Figures
Chronic bladder infection by E. coli strain CFT073 causes mucosal remodeling that lasts after antibiotic therapy
Immunofluorescence microscopy was used to stain for bladder epithelial differentiation markers like keratin 20 (white) and Trp63 (red). We found that mice with a history of chronic bladder infection had aberrant epithelial differentiation and bladder mucosal remodeling that persisted after antibiotic treatment and increased their susceptibility to recurrent infections. O'Brien et al.
Image Credit: Valerie P. O'Brien, Denise A. Dorsey, Thomas J. Hannan, Scott J. Hultgren
Citation: (2018) PLoS Pathogens Issue Image | Vol. 14(12) December 2018. PLoS Pathog 14(12): ev14.i12. https://doi.org/10.1371/image.ppat.v14.i12
Published: December 31, 2018
Copyright: © 2018 O'Brien, Dorsey, Hannan, Hultgren. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Immunofluorescence microscopy was used to stain for bladder epithelial differentiation markers like keratin 20 (white) and Trp63 (red). We found that mice with a history of chronic bladder infection had aberrant epithelial differentiation and bladder mucosal remodeling that persisted after antibiotic treatment and increased their susceptibility to recurrent infections. O'Brien et al.
Image Credit: Valerie P. O'Brien, Denise A. Dorsey, Thomas J. Hannan, Scott J. Hultgren