August 2012

Alternatively activated macrophages regulate immune responses in the granulomas around S. mansoni eggs. These cells are an important source of retinoic acid and enhance the differentiation of Foxp3⁺ T cell differentiation (see Broadhurst et al., doi:10.1371/journal.ppat.1002883). By intravital confocal imaging, autofluorescent eggs are observed in red, hepatocyte nuclei in blue, and CX₃CR1+ macrophages in green.

Image Credit: Natasha M. Girgis, New York University Langone Medical Center.

Viewpoints

Nonhuman Primate Models for HIV Cure Research

Cristian Apetrei, Ivona Pandrea, John W. Mellors

PLOS Pathogens: published August 30, 2012 | https://doi.org/10.1371/journal.ppat.1002892

Opinion

Routine Use of Microbial Whole Genome Sequencing in Diagnostic and Public Health Microbiology

Claudio U. Köser, Matthew J. Ellington, Edward J. P. Cartwright, Stephen H. Gillespie, Nicholas M. Brown, Mark Farrington, Matthew T. G. Holden, Gordon Dougan, Stephen D. Bentley, Julian Parkhill, Sharon J. Peacock

PLOS Pathogens: published August 2, 2012 | https://doi.org/10.1371/journal.ppat.1002824

Pearls

Bacterial Cell Surface Heterogeneity: A Pathogen's Disguise

Henny C. van der Mei, Henk J. Busscher

PLOS Pathogens: published August 30, 2012 | https://doi.org/10.1371/journal.ppat.1002821

Five Mechanisms of Manipulation by Bacterial Effectors: A Ubiquitous Theme

David M. Anderson, Dara W. Frank

PLOS Pathogens: published August 23, 2012 | https://doi.org/10.1371/journal.ppat.1002823

Fungi and the Rise of Mammals

Arturo Casadevall

PLOS Pathogens: published August 16, 2012 | https://doi.org/10.1371/journal.ppat.1002808

Trichomonosis, a Common Curable STI, and Prostate Carcinogenesis—A Proposed Molecular Mechanism

Siobhan Sutcliffe, Calvin Neace, Nancy S. Magnuson, Raymond Reeves, J. F. Alderete

PLOS Pathogens: published August 9, 2012 | https://doi.org/10.1371/journal.ppat.1002801

Host Defense and Tolerance: Unique Challenges in the Placenta

Varvara B. Zeldovich, Anna I. Bakardjiev

PLOS Pathogens: published August 9, 2012 | https://doi.org/10.1371/journal.ppat.1002804

Phagocyte Responses to Protozoan Infection and How Toxoplasma gondii Meets the Challenge

Eric Y. Denkers, Anne G. Schneider, Sara B. Cohen, Barbara A. Butcher

PLOS Pathogens: published August 2, 2012 | https://doi.org/10.1371/journal.ppat.1002794

Review

Invariant NKT Cells: Regulation and Function during Viral Infection

Jennifer A. Juno, Yoav Keynan, Keith R. Fowke

PLOS Pathogens: published August 16, 2012 | https://doi.org/10.1371/journal.ppat.1002838

Research Articles

Inhibition of Candida parapsilosis Fatty Acid Synthase (Fas2) Induces Mitochondrial Cell Death in Serum

Long Nam Nguyen, Gabriele Vargas Cesar, Giang Thi Thu Le, David L. Silver, Leonardo Nimrichter, Joshua D. Nosanchuk

PLOS Pathogens: published August 30, 2012 | https://doi.org/10.1371/journal.ppat.1002879

Measles Immune Suppression: Lessons from the Macaque Model

Rory D. de Vries, Stephen McQuaid, Geert van Amerongen, Selma Yüksel, R. Joyce Verburgh, Albert D. M. E. Osterhaus, W. Paul Duprex, Rik L. de Swart

PLOS Pathogens: published August 30, 2012 | https://doi.org/10.1371/journal.ppat.1002885

Human Monoclonal Antibody HCV1 Effectively Prevents and Treats HCV Infection in Chimpanzees

Trevor J. Morin, Teresa J. Broering, Brett A. Leav, Barbra M. Blair, Kirk J. Rowley, Elisabeth N. Boucher, Yang Wang, Peter S. Cheslock, Michael Knauber, David B. Olsen, Steve W. Ludmerer, Gyongyi Szabo, Robert W. Finberg, Robert H. Purcell, Robert E. Lanford, Donna M. Ambrosino, Deborah C. Molrine, Gregory J. Babcock

PLOS Pathogens: published August 30, 2012 | https://doi.org/10.1371/journal.ppat.1002895

CPSF6 Defines a Conserved Capsid Interface that Modulates HIV-1 Replication

Amanda J. Price, Adam J. Fletcher, Torsten Schaller, Tom Elliott, KyeongEun Lee, Vineet N. KewalRamani, Jason W. Chin, Greg J. Towers, Leo C. James

PLOS Pathogens: published August 30, 2012 | https://doi.org/10.1371/journal.ppat.1002896

Roles of ATM and ATR-Mediated DNA Damage Responses during Lytic BK Polyomavirus Infection

Mengxi Jiang, Linbo Zhao, Monica Gamez, Michael J. Imperiale

PLOS Pathogens: published August 30, 2012 | https://doi.org/10.1371/journal.ppat.1002898

Establishment of a Reverse Genetics System for Studying Human Bocavirus in Human Airway Epithelia

Qinfeng Huang, Xuefeng Deng, Ziying Yan, Fang Cheng, Yong Luo, Weiran Shen, Diana C. M. Lei-Butters, Aaron Yun Chen, Yi Li, Liang Tang, Maria Söderlund-Venermo, John F. Engelhardt, Jianming Qiu

PLOS Pathogens: published August 30, 2012 | https://doi.org/10.1371/journal.ppat.1002899

Telomere Length Affects the Frequency and Mechanism of Antigenic Variation in Trypanosoma brucei

Galadriel A. Hovel-Miner, Catharine E. Boothroyd, Monica Mugnier, Oliver Dreesen, George A. M. Cross, F. Nina Papavasiliou

PLOS Pathogens: published August 30, 2012 | https://doi.org/10.1371/journal.ppat.1002900

Ablation of the Regulatory IE1 Protein of Murine Cytomegalovirus Alters In Vivo Pro-inflammatory TNF-alpha Production during Acute Infection

Sara Rodríguez-Martín, Kai Alexander Kropp, Vanessa Wilhelmi, Vanda Juranic Lisnic, Wei Yuan Hsieh, Mathieu Blanc, Andrew Livingston, Andreas Busche, Hille Tekotte, Martin Messerle, Manfred Auer, Iain Fraser, Stipan Jonjic, Ana Angulo, Matthias J. Reddehase, Peter Ghazal

PLOS Pathogens: published August 30, 2012 | https://doi.org/10.1371/journal.ppat.1002901

A Novel Virulence Strategy for Pseudomonas aeruginosa Mediated by an Autotransporter with Arginine-Specific Aminopeptidase Activity

Jeni C. A. Luckett, Owen Darch, Chase Watters, Manal AbuOun, Victoria Wright, Esteban Paredes-Osses, Jenny Ward, Hana Goto, Stephan Heeb, Stéphanie Pommier, Kendra P. Rumbaugh, Miguel Cámara, Kim R. Hardie

PLOS Pathogens: published August 23, 2012 | https://doi.org/10.1371/journal.ppat.1002854

The Irish Potato Famine Pathogen Phytophthora infestans Translocates the CRN8 Kinase into Host Plant Cells

Mireille van Damme, Tolga O. Bozkurt, Cahid Cakir, Sebastian Schornack, Jan Sklenar, Alexandra M. E. Jones, Sophien Kamoun

PLOS Pathogens: published August 23, 2012 | https://doi.org/10.1371/journal.ppat.1002875

A Unique Bivalent Binding and Inhibition Mechanism by the Yatapoxvirus Interleukin 18 Binding Protein

Brian Krumm, Xiangzhi Meng, Zhixin Wang, Yan Xiang, Junpeng Deng

PLOS Pathogens: published August 23, 2012 | https://doi.org/10.1371/journal.ppat.1002876

Elucidation of Hepatitis C Virus Transmission and Early Diversification by Single Genome Sequencing

Hui Li, Mark B. Stoddard, Shuyi Wang, Lily M. Blair, Elena E. Giorgi, Erica H. Parrish, Gerald H. Learn, Peter Hraber, Paul A. Goepfert, Michael S. Saag, Thomas N. Denny, Barton F. Haynes, Beatrice H. Hahn, Ruy M. Ribeiro, Alan S. Perelson, Bette T. Korber, Tanmoy Bhattacharya, George M. Shaw

PLOS Pathogens: published August 23, 2012 | https://doi.org/10.1371/journal.ppat.1002880

Quantifying the Diversification of Hepatitis C Virus (HCV) during Primary Infection: Estimates of the In Vivo Mutation Rate

Ruy M. Ribeiro, Hui Li, Shuyi Wang, Mark B. Stoddard, Gerald H. Learn, Bette T. Korber, Tanmoy Bhattacharya, Jeremie Guedj, Erica H. Parrish, Beatrice H. Hahn, George M. Shaw, Alan S. Perelson

PLOS Pathogens: published August 23, 2012 | https://doi.org/10.1371/journal.ppat.1002881

Surface α-1,3-Glucan Facilitates Fungal Stealth Infection by Interfering with Innate Immunity in Plants

Takashi Fujikawa, Ayumu Sakaguchi, Yoko Nishizawa, Yusuke Kouzai, Eiichi Minami, Shigekazu Yano, Hironori Koga, Tetsuo Meshi, Marie Nishimura

PLOS Pathogens: published August 23, 2012 | https://doi.org/10.1371/journal.ppat.1002882

Upregulation of Retinal Dehydrogenase 2 in Alternatively Activated Macrophages during Retinoid-dependent Type-2 Immunity to Helminth Infection in Mice

Mara J. Broadhurst, Jacqueline M. Leung, K. C. Lim, Natasha M. Girgis, Uma Mahesh Gundra, Padraic G. Fallon, Mary Premenko-Lanier, James H. McKerrow, Joseph M. McCune, P'ng Loke

PLOS Pathogens: published August 23, 2012 | https://doi.org/10.1371/journal.ppat.1002883

Ago HITS-CLIP Expands Understanding of Kaposi's Sarcoma-associated Herpesvirus miRNA Function in Primary Effusion Lymphomas

Irina Haecker, Lauren A. Gay, Yajie Yang, Jianhong Hu, Alison M. Morse, Lauren M. McIntyre, Rolf Renne

PLOS Pathogens: published August 23, 2012 | https://doi.org/10.1371/journal.ppat.1002884

Protease Cleavage Leads to Formation of Mature Trimer Interface in HIV-1 Capsid

Xin Meng, Gongpu Zhao, Ernest Yufenyuy, Danxia Ke, Jiying Ning, Maria DeLucia, Jinwoo Ahn, Angela M. Gronenborn, Christopher Aiken, Peijun Zhang

PLOS Pathogens: published August 23, 2012 | https://doi.org/10.1371/journal.ppat.1002886

Abc3-Mediated Efflux of an Endogenous Digoxin-like Steroidal Glycoside by Magnaporthe oryzae Is Necessary for Host Invasion during Blast Disease

Rajesh N. Patkar, Yang Kui Xue, Guanghou Shui, Markus R. Wenk, Naweed I. Naqvi

PLOS Pathogens: published August 23, 2012 | https://doi.org/10.1371/journal.ppat.1002888

ADCC Develops Over Time during Persistent Infection with Live-Attenuated SIV and Is Associated with Complete Protection against SIV_mac251 Challenge

Michael D. Alpert, Jackson D. Harvey, W. Anderson Lauer, R. Keith Reeves, Michael Piatak Jr., Angela Carville, Keith G. Mansfield, Jeffrey D. Lifson, Wenjun Li, Ronald C. Desrosiers, R. Paul Johnson, David T. Evans

PLOS Pathogens: published August 23, 2012 | https://doi.org/10.1371/journal.ppat.1002890

CD160 and PD-1 Co-Expression on HIV-Specific CD8 T Cells Defines a Subset with Advanced Dysfunction

Yoav Peretz, Zhong He, Yu Shi, Bader Yassine-Diab, Jean-Philippe Goulet, Rebeka Bordi, Ali Filali-Mouhim, Jean-Baptiste Loubert, Mohamed El-Far, Franck P. Dupuy, Mohamed Rachid Boulassel, Cécile Tremblay, Jean-Pierre Routy, Nicole Bernard, Robert Balderas, Elias K. Haddad, Rafick-Pierre Sékaly

PLOS Pathogens: published August 16, 2012 | https://doi.org/10.1371/journal.ppat.1002840

Asparagine Endopeptidase Controls Anti-Influenza Virus Immune Responses through TLR7 Activation

Sophia Maschalidi, Signe Hässler, Fany Blanc, Fernando E. Sepulveda, Mira Tohme, Michel Chignard, Peter van Endert, Mustapha Si-Tahar, Delphyne Descamps, Bénédicte Manoury

PLOS Pathogens: published August 16, 2012 | https://doi.org/10.1371/journal.ppat.1002841

Identification and Targeting of an Interaction between a Tyrosine Motif within Hepatitis C Virus Core Protein and AP2M1 Essential for Viral Assembly

Gregory Neveu, Rina Barouch-Bentov, Amotz Ziv-Av, Doron Gerber, Yves Jacob, Shirit Einav

PLOS Pathogens: published August 16, 2012 | https://doi.org/10.1371/journal.ppat.1002845

Cytomegalovirus Infection Impairs Immune Responses and Accentuates T-cell Pool Changes Observed in Mice with Aging

Luka Cicin-Sain, James D. Brien, Jennifer L. Uhrlaub, Anja Drabig, Thomas F. Marandu, Janko Nikolich-Zugich

PLOS Pathogens: published August 16, 2012 | https://doi.org/10.1371/journal.ppat.1002849

Immune Senescence: Relative Contributions of Age and Cytomegalovirus Infection

Andrea Mekker, Vincent S. Tchang, Lea Haeberli, Annette Oxenius, Alexandra Trkola, Urs Karrer

PLOS Pathogens: published August 16, 2012 | https://doi.org/10.1371/journal.ppat.1002850

Self-Enhancement of Hepatitis C Virus Replication by Promotion of Specific Sphingolipid Biosynthesis

Yuichi Hirata, Kazutaka Ikeda, Masayuki Sudoh, Yuko Tokunaga, Akemi Suzuki, Leiyun Weng, Masatoshi Ohta, Yoshimi Tobita, Ken Okano, Kazuhisa Ozeki, Kenichi Kawasaki, Takuo Tsukuda, Asao Katsume, Yuko Aoki, Takuya Umehara, Satoshi Sekiguchi, Tetsuya Toyoda, Kunitada Shimotohno, Tomoyoshi Soga, Masahiro Nishijima, Ryo Taguchi, Michinori Kohara

PLOS Pathogens: published August 16, 2012 | https://doi.org/10.1371/journal.ppat.1002860

Functional Genomic Analysis of Candida glabrata-Macrophage Interaction: Role of Chromatin Remodeling in Virulence

Maruti Nandan Rai, Sriram Balusu, Neelima Gorityala, Lakshmi Dandu, Rupinder Kaur

PLOS Pathogens: published August 16, 2012 | https://doi.org/10.1371/journal.ppat.1002863

Chemokine Receptor Ccr1 Drives Neutrophil-Mediated Kidney Immunopathology and Mortality in Invasive Candidiasis

Michail S. Lionakis, Brett G. Fischer, Jean K. Lim, Muthulekha Swamydas, Wuzhou Wan, Chyi-Chia Richard Lee, Jeffrey I. Cohen, Phillip Scheinberg, Ji-Liang Gao, Philip M. Murphy

PLOS Pathogens: published August 16, 2012 | https://doi.org/10.1371/journal.ppat.1002865

Global Metabolic Profiling of Infection by an Oncogenic Virus: KSHV Induces and Requires Lipogenesis for Survival of Latent Infection

Tracie Delgado, Erica L. Sanchez, Roman Camarda, Michael Lagunoff

PLOS Pathogens: published August 16, 2012 | https://doi.org/10.1371/journal.ppat.1002866

Convergent Evolution of Argonaute-2 Slicer Antagonism in Two Distinct Insect RNA Viruses

Joël T. van Mierlo, Alfred W. Bronkhorst, Gijs J. Overheul, Sajna A. Sadanandan, Jens-Ola Ekström, Marco Heestermans, Dan Hultmark, Christophe Antoniewski, Ronald P. van Rij

PLOS Pathogens: published August 16, 2012 | https://doi.org/10.1371/journal.ppat.1002872

Listeria monocytogenes Cytoplasmic Entry Induces Fetal Wastage by Disrupting Maternal Foxp3⁺ Regulatory T Cell-Sustained Fetal Tolerance

Jared H. Rowe, James M. Ertelt, Lijun Xin, Sing Sing Way

PLOS Pathogens: published August 16, 2012 | https://doi.org/10.1371/journal.ppat.1002873

IFNγ Inhibits the Cytosolic Replication of Shigella flexneri via the Cytoplasmic RNA Sensor RIG-I

Stephanie P. Jehl, Catarina V. Nogueira, Xuqing Zhang, Michael N. Starnbach

PLOS Pathogens: published August 9, 2012 | https://doi.org/10.1371/journal.ppat.1002809

HSV-1 Genome Subnuclear Positioning and Associations with Host-Cell PML-NBs and Centromeres Regulate LAT Locus Transcription during Latency in Neurons

Frédéric Catez, Christel Picard, Kathrin Held, Sylvain Gross, Antoine Rousseau, Diethilde Theil, Nancy Sawtell, Marc Labetoulle, Patrick Lomonte

PLOS Pathogens: published August 9, 2012 | https://doi.org/10.1371/journal.ppat.1002852

The Human Adenovirus Type 5 E1B 55 kDa Protein Obstructs Inhibition of Viral Replication by Type I Interferon in Normal Human Cells

Jasdave S. Chahal, Ji Qi, S. J. Flint

PLOS Pathogens: published August 9, 2012 | https://doi.org/10.1371/journal.ppat.1002853

Structure of the Ulster Strain Newcastle Disease Virus Hemagglutinin-Neuraminidase Reveals Auto-Inhibitory Interactions Associated with Low Virulence

Ping Yuan, Reay G. Paterson, George P. Leser, Robert A. Lamb, Theodore S. Jardetzky

PLOS Pathogens: published August 9, 2012 | https://doi.org/10.1371/journal.ppat.1002855

Surface Proteome Analysis and Characterization of Surface Cell Antigen (Sca) or Autotransporter Family of Rickettsia typhi

Khandra T. Sears, Shane M. Ceraul, Joseph J. Gillespie, Edwin D. Allen Jr., Vsevolod L. Popov, Nicole C. Ammerman, M. Sayeedur Rahman, Abdu F. Azad

PLOS Pathogens: published August 9, 2012 | https://doi.org/10.1371/journal.ppat.1002856

Encephalomyocarditis Virus Viroporin 2B Activates NLRP3 Inflammasome

Minako Ito, Yusuke Yanagi, Takeshi Ichinohe

PLOS Pathogens: published August 9, 2012 | https://doi.org/10.1371/journal.ppat.1002857

Arrest of Nuclear Division in Plasmodium through Blockage of Erythrocyte Surface Exposed Ribosomal Protein P2

Sudipta Das, Himanish Basu, Reshma Korde, Rita Tewari, Shobhona Sharma

PLOS Pathogens: published August 9, 2012 | https://doi.org/10.1371/journal.ppat.1002858

The HSV-1 Exonuclease, UL12, Stimulates Recombination by a Single Strand Annealing Mechanism

April J. Schumacher, Kareem N. Mohni, Yinan Kan, Eric A. Hendrickson, Jeremy M. Stark, Sandra K. Weller

PLOS Pathogens: published August 9, 2012 | https://doi.org/10.1371/journal.ppat.1002862

Genome-Wide Analysis of Germline Signaling Genes Regulating Longevity and Innate Immunity in the Nematode Pristionchus pacificus

Robbie Rae, Amit Sinha, Ralf J. Sommer

PLOS Pathogens: published August 9, 2012 | https://doi.org/10.1371/journal.ppat.1002864

Lymphotoxin, but Not TNF, Is Required for Prion Invasion of Lymph Nodes

Tracy O'Connor, Nathalie Frei, Jana Sponarova, Petra Schwarz, Mathias Heikenwalder, Adriano Aguzzi

PLOS Pathogens: published August 9, 2012 | https://doi.org/10.1371/journal.ppat.1002867

Interferon-alpha Subtype 11 Activates NK Cells and Enables Control of Retroviral Infection

Kathrin Gibbert, Jara J. Joedicke, Andreas Meryk, Mirko Trilling, Sandra Francois, Janine Duppach, Anke Kraft, Karl S. Lang, Ulf Dittmer

PLOS Pathogens: published August 9, 2012 | https://doi.org/10.1371/journal.ppat.1002868

Transposon-mediated Chromosomal Integration of Transgenes in the Parasitic Nematode Strongyloides ratti and Establishment of Stable Transgenic Lines

Hongguang Shao, Xinshe Li, Thomas J. Nolan, Holman C. Massey Jr., Edward J. Pearce, James B. Lok

PLOS Pathogens: published August 9, 2012 | https://doi.org/10.1371/journal.ppat.1002871

Identification of MrtAB, an ABC Transporter Specifically Required for Yersinia pseudotuberculosis to Colonize the Mesenteric Lymph Nodes

Gregory T. Crimmins, Sina Mohammadi, Erin R. Green, Molly A. Bergman, Ralph R. Isberg, Joan Mecsas

PLOS Pathogens: published August 2, 2012 | https://doi.org/10.1371/journal.ppat.1002828

Structural and Biochemical Basis for Development of Influenza Virus Inhibitors Targeting the PA Endonuclease

Rebecca M. DuBois, P. Jake Slavish, Brandi M. Baughman, Mi-Kyung Yun, Ju Bao, Richard J. Webby, Thomas R. Webb, Stephen W. White

PLOS Pathogens: published August 2, 2012 | https://doi.org/10.1371/journal.ppat.1002830

Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza pH1N1 (2009) Polymerase

Eva Kowalinski, Chloe Zubieta, Andrea Wolkerstorfer, Oliver H. J. Szolar, Rob W. H. Ruigrok, Stephen Cusack

PLOS Pathogens: published August 2, 2012 | https://doi.org/10.1371/journal.ppat.1002831

AsrR Is an Oxidative Stress Sensing Regulator Modulating Enterococcus faecium Opportunistic Traits, Antimicrobial Resistance, and Pathogenicity

François Lebreton, Willem van Schaik, Maurizio Sanguinetti, Brunella Posteraro, Riccardo Torelli, Florian Le Bras, Nicolas Verneuil, Xinglin Zhang, Jean-Christophe Giard, Anne Dhalluin, Rob J. L. Willems, Roland Leclercq, Vincent Cattoir

PLOS Pathogens: published August 2, 2012 | https://doi.org/10.1371/journal.ppat.1002834

Small Protease Sensitive Oligomers of PrP^Sc in Distinct Human Prions Determine Conversion Rate of PrP^C

Chae Kim, Tracy Haldiman, Krystyna Surewicz, Yvonne Cohen, Wei Chen, Janis Blevins, Man-Sun Sy, Mark Cohen, Qingzhong Kong, Glenn C. Telling, Witold K. Surewicz, Jiri G. Safar

PLOS Pathogens: published August 2, 2012 | https://doi.org/10.1371/journal.ppat.1002835

Cedar Virus: A Novel Henipavirus Isolated from Australian Bats

Glenn A. Marsh, Carol de Jong, Jennifer A. Barr, Mary Tachedjian, Craig Smith, Deborah Middleton, Meng Yu, Shawn Todd, Adam J. Foord, Volker Haring, Jean Payne, Rachel Robinson, Ivano Broz, Gary Crameri, Hume E. Field, Lin-Fa Wang

PLOS Pathogens: published August 2, 2012 | https://doi.org/10.1371/journal.ppat.1002836

Natural Transformation Facilitates Transfer of Transposons, Integrons and Gene Cassettes between Bacterial Species

Sara Domingues, Klaus Harms, W. Florian Fricke, Pål J. Johnsen, Gabriela J. da Silva, Kaare Magne Nielsen

PLOS Pathogens: published August 2, 2012 | https://doi.org/10.1371/journal.ppat.1002837

Uridine Composition of the Poly-U/UC Tract of HCV RNA Defines Non-Self Recognition by RIG-I

Gretja Schnell, Yueh-Ming Loo, Joseph Marcotrigiano, Michael Gale Jr.

PLOS Pathogens: published August 2, 2012 | https://doi.org/10.1371/journal.ppat.1002839

CPAF: A Chlamydial Protease in Search of an Authentic Substrate

Allan L. Chen, Kirsten A. Johnson, Jennifer K. Lee, Christine Sütterlin, Ming Tan

PLOS Pathogens: published August 2, 2012 | https://doi.org/10.1371/journal.ppat.1002842

Bap, a Biofilm Matrix Protein of Staphylococcus aureus Prevents Cellular Internalization through Binding to GP96 Host Receptor

Jaione Valle, Cristina Latasa, Carmen Gil, Alejandro Toledo-Arana, Cristina Solano, José R. Penadés, Iñigo Lasa

PLOS Pathogens: published August 2, 2012 | https://doi.org/10.1371/journal.ppat.1002843

Exon Level Transcriptomic Profiling of HIV-1-Infected CD4⁺ T Cells Reveals Virus-Induced Genes and Host Environment Favorable for Viral Replication

Michaël Imbeault, Katia Giguère, Michel Ouellet, Michel J. Tremblay

PLOS Pathogens: published August 2, 2012 | https://doi.org/10.1371/journal.ppat.1002861

Cover

Macrophages in a liver granuloma around Schistosoma mansoni eggs.

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**Macrophages in a liver granuloma around Schistosoma mansoni eggs.**