-2 Production of Effector T Cells through CD39/Adenosine Pathway in HIV Infection

Mohammad-Ali Jenabian, Nabila Seddiki, Ahmad Yatim, Matthieu Carriere, Anne Hulin, Mehwish Younas, Elnaz Ghadimi, Ayrin Kök, Jean-Pierre Routy, Alain Tremblay, Jean Sévigny, Jean-Daniel Lelievre, Yves Levy

PLOS Pathogens: published April 25, 2013 | https://doi.org/10.1371/journal.ppat.1003319

Guanylate-binding Protein 1 (Gbp1) Contributes to Cell-autonomous Immunity against Toxoplasma gondii

Elizabeth M. Selleck, Sarah J. Fentress, Wandy L. Beatty, Daniel Degrandi, Klaus Pfeffer, Herbert W. Virgin IV, John D. MacMicking, L. David Sibley

PLOS Pathogens: published April 25, 2013 | https://doi.org/10.1371/journal.ppat.1003320

Complex Structure of OspI and Ubc13: The Molecular Basis of Ubc13 Deamidation and Convergence of Bacterial and Host E2 Recognition

Panhan Fu, Xiaoqing Zhang, Mengmeng Jin, Li Xu, Chong Wang, Zongping Xia, Yongqun Zhu

PLOS Pathogens: published April 25, 2013 | https://doi.org/10.1371/journal.ppat.1003322

Early Apoptosis of Macrophages Modulated by Injection of Yersinia pestis YopK Promotes Progression of Primary Pneumonic Plague

Kristen N. Peters, Miqdad O. Dhariwala, Jennifer M. Hughes Hanks, Charles R. Brown, Deborah M. Anderson

PLOS Pathogens: published April 25, 2013 | https://doi.org/10.1371/journal.ppat.1003324

The Chlamydia pneumoniae Invasin Protein Pmp21 Recruits the EGF Receptor for Host Cell Entry

Katja Mölleken, Elisabeth Becker, Johannes H. Hegemann

PLOS Pathogens: published April 25, 2013 | https://doi.org/10.1371/journal.ppat.1003325

Immunodomination during Peripheral Vaccinia Virus Infection

Leon C. W. Lin, Inge E. A. Flesch, David C. Tscharke

PLOS Pathogens: published April 25, 2013 | https://doi.org/10.1371/journal.ppat.1003329

IL-1β Production through the NLRP3 Inflammasome by Hepatic Macrophages Links Hepatitis C Virus Infection with Liver Inflammation and Disease

Amina A. Negash, Hilario J. Ramos, Nanette Crochet, Daryl T. Y. Lau, Brian Doehle, Neven Papic, Don A. Delker, Juandy Jo, Antonio Bertoletti, Curt H. Hagedorn, Michael Gale Jr

PLOS Pathogens: published April 25, 2013 | https://doi.org/10.1371/journal.ppat.1003330

OncomiR Addiction Is Generated by a miR-155 Feedback Loop in Theileria-Transformed Leukocytes

Justine Marsolier, Sandra Pineau, Souhila Medjkane, Martine Perichon, Qinyan Yin, Erik Flemington, Matthew D. Weitzman, Jonathan B. Weitzman

PLOS Pathogens: published April 18, 2013 | https://doi.org/10.1371/journal.ppat.1003222

Salmonella Uses Energy Taxis to Benefit from Intestinal Inflammation

Fabian Rivera-Chávez, Sebastian E. Winter, Christopher A. Lopez, Mariana N. Xavier, Maria G. Winter, Sean-Paul Nuccio, Joseph M. Russell, Richard C. Laughlin, Sara D. Lawhon, Torsten Sterzenbach, Charles L. Bevins, Renée M. Tsolis, Rasika Harshey, L. Garry Adams, Andreas J. Bäumler

PLOS Pathogens: published April 18, 2013 | https://doi.org/10.1371/journal.ppat.1003267

Puf Mediates Translation Repression of Transmission-Blocking Vaccine Candidates in Malaria Parasites

Jun Miao, Qi Fan, Daniel Parker, Xiaolian Li, Jianyong Li, Liwang Cui

PLOS Pathogens: published April 18, 2013 | https://doi.org/10.1371/journal.ppat.1003268

Defining the Conformational Features of Anchorless, Poorly Neuroinvasive Prions

Cyrus Bett, Tim D. Kurt, Melanie Lucero, Margarita Trejo, Annemieke J. Rozemuller, Qingzhong Kong, K. Peter R. Nilsson, Eliezer Masliah, Michael B. Oldstone, Christina J. Sigurdson

PLOS Pathogens: published April 18, 2013 | https://doi.org/10.1371/journal.ppat.1003280

A Mechanistic Paradigm for Broad-Spectrum Antivirals that Target Virus-Cell Fusion

Frederic Vigant, Jihye Lee, Axel Hollmann, Lukas B. Tanner, Zeynep Akyol Ataman, Tatyana Yun, Guanghou Shui, Hector C. Aguilar, Dong Zhang, David Meriwether, Gleyder Roman-Sosa, Lindsey R. Robinson, Terry L. Juelich, Hubert Buczkowski, Sunwen Chou, Miguel A. R. B. Castanho, Mike C. Wolf, Jennifer K. Smith, Ashley Banyard, Margaret Kielian, Srinivasa Reddy, Markus R. Wenk, Matthias Selke, Nuno C. Santos, Alexander N. Freiberg, Michael E. Jung, Benhur Lee

PLOS Pathogens: published April 18, 2013 | https://doi.org/10.1371/journal.ppat.1003297

Genetic Control of Conventional and Pheromone-Stimulated Biofilm Formation in Candida albicans

Ching-Hsuan Lin, Shail Kabrawala, Emily P. Fox, Clarissa J. Nobile, Alexander D. Johnson, Richard J. Bennett

PLOS Pathogens: published April 18, 2013 | https://doi.org/10.1371/journal.ppat.1003305

IgG Subclass and Heavy Chain Domains Contribute to Binding and Protection by mAbs to the Poly γ-D-glutamic Acid Capsular Antigen of Bacillus anthracis

Maria Hovenden, Mark A. Hubbard, David P. AuCoin, Peter Thorkildson, Dana E. Reed, William H. Welch, C. Rick Lyons, Julie A. Lovchik, Thomas R. Kozel

PLOS Pathogens: published April 18, 2013 | https://doi.org/10.1371/journal.ppat.1003306

Microbes Bind Complement Inhibitor Factor H via a Common Site

T. Meri, H. Amdahl, M. J. Lehtinen, S. Hyvärinen, J. V. McDowell, A. Bhattacharjee, S. Meri, R. Marconi, A. Goldman, T. S. Jokiranta

PLOS Pathogens: published April 18, 2013 | https://doi.org/10.1371/journal.ppat.1003308

Accelerated In Vivo Proliferation of Memory Phenotype CD4⁺ T-cells in Human HIV-1 Infection Irrespective of Viral Chemokine Co-receptor Tropism

Yan Zhang, Catherine de Lara, Andrew Worth, Andrea Hegedus, Karoliina Laamanen, Peter Beverley, Derek Macallan

PLOS Pathogens: published April 18, 2013 | https://doi.org/10.1371/journal.ppat.1003310

Development of a Highly Protective Combination Monoclonal Antibody Therapy against Chikungunya Virus

Pankaj Pal, Kimberly A. Dowd, James D. Brien, Melissa A. Edeling, Sergey Gorlatov, Syd Johnson, Iris Lee, Wataru Akahata, Gary J. Nabel, Mareike K. S. Richter, Jolanda M. Smit, Daved H. Fremont, Theodore C. Pierson, Mark T. Heise, Michael S. Diamond

PLOS Pathogens: published April 18, 2013 | https://doi.org/10.1371/journal.ppat.1003312

Mutations in FLS2 Ser-938 Dissect Signaling Activation in FLS2-Mediated Arabidopsis Immunity

Yangrong Cao, David J. Aceti, Grzegorz Sabat, Junqi Song, Shin-ichi Makino, Brian G. Fox, Andrew F. Bent

PLOS Pathogens: published April 18, 2013 | https://doi.org/10.1371/journal.ppat.1003313

Differential Adaptation of Candida albicans In Vivo Modulates Immune Recognition by Dectin-1

Mohlopheni J. Marakalala, Simon Vautier, Joanna Potrykus, Louise A. Walker, Kelly M. Shepardson, Alex Hopke, Hector M. Mora-Montes, Ann Kerrigan, Mihai G. Netea, Graeme I. Murray, Donna M. MacCallum, Robert Wheeler, Carol A. Munro, Neil A. R. Gow, Robert A. Cramer, Alistair J. P. Brown, Gordon D. Brown

PLOS Pathogens: published April 18, 2013 | https://doi.org/10.1371/journal.ppat.1003315

Hepatitis C Virus Pathogen Associated Molecular Pattern (PAMP) Triggers Production of Lambda-Interferons by Human Plasmacytoid Dendritic Cells

Amy E. L. Stone, Silvia Giugliano, Gretja Schnell, Linling Cheng, Katelyn F. Leahy, Lucy Golden-Mason, Michael Gale Jr, Hugo R. Rosen

PLOS Pathogens: published April 18, 2013 | https://doi.org/10.1371/journal.ppat.1003316

A Single Amino Acid Substitution in the Group 1 Trypanosoma brucei gambiense Haptoglobin-Hemoglobin Receptor Abolishes TLF-1 Binding

E. DeJesus, R. Kieft, B. Albright, N. A. Stephens, S. L. Hajduk

PLOS Pathogens: published April 18, 2013 | https://doi.org/10.1371/journal.ppat.1003317

Trypanosome Infection Establishment in the Tsetse Fly Gut Is Influenced by Microbiome-Regulated Host Immune Barriers

Brian L. Weiss, Jingwen Wang, Michele A. Maltz, Yineng Wu, Serap Aksoy

PLOS Pathogens: published April 18, 2013 | https://doi.org/10.1371/journal.ppat.1003318

Factor H Binds to the Hypervariable Region of Many Streptococcus pyogenes M Proteins but Does Not Promote Phagocytosis Resistance or Acute Virulence

Mattias C. U. Gustafsson, Jonas Lannergård, O. Rickard Nilsson, Bodil M. Kristensen, John E. Olsen, Claire L. Harris, Rafael L. Ufret-Vincenty, Margaretha Stålhammar-Carlemalm, Gunnar Lindahl

PLOS Pathogens: published April 18, 2013 | https://doi.org/10.1371/journal.ppat.1003323

The Serine Phosphatase SerB of Porphyromonas gingivalis Suppresses IL-8 Production by Dephosphorylation of NF-κB RelA/p65

Hiroki Takeuchi, Takanori Hirano, Sarah E. Whitmore, Ichijiro Morisaki, Atsuo Amano, Richard J. Lamont

PLOS Pathogens: published April 18, 2013 | https://doi.org/10.1371/journal.ppat.1003326

Increased CD8+ T Cell Response to Epstein-Barr Virus Lytic Antigens in the Active Phase of Multiple Sclerosis

Daniela F. Angelini, Barbara Serafini, Eleonora Piras, Martina Severa, Eliana M. Coccia, Barbara Rosicarelli, Serena Ruggieri, Claudio Gasperini, Fabio Buttari, Diego Centonze, Rosella Mechelli, Marco Salvetti, Giovanna Borsellino, Francesca Aloisi, Luca Battistini

PLOS Pathogens: published April 11, 2013 | https://doi.org/10.1371/journal.ppat.1003220

Caveolin-1 Protects B6129 Mice against Helicobacter pylori Gastritis

Ivana Hitkova, Gang Yuan, Florian Anderl, Markus Gerhard, Thomas Kirchner, Simone Reu, Christoph Röcken, Claus Schäfer, Roland M. Schmid, Roger Vogelmann, Matthias P. A. Ebert, Elke Burgermeister

PLOS Pathogens: published April 11, 2013 | https://doi.org/10.1371/journal.ppat.1003251

Type I IFN Triggers RIG-I/TLR3/NLRP3-dependent Inflammasome Activation in Influenza A Virus Infected Cells

Julien Pothlichet, Isabelle Meunier, Beckley K. Davis, Jenny P-Y. Ting, Emil Skamene, Veronika von Messling, Silvia M. Vidal

PLOS Pathogens: published April 11, 2013 | https://doi.org/10.1371/journal.ppat.1003256

Cell Death Control: The Interplay of Apoptosis and Autophagy in the Pathogenicity of Sclerotinia sclerotiorum

Mehdi Kabbage, Brett Williams, Martin B. Dickman

PLOS Pathogens: published April 11, 2013 | https://doi.org/10.1371/journal.ppat.1003287

Low-Volume Toolbox for the Discovery of Immunosuppressive Fungal Secondary Metabolites

Erwin Berthier, Fang Yun Lim, Qing Deng, Chun-Jun Guo, Dimitrios P. Kontoyiannis, Clay C. C. Wang, Julie Rindy, David J. Beebe, Anna Huttenlocher, Nancy P. Keller

PLOS Pathogens: published April 11, 2013 | https://doi.org/10.1371/journal.ppat.1003289

Interferon-Inducible Mechanism of Dendritic Cell-Mediated HIV-1 Dissemination Is Dependent on Siglec-1/CD169

Wendy Blay Puryear, Hisashi Akiyama, Suzanne D. Geer, Nora P. Ramirez, Xinwei Yu, Björn M. Reinhard, Suryaram Gummuluru

PLOS Pathogens: published April 11, 2013 | https://doi.org/10.1371/journal.ppat.1003291

IL-27 Receptor Signalling Restricts the Formation of Pathogenic, Terminally Differentiated Th1 Cells during Malaria Infection by Repressing IL-12 Dependent Signals

Ana Villegas-Mendez, J. Brian de Souza, Seen-Wai Lavelle, Emily Gwyer Findlay, Tovah N. Shaw, Nico van Rooijen, Christiaan J. Saris, Christopher A. Hunter, Eleanor M. Riley, Kevin N. Couper

PLOS Pathogens: published April 11, 2013 | https://doi.org/10.1371/journal.ppat.1003293

Lipid Droplet-Binding Protein TIP47 Regulates Hepatitis C Virus RNA Replication through Interaction with the Viral NS5A Protein

Dorothee A. Vogt, Grégory Camus, Eva Herker, Brian R. Webster, Chia-Lin Tsou, Warner C. Greene, Tien-Sze Benedict Yen, Melanie Ott

PLOS Pathogens: published April 11, 2013 | https://doi.org/10.1371/journal.ppat.1003302

Host Cell Entry of Respiratory Syncytial Virus Involves Macropinocytosis Followed by Proteolytic Activation of the F Protein

Magdalena Anna Krzyzaniak, Michael Thomas Zumstein, Juan Atilio Gerez, Paola Picotti, Ari Helenius

PLOS Pathogens: published April 11, 2013 | https://doi.org/10.1371/journal.ppat.1003309

Allosteric Modulation of the HIV-1 gp120-gp41 Association Site by Adjacent gp120 Variable Region 1 (V1) N-Glycans Linked to Neutralization Sensitivity

Heidi E. Drummer, Melissa K. Hill, Anne L. Maerz, Stephanie Wood, Paul A. Ramsland, Johnson Mak, Pantelis Poumbourios

PLOS Pathogens: published April 4, 2013 | https://doi.org/10.1371/journal.ppat.1003218

Brain Inositol Is a Novel Stimulator for Promoting Cryptococcus Penetration of the Blood-Brain Barrier

Tong-Bao Liu, Jong-Chul Kim, Yina Wang, Dena L. Toffaletti, Eliseo Eugenin, John R. Perfect, Kee Jun Kim, Chaoyang Xue

PLOS Pathogens: published April 4, 2013 | https://doi.org/10.1371/journal.ppat.1003247

Human Cytomegalovirus Infection Elicits New Decidual Natural Killer Cell Effector Functions

Johan Siewiera, Hicham El Costa, Julie Tabiasco, Alain Berrebi, Géraldine Cartron, Philippe Bouteiller, Nabila Jabrane-Ferrat

PLOS Pathogens: published April 4, 2013 | https://doi.org/10.1371/journal.ppat.1003257

Release of Luminal Exosomes Contributes to TLR4-Mediated Epithelial Antimicrobial Defense

Guoku Hu, Ai-Yu Gong, Amanda L. Roth, Bing Q. Huang, Honorine D. Ward, Guan Zhu, Nicholas F. LaRusso, Nancy D. Hanson, Xian-Ming Chen

PLOS Pathogens: published April 4, 2013 | https://doi.org/10.1371/journal.ppat.1003261

Strongyloidiasis and Infective Dermatitis Alter Human T Lymphotropic Virus-1 Clonality in vivo

Nicolas A. Gillet, Lucy Cook, Daniel J. Laydon, Carol Hlela, Kristien Verdonck, Carolina Alvarez, Eduardo Gotuzzo, Daniel Clark, Lourdes Farré, Achiléa Bittencourt, Becca Asquith, Graham P. Taylor, Charles R. M. Bangham

PLOS Pathogens: published April 4, 2013 | https://doi.org/10.1371/journal.ppat.1003263

Relative Contribution of Th1 and Th17 Cells in Adaptive Immunity to Bordetella pertussis: Towards the Rational Design of an Improved Acellular Pertussis Vaccine

Pádraig J. Ross, Caroline E. Sutton, Sarah Higgins, Aideen C. Allen, Kevin Walsh, Alicja Misiak, Ed C. Lavelle, Rachel M. McLoughlin, Kingston H. G. Mills

PLOS Pathogens: published April 4, 2013 | https://doi.org/10.1371/journal.ppat.1003264

PKR-Like Endoplasmic Reticulum Kinase Is Necessary for Lipogenic Activation during HCMV Infection

Yongjun Yu, Francis J. Pierciey Jr, Tobi G. Maguire, James C. Alwine

PLOS Pathogens: published April 4, 2013 | https://doi.org/10.1371/journal.ppat.1003266

Mobile Genetic Element SCCmec-encoded psm-mec RNA Suppresses Translation of agrA and Attenuates MRSA Virulence

Chikara Kaito, Yuki Saito, Mariko Ikuo, Yosuke Omae, Han Mao, Gentaro Nagano, Tomoko Fujiyuki, Shunsuke Numata, Xiao Han, Kazuaki Obata, Setsuo Hasegawa, Hiroki Yamaguchi, Koiti Inokuchi, Teruyo Ito, Keiichi Hiramatsu, Kazuhisa Sekimizu

PLOS Pathogens: published April 4, 2013 | https://doi.org/10.1371/journal.ppat.1003269

Viral Uncoating Is Directional: Exit of the Genomic RNA in a Common Cold Virus Starts with the Poly-(A) Tail at the 3′-End

Shushan Harutyunyan, Mohit Kumar, Arthur Sedivy, Xavier Subirats, Heinrich Kowalski, Gottfried Köhler, Dieter Blaas

PLOS Pathogens: published April 4, 2013 | https://doi.org/10.1371/journal.ppat.1003270

Rab11-FIP1C and Rab14 Direct Plasma Membrane Sorting and Particle Incorporation of the HIV-1 Envelope Glycoprotein Complex

Mingli Qi, Janice A. Williams, Hin Chu, Xuemin Chen, Jaang-Jiun Wang, Lingmei Ding, Ehiole Akhirome, Xiaoyun Wen, Lynne A. Lapierre, James R. Goldenring, Paul Spearman

PLOS Pathogens: published April 4, 2013 | https://doi.org/10.1371/journal.ppat.1003278

Mycobacterium tuberculosis Responds to Chloride and pH as Synergistic Cues to the Immune Status of its Host Cell

Shumin Tan, Neelima Sukumar, Robert B. Abramovitch, Tanya Parish, David G. Russell

PLOS Pathogens: published April 4, 2013 | https://doi.org/10.1371/journal.ppat.1003282

ATM and ATR Activities Maintain Replication Fork Integrity during SV40 Chromatin Replication

Gregory A. Sowd, Nancy Yan Li, Ellen Fanning

PLOS Pathogens: published April 4, 2013 | https://doi.org/10.1371/journal.ppat.1003283

HPV16 E7 Protein and hTERT Proteins Defective for Telomere Maintenance Cooperate to Immortalize Human Keratinocytes

Jonathan Miller, Aleksandra Dakic, Renxiang Chen, Nancy Palechor-Ceron, Yuhai Dai, Bhaskar Kallakury, Richard Schlegel, Xuefeng Liu

PLOS Pathogens: published April 4, 2013 | https://doi.org/10.1371/journal.ppat.1003284

Post-Transcriptional Regulation of the Trypanosome Heat Shock Response by a Zinc Finger Protein

Dorothea Droll, Igor Minia, Abeer Fadda, Aditi Singh, Mhairi Stewart, Rafael Queiroz, Christine Clayton

PLOS Pathogens: published April 4, 2013 | https://doi.org/10.1371/journal.ppat.1003286

The Plant Actin Cytoskeleton Responds to Signals from Microbe-Associated Molecular Patterns

Jessica L. Henty-Ridilla, Masaki Shimono, Jiejie Li, Jeff H. Chang, Brad Day, Christopher J. Staiger

PLOS Pathogens: published April 4, 2013 | https://doi.org/10.1371/journal.ppat.1003290

Illumination of Murine Gammaherpesvirus-68 Cycle Reveals a Sexual Transmission Route from Females to Males in Laboratory Mice

Sylvie François, Sarah Vidick, Mickaël Sarlet, Daniel Desmecht, Pierre Drion, Philip G. Stevenson, Alain Vanderplasschen, Laurent Gillet

PLOS Pathogens: published April 4, 2013 | https://doi.org/10.1371/journal.ppat.1003292

Comparison of SIV and HIV-1 Genomic RNA Structures Reveals Impact of Sequence Evolution on Conserved and Non-Conserved Structural Motifs

Elizabeth Pollom, Kristen K. Dang, E. Lake Potter, Robert J. Gorelick, Christina L. Burch, Kevin M. Weeks, Ronald Swanstrom

PLOS Pathogens: published April 4, 2013 | https://doi.org/10.1371/journal.ppat.1003294

The JAK-STAT Transcriptional Regulator, STAT-5, Activates the ATM DNA Damage Pathway to Induce HPV 31 Genome Amplification upon Epithelial Differentiation

Shiyuan Hong, Laimonis A. Laimins

PLOS Pathogens: published April 4, 2013 | https://doi.org/10.1371/journal.ppat.1003295

The Pharmaco –, Population and Evolutionary Dynamics of Multi-drug Therapy: Experiments with S. aureus and E. coli and Computer Simulations

Peter Ankomah, Paul J. T. Johnson, Bruce R. Levin

PLOS Pathogens: published April 4, 2013 | https://doi.org/10.1371/journal.ppat.1003300

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Immune regulation during helminth infections

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