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PLoS Pathogens Issue Image | Vol. 14(12) December 2018

PLoS Pathogens Issue Image | Vol. 14(12) December 2018

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Chronic bladder infection by E. coli strain CFT073 causes mucosal remodeling that lasts after antibiotic therapy

Immunofluorescence microscopy was used to stain for bladder epithelial differentiation markers like keratin 20 (white) and Trp63 (red). We found that mice with a history of chronic bladder infection had aberrant epithelial differentiation and bladder mucosal remodeling that persisted after antibiotic treatment and increased their susceptibility to recurrent infections. O'Brien et al.

Image Credit: Valerie P. O'Brien, Denise A. Dorsey, Thomas J. Hannan, Scott J. Hultgren

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Chronic bladder infection by E. coli strain CFT073 causes mucosal remodeling that lasts after antibiotic therapy

Immunofluorescence microscopy was used to stain for bladder epithelial differentiation markers like keratin 20 (white) and Trp63 (red). We found that mice with a history of chronic bladder infection had aberrant epithelial differentiation and bladder mucosal remodeling that persisted after antibiotic treatment and increased their susceptibility to recurrent infections. O'Brien et al.

Image Credit: Valerie P. O'Brien, Denise A. Dorsey, Thomas J. Hannan, Scott J. Hultgren

https://doi.org/10.1371/image.ppat.v14.i12.g001