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Table of Contents

March 2006

Cover

XMRV-infected stromal cells
Issue Image

A novel gammaretrovirus, XMRV, has been identified in a set of tumor samples from patients with prostate cancer. XMRV was found almost exclusively in prostates of men homozygous for a common RNase L variant, R462Q, previously associated with increased risk of prostate cancer (see Urisman et al).

Image Credit: XMRV-infected stromal cells are detected in prostate tumor sections by fluorescence in situ hybridization. Green represents XMRV nucleic acid, and blue represents DAPI-stained nuclei. Photo by Ross J. Molinaro.

Opinion

The Integration Hypothesis: An Evolutionary Pathway to Benign SIV Infection

Viktor Müller, Rob J De Boer

PLOS Pathogens: published March 31, 2006 | https://doi.org/10.1371/journal.ppat.0020015

Review

The Expanding Universe of Prion Diseases

Joel C Watts, Aru Balachandran, David Westaway

PLOS Pathogens: published March 31, 2006 | https://doi.org/10.1371/journal.ppat.0020026

Research Articles

Specific Remodeling of Splenic Architecture by Cytomegalovirus

Chris A Benedict, Carl De Trez, Kirsten Schneider, Sukwon Ha, Ginelle Patterson, Carl F Ware

PLOS Pathogens: published March 3, 2006 | https://doi.org/10.1371/journal.ppat.0020016

Flagellin-Deficient Legionella Mutants Evade Caspase-1- and Naip5-Mediated Macrophage Immunity

Tao Ren, Dario S Zamboni, Craig R Roy, William F Dietrich, Russell E Vance

PLOS Pathogens: published March 17, 2006 | https://doi.org/10.1371/journal.ppat.0020018

Borna Disease Virus Blocks Potentiation of Presynaptic Activity through Inhibition of Protein Kinase C Signaling

Romain Volmer, Céline Monnet, Daniel Gonzalez-Dunia

PLOS Pathogens: published March 17, 2006 | https://doi.org/10.1371/journal.ppat.0020019

Control of the C. albicans Cell Wall Damage Response by Transcriptional Regulator Cas5

Vincent M Bruno, Sergey Kalachikov, Ryan Subaran, Clarissa J Nobile, Christos Kyratsous, Aaron P Mitchell

PLOS Pathogens: published March 17, 2006 | https://doi.org/10.1371/journal.ppat.0020021

Mutually Exclusive Expression of Virulence Genes by Malaria Parasites Is Regulated Independently of Antigen Production

Ron Dzikowski, Matthias Frank, Kirk Deitsch

PLOS Pathogens: published March 3, 2006 | https://doi.org/10.1371/journal.ppat.0020022

Epstein–Barr Virus MicroRNAs Are Evolutionarily Conserved and Differentially Expressed

Xuezhong Cai, Alexandra Schäfer, Shihua Lu, John P Bilello, Ronald C Desrosiers, Rachel Edwards, Nancy Raab-Traub, Bryan R Cullen

PLOS Pathogens: published March 24, 2006 | https://doi.org/10.1371/journal.ppat.0020023

Ancestral Genomes, Sex, and the Population Structure of Trypanosoma cruzi

Jorge M. de Freitas, Luiz Augusto-Pinto, Juliana R Pimenta, Luciana Bastos-Rodrigues, Vanessa F Gonçalves, Santuza M. R Teixeira, Egler Chiari, Ângela C. V Junqueira, Octavio Fernandes, Andréa M Macedo, Carlos Renato Machado, Sérgio D. J Pena

PLOS Pathogens: published March 31, 2006 | https://doi.org/10.1371/journal.ppat.0020024

Identification of a Novel Gammaretrovirus in Prostate Tumors of Patients Homozygous for R462Q RNASEL Variant

Anatoly Urisman, Ross J Molinaro, Nicole Fischer, Sarah J Plummer, Graham Casey, Eric A Klein, Krishnamurthy Malathi, Cristina Magi-Galluzzi, Raymond R Tubbs, Don Ganem, Robert H Silverman, Joseph L DeRisi

PLOS Pathogens: published March 31, 2006 | https://doi.org/10.1371/journal.ppat.0020025

Related Articles

  1. Retraction: Identification of a Novel Gammaretrovirus in Prostate Tumors of Patients Homozygous for R462Q RNASEL Variant